当前位置： SCI文献检索 > THROMBOSIS RESEARCH期刊下所有文献 > Mild hyperhomocysteinemia and fibrinolytic factors in patients with history of venous thromboembolism.

Mild hyperhomocysteinemia and fibrinolytic factors in patients with history of venous thromboembolism.

Abstract：

:Mild hyperhomocysteinemia is recognized as a risk factor for venous thromboembolism (VTE), though its role in the thrombogenic processes is not understood. Its possible association with impaired fibrinolysis was investigated in 157 patients (61 women, 96 men) below the age of 60 years (43+/-11, mean+/-SD) with a history of objectively confirmed VTE. Patients had significantly higher fasting total plasma homocysteine (tHcy) levels than 138 apparently healthy subjects (8.0, 6.6-9.9 micromol/L vs. 7.2, 5.9-8.6 micromol/L, P=0. 001; median, range between first and third quartile). In 17 of 157 patients (12%) hyperhomocysteinemia (tHcy>11.4 micromol/L for women and tHcy>12.6 micromol/L for men) was established. The adjusted odds ratio as an estimate of relative risk for VTE was 2.3 (0.8-7.0; 95% confidence interval). When patients with hyperhomocysteinemia were compared to patients without hyperhomocysteinemia, no significant differences in t-PA (antigen 9.2+/-5.5 microg/L and 9.7+/-4.7 microg/L, respectively; activity 1.3+/-0.5 IU/mL and 1.3+/-0.7 IU/mL, respectively) and PAI-1 (antigen 19.3+/-17.5 microg/L and 22.6+/-20. 4 microg/L, respectively; activity 15.0+/-12.6 and 15.8+/-13.3 IU/mL, respectively) were observed. In conclusion, this study showed an association between mild hyperhomocysteinemia and VTE, but provided no evidence for an independent association between hyperhomocysteinemia and alterations in fibrinolytic proteins.

journal_name

Thromb Res

journal_title

Thrombosis research

authors

Bozic M,Stegnar M,Fermo I,Ritonja A,Peternel P,Stare J,D'Angelo A

doi

10.1016/s0049-3848(00)00324-8

subject

Has Abstract

pub_date

2000-11-15 00:00:00

pages

271-8

issue

4

eissn

0049-3848

issn

1879-2472

pii

S0049-3848(00)00324-8

journal_volume

100

pub_type

杂志文章

相关文献

THROMBOSIS RESEARCH文献大全
  • Role of protein kinase C in U46619-induced platelet shape change, aggregation and secretion.

    abstract：:Stimulation of rat platelets with U46619 induced Ca2+ mobilization and platelet shape change, but aggregation and secretion were induced when platelets were stimulated with U46619 plus phorbol 12-myristate 13-acetate (PMA). However, stimulation of rabbit platelets with U46619 induced all the three platelet responses. ...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(89)90171-0

    authors： Nakano T,Hanasaki K,Arita H

    更新日期：1989-10-15 00:00:00

  • Aspirin non-responsiveness as measured by PFA-100 in patients with coronary artery disease.

    abstract：INTRODUCTION:The purpose of the present study was to study the concept of aspirin resistance or non-responsiveness by investigating the response to long-term aspirin therapy in patients with a former acute myocardial infarction (AMI). MATERIALS AND METHODS:Patients with an AMI (n=202) randomly assigned to aspirin 160 ...

    journal_title：Thrombosis research

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0049-3848(02)00405-x

    authors： Andersen K,Hurlen M,Arnesen H,Seljeflot I

    更新日期：2002-10-01 00:00:00

  • Anticoagulant activity of a bacterial glycopeptide.

    abstract：:The anticoagulant properties of myxalin, a glycopeptide secreted by a Gram negative bacterium strain (Myxococcus xanthus) are studied and compared to those of heparin. This soluble material exhibits an anticoagulant activity which implies the inhibition of some serine proteases, thrombin and factor Xa. In the presence...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(90)90335-a

    authors： Akoum A,Josefonvicz J,Sigot M

    更新日期：1990-10-01 00:00:00

  • DHG, a new depolymerized holothurian glycosaminoglycan, exerts an antithrombotic effect with less bleeding than unfractionated or low molecular weight heparin, in rats.

    abstract：:We characterized the antithrombotic, haemorrhagic, and ex vivo anticoagulant effects of a recently identified depolymerized holothurian glycosaminoglycan (DHG), and compared these effects with those of unfractionated heparin (UFH), low molecular weight heparin (LMWH), and dermatan sulfate (DS). In thrombin-induced ven...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(96)00166-1

    authors： Kitazato K,Kitazato KT,Nagase H,Minamiguchi K

    更新日期：1996-10-15 00:00:00

  • The effect of myelin basic protein on the endogenous phosphorylation of platelets.

    abstract：:Bovine myelin basic protein (BP) induced a shape change and endogenous phosphorylation of a 45,000 (45K) molecular weight protein of intact human platelets. This effect occurred rapidly over an effective concentration range of 5-100 microM BP. BP peptides encompassing residues 1-42, 43-88, and 89-169 from the BP molec...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(82)90090-1

    authors： Chiang TM,Whitaker JN,Kang AH,Beachey EH

    更新日期：1982-03-15 00:00:00

  • Inherited platelet glycoprotein polymorphisms and a risk for coronary heart disease in young central Europeans.

    abstract：:Among central Europeans polymorphisms of GPIIIa, GPIb, GPIIb, and GPIa named human platelet antigen-1 (HPA-1), -2, -3, and -5 are the clinically most relevant systems in which alloimmunization occurs. These genetically determined polymorphisms of glycoproteins may render platelets sensible for plaque formation and thu...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/s0049-3848(98)00042-5

    authors： Sperr WR,Huber K,Roden M,Janisiw M,Lang T,Graf S,Maurer G,Mayr WR,Panzer S

    更新日期：1998-05-01 00:00:00

  • Fibrinogen synthesis by megakaryocyte rich human marrow cell concentrates.

    abstract：:A rapid method is described for the production of a human marrow cell suspension highly enriched in megakaryocytes. These concentrates were incubated with radiolabelled amino-acids, and cell lysates were then analysed for fibrinogen synthesis. Neosynthesized proteins were detected by immunoprecipitation, immuno-affini...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(85)90133-1

    authors： Belloc F,Hourdille P,Fialon P,Boisseau MR,Soria J

    更新日期：1985-05-15 00:00:00

  • Platelet CLEC-2 and podoplanin in cancer metastasis.

    abstract：:It has long been recognised that the function of platelets in health and disease span far beyond their roles in haemostasis and thrombosis. The observation that tumour cells induce platelet aggregation was followed by extensive experimental evidence linking platelets to cancer progression. Aggregated platelets coat tu...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/S0049-3848(12)70013-0

    authors： Lowe KL,Navarro-Nunez L,Watson SP

    更新日期：2012-04-01 00:00:00

  • Interleukin 1 enhances arterial thrombogenicity in vitro.

    abstract：:An in vitro model of platelet adhesion, the annular perfusion chamber, was utilized to test the effects of Interleukin 1 on vascular thrombogenicity for platelets. De-endothelialized, everted human umbilical arteries were placed in cell culture media with or without Interleukin 1. The arteries were later perfused with...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(89)90235-1

    authors： Schorer AE,White JG

    更新日期：1989-11-15 00:00:00

  • Impact of clopidogrel resistance on thrombotic events after percutaneous coronary intervention with drug-eluting stent.

    abstract：OBJECTIVES:This study examines whether patient resistance to clopidogrel is associated with long-term thrombotic events after elective coronary drug-eluting stent (DES) implantation. METHODS:We prospectively enrolled 386 patients with stable angina who received elective percutaneous coronary intervention (PCI) with DE...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2008.10.007

    authors： Wang ZJ,Zhou YJ,Liu YY,Yu M,Shi DM,Zhao YX,Guo YH,Cheng WJ,Jia de A,Cao Z,Nie B,Ge HL,Yang SW,Yan ZX

    更新日期：2009-05-01 00:00:00

  • The relationship between heparanase levels, thrombus burden and thromboembolism in patients receiving unfractionated heparin treatment for prosthetic valve thrombosis.

    abstract：INTRODUCTION:Procoagulant activity of heparanase has been recently described in several arterial and venous thrombotic disorders. In this study, we aimed to investigate the role of heparanase with regard to thrombus burden, thromboembolism, and treatment success with unfractionated heparin (UFH) in patients with prosth...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2018.09.061

    authors： Bayam E,Kalçık M,Gürbüz AS,Yesin M,Güner A,Gündüz S,Gürsoy MO,Karakoyun S,Cerşit S,Kılıçgedik A,Candan Ö,Yaman A,Özkan M

    更新日期：2018-11-01 00:00:00

  • Thrombin reduces large heparan sulfate proteoglycan molecules in cultured vascular endothelial cell layers through inhibition of core protein synthesis.

    abstract：:We investigated the alteration of heparan sulfate proteoglycans induced by thrombin in cultured vascular endothelial cells. Heparan sulfate proteoglycans, which were metabolically labeled with [3H] glucosamine and [35S] sulfate, were isolated by DEAE-Sephacel ion-exchange chromatography and characterized by molecular ...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/s0049-3848(97)00257-0

    authors： Fujii N,Kaji T,Akai T,Koizumi F

    更新日期：1997-11-01 00:00:00

  • Impaired platelet binding of fibrinogen due to a lower number of GPIIB/IIIA receptors in polycythemia vera.

    abstract：:We have previously described a stimulus-specific defect in platelet aggregation in polycythaemia vera (PV) after stimulation with surface receptor dependent agonists such as platelet activating factor (PAF). In contrast, responses to phorbol myristate acetate (PMA) were normal. We now report that after PAF stimulation...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/s0049-3848(98)00096-6

    authors： Le Blanc K,Lindahl T,Rosendahl K,Samuelsson J

    更新日期：1998-09-15 00:00:00

  • Postprocedural PAI-1 activity is a risk marker of subsequent clinical restenosis in patients both with and without stent implantation after elective balloon PTCA.

    abstract：:Stent implantation after balloon dilation of coronary arteries has improved clinical prognosis in patients undergoing transluminal coronary angioplasty (PTCA), but late restenosis remains a relevant problem. A previous study has indicated that PAI-1 activity changes immediately after PTCA without stent implantation ar...

    journal_title：Thrombosis research

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0049-3848(01)00360-7

    authors： Prisco D,Fedi S,Antonucci E,Capanni M,Chiarugi L,Chioccioli M,Falai M,Giglioli C,Abbate R,Gensini GF

    更新日期：2001-11-01 00:00:00

  • Comparison of the in vitro effect of eicosapentaenoic acid (EPA)-derived lipoxygenase metabolites on human platelet function with those of arachidonic acid.

    abstract：:Eicosapentaenoic acid (EPA) has been reported to have a potent anti-aggregatory activity and to be efficiently metabolized by 12-lipoxygenase, not by cyclooxygenase in platelets. In vitro effect of 12-lipoxygenase metabolites of EPA on platelet function was studied and compared with those of arachidonic acid (AA). The...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(86)90248-3

    authors： Takenaga M,Hirai A,Terano T,Tamura Y,Kitagawa H,Yoshida S

    更新日期：1986-02-01 00:00:00

  • Low endogenous thrombin potential in trained subjects.

    abstract：INTRODUCTION:A paradox seems to exist: exercising leads to clotting activation in conventional clotting tests, but exercising persons have a low risk of thrombosis. In this study we tried to evaluate the effect of exercise performance status on in vitro plasma thrombin generation, which represents an overall function t...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2013.04.009

    authors： Cimenti C,Schlagenhauf A,Leschnik B,Schretter M,Tschakert G,Gröschl W,Seibert FJ,Hofmann P,Muntean WE

    更新日期：2013-06-01 00:00:00

  • Changes in thrombomodulin level in plasma of endotoxin-infused rabbits.

    abstract：:Changes in the plasma thrombomodulin (TM) level were examined in endotoxin-infused rabbits. The plasma TM level in normal rabbits was 143.8 +/- 8.4 ng/ml (n = 67) and the molecular weight of the major TM was about 55 kd. Endotoxin (lipopolysaccharide, LPS, E. Coli B8:0127) was intravenously infused. LPS infusion incre...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(92)90240-b

    authors： Sawada K,Yamamoto H,Matsumoto K,Yago H,Suehiro S,Tahara C,Ishii H,Kazama M,Abe T

    更新日期：1992-01-15 00:00:00

  • Physiological changes in membrane-expressed platelet factor 4: implications in heparin-induced thrombocytopenia.

    abstract：BACKGROUND:Many heparin-induced thrombocytopenia (HIT) antibodies cause platelet activation in the serotonin release assay (SRA) in the absence of heparin. This in vitro observation may help unravel the mechanism of delayed-onset HIT, where seropositive patients develop thrombocytopenia and associated thrombosis after ...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2009.10.021

    authors： Prechel MM,Jeske WP,Walenga JM

    更新日期：2010-04-01 00:00:00

  • Decryption of tissue factor.

    abstract：:Tissue factor (TF) is a transmembrane protein which, in complex with factor (F)VIIa, initiates blood coagulation. Numerous studies have determined TF epitopes and individual amino acids which play an important role in the TF/FVIIa complex formation and its activity towards natural substrates. However the subject of ce...

    journal_title：Thrombosis research

    pub_type： 杂志文章,评审

    doi：10.1016/j.thromres.2012.02.022

    authors： Butenas S,Krudysz-Amblo J

    更新日期：2012-05-01 00:00:00

  • Resistance to activated protein C: evaluation of three functional assays.

    abstract：:Resistance to Activated Protein C (APC) was evaluated using 3 different methods: two of them were based on the prolongation of the Activated Partial Thromboplastin Time (APTT) using 2 different APTT reagents in the presence of APC, whereas the third method was based on the prolongation of prothrombin time when APC is ...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(94)90206-2

    authors： Vasse M,Leduc O,Borg JY,Chrétien MH,Monconduit M

    更新日期：1994-10-01 00:00:00

  • Effect of exercise, DDAVP, and epinephrine on the factor VIII:C/von Willebrand factor complex in normal dogs and von Willebrand factor deficient Doberman pinscher dogs.

    abstract：:Endothelial cells in biopsied blood vessels from von Willebrand factor (vWf)-deficient Doberman pinscher dogs contain immunologically detectable vWf. These dogs and normal dogs were treated with DDAVP (0.6 microgram/kg) and epinephrine (0.5 microgram/kg/min for 30 minutes) and were exercised, using 5 different exercis...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(90)90198-l

    authors： Meyers KM,Wardrop KJ,Dodds WJ,Brassard J

    更新日期：1990-01-01 00:00:00

  • Pharmacological profile of G619, a new platelet aggregation inhibitor.

    abstract：:G619, a 4-OH-isophthalic acid derivative, was studied for its capacity to inhibit platelet aggregation. G619 dose-dependently inhibited U46619, collagen, ADP, PAF, thrombin and epinephrine-induced platelet aggregation in vitro. The IC50 values for inhibition of U46619-induced human and rabbit platelet aggregation were...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(92)90283-g

    authors： Yue TL,Smith EF 3rd,Ohlstein EH,Sulpizio A,Slivjak MJ,Rabinovici R,Sellers TS,Lynch KM,Poyser R,Feuerstein G

    更新日期：1992-05-15 00:00:00

  • Modulation of megakaryopoiesis and platelet production during inflammation.

    abstract：:Megakaryocytes (MKs) are widely known as the progenitor cells of platelets. These large, polyploid cells are a derivative of the hematopoietic stem cell (HSC), and reside in the bone marrow, lining blood vessel walls where they release their platelet progeny into circulation. Although little is known about how MKs dif...

    journal_title：Thrombosis research

    pub_type： 杂志文章,评审

    doi：10.1016/j.thromres.2019.05.008

    authors： Couldwell G,Machlus KR

    更新日期：2019-07-01 00:00:00

  • Effects of desmopressin and dextran on coagulation and fibrinolysis in healthy volunteers.

    abstract：:The effects of desmopressin and dextran on haemostasis and fibrinolysis were studied in four healthy volunteers. Both drugs were compared to placebo, each volunteer being subject to four experiments. Dextran 70 (30 g i.v.) moderately decreased VIII:C and vWF:Ag and slightly increased antithrombin III, also when haemod...

    journal_title：Thrombosis research

    pub_type： 临床试验,杂志文章

    doi：10.1016/0049-3848(91)90009-l

    authors： Flordal PA,Svensson J,Ljungström KG

    更新日期：1991-06-01 00:00:00

  • Comparison of methods for detecting soluble fibrin in plasma. An in vitro study.

    abstract：:The ability of the COA-SET Fibrin monomer (COA-SET FM) test to detect soluble fibrin was evaluated by comparing the results of the COA-SET FM test with fibrinopeptide A (FPA) determinations following thrombin incubation of plasma or whole blood. In addition, two semiquantitative tests (erythrocytes-agglutination test ...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(90)90066-l

    authors： Halvorsen S,Skjønsberg OH,Ruyter R,Godal HC

    更新日期：1990-02-15 00:00:00

  • Effects of armagnac or vodka on platelet aggregation in healthy volunteers: a randomized controlled clinical trial.

    abstract：BACKGROUND:Cardiovascular mortality is especially low in southwest France (the French Paradox). In previous experimental studies, we found that alcohol-free extracts of armagnac could inhibit human platelet function in vitro and experimental thrombosis in vivo. To test the possible relevance of these findings, we teste...

    journal_title：Thrombosis research

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/j.thromres.2004.07.006

    authors： Umar A,Depont F,Jacquet A,Lignot S,Segur MC,Boisseau M,Bégaud B,Moore N

    更新日期：2005-01-01 00:00:00

  • A multicolor flow cytometric assay for measurement of platelet-derived microparticles.

    abstract：INTRODUCTION:Flow cytometry (FCM) is the most commonly used method for detection of platelet-derived microparticles (PDMPs), but it is poorly standardized and mainly used for "bedside" analyses in fresh samples. If PDMPs could be analyzed in previously frozen samples it would increase the usefulness of the method. Howe...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2009.10.006

    authors： Mobarrez F,Antovic J,Egberg N,Hansson M,Jörneskog G,Hultenby K,Wallén H

    更新日期：2010-03-01 00:00:00

  • Augmentation of in-stent clot dissolution by low frequency ultrasound combined with aspirin and heparin. An ex-vivo canine shunt study.

    abstract：INTRODUCTION:Ultrasound can accelerate clot dissolution in vitro and in vivo. We used an ex vivo canine shunt to investigate low frequency ultrasound effects on platelet-rich stent thrombosis. METHODS AND RESULTS:Nitinol stents were expanded to 2 mm in diameter in two perfusion chambers in a parallel shunt and exposed...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2003.10.023

    authors： Neuman Y,Rukshin V,Tsang V,Atar S,Miyamoto T,Luo H,Kobal S,Thompson T,Birnbaum Y,Horzewski M,Siegel RJ,Kaul S

    更新日期：2003-01-01 00:00:00

  • Platelet procoagulant activity induced in vivo by muromonab-CD3 infusion in uremic patients.

    abstract：BACKGROUND:Muromonab-CD3 is a murine monoclonal antibody (MoAb) that is used in the prophylaxis and treatment of acute graft rejection. Activation of coagulation and fibrinolysis following anti-CD3 administration have been reported in some patients to lead to irreversible intragraft thrombosis. DESIGN AND METHODS:We h...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/s0049-3848(01)00396-6

    authors： Lozano M,Oppenheimer F,Cofan F,Rosinyol L,Mazzara R,Escolar G,Ordinas A

    更新日期：2001-12-15 00:00:00

  • The effects of recombinant activated factor VII dose on the incidence of thromboembolic events in patients with coagulopathic bleeding.

    abstract：INTRODUCTION:Previous studies have suggested the used of off-label recombinant factor VII (rFVIIa) increases the risk of thromboembolic events, but the effect of the dose of rFVIIa is not well described in the literature. MATERIALS AND METHODS:All adult patients that received off-label rFVIIa from 2005-2012 were inclu...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2014.02.026

    authors： Bucklin MH,Acquisto NM,Nelson C

    更新日期：2014-05-01 00:00:00