Blood clotting factor IX Nagoya 3: the molecular defect of zymogen activation caused by an arginine-145 to histidine substitution.

abstract：:Full-length Tissue Factor (flTF) - the obligatory co-factor for the serine protease (factor) VII/VIIa - serves as the initiator of blood coagulation. The flTF/VIIa complex triggers a sequence of proteolytic events that lead to the formation of a hemostatic plug. Aside from hemostatic maintenance, flTF can contribute t...

journal_title：Thrombosis research

authors： Srinivasan R,Bogdanov VY

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND:Thrombosis and complement activation are pathogenic features of antiphospholipid syndrome (APS). Their molecular link is Plasma carboxypeptidase-B, also known as thrombin activatable fibrinolysis inhibitor (TAFIa), which plays a dual role: anti-fibrinolytic, by cleaving carboxyl-terminal lysine residues from...

journal_title：Thrombosis research

authors： Grosso G,Vikerfors A,Woodhams B,Adam M,Bremme K,Holmström M,Ågren A,Eelde A,Bruzelius M,Svenungsson E,Antovic A

更新日期：2017-10-01 00:00:00

abstract：:Anticoagulant properties of three sulfated compounds prepared from xylans isolated from corn cobs, larchwood and oatspelts were compared with heparin and sodium pentosan polysulfate (SP-54) by studying their effects on activated partial thromboplastin time (APTT), prothrombin time (PT) and thrombin time (TT) using poo...

journal_title：Thrombosis research

authors： Campbell A,Nesheim ME,Doctor VM

更新日期：1987-08-01 00:00:00

abstract：:ZK-807834 (also known as CI-1031) is a small molecule that potently and selectively inhibits Factor Xa. Studies in animals have shown that ZK-807834 attenuates thrombosis and thrombus progression after fibrinolysis and exhibits an increased antithrombotic-to-bleeding risk ratio compared with conventional agents. The p...

journal_title：Thrombosis research

authors： Post JM,Sullivan ME,Abendschein D,Ewing J,Hinchman JW,Light DR

更新日期：2002-02-15 00:00:00

abstract：:Thrombin was acetylated by treatment with acetic anhydride, and the potency for protein C activation and the fibrinogen clotting activity of the resultant acetylthrombin were investigated in vitro and in vivo. The acetylthrombin retained an amidolytic activity to the synthetic substrate, S-2238, and reduced both of th...

journal_title：Thrombosis research

authors： Nakagomi K,Ajisaka K,Yokota I

更新日期：1990-08-15 00:00:00

abstract：INTRODUCTION:Cytomegalovirus (CMV)-associated thrombosis has been reported sporadically in the medical literature until now. However, thrombosis incidence and its risk factors have never been studied in a cohort of patients with acute CMV infection. MATERIALS AND METHODS:A retrospective case-control study. Medical cha...

journal_title：Thrombosis research

authors： Atzmony L,Halutz O,Avidor B,Finn T,Zimmerman O,Steinvil A,Zeltser D,Giladi M,Justo D

更新日期：2010-12-01 00:00:00

abstract：:Beta-thromboglobulin (beta-TG) is a platelet-specific protein present in the alpha-granules and secreted into the surrounding medium on cell activation. The sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE) of platelet releasate after inhibition of metalloproteinases with ethyleneglycol-bis-(beta-a...

journal_title：Thrombosis research

authors： Resmi KR,Krishnan LK

更新日期：2002-05-15 00:00:00

abstract：:When single-chain pro-UK is activated by plasmin or kallikrein, the Lys158-Ile159 bond is cleaved, leaving a C-terminal lysine on the A-chain (Lys-UK). Two-chain, high molecular weight urokinase (UK) purified from urine, however, has been shown to contain a phenylalanine residue as the C-terminal of the A-chain (Phe-U...

journal_title：Thrombosis research

authors： Lenich C,Pannell R,Gurewich V

更新日期：1991-10-01 00:00:00

abstract：OBJECTIVES:Screening of patients with sepsis for disseminated intravascular coagulation (DIC) has been recommended in several guidelines. However, DIC screening is still not widely accepted as an essential component of sepsis management, partly because of a lack of evidence that DIC screening has an effect on mortality...

journal_title：Thrombosis research

authors： Umemura Y,Yamakawa K,Hayakawa M,Hamasaki T,Fujimi S,Japan Septic Disseminated Intravascular Coagulation (J-Septic DIC) study group.

更新日期：2018-01-01 00:00:00

abstract：INTRODUCTION:Although the procoagulant reactivity of monocytes largely depends on expression and cell surface presentation of tissue factor (TF), little is known about the impact of tissue factor pathway inhibitor (TFPI) on regulation of TF function on the monocyte surface. MATERIALS AND METHODS:Peripheral blood monon...

journal_title：Thrombosis research

authors： Basavaraj MG,Gruber FX,Sovershaev M,Appelbom HI,Osterud B,Petersen LC,Hansen JB

更新日期：2010-11-01 00:00:00

abstract：INTRODUCTION:Even though thrombocytopenia following transcatheter aortic valve implantation (TAVI) has been described, further investigation of this phenomenon is needed. AIMS:To determine which factors may explain the fall in platelet count that occurs after implantation of a TAVI device, including markers of platele...

journal_title：Thrombosis research

authors： Mitrosz M,Kazimierczyk R,Sobkowicz B,Waszkiewicz E,Kralisz P,Frank M,Piszcz J,Galar M,Dobrzycki S,Musial WJ,Hirnle T,Kaminski KA,Tycinska AM

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:The "HERDOO2 rule" is a prospectively validated clinical decision rule used to identify low-risk women who can safely discontinue anticoagulants after completing 5-12 months of anticoagulant treatment for unprovoked venous thromboembolism. The VIDAS®d-Dimer (DD) assay, a component of the rule, was used in th...

journal_title：Thrombosis research

authors： Rodger MA,Le Gal G,Langlois NJ,Gin B,Mallick R,Giulivi A,Freedman M,Kovacs MJ,REVERSE II investigators.

更新日期：2018-09-01 00:00:00

abstract：:Patients with Familial Hyperlipoproteinaemia Type II showed evidence of increased platelet aggregability when compared to normal controls. This abnormality was not influenced by oral therapy with probucol whether or not the serum cholesterol levels were lowered during the study period. Probucol assays indicated adequa...

journal_title：Thrombosis research

authors： Bradlow BA,Chetty N,Birnbaum M,Baker SG,Seftel HC

更新日期：1982-04-15 00:00:00

abstract：BACKGROUND:Serious bleeding is a frequent and feared treatment complication in patients treated with oral anticoagulants (OACs). Levels of von Willebrand factor (VWF) antigen have been linked to the risk of bleeding complications, mortality, and cardiovascular events. OBJECTIVES:In this longitudinal cohort study of ev...

journal_title：Thrombosis research

authors： Lind M,Johansson L,Nilsson TK,Jansson JH,Hollestelle MJ

更新日期：2015-11-01 00:00:00

abstract：:Acutely ill medical patients are at moderate to high risk of venous thromboembolism (VTE): approximately 10-30% of general medical patients may develop deep-vein thrombosis or pulmonary embolism, and the latter is a leading contributor to deaths in hospital. Medical conditions associated with a high risk of VTE includ...

journal_title：Thrombosis research

authors： Cohen AT,Nandini B,Wills JO,Ota S

更新日期：2010-04-01 00:00:00

abstract：:Effects of Ca2+ on phospholipid methylation in rabbit platelet membranes were studied using S-adenosyl-L-[3H-methyl]methionine as a substrate. The methylation was inhibited to 30% of the basal activity with 100 microM Ca2+. The inhibition was completely counteracted by various calmodulin antagonists. Their concentrati...

journal_title：Thrombosis research

authors： Taniguchi S,Mori K,Hayashi H,Fujiwara M,Fujiwara M

更新日期：1983-12-01 00:00:00

abstract：:Gastrointestinal bleeding due to colonic angiodysplasia is a well-recognised complication of von Willebrand disease (vWD), occurring almost exclusively in subtypes of the disease associated with a reduction in high-molecular-weight (HMW) multimers of von Willebrand factor (vWF). A deficiency of vWF HMW multimers also ...

journal_title：Thrombosis research

authors： Makris M

更新日期：2006-01-01 00:00:00

abstract：:We compared the effects of dipyridamole, RA-642, and mopidamol on platelet activity and thromboxane/prostacyclin balance in relation to the degree of retinal vascularization in a model of experimental streptozotocin-induced diabetes in rats. After 3 months, collagen-induced platelet aggregation in whole blood was 25% ...

journal_title：Thrombosis research

authors： De La Cruz JP,Moreno A,Mérida F,García Campos J,Sánchez de la Cuesta F

更新日期：1996-02-01 00:00:00

abstract：:The antithrombotic effect of aspirin (ASA) and dipyridamole (DIP) was evaluated in rabbits in which platelet thromboxane A2 (TXA2) and arterial prostacyclin (PGI2) were measured. An intracarotid cannula thrombosis model previously shown to be sensitive to antiplatelet agents was used. Prostaglandins were determined by...

journal_title：Thrombosis research

authors： Louie S,Gurewich V

更新日期：1983-05-15 00:00:00

abstract：:Therapeutic developments have seen significant improvement in mortality over the past thirty years for breast, colorectal and prostate cancer. Lung cancer is the commonest cancer in the world, but has seen little improvement in survival figures. The role of low-molecular-weight heparin (LMWH) in improving cancer survi...

journal_title：Thrombosis research

authors： Noble S

更新日期：2012-04-01 00:00:00

abstract：:Washed human platelets were incubated with commercial factor VIII concentrate, or with purified factor VIII coagulant moiety. Platelets were then washed again and lysed by sonication. VIII:Ag and vWf:Ag were measured in the platelet lysate prior to and after incubation of the lysate with phospholipase C (PL-C). Platel...

journal_title：Thrombosis research

authors： Muntean W,Leschnik B,Haas J

更新日期：1987-02-15 00:00:00

abstract：INTRODUCTION:Plasma viscosity (PV) constitutes an independent important predictor of initial and recurrent cardiac events and mortality. It has been suggested that there is a geographical variation in PV values related to coronary event rates. Little information exists regarding PV in Spain. Therefore, our objective wa...

journal_title：Thrombosis research

authors： Vayá A,Simó M,Santaolaria M,Carrasco P,Corella D

更新日期：2007-01-01 00:00:00

abstract：:Coagulation is initiated by tissue factor (TF). Coagulant TF is constitutively expressed by extravascular cells, but there is increasing evidence that TF can also be present within the blood, in particular during pathological conditions. Such TF is exposed on circulating cell-derived vesicles, and its presence has bee...

journal_title：Thrombosis research

authors： Kleinjan A,Böing AN,Sturk A,Nieuwland R

更新日期：2012-10-01 00:00:00

abstract：INTRODUCTION:Peripheral artery disease (PAD) affects 8.5 million Americans and thus improving our understanding of PAD is critical to developing strategies to reduce disease burden. The objective of the study was to determine the association of ABO blood type with ankle brachial index (ABI) as well as prevalent and inc...

journal_title：Thrombosis research

authors： Pike MM,Larson NB,Wassel CL,Cohoon KP,Tsai MY,Pankow JS,Hanson NQ,Decker PA,Berardi C,Alexander KS,Cushman M,Zakai NA,Bielinski SJ

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:Coagulopathy is a major cause of early death when arsenic trioxide (As(2)O(3)) therapy fails. In addition to the procoagulant properties of blast cells, the cytotoxic therapy may contribute to the coagulation disorders. The aim of the present study was to evaluate the possible impact of As(2)O(3) on membrane...

journal_title：Thrombosis research

authors： Zhou J,Li H,Fu Y,Shi J,Hou J,Zhang Y,Liu X,Song P

更新日期：2011-05-01 00:00:00

abstract：:The heparin-derived oligosaccharide C3 (C3) is currently underdevelopment for the prevention and treatment of vascular dementia and senile dementia of Alzheimer's type. C3 exhibits a molecular weight of 2200-2500 Da with a narrow distribution. The objective of the present study was to assess the pharmacodynamics and p...

journal_title：Thrombosis research

authors： Ma Q,Schultz C,Neville B,Jeske W,Hoppensteadt D,Cornelli U,Lee J,Lorens S,Hanin I,Fareed J

更新日期：2003-01-01 00:00:00

abstract：:Carotid artery dissections are the second leading cause of stroke in young adults. The hemostatic response to a dissection involves exposure of the subendothelium to the intravascular environment. Platelet activation/aggregation superimposed by secondary coagulation cascade activity attempts to heal the injury. Failur...

journal_title：Thrombosis research

authors： Stevic I,Chan HH,Chan AK

更新日期：2011-10-01 00:00:00

abstract：:Rabbit platelets pretreated with CV-3988 had reduced responsiveness to platelet activating factor(PAF) even after the platelets had been washed with a buffer. This was due to its tight binding to receptor sites for PAF, but not conformational changes of the receptor, because the platelets that were pretreated with CV-...

journal_title：Thrombosis research

authors： Tokumura A,Yoshida J,Okasaka N,Fukuzawa K,Tsukatani H

更新日期：1987-04-01 00:00:00

abstract：INTRODUCTION:A fraction of fibrinogen molecules contain an alternatively spliced variant chain called gamma'. Plasma levels of this variant have been associated with both myocardial infarction and venous thrombosis. Because clot structure has been associated with cardiovascular risk, we examined the effect of gamma' ch...

journal_title：Thrombosis research

authors： Gersh KC,Nagaswami C,Weisel JW,Lord ST

更新日期：2009-07-01 00:00:00

abstract：BACKGROUND:Ambient particulate matter (PM) is associated with cardiovascular morbidity and mortality. It has been proposed that PM induces a pro-thrombotic process, increasing the risk of cardiovascular events, with some support from epidemiological and laboratory-based models. Diesel exhaust is a major contributor to ...

journal_title：Thrombosis research

authors： Carlsten C,Kaufman JD,Peretz A,Trenga CA,Sheppard L,Sullivan JH

更新日期：2007-01-01 00:00:00