当前位置： SCI文献检索 > THROMBOSIS RESEARCH期刊下所有文献 > Coagulation markers in healthy human subjects exposed to diesel exhaust.

Coagulation markers in healthy human subjects exposed to diesel exhaust.

Abstract：

BACKGROUND:Ambient particulate matter (PM) is associated with cardiovascular morbidity and mortality. It has been proposed that PM induces a pro-thrombotic process, increasing the risk of cardiovascular events, with some support from epidemiological and laboratory-based models. Diesel exhaust is a major contributor to urban PM, and we conducted a controlled human exposure of diesel exhaust in healthy subjects. OBJECTIVE:To evaluate diesel exhaust exposure effects on fibrinolytic burden (D-dimer), platelet number, and endothelial injury (von Willebrand's factor, VWF), inhibition of the fibrinolytic pathway (plasminogen activator inhibitor-1 [PAI-1]), and inflammation (C-reactive protein, CRP). MATERIALS AND METHODS:Randomized, crossover, double-blinded design, with 13 healthy participants exposed on three different days (>or=2 weeks washout) to diesel exhaust at 0 (filtered air), 100 microg PM(2.5)/m(3) and 200 microg PM(2.5)/m(3). We assessed diesel exhaust-associated changes in D-dimer, VWF, PAI-1 and platelets at 3, 6 and 22 h, and CRP at 22 h, after exposure initiation. RESULT:Significant changes did not occur in any primary endpoints. Among secondary endpoints, diesel exhaust (200 microg PM(2.5)/m(3)) effect on PAI-1 levels at 22 h was of borderline significance, with a 1.32-fold decrease after exposure to diesel exhaust (200 microg PM(2.5)/m(3)), relative to filtered air (CI 1.00 to 1.54). Diurnal patterns in D-dimer and PAI-1 were observed. CONCLUSIONS:In healthy individuals, exposure to 200 microg PM(2.5)/m(3) diesel exhaust did not affect primary pro-thrombotic endpoints. Thus, these data do not support a diesel exhaust-induced pro-thrombotic phenomenon. Replication of these studies should be carried out to ascertain whether or not they inform our mechanistic understanding of air pollution's cardiovascular effects.

journal_name

Thromb Res

journal_title

Thrombosis research

authors

Carlsten C,Kaufman JD,Peretz A,Trenga CA,Sheppard L,Sullivan JH

doi

10.1016/j.thromres.2007.01.005

subject

Has Abstract

pub_date

2007-01-01 00:00:00

pages

849-55

issue

eissn

0049-3848

issn

1879-2472

pii

S0049-3848(07)00034-5

journal_volume

120

pub_type

杂志文章,随机对照试验

在线工具

Coagulation markers in healthy human subjects exposed to diesel exhaust.