Abstract:
:A quantitative assessment was made of the distribution of arachidonic acid (AA), eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), and docosahexaenoic acid (DHA) among the individual sub-classes (diacyl, alkylacyl, alkenylacyl) of the various platelet phospholipids of human subjects consuming a fish oil concentrate (as MaxEPA) enriched in EPA plus DHA. This work was of interest since dietary fish oils provide for a pronounced enrichment of platelet phospholipid in EPA as well as DPA plus DHA to a lesser extent while reducing AA-phospholipid and platelet reactivity. After 42 days of MaxEPA supplementation (providing 3.6 g EPA and 2.4 g DHA per day), the majority of the mass of all four polyunsaturated fatty acids in the choline-containing phospholipid (PC) was found in the diacyl species (76-87% of total PC). In contrast, twice as much of the EPA in the ethanolamine-containing phospholipid (PE) resided in the alkenylacyl species (62.7% of total PE) relative to the diacyl species (32.3%) with minor amounts in the alkylacyl fraction (5.1%). The major single reservoir of total EPA-containing phospholipid was the alkenylacyl PE (38.2% of total) followed by diacyl PC (27.8%), diacyl PE (19.6%), with progressively lesser amounts in the alkylacyl PC, alkylacyl PE, diacyl PS (phosphatidylserine), alkenylacyl PC, and diacyl PI (phosphatidylinositol) at 6.7, 3.1, 2.3, 1.4, and 0.8% of the total mass, respectively. In contrast, only 27.1% of the total mass of AA-phospholipid was represented by the alkenylacyl PE with the bulk of the remainder being distributed in the diacyl species of PE, PC, PI, and PS.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Thromb Resjournal_title
Thrombosis researchauthors
Holub BJ,Celi B,Skeaff CMdoi
10.1016/0049-3848(88)90181-8subject
Has Abstractpub_date
1988-04-01 00:00:00pages
135-43issue
1eissn
0049-3848issn
1879-2472pii
0049-3848(88)90181-8journal_volume
50pub_type
杂志文章abstract:BACKGROUND:Cancer patients have an increased risk of thrombosis. Tissue factor (TF) antigen and TF activity associated with microparticles in plasma are elevated in patients with various types of cancer. Of these two measurements, TF activity is considered superior to TF antigen levels because the activity more closely...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2007.12.023
更新日期:2008-01-01 00:00:00
abstract:INTRODUCTION:The contribution of platelet activation to the pathogenesis of sickle cell disease (SCD) remains uncertain. We evaluated the safety and efficacy of eptifibatide, a synthetic peptide inhibitor of the αIIbβ3 receptor, in SCD patients during acute painful episodes. MATERIALS AND METHODS:In this single site, ...
journal_title:Thrombosis research
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.thromres.2013.08.002
更新日期:2013-09-01 00:00:00
abstract::Stimulation of rat platelets with U46619 induced Ca2+ mobilization and platelet shape change, but aggregation and secretion were induced when platelets were stimulated with U46619 plus phorbol 12-myristate 13-acetate (PMA). However, stimulation of rabbit platelets with U46619 induced all the three platelet responses. ...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(89)90171-0
更新日期:1989-10-15 00:00:00
abstract::Plasma antithrombin III (AT-III) levels were measured in 61 patients undergoing general surgery. The patients were randomly allocated to a test or a control group. The test group received 5000iu of subcutaneous heparin two hours before operation and then twelve hourly for seven days. The control group received subcuta...
journal_title:Thrombosis research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0049-3848(86)90102-7
更新日期:1986-09-15 00:00:00
abstract::Concentration-response relationships of human platelet aggregation rates were analyzed for a variety of agonists and inhibitors. Their approximation by the Hill equation showed that the values of the Hill coefficient (h) were agonist-dependent and increased as follows: hADP = hL-EPINEPHRINE = hPAF = hPGH2 = hU46619 le...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(92)90308-w
更新日期:1992-06-01 00:00:00
abstract::Individuals with more than one defect in the natural anticoagulant system exhibit an increased risk for thrombosis. We report on a family with two cases of combined protein C (PROC) and protein S (PROS) deficiency, five cases of isolated PROC deficiency Type I, and two cases of isolated PROS deficiency Type I. PROC an...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/s0049-3848(01)00232-8
更新日期:2001-07-01 00:00:00
abstract::Properties of a new concentrate of FVII/FVIIa, obtained by adsorption onto an inorganic adsorbent followed by a chromatographic step onto Q-Sepharose using a by-product of routine fractionation as starting material, are described. This fraction contains only small amounts of the other components of the prothrombin com...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(89)90126-6
更新日期:1989-06-15 00:00:00
abstract::A synthetic xanthone derivative, 3-[2-(cyclopropylamino)ethoxy] xanthone (CPEX), was investigated for its antiplatelet activities in washed rabbit platelets and human platelet-rich plasma. CPEX inhibited concentration-dependently the aggregation and ATP release of rabbit platelets caused by arachidonic acid (AA; 100 m...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(94)90142-2
更新日期:1994-07-01 00:00:00
abstract::Anticoagulants used for platelet function studies in vitro may affect platelet responsiveness. In the present study we compared the influence of three different anticoagulants, sodium citrate, low molecular mass heparin, and recombinant hirudin, on platelet aggregation in whole blood in vitro, using impedance aggregom...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/s0049-3848(97)00114-x
更新日期:1997-07-01 00:00:00
abstract:BACKGROUND:The purpose of this study was to determine whether the administration of multiple boluses of oral and intravenous tranexamic acid (TXA) postoperatively was equivalent in reducing blood loss in primary THA. METHODS:A total of 108 patients were randomized into two groups: oral TXA group (54 patients receiving...
journal_title:Thrombosis research
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.thromres.2018.02.007
更新日期:2018-04-01 00:00:00
abstract:INTRODUCTION:The effects of multiple inherited and acquired thrombophilic defects on the outcome of in-vitro fertilization (IVF) remain unexplored. The aim of this study was to evaluate the association between multiple thrombophilia and clinical outcomes in a large prospective cohort of women undergoing IVF. MATERIALS...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2018.05.006
更新日期:2018-07-01 00:00:00
abstract:BACKGROUND:The aim of this study was to describe platelet aggregation characteristics by multiple electrode aggregometry (MEA) and to evaluate MEA for its potential to detect platelet dysfunction and response to anti-aggregatory drugs in patients with myeloproliferative disorders (MPD). METHODS:We compared the platele...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2010.06.014
更新日期:2010-09-01 00:00:00
abstract:BACKGROUND:Peripheral pulmonary artery thrombus (PPT) is common in the clinic. However, due to the lack of an ideal diagnostic tool, PPT cannot be quickly diagnosed and effectively treated at present. Optical coherence tomography (OCT) is a new intravascular imaging technique that is characterized by high image resolut...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2017.10.021
更新日期:2018-01-01 00:00:00
abstract:INTRODUCTION:It has been widely accepted that genetic factors were the major sources of the variation in warfarin dose. This study is intended to investigate whether the 3261G>A variation in GGCX gene influences stable warfarin dose in Chinese patient population. MATERIALS AND METHODS:A total of 217 patients with stab...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2010.10.027
更新日期:2011-02-01 00:00:00
abstract:INTRODUCTION:Fibrin structure and cellular composition of thrombi profoundly affect the clinical outcomes in ischemic coronary and peripheral artery disease. Our study addressed the interrelations of structural features of thrombi and routinely measured laboratory parameters. MATERIALS AND METHODS:Thrombi removed by t...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2015.02.004
更新日期:2015-04-01 00:00:00
abstract:BACKGROUND:Ambient particulate matter (PM) is associated with cardiovascular morbidity and mortality. It has been proposed that PM induces a pro-thrombotic process, increasing the risk of cardiovascular events, with some support from epidemiological and laboratory-based models. Diesel exhaust is a major contributor to ...
journal_title:Thrombosis research
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.thromres.2007.01.005
更新日期:2007-01-01 00:00:00
abstract:INTRODUCTION:Blood flow induced shear stress plays an important role in platelet and endothelial cell functions. The goal of this study was to investigate the effect of physiologically relevant dynamic shear stress on platelet and endothelial cells. MATERIALS AND METHODS:Pulsatile shear stress waveforms mimicking the ...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2010.11.021
更新日期:2011-03-01 00:00:00
abstract::Arthral, abdominal and renal symptoms in Henoch-Schönlein purpura (HSP) were scored. Coagulation factor XIII (F XIII) activity was determined in fifty-six children with HSP and the correlation with the severity score of the clinical symptoms was investigated. As a result, it was found that the decrease in F XIII level...
journal_title:Thrombosis research
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1016/0049-3848(89)90284-3
更新日期:1989-12-15 00:00:00
abstract::Endothelial cells synthesize and release different proteins involved in their function, and some of these proteins may play important roles in the cellular response to injury, infection, or glucocorticoids. We have examined the profile of proteins released from rabbit coronary microvascular endothelial (RCME) and huma...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(90)90202-n
更新日期:1990-01-01 00:00:00
abstract::Thrombus formation was electrically induced in the left common carotid artery of rats with preoccluded both vertebral and right carotid arteries. Following thrombus induction, animals became unresponsive and lost their righting reflex. The loss of righting reflex was observed when cortical tissular pO2 reached 55 +/- ...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(87)90340-9
更新日期:1987-10-01 00:00:00
abstract:INTRODUCTION:Randomized clinical trials have demonstrated non-inferiority of rivaroxaban compared with vitamin K antagonists (VKAs) in the treatment of venous thromboembolism (VTE). Our objective was to analyze in real life, tolerance, recurrence, bleeding and adverse events of rivaroxaban in patients with acute sympto...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2014.06.032
更新日期:2014-09-01 00:00:00
abstract::Increased fibrinolytic activity is a well recognized constant finding observed during cardiopulmonary bypass (CPB). The purpose of the present work was to study and estimate the factors involved in the plasminogen activation and prekallikrein-kallikrein systems in a population of adult patients undergoing open heart s...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(92)90018-6
更新日期:1992-09-01 00:00:00
abstract::A simple and discriminating assay for the determination of the fast-acting plasminogen activator inhibitor (PAI) activity in human plasma is described. The method is based on the inhibition of purified tissue plasminogen activator (tPA) by plasma diluted with a PAI-depleted plasma and the subsequent measurement of res...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(89)90250-8
更新日期:1989-11-01 00:00:00
abstract:INTRODUCTION:Antithrombin deficiency is associated with increased risk of venous thromboembolism (VTE). We aimed to identify variants causing antithrombin deficiency in a Danish population. MATERIALS AND METHODS:We performed Sanger sequencing and, in relevant cases, multiplex ligation-dependent probe amplification ana...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2019.01.022
更新日期:2019-03-01 00:00:00
abstract:INTRODUCTION:Pre-eclampsia is an important cause of maternal morbidity and mortality. Its etiology is still unknown. Clinical symptoms correlate with activation of coagulation and inherited thrombophilia has been associated with pre-eclampsia. ABO blood group has been associated with thrombotic disorders and pre-eclamp...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2008.11.012
更新日期:2009-06-01 00:00:00
abstract::Activated platelets may adhere to leukocytes and form circulating mixed aggregates. The latter are considered a reliable marker of a prothrombotic state and are associated with several cardiovascular conditions. The molecular mechanisms responsible of this cellular interaction include a central role of platelet P-sele...
journal_title:Thrombosis research
pub_type: 杂志文章,评审
doi:10.1016/j.thromres.2011.10.010
更新日期:2012-03-01 00:00:00
abstract:BACKGROUND:Brain tumor patients have an increased risk of venous thromboembolism (VTE). An important role in cancer-related VTE has been suggested for tissue factor (TF), the main initiator of the coagulation cascade. We conducted a prospective cohort study to determine whether expression levels of TF in brain tumors a...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2012.09.020
更新日期:2013-02-01 00:00:00
abstract::Cell based models of coagulation (CBM) have provided mechanistic insight into numerous hematological issues for nearly two decades. This review discusses another coagulation model system--the clot lifespan model (CLSM)--that has been designed to compliment the CBM-based approach to elucidating the mechanisms responsib...
journal_title:Thrombosis research
pub_type: 杂志文章,评审
doi:10.1016/j.thromres.2007.09.003
更新日期:2008-01-01 00:00:00
abstract::We have studied the synthesis and subcellular distribution of the glycosylated membrane protein tissue factor (TF) in human blood monocytes and the inducible monocyte like cell line, HL-60. Following induction with endotoxin or the phorbol ester, TPA, tissue factor specific activity was measured in intact cells, sonic...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(87)90405-1
更新日期:1987-11-15 00:00:00
abstract::Whilst the term cancer associated thrombosis (CAT) offers an overarching term for all thrombotic events encountered during the cancer journey, the reality is that this is a far too simplistic reflection of a complex multifactorial process occurring within a heterogeneous population. The management of CAT needs to cons...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/S0049-3848(16)30115-3
更新日期:2016-04-01 00:00:00