当前位置： SCI文献检索 > THROMBOSIS RESEARCH期刊下所有文献 > Ajoene, the antiplatelet principle of garlic, synergistically potentiates the antiaggregatory action of prostacyclin, forskolin, indomethacin and dypiridamole on human platelets.

Ajoene, the antiplatelet principle of garlic, synergistically potentiates the antiaggregatory action of prostacyclin, forskolin, indomethacin and dypiridamole on human platelets.

Abstract：

:Ajoene, the major antiplatelet compound derived from garlic, synergistically potentiates the antiaggregatory action of prostacyclin, forskolin, indomethacin and dypiridamole. For collagen-induced platelet aggregation in human PRP, the ID50 for ajoene is 95 +/- 5 microM. However, in the presence of the antiaggregatory drugs mentioned above, the ID50 for ajoene decreases more than what would be predicted on the basis of simple additive effects. Similarly, the ID50 for prostacyclin decreases from 1 nM to 0.15 nM in the presence of 80 microM ajoene. Isobolic curves for the various combinations of ajoene with prostacyclin or indomethacin exhibit departure from linearity, as predicted for a potentiated synergism between ajoene and these drugs. Dypiridamole, which in PRP has very little effect on the dose-response curve for ajoene, when assayed in whole blood decreases the ID50 for ajoene by a factor of four. These results demonstrate that the antithrombotic potential of ajoene is substantially increased in the presence of physiologically and pharmacologically active antiplatelet agents.

journal_name

Thromb Res

journal_title

Thrombosis research

authors

Apitz-Castro R,Escalante J,Vargas R,Jain MK

doi

10.1016/0049-3848(86)90259-8

subject

Has Abstract

pub_date

1986-05-01 00:00:00

pages

303-11

issue

3

eissn

0049-3848

issn

1879-2472

journal_volume

42

pub_type

杂志文章

相关文献

THROMBOSIS RESEARCH文献大全
  • Effect of exercise, DDAVP, and epinephrine on the factor VIII:C/von Willebrand factor complex in normal dogs and von Willebrand factor deficient Doberman pinscher dogs.

    abstract：:Endothelial cells in biopsied blood vessels from von Willebrand factor (vWf)-deficient Doberman pinscher dogs contain immunologically detectable vWf. These dogs and normal dogs were treated with DDAVP (0.6 microgram/kg) and epinephrine (0.5 microgram/kg/min for 30 minutes) and were exercised, using 5 different exercis...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(90)90198-l

    authors： Meyers KM,Wardrop KJ,Dodds WJ,Brassard J

    更新日期：1990-01-01 00:00:00

  • Alloxan-induced hyperglycemia in rabbits and the response of platelets to aggregating agents in vitro and to exposed subendothelium in vivo.

    abstract：:Many patients with diabetes mellitus show increased platelet aggregation and prostaglandin synthesis in response to physiological agents such as ADP and collagen when their platelets are tested in platelet-rich plasma or washed platelet suspensions. However, the relationship between increased platelet aggregation in v...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(87)90265-9

    authors： Ingerman-Wojenski CM,Smith M,Silver MJ

    更新日期：1987-06-01 00:00:00

  • Comparison of standard fibrinogen measurement methods with fibrin clot firmness assessed by thromboelastometry in patients with cirrhosis.

    abstract：BACKGROUND:The Clauss fibrinogen method and thrombin clotting time (TCT) are still routinely used in patients with cirrhosis to define fibrinogen concentration and clotting potential. The thromboelastometric functional fibrinogen FIBTEM assay evaluates the strength of fibrin-based clots in whole blood, providing inform...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2015.04.003

    authors： Vucelic D,Jesic R,Jovicic S,Zivotic M,Grubor N,Trajkovic G,Canic I,Elezovic I,Antovic A

    更新日期：2015-06-01 00:00:00

  • Screening itself for disseminated intravascular coagulation may reduce mortality in sepsis: A nationwide multicenter registry in Japan.

    abstract：OBJECTIVES:Screening of patients with sepsis for disseminated intravascular coagulation (DIC) has been recommended in several guidelines. However, DIC screening is still not widely accepted as an essential component of sepsis management, partly because of a lack of evidence that DIC screening has an effect on mortality...

    journal_title：Thrombosis research

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.thromres.2017.11.023

    authors： Umemura Y,Yamakawa K,Hayakawa M,Hamasaki T,Fujimi S,Japan Septic Disseminated Intravascular Coagulation (J-Septic DIC) study group.

    更新日期：2018-01-01 00:00:00

  • Anticoagulant activity of a bacterial glycopeptide.

    abstract：:The anticoagulant properties of myxalin, a glycopeptide secreted by a Gram negative bacterium strain (Myxococcus xanthus) are studied and compared to those of heparin. This soluble material exhibits an anticoagulant activity which implies the inhibition of some serine proteases, thrombin and factor Xa. In the presence...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(90)90335-a

    authors： Akoum A,Josefonvicz J,Sigot M

    更新日期：1990-10-01 00:00:00

  • Studies on the prolonged bleeding time in von Willebrand's disease.

    abstract：:Ten studies of the effect of cryoprecipitate infusion in four patients with von Willebrand's Disease (vWD) are reported. The doses studied (4, 8 and in one case 10 bags of cryoprecipitate) were based on previous reports of correction of the bleeding time (BT) with such doses. A modest shortening of the BT was observed...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(89)90196-5

    authors： Smiley RK,Tittley P,Rock G

    更新日期：1989-03-01 00:00:00

  • Accumulation and release of acridine derivatives by intact platelets.

    abstract：:A new approach to the investigation of accumulation of acridine derivatives and release by platelets is proposed. At high concentrations of acridine orange (AO) inside dense bodies, a two component fluorescence spectrum with maxima at 530 and 640 nm has been recorded. Computer deconvolution of spectra provided additio...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(87)90102-2

    authors： Popov EG,Gabbasov ZA,Gavrilov IYu,Pozin EYa,Mejlumian AG

    更新日期：1987-09-15 00:00:00

  • Immunopurification of an S-antigen-like protein from human platelets.

    abstract：:S-antigen (also named arrestin or 48K protein) is a protein abundant in photoreceptor cells of vertebrates and invertebrates. The presently known function of this protein in retina is to arrest the enzymatic cascade of phototransduction in retinal rods, through its binding to photoactivated and phosphorylated rhodopsi...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：

    authors： Mirshahi M,Razaghi A,Mirshahi SS,Van Tuyen V,Faure JP

    更新日期：1991-12-01 00:00:00

  • Growth and function of the normal human placenta.

    abstract：:The placenta is the highly specialised organ of pregnancy that supports the normal growth and development of the fetus. Growth and function of the placenta are precisely regulated and coordinated to ensure the exchange of nutrients and waste products between the maternal and fetal circulatory systems operates at maxim...

    journal_title：Thrombosis research

    pub_type： 杂志文章,评审

    doi：10.1016/j.thromres.2004.06.038

    authors： Gude NM,Roberts CT,Kalionis B,King RG

    更新日期：2004-01-01 00:00:00

  • On the interaction of heparin-containing polymers with plasma proteins and blood.

    abstract：:In vitro exper iments showed that polymeric hydrogels containing covalently immobilized heparin affect the parameters of blood clotting system. This is not accounted for by the elution of heparin into the surrounding medium and this property of heparin-containing polymers is caused by specific interaction of immobiliz...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(82)90192-x

    authors： Platé NA,Valuev LI

    更新日期：1982-07-15 00:00:00

  • The pyrimido-pyrimidine derivatives, dipyridamole, mopidamol and RA-642, prevent from retinal vascular defects in experimental diabetes mellitus.

    abstract：:We compared the effects of dipyridamole, RA-642, and mopidamol on platelet activity and thromboxane/prostacyclin balance in relation to the degree of retinal vascularization in a model of experimental streptozotocin-induced diabetes in rats. After 3 months, collagen-induced platelet aggregation in whole blood was 25% ...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(96)00004-7

    authors： De La Cruz JP,Moreno A,Mérida F,García Campos J,Sánchez de la Cuesta F

    更新日期：1996-02-01 00:00:00

  • Efficacy and safety of the use of heparin as thromboprophylaxis in patients with liver cirrhosis: a systematic review and meta-analysis.

    abstract：INTRODUCTION:Venous thromboembolism is a common cause of morbidity and mortality. Although cirrhosis has classically been considered as an acquired bleeding diathesis, there is increasing evidence that rejects the traditional belief that these patients are naturally protected against venous thromboembolism. However, an...

    journal_title：Thrombosis research

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.thromres.2013.08.001

    authors： Gómez Cuervo C,Bisbal Pardo O,Pérez-Jacoiste Asín MA

    更新日期：2013-10-01 00:00:00

  • Impact of clopidogrel resistance on thrombotic events after percutaneous coronary intervention with drug-eluting stent.

    abstract：OBJECTIVES:This study examines whether patient resistance to clopidogrel is associated with long-term thrombotic events after elective coronary drug-eluting stent (DES) implantation. METHODS:We prospectively enrolled 386 patients with stable angina who received elective percutaneous coronary intervention (PCI) with DE...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2008.10.007

    authors： Wang ZJ,Zhou YJ,Liu YY,Yu M,Shi DM,Zhao YX,Guo YH,Cheng WJ,Jia de A,Cao Z,Nie B,Ge HL,Yang SW,Yan ZX

    更新日期：2009-05-01 00:00:00

  • Effects of insulin on platelet and leukocyte activity in whole blood.

    abstract：:Diabetes mellitus (DM) is associated with platelet and leukocyte dysfunction. Previous observations with regard to insulin effects on platelet and leukocyte function are less than consistent. We thus investigated the effects of insulin on platelets and leukocytes, as well as on platelet-leukocyte interactions in whole...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/s0049-3848(02)00306-7

    authors： Hu H,Hjemdahl P,Li N

    更新日期：2002-09-01 00:00:00

  • Urinary procoagulant behaves as tissue factor by promoting factor VIIa-catalyzed activation of factor X.

    abstract：:We purified the urinary procoagulant from frozen human urine by introducing phenyl-Sepharose hydrophobic chromatography. By this method, the apoprotein of the procoagulant and the lipid-like substance were separately recovered. Upon reassociation with the lipid-like substance or exogenous crude phospholipids, the apop...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(84)90114-2

    authors： Kurosawa S,Matsuda M,Aoki N

    更新日期：1984-03-15 00:00:00

  • The use of prothrombin complex concentrates in the treatment of hemorrhages induced by oral anticoagulation.

    abstract：:Bleeding events are a common adverse effect in oral anticoagulation that frequently depend on the duration and intensity of treatment. Major bleeding events, particularly intracerebral hemorrhages, are a serious complication in cases that require the rapid reversal of anticoagulation. Urgent correction of the coagulat...

    journal_title：Thrombosis research

    pub_type： 杂志文章,评审

    doi：10.1016/s0049-3848(99)00085-7

    authors： Pindur G,Mörsdorf S

    更新日期：1999-08-15 00:00:00

  • Variations of prothrombin time and international normalized ratio in patients treated with warfarin.

    abstract：:Prothrombin time is a standard screening test to monitor patients treated with oral anticoagulants. We hypothesize that INR measurements will not vary a lot within a given day in a given patient. The present study was thus conducted to compare the change of the international normalized ratio (INR) of prothrombin time ...

    journal_title：Thrombosis research

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0049-3848(02)00339-0

    authors： Ho CH,Lin MW,You JY,Chen CC,Yu TJ

    更新日期：2002-09-01 00:00:00

  • Thrombin enhances tumor cell adhesive and metastatic properties via increased alpha IIb beta 3 expression on the cell surface.

    abstract：:The association between blood coagulation and cancer growth and metastatic dissemination is not yet completely understood. In this study we demonstrate that thrombin is capable of enhancing tumor cell adhesive properties and thereby increases tumor cell metastatic potential. Following exposure to alpha-thrombin, Walke...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(92)90081-k

    authors： Wojtukiewicz MZ,Tang DG,Nelson KK,Walz DA,Diglio CA,Honn KV

    更新日期：1992-11-01 00:00:00

  • Cloning, purification and characterization of a recombinant protease with novel thrombolytic activity in human plasma and rat thrombosis models.

    abstract：BACKGROUND:There is a need to identify and develop novel thrombolytic agents that can directly digest fibrin clots from various biological resources. OBJECTIVE:To clone, express, purify, and characterize a recombinant protease named rvFMP capable of cleaving fibrinogen, fibrin polymer, and cross-linked fibrin in human...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2020.04.040

    authors： Lim DS,Park JE,Park JW,Cho YH,Park JK,Lee JS

    更新日期：2020-07-01 00:00:00

  • Determination of plasminogen activator inhibitor (PAI) activity of human plasma after dilution in a PAI-depleted plasma.

    abstract：:A simple and discriminating assay for the determination of the fast-acting plasminogen activator inhibitor (PAI) activity in human plasma is described. The method is based on the inhibition of purified tissue plasminogen activator (tPA) by plasma diluted with a PAI-depleted plasma and the subsequent measurement of res...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(89)90250-8

    authors： Contant G,Martinoli JL

    更新日期：1989-11-01 00:00:00

  • Inhibitory effects of TFPI on thrombin and factor Xa generation in vitro--modulatory action of glycosaminoglycans.

    abstract：:The effect of tissue factor pathway inhibitor (TFPI) on thrombin and factor Xa generation was studied in an in vitro system using a prothrombin complex concentrate. It was found that TFPI, via the direct inhibition of factor Xa and the tissue factor/factor VIIa complex, inhibited both the further generation of factor ...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(94)90173-2

    authors： Kaiser B,Hoppensteadt DA,Jeske W,Wun TC,Fareed J

    更新日期：1994-09-15 00:00:00

  • The alkenylacyl class of ethanolamine phospholipid represents a major form of eicosapentaenoic acid (EPA)-containing phospholipid in the platelets of human subjects consuming a fish oil concentrate.

    abstract：:A quantitative assessment was made of the distribution of arachidonic acid (AA), eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), and docosahexaenoic acid (DHA) among the individual sub-classes (diacyl, alkylacyl, alkenylacyl) of the various platelet phospholipids of human subjects consuming a fish oil concen...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(88)90181-8

    authors： Holub BJ,Celi B,Skeaff CM

    更新日期：1988-04-01 00:00:00

  • Oxidized lipoprotein(a) enhanced the expression of P-selectin in cultured human umbilical vein endothelial cells.

    abstract：:Lipoprotein(a) [Lp(a)] has been demonstrated to be an independent risk factor for coronary heart disease. However, the precise mechanism by which it contributes to the development of atherosclerosis remains unclear. P-selectin is one of the major adhesion molecules to mediate the interaction between monocytes, platele...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/s0049-3848(00)00363-7

    authors： Zhao SP,Xu DY

    更新日期：2000-12-15 00:00:00

  • Treatment of venous thromboembolism in patients with cancer: from clinical trials to real life.

    abstract：:Approximately one-fifth of all cases of venous thromboembolism (VTE) are related to cancer. VTE complications may have a substantial impact on prognosis, quality of life and care in patients with cancer. Patients with cancer-related VTE are at increased risk of developing recurrent VTE compared to patients without can...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/S0049-3848(20)30409-6

    authors： Verso M,Agnelli G

    更新日期：2020-07-01 00:00:00

  • Increased number of circulating endothelial cells and plasma markers of endothelial damage in chronic cocaine users.

    abstract：BACKGROUND:Cocaine use has been related with the development of accelerated atherosclerosis and with an increased risk of cardiac and cerebrovascular events, such as myocardial infarction, sudden cardiac death, and ischemic stroke. The underlying mechanisms leading to these complications are not fully understood, altho...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2011.04.019

    authors： Sáez CG,Olivares P,Pallavicini J,Panes O,Moreno N,Massardo T,Mezzano D,Pereira J

    更新日期：2011-10-01 00:00:00

  • Clinical outcomes of venous thromboembolism with dalteparin therapy in multiple myeloma patients.

    abstract：:This study focused on the clinical outcomes in multiple myeloma (MM) patients with venous thromboembolism (VTE) who received low-molecular-weight heparin (dalteparin) therapy. Changes in D-dimer levels before and after VTE were also evaluated. Among 549 patients treated with various chemotherapeutic agents, a total of...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2015.09.021

    authors： Lee SE,Jeon YW,Yoon JH,Cho BS,Eom KS,Kim YJ,Kim HJ,Lee S,Cho SG,Kim DW,Lee JW,Min WS,Kim M,Min CK

    更新日期：2015-11-01 00:00:00

  • Low dose of aPCC after the initial treatment in acquired haemophilia A is useful to reduce bleeding relapses: Data from the FAIR registry.

    abstract：BACKGROUND:Bypassing agents are the first line therapy in patients with acquired haemophilia A (AHA). Activated prothrombin complex concentrate (aPCC) proved to be effective as initial treatment, but 20% of patients (pts) had relapses. aPCC as short-term prophylaxis to reduce subsequent bleeds is still not clear. AIM:...

    journal_title：Thrombosis research

    pub_type： 信件

    doi：10.1016/j.thromres.2018.12.006

    authors： Zanon E,Pasca S,Siragusa S,Napolitano M,Santoro C,Mameli L,Rocino A,FAIR Study Group.

    更新日期：2019-02-01 00:00:00

  • Effect of resveratrol, a natural polyphenolic compound, on platelet activation induced by endotoxin or thrombin.

    abstract：:Resveratrol (3, 4', 5-trihydroxystilbene), a natural polyphenol, is found in some plants that are used in human nutrition. Grapes are a major source for resveratrol, and a significant amount can also be found in red wine. Several experimental studies have demonstrated biological properties of resveratrol, especially i...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/s0049-3848(02)00273-6

    authors： Olas B,Wachowicz B,Saluk-Juszczak J,Zieliński T

    更新日期：2002-08-15 00:00:00

  • The synthetic pentasaccharide SR 90107A/Org 31540 does not release lipase activity into the plasma.

    abstract：:The present study was designed to find out whether the synthetic pentasaccharide SR 90107A/Org 31540, which is presently being evaluated in clinical trials as an antithrombotic agent, influences lipoprotein metabolism in rats as determined by plasma triglyceride (TG) lipase activity. A comparison with three clinically...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/s0049-3848(97)00075-3

    authors： Hoffmann P,Bernat A,Dumas A,Petitou M,Hérault JP,Herbert JM

    更新日期：1997-05-15 00:00:00

  • Activators and inhibitors of coagulation and fibrinolysis in patients with prostatic cancer treated with oestrogen or orchidectomy.

    abstract：:The treatment of prostatic cancer with oestrogen has been reported to be associated with cardiovascular side effects. Twenty patients with recently diagnosed prostatic cancer were randomly allocated to oestrogen therapy or orchidectomy. As compared to healthy age matched controls the patients with prostatic cancer had...

    journal_title：Thrombosis research

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/0049-3848(86)90024-1

    authors： Henriksson P,Blombäck M,Bratt G,Edhag O,Eriksson A

    更新日期：1986-12-15 00:00:00