Abstract:
BACKGROUND:Cocaine use has been related with the development of accelerated atherosclerosis and with an increased risk of cardiac and cerebrovascular events, such as myocardial infarction, sudden cardiac death, and ischemic stroke. The underlying mechanisms leading to these complications are not fully understood, although thrombus formation and altered vascular function are prominent findings. OBJECTIVES:Our aim was to evaluate markers of endothelial dysfunction in chronic cocaine consumers before and after drug withdrawal. PATIENTS/METHODS:We determined circulating endothelial cells (CECs) and plasma levels of stromal cell-derived factor-1 (SDF-1), monocyte chemotactic protein-1(MCP-1), soluble intracellular adhesion molecule (sICAM), high-sensitivity C reactive protein (hsCRP) and endothelin-1(ET-1), in DSM-IV cocaine addicts at baseline and after one month of cocaine abstinence. RESULTS:Cocaine users showed a strikingly higher numbers of CEC (62.35 ± 18.4 vs 8.25 ± 13.8 CEC/mL) and significantly elevated plasma levels for all the markers evaluated as compared to the control group. After cocaine withdrawal, patients improved SDF-1, ET-1, hsCRP and sICAM levels. However, CEC number and MCP-1 plasma levels remained significantly elevated. All the results were adjusted for blood levels of cholesterol and triglycerides and for smoking habit. CONCLUSIONS:Our results demonstrated that chronic cocaine consumption alters several functions of the endothelium towards a pro-thrombotic condition and that some of those functions remain abnormal even after short-term drug withdrawal. These observations support the notion that endothelial dysfunction may play a key role in the pathogenesis of ischemic vascular disease observed in cocaine abusers.
journal_name
Thromb Resjournal_title
Thrombosis researchauthors
Sáez CG,Olivares P,Pallavicini J,Panes O,Moreno N,Massardo T,Mezzano D,Pereira Jdoi
10.1016/j.thromres.2011.04.019subject
Has Abstractpub_date
2011-10-01 00:00:00pages
e18-23issue
4eissn
0049-3848issn
1879-2472pii
S0049-3848(11)00182-4journal_volume
128pub_type
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journal_title:Thrombosis research
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doi:10.1016/0049-3848(89)90041-8
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doi:10.1016/0049-3848(86)90330-0
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journal_title:Thrombosis research
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journal_title:Thrombosis research
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journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(85)90065-9
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journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(96)00051-5
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journal_title:Thrombosis research
pub_type: 杂志文章
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更新日期:2014-08-01 00:00:00
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pub_type: 临床试验,杂志文章
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doi:10.1016/j.thromres.2007.02.001
更新日期:2007-01-01 00:00:00
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journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(86)90326-9
更新日期:1986-11-15 00:00:00
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journal_title:Thrombosis research
pub_type: 杂志文章
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doi:10.1016/j.thromres.2014.04.016
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pub_type: 杂志文章
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journal_title:Thrombosis research
pub_type: 杂志文章
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更新日期:2010-03-01 00:00:00
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journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2006.05.005
更新日期:2007-01-01 00:00:00
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journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(89)90171-0
更新日期:1989-10-15 00:00:00
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journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(89)90102-3
更新日期:1989-02-01 00:00:00
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journal_title:Thrombosis research
pub_type: 临床试验,杂志文章
doi:10.1016/j.thromres.2006.07.009
更新日期:2007-01-01 00:00:00
abstract::Mild hyperhomocysteinemia is recognized as a risk factor for venous thromboembolism (VTE), though its role in the thrombogenic processes is not understood. Its possible association with impaired fibrinolysis was investigated in 157 patients (61 women, 96 men) below the age of 60 years (43+/-11, mean+/-SD) with a histo...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/s0049-3848(00)00324-8
更新日期:2000-11-15 00:00:00