Abstract：
:Thrombus formation was electrically induced in the left common carotid artery of rats with preoccluded both vertebral and right carotid arteries. Following thrombus induction, animals became unresponsive and lost their righting reflex. The loss of righting reflex was observed when cortical tissular pO2 reached 55 +/- 9% of its initial value. A similar decrease in pO2 was induced by mechanical occlusion of the left carotid artery. The delay between discontinuation of current and the loss of righting reflex was measured to indirectly evaluate occlusive thrombus formation. The capacity of various antithrombotic agents to delay the righting reflex loss was studied. Heparin, ticlopidine and the thromboxane-endoperoxides receptor blocker, BM 13177, exerted a significant activity, whereas acetylsalicylic acid and the thromboxane synthetase inhibitors, OKY O46 and dazmegrel, were inefficient.
journal_name
Thromb Resjournal_title
Thrombosis researchauthors
Massad L,Plotkine M,Capdeville C,Boulu RGdoi
10.1016/0049-3848(87)90340-9subject
Has Abstractpub_date
1987-10-01 00:00:00pages
1-10issue
1eissn
0049-3848issn
1879-2472pii
0049-3848(87)90340-9journal_volume
48pub_type
杂志文章abstract：INTRODUCTION:Cell surface thiol isomerase enzymes, principally protein disulphide isomerase (PDI), have emerged as important regulators of platelet function and tissue factor activation via their action on allosteric disulphide bonds. Allosteric disulphides are present in other haemostasis-related proteins, and we have...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2015.01.034
更新日期：2015-04-01 00:00:00
abstract：BACKGROUND:Systemic thrombolysis rapidly improves right ventricular (RV) dysfunction in patients with acute pulmonary embolism (PE) but is associated with major bleeding complications in up to 20%. The efficacy of low-dose, catheter-directed ultrasound-accelerated thrombolysis (USAT) on the reversal of RV dysfunction i...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2011.05.014
更新日期：2011-08-01 00:00:00
abstract：:In this study, we investigated the effects of a 3-min insulin incubation both at physiological and at supraphysiological concentrations on platelet aggregation and intraplatelet cyclic guanosine monophosphate (cGMP) levels both in the absence and in the presence of phosphodiesterase inhibition. We observed that insuli...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(96)00051-5
更新日期：1996-04-01 00:00:00
abstract：:In vitro exper iments showed that polymeric hydrogels containing covalently immobilized heparin affect the parameters of blood clotting system. This is not accounted for by the elution of heparin into the surrounding medium and this property of heparin-containing polymers is caused by specific interaction of immobiliz...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(82)90192-x
更新日期：1982-07-15 00:00:00
abstract：INTRODUCTION:Edoxaban is an oral, once-daily direct factor Xa (FXa) inhibitor. Although rapidly cleared, strategies to reverse edoxaban-mediated effects on anticoagulation are needed in cases of excessive bleeding or emergency. This study evaluated the effect of two prohemostatic agents, recombinant factor VIIa (rFVIIa...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2014.07.036
更新日期：2014-10-01 00:00:00
abstract：:Sandwich ELISA systems were developed to measure human von Willebrand factor (vWF). In one system the microtitre plates were coated with goat F(ab')2 to vWF. The F(ab')2 different molecular forms in the soluble phase. VWF antigen bound by the F(ab')2 antibody was subsequently determined by using horse-radish peroxidas...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(86)90047-2
更新日期：1986-07-01 00:00:00
abstract：:The potency for the inhibition of 5-hydroxytryptamine (5-HT)-induced human platelet aggregation by ketanserin, pipamperone, spiperone, cyproheptadine and BW 501 in vitro decreased as the reaction pH increased progressively from 7.4 to 8.6, the largest shift (X 1125) in IC50 value (pH 7.4: 4 X 10(-9) M; pH 8.6: 4.5 X 1...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(85)90297-x
更新日期：1985-12-01 00:00:00
abstract：:The hemolytic uremic syndrome involves the presence of Shiga toxin producing strains of Escherichia coli and is associated with thrombocytopenia, platelet activation, and microthrombi formation. We have, therefore, investigated the ability of Shiga toxin isotypes 1 and 2 to cause or enhance platelet aggregation under ...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/s0049-3848(00)00191-2
更新日期：2000-06-01 00:00:00
abstract：:Mild hyperhomocysteinemia is recognized as a risk factor for venous thromboembolism (VTE), though its role in the thrombogenic processes is not understood. Its possible association with impaired fibrinolysis was investigated in 157 patients (61 women, 96 men) below the age of 60 years (43+/-11, mean+/-SD) with a histo...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/s0049-3848(00)00324-8
更新日期：2000-11-15 00:00:00
abstract：BACKGROUND:Peripheral pulmonary artery thrombus (PPT) is common in the clinic. However, due to the lack of an ideal diagnostic tool, PPT cannot be quickly diagnosed and effectively treated at present. Optical coherence tomography (OCT) is a new intravascular imaging technique that is characterized by high image resolut...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2017.10.021
更新日期：2018-01-01 00:00:00
abstract：:Platelets from rats fed a diet high in linoleic acid (6%) bound increased amounts of fibrinogen on stimulation with ADP, compared to those from rats fed diets with low (2%) or no linoleic acid. However, this increased fibrinogen binding was associated with a decrease in platelet aggregation induced by ADP. Changes in ...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(84)90107-5
更新日期：1984-04-01 00:00:00
abstract：INTRODUCTION:Inherited thrombophilia has been associated with unexplained recurrent pregnancy loss (RPL) and stillbirth. This thrombotic tendency can manifest as thrombotic lesions in the placenta, and may lead to abortion and stillbirth. The aim of our case-control study was to investigate the prevalence of FVL and FI...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2005.06.005
更新日期：2006-01-01 00:00:00
abstract：IMPORTANCE:Unprovoked venous thromboembolism (VTE) can be the first manifestation of cancer. It is unclear if extensive screening for occult cancer including a comprehensive computed tomography (CT) scan of the abdomen/pelvis is cost-effective in this patient population. OBJECTIVE:To assess the health care related cos...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2017.01.007
更新日期：2017-03-01 00:00:00
abstract：INTRODUCTION:There is an exponential rise of thromboembolic risk with age because of co-morbidities, immobility and pharmacotherapy. We aimed to investigate the benefits and risks of heparin prophylaxis in very elderly patients ≥80 years and the type of heparin used in a subgroup analysis of the CERTIFY trial. PATIENT...
journal_title：Thrombosis research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.thromres.2011.05.002
更新日期：2011-11-01 00:00:00
abstract：:In rabbits, a clear microscopic image of individual, fluorescent blood platelets flowing in a mesenteric microvessel could be obtained over the whole cross-sectional area of the vessel, following an intravenous injection of a solution containing 5-15 mg of the fluorochrome Acridine Red. Most of the circulating platele...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(82)90106-2
更新日期：1982-12-15 00:00:00
abstract：:The influence of acute hypoxemia on blood fibrinolytic activity was investigated in 12 healthy males. Physiologically significant hypoxemia was produced by inspiration of 13% oxygen for 30 min. Six healthy males were exposed to hypoxemia at rest and 6 males to hypoxemia during exhaustive physical exercise on an ergocy...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(87)90222-2
更新日期：1987-02-15 00:00:00
abstract：INTRODUCTION:We showed previously that the prothrombotic effect of one hour aldosterone (ALDO) infusion in rats was only partially mediated by the mineralocorticoid receptor (MR). Bearing in mind that ALDO potentiates the effects of angiotensin II (Ang II), in the present study we investigated the role of Ang II recept...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2015.12.008
更新日期：2016-02-01 00:00:00
abstract：INTRODUCTION:Inherited abnormalities of fibrinogen (FG) are rare coagulation disorders divided into two types: quantitative abnormalities (afibrinogenemia and hypofibrinogenemia) or qualitative abnormalities (dysfibrinogenemia and hypo-dysfibrinogenemia) of circulating fibrinogen. In particular, congenital afibrinogene...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2016.04.016
更新日期：2016-07-01 00:00:00
abstract：:When human citrated plasma is dialysed against a phosphate buffer containing Ca++, citrate anions are removed, thrombin is generated and soluble fibrinogen derivatives (fibrin monomers and/or soluble fibrin polymers) are formed. These derivatives are able to combine with human or bovine elastin to form a very stable a...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(86)90061-7
更新日期：1986-07-15 00:00:00
abstract：:Three collagenases were purified from the culture medium of human skin fibroblasts using ammonium sulfate fractionation, ion-exchange chromatography and gel filtration. The cationic collagenase had a molecular weight of 42,000; two anionic collagenases had molecular weights of 63,000 and 115,000. Preincubation of the ...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(84)90211-1
更新日期：1984-07-15 00:00:00
abstract：:We constructed a new factor IX expression vector containing a full length factor IX cDNA. The Moloney Murine Leukemia Virus (MoMLV)-based retroviral vector pLRNL was cloned with the entire coding region of human factor IX down stream of the promoter of Rous sarcoma virus, giving rise to the construct pL9RNL. The GP+E ...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(93)90038-p
更新日期：1993-02-15 00:00:00
abstract：:Fibrinogen is a hexameric glycoprotein consisting of two sets of three polypeptides (the Aα, Bβ, and γ chains, encoded by the three genes FGA, FGB, and FGG). It is involved in the final phase of the coagulation process, being the precursor of the fibrin monomers necessary for the formation of the hemostatic plug. Rare...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2015.05.007
更新日期：2015-07-01 00:00:00
abstract：:Envenomation caused by Lonomia obliqua caterpillars is an increasing problem in Southern Brazil. The clinical profile is characterized by a profound hemorrhagic disorder. In the present study, we describe the characterization of a fibrin(ogen)olytic factor (lonofibrase) isolated from a venomous secretion of the caterp...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2004.01.012
更新日期：2004-01-01 00:00:00
abstract：:Megakaryocytes (MKs) are widely known as the progenitor cells of platelets. These large, polyploid cells are a derivative of the hematopoietic stem cell (HSC), and reside in the bone marrow, lining blood vessel walls where they release their platelet progeny into circulation. Although little is known about how MKs dif...
journal_title：Thrombosis research
pub_type： 杂志文章,评审
doi：10.1016/j.thromres.2019.05.008
更新日期：2019-07-01 00:00:00
abstract：:Platelet alpha adrenoceptor status was examined using the radioligands 3H-yohimbine (3H-YOH) and 3H-dihydroergocryptine (3H-DHE) in 14 patients with myeloproliferative disorder (MPD) and 10 normal controls. Platelets from normal controls and MPD patients sensitive to adrenaline induced aggregation exhibited approximat...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(85)90300-7
更新日期：1985-12-01 00:00:00
abstract：:Use of low molecular weight heparins (LMWHs) is now generally accepted as an ideal method of prophylaxis against postoperative venous thromboembolism. However, the long-term effects on the development of postthrombotic deep vein insufficiency are not known. Every patient developing such complications consumes a vast a...
journal_title：Thrombosis research
pub_type： 杂志文章,评审
doi：10.1016/0049-3848(95)00232-4
更新日期：1996-01-01 00:00:00
abstract：BACKGROUND:The usefulness of coagulation tests performed before epidural analgesia for surgery or to alleviate labour pain is controversial. The aims of this study were: (1) to evaluate the prevalence of abnormal tests in a large cohort of healthy pregnant women and their association with epidural hematoma; (2) to asse...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2011.02.023
更新日期：2011-07-01 00:00:00
abstract：:To determine whether inherent fibrinolytic differences may exist in racial groups (black americans, BA vs. white americans, WA), 55 different individual racially-derived human umbilical vein endothelial cell (HUVEC) cultures (35 BA and 20 WA) were analyzed in terms of their fibrinolytic protein (t-PA, u-PA and PAI-1) ...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(95)91615-r
更新日期：1995-02-01 00:00:00
abstract：INTRODUCTION:Venous thromboembolism (VTE) occurs frequently in at-risk hospitalized patients, and prophylaxis of VTE is significantly underused. We sought to preliminarily assess the validity of Caprini risk assessment model, a famous individual VTE risk assessment model, in Chinese hospitalized patients with VTE. MAT...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2012.08.001
更新日期：2012-11-01 00:00:00
abstract：:Factor IX Nagoya 3 (IX Nagoya 3) is a natural mutant of factor IX recognized in a patient with moderately severe hemophilia B. The patient had 0.60 units/ml of factor IX antigen and 2-5% of clotting activity. IX Nagoya 3 was purified from the patient's plasma by immunoaffinity chromatography with an anti-factor IX mon...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(90)90109-p
更新日期：1990-11-15 00:00:00
