Dexamethasone increases the release of three 44 kD proteins immunologically related to plasminogen activator inhibitor-1 from human umbilical vein endothelial and rabbit coronary microvessel endothelial cells.

abstract：:The diagnosis of preeclampsia, with all of its consequences, is at times difficult to establish, especially when the patient has underlying chronic hypertension and is not known from prior prenatal care visits. Many screening tests have been proposed. These should be sensitive, relatively specific, easy to perform, of...

journal_title：Thrombosis research

authors： Saleh AA,Bottoms SF,Gerbasi FR,Mammen EF

更新日期：1994-07-15 00:00:00

abstract：:The complex relation between thrombotic thrombocytopenic purpura (TTP) and pregnancy is concisely reviewed. Pregnancy is a very strong trigger for acute disease manifestation in patients with hereditary TTP caused by double heterozygous or homozygous mutations of ADAMTS13 (ADisintegrin And Metalloprotease with Thrombo...

journal_title：Thrombosis research

authors： von Auer C,von Krogh AS,Kremer Hovinga JA,Lämmle B

更新日期：2015-02-01 00:00:00

abstract：:The Calibrated Automated Thrombogram (CAT), a plate-based assay that measures thrombin generation and inhibition in plasma samples, is modified to measure the procoagulant activity of phospholipid associated with plasma microparticles (MP). The assay uses a tissue factor trigger without addition of 4 μM exogenous phos...

journal_title：Thrombosis research

authors： Owen BA,Xue A,Heit JA,Owen WG

更新日期：2011-01-01 00:00:00

abstract：:Effects of Ca2+ on phospholipid methylation in rabbit platelet membranes were studied using S-adenosyl-L-[3H-methyl]methionine as a substrate. The methylation was inhibited to 30% of the basal activity with 100 microM Ca2+. The inhibition was completely counteracted by various calmodulin antagonists. Their concentrati...

journal_title：Thrombosis research

authors： Taniguchi S,Mori K,Hayashi H,Fujiwara M,Fujiwara M

更新日期：1983-12-01 00:00:00

abstract：BACKGROUND:Integrin αIIbβ3 mediates platelet adhesion, aggregation and fibrin clot retraction. These processes require activation of αIIbβ3 and post-ligation signaling. Disulfide bond exchanges are involved in αIIbβ3 and αvβ3 activation. METHODS:In order to investigate the role of integrin activation and disulfide bon...

journal_title：Thrombosis research

authors： Mor-Cohen R,Rosenberg N,Averbukh Y,Seligsohn U,Lahav J

更新日期：2014-05-01 00:00:00

abstract：:The susceptibility of von Willebrand factor /vWF/ to digestion by human neutrophil cathepsin G in highly purified FVIII/vWF concentrate /BHS/ and in cryoprecipitate has been studied. In contrast to human neutrophil elastase, cathepsin G inactivates and degrades vWF not only in BHS but also in cryoprecipitate. Fibrinog...

journal_title：Thrombosis research

authors： Jeleńska M,Kopeć M,Sopata I,Vigh Z,Scharrer I,Breddin K

更新日期：1991-02-15 00:00:00

abstract：:Hemorrhagic tendency is frequent in uremic patients and is often associated with prolonged bleeding time and decreased platelet functions in vitro. Similarly, in multiple myeloma, platelet functions are affected, mainly by the inhibitory effect of paraprotein. We have studied patients with renal insufficiency and mult...

journal_title：Thrombosis research

authors： Cieslar P,Másová L,Scheiner T,Rysavá J,Krízová P,Danzigová Z,Spicka I,Tesar V

更新日期：2002-02-15 00:00:00

abstract：:Defibrotide (D) was labelled with 125I or with 32P. The radiolabelled compounds ([125I]-Defibrotide ([125I]-D), [32P]-Defibrotide ([32P]-D) retained the same profibrinolytic activity, in vitro, as the parent drug, suggesting that the labelling procedures had not modified the pharmacological properties of D and hence t...

journal_title：Thrombosis research

authors： Fisher J,Holland TK,Pescador R,Porta R,Ferro L

更新日期：1996-01-01 00:00:00

abstract：:We characterized a platelet specific alloantigen (Yukb). In immunoblotting, anti-Yukb antibody was found to react with both 110 kDa and 96 kDa bands under nonreducing condition. Immunoblotting followed by separation by two-dimensional electrophoresis (isoelectric focusing/SDS-PAGE) showed that the 96 kDa band had a pI...

journal_title：Thrombosis research

authors： Sugano W,Ryo R,Yamaguchi N,Shibata Y

更新日期：1992-07-15 00:00:00

abstract：INTRODUCTION:Aging and renal impairment may prolong the half-life and lead to accumulation of low molecular weight heparins. Correct dosing is critical to prevent bleeding or thrombosis. MATERIALS AND METHODS:Open, parallel study. Healthy adult [n=13] and elderly (>65yrs) [n=12] volunteers; and subjects with mild (ClC...

journal_title：Thrombosis research

authors： Rico S,Antonijoan RM,Ballester MR,Gutierro I,Ayani I,Martinez-Gonzalez J,Borrell M,Fontcuberta J,Gich I

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND:Clinical and epidemiological studies have associated selective COX-2 inhibitors with an increased risk of cardiovascular events. There are no clinical studies on the possible effects of these drugs on secondary hemostasis. The hypothesis for this study is that the use of selective COX-2 inhibitors could affe...

journal_title：Thrombosis research

authors： Schjerning O,Larsen TB,Damkier P

更新日期：2009-06-01 00:00:00

abstract：:Factor IX Nagoya 3 (IX Nagoya 3) is a natural mutant of factor IX recognized in a patient with moderately severe hemophilia B. The patient had 0.60 units/ml of factor IX antigen and 2-5% of clotting activity. IX Nagoya 3 was purified from the patient's plasma by immunoaffinity chromatography with an anti-factor IX mon...

journal_title：Thrombosis research

authors： Suehiro K,Miyata T,Takeya H,Takamatsu J,Saito H,Murakawa M,Okamura T,Niho Y,Iwanaga S

更新日期：1990-11-15 00:00:00

abstract：:Arthral, abdominal and renal symptoms in Henoch-Schönlein purpura (HSP) were scored. Coagulation factor XIII (F XIII) activity was determined in fifty-six children with HSP and the correlation with the severity score of the clinical symptoms was investigated. As a result, it was found that the decrease in F XIII level...

journal_title：Thrombosis research

authors： Fukui H,Kamitsuji H,Nagao T,Yamada K,Akatsuka J,Inagaki M,Shike S,Kobayashi Y,Yoshioka K,Maki S

更新日期：1989-12-15 00:00:00

abstract：:The three polypeptide chains of fibrinogen, A alpha, B beta and gamma chain, are synthesized on separate polysomes. Fully formed fibrinogen is a six chain, disulfide-linked, dimeric molecule with a molecular weight of 340kDa. Previous pulse-chase studies with L-35 S methionine using the human hepatocellular carcinoma ...

journal_title：Thrombosis research

authors： Yu S,Kong V,Kudryk B,Redman C

更新日期：1987-04-15 00:00:00

abstract：:We previously reported that the expression of thrombomodulin on the MEG-01, a cell line from human megakaryoblastic leukemia, was increased by agents that increase intracellular cAMP. In this paper we examine the effect of these agents on cultured human umbilical vein endothelial cells (HUVEC) and mouse hemangioma cel...

journal_title：Thrombosis research

authors： Maruyama I,Soejima Y,Osame M,Ito T,Ogawa K,Yamamoto S,Dittman WA,Saito H

更新日期：1991-02-01 00:00:00

abstract：:A synthetic xanthone derivative, 3-[2-(cyclopropylamino)ethoxy] xanthone (CPEX), was investigated for its antiplatelet activities in washed rabbit platelets and human platelet-rich plasma. CPEX inhibited concentration-dependently the aggregation and ATP release of rabbit platelets caused by arachidonic acid (AA; 100 m...

journal_title：Thrombosis research

authors： Chen WY,Ko FN,Lin CN,Teng CM

更新日期：1994-07-01 00:00:00

abstract：:The purpose of this study was to investigate the effects of tissue factor (thromboplastin), the initiating factor of the extrinsic clotting system, on angiogenesis in vivo and in vitro. In vivo angiogenesis was examined using a diffusion chamber assay in rats. After a week of implantation of the diffusion chambers con...

journal_title：Thrombosis research

authors： Watanabe T,Yasuda M,Yamamoto T

更新日期：1999-11-01 00:00:00

abstract：:Activation of washed platelets in the presence of EDTA with either 1 U/ml of alpha-thrombin or 2 microM calcium ionophore (A23187) caused the release of one-third to one-half of the platelet factor VIII/von Willebrand factor (FVIII/vWF) into the supernatant. When calcium was present in excess, only 10% of the platelet...

journal_title：Thrombosis research

authors： Furby FH,Berndt MC,Castaldi PA,Koutts J

更新日期：1984-09-01 00:00:00

abstract：:The efficacy and the safety of a new urokinase dosage regimen (loading dose 250,000 IU, initial maintenance dosage 2,000 IU/kg/h in combination with heparin) was studied in ten cases of deep vein thrombosis with regard to the changes of the blood coagulation and fibrinolytic enzyme system. The coagulation analyses dem...

journal_title：Thrombosis research

authors： Schöffel G,Zimmermann R,Harenberg J,Mörl H

更新日期：1982-01-01 00:00:00

abstract：:Understanding the intracellular events triggered by antiphospholipid (aPL) antibodies in platelets and endothelial cells (ECs) is important in designing new modalities of targeted therapies for the treatment of thrombosis in Antiphospholipid Syndrome (APS). A recent study showed a significant increase in the expressio...

journal_title：Thrombosis research

authors： Pierangeli SS,Vega-Ostertag M,Harris EN

更新日期：2004-01-01 00:00:00

abstract：INTRODUCTION:Electronic consultations (eConsults) are asynchronous, consultative electronic-based communications that are aimed to improve efficient and timely access to specialist advice. Our study aim was to evaluate the use and impact of the Canadian Champlain BASE™ (Building Access to Specialists through eConsultat...

journal_title：Thrombosis research

authors： Skeith L,Mohamed M,Karovitch A,Liddy C,Afkham A,Archibald D,Keely E

更新日期：2017-12-01 00:00:00

abstract：:Thrombus formation was electrically induced in the left common carotid artery of rats with preoccluded both vertebral and right carotid arteries. Following thrombus induction, animals became unresponsive and lost their righting reflex. The loss of righting reflex was observed when cortical tissular pO2 reached 55 +/- ...

journal_title：Thrombosis research

authors： Massad L,Plotkine M,Capdeville C,Boulu RG

更新日期：1987-10-01 00:00:00

abstract：:Arterial thrombosis and venous thromboembolism (VTE) are traditionally considered two different entities. However, patients with unprovoked VTE are at higher risk of developing subclinical and overt atherosclerosis compared to healthy controls challenging these distinctions. Obesity may explain the association between...

journal_title：Thrombosis research

authors： Delluc A,Lacut K,Rodger MA

更新日期：2020-07-01 00:00:00

abstract：:The need for anticoagulation in dialysis patients is common and the incidence of venous thromboembolism (VTE) and atrial fibrillation in this population is high. While direct data are lacking on the management of anticoagulation in dialysis patients, careful weighing of risks and benefits on the basis of evidence from...

journal_title：Thrombosis research

authors： Lo DS,Rabbat CG,Clase CM

更新日期：2006-01-01 00:00:00

abstract：:Blood was obtained from four patients envenomated by the Australian common brown snake, Pseudonaja textilis textilis. This elapid snake has one of the most toxic venoms in the world, containing extremely potent neurotoxic and coagulant components. The latter is a potent complete prothrombinase, converting prothrombin ...

journal_title：Thrombosis research

authors： Masci PP,Rowe EA,Whitaker AN,de Jersey J

更新日期：1990-09-01 00:00:00

abstract：:Ca2+ influx and efflux in unstimulated platelets and Ca2+ uptake by simultaneously isolated two membrane fractions of platelets from patients with myeloproliferative disorders (MPD) have been investigated. In MPD, Ca2+ influx and efflux across the plasma membrane in unstimulated platelets were in equilibrium at signif...

journal_title：Thrombosis research

authors： Fujimoto T,Fujimura K,Kuramoto A

更新日期：1989-01-15 00:00:00

abstract：:The aim was to describe the phlebographic pattern of asymptomatic and symptomatic deep vein thrombosis (DVT) after total hip replacement by the use of a scoring system in 102 consecutive patients (54 asymptomatic, 48 symptomatic). The DVTs were scored from 1 to 3, and registered in a scoring system dividing the deep v...

journal_title：Thrombosis research

authors： Björgell O,Nilsson PE,Benoni G,Bergqvist D

更新日期：2000-09-01 00:00:00

abstract：:We investigated the intracellular processes of the shape change in human megakaryoblastic leukemic cells, MEG-01, by platelet agonists. Thrombin induced the formation of many pseudopods. This shape change was also induced by phorbol 12-myristate 13 acetate (TPA) and weakly by Ca2+ ionophore, A23187, but not by ADP, co...

journal_title：Thrombosis research

authors： Goto S,Kobayashi M,Murate T,Hotta T,Hagiwara M,Hoshino T,Hidaka H,Saito H

更新日期：1992-10-01 00:00:00

abstract：:This study compared the responses of canine and human platelets to various aggregating agonists in the presence or absence of extracellular ATP and ATP analogues. Canine and human platelets were approximately equally reactive with ADP or collagen while the canine platelets were about 10 fold more sensitive to thrombin...

journal_title：Thrombosis research

authors： Soslau G,Arabe L,Parker J,Pelleg A

更新日期：1993-10-15 00:00:00

abstract：BACKGROUND:Venous thromboembolism (VTE) can be the first manifestation of cancer; however, the current incidence of malignancy in unselected patients with first unprovoked VTE needs to be confirmed. MATERIAL AND METHODS:Between March 1st, 2013 and February 28th, 2015 we included and followed-up all patients living in ...

journal_title：Thrombosis research

authors： Delluc A,Ianotto JC,Tromeur C,De Moreuil C,Couturaud F,Lacut K,Le Moigne E,Louis P,Thereaux J,Metges JP,Mottier D

更新日期：2018-04-01 00:00:00