Abstract:
INTRODUCTION:Ultrasound can accelerate clot dissolution in vitro and in vivo. We used an ex vivo canine shunt to investigate low frequency ultrasound effects on platelet-rich stent thrombosis. METHODS AND RESULTS:Nitinol stents were expanded to 2 mm in diameter in two perfusion chambers in a parallel shunt and exposed to flowing arterial blood at 2100 s(-1) to generate stent thrombi (n=224 perfusion runs). Dethrombotic effects were assessed during treatment with saline and combined treatment with aspirin and heparin. One stent was exposed to ultrasound (27 kHz, 1.4 W/cm2), while the other was not. Stent thrombi were weighed before and after treatment. There was no significant effect of ultrasound during saline infusion. Treatment with aspirin+heparin alone reduced thrombus weight by 37+/-25% (18.9+/-6.1 to 11.8+/-7.7 mg, p<0.0001). Combined treatment with aspirin+heparin+ultrasound produced a 49+/-23% reduction in thrombus weight (19.0+/-6.3 to 9.6+/-7.8 mg, p<0.0001). The reduction in thrombus weight was significantly greater in aspirin+heparin+ultrasound compared with aspirin+heparin alone (p=0.04). CONCLUSIONS:Transcutaneous ultrasound significantly enhances dethrombotic effect of aspirin plus heparin on preformed stent thrombi. These findings suggest the potential of ultrasound as an adjunct to antithrombotic therapy to improve effectiveness without increasing the risk of bleeding complications during treatment of vascular thrombosis.
journal_name
Thromb Resjournal_title
Thrombosis researchauthors
Neuman Y,Rukshin V,Tsang V,Atar S,Miyamoto T,Luo H,Kobal S,Thompson T,Birnbaum Y,Horzewski M,Siegel RJ,Kaul Sdoi
10.1016/j.thromres.2003.10.023subject
Has Abstractpub_date
2003-01-01 00:00:00pages
99-104issue
1-2eissn
0049-3848issn
1879-2472pii
S0049384803005437journal_volume
112pub_type
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journal_title:Thrombosis research
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journal_title:Thrombosis research
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journal_title:Thrombosis research
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journal_title:Thrombosis research
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journal_title:Thrombosis research
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journal_title:Thrombosis research
pub_type: 杂志文章
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journal_title:Thrombosis research
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journal_title:Thrombosis research
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journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(95)00159-o
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journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(91)90120-l
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journal_title:Thrombosis research
pub_type: 杂志文章,评审
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更新日期:2004-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.thromres.2009.02.014
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journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(85)90103-3
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journal_title:Thrombosis research
pub_type: 临床试验,杂志文章
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journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2019.08.016
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Thrombosis research
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doi:10.1016/j.thromres.2006.05.005
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journal_title:Thrombosis research
pub_type: 杂志文章,评审
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更新日期:2000-05-01 00:00:00
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journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/s0049-3848(99)00241-8
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journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(90)90053-f
更新日期:1990-08-15 00:00:00
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journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2006.11.009
更新日期:2007-01-01 00:00:00
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journal_title:Thrombosis research
pub_type: 传,历史文章,杂志文章
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更新日期:2007-01-01 00:00:00
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journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(95)00029-1
更新日期:1995-03-15 00:00:00
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journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2012.05.003
更新日期:2012-09-01 00:00:00
abstract::Incubation of recombinant human tissue factor apoprotein (Apo-TF) with human plasma decreased the recalcified clotting time of this plasma in a time-and dose-dependent manner suggesting relipidation of the Apo-TF by plasma lipoproteins. Incubation of Apo-TF with purified preparations of human very low density, low den...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(90)90182-c
更新日期:1990-11-01 00:00:00
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journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(85)90284-1
更新日期:1985-11-15 00:00:00