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Prognostic value of pre-surgical plasma PAI-1 (plasminogen activator inhibitor-1) levels in breast cancer.

Abstract：

INTRODUCTION:Plasminogen activator inhibitor (PAI-1) may have an independent prognostic value in breast cancer (BC). PAI-1 4G/5G polymorphism may have significance for antigen expression. Thus, we analyzed the possible associations between PAI-1 4G/5G polymorphism, plasma PAI-1 levels, and clinicopathological features of breast cancer (BC) patients. PATIENTS AND METHODS:PAI-1 4G/5G polymorphism (both on germinal and tumor DNA) and plasma PAI-1 levels were investigated in 99 BC patients and 50 unrelated healthy women similar for age and menopausal status. RESULTS:No association was found between allele frequencies and clinicopathological features of BC or plasma antigen levels. Plasma PAI-1 levels were higher in BC compared to controls (p=0.002), particularly in patients with large tumors (p<0.001). 5-year follow-up was achieved in 79 patients: 30% had relapsing disease, 63% with positive compared to 37% with negative PAI-1 levels (p<0.05). 5-year relapse-free survival rate of positive PAI-1 was 46% vs., 77% of negative patients (p=0.02). CONCLUSIONS:We may conclude that plasma PAI-1 levels in BC patients could represent a useful prognostic variable for relapse, although PAI-1 polymorphism might not represent a genetic susceptibility factor.

journal_name

Thromb Res

journal_title

Thrombosis research

authors

Palmirotta R,Ferroni P,Savonarola A,Martini F,Ciatti F,Laudisi A,Sini V,Del Monte G,Guadagni F,Roselli M

doi

10.1016/j.thromres.2009.02.014

subject

Has Abstract

pub_date

2009-09-01 00:00:00

pages

403-8

issue

4

eissn

0049-3848

issn

1879-2472

pii

S0049-3848(09)00128-5

journal_volume

124

pub_type

杂志文章

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