Effects of armagnac or vodka on platelet aggregation in healthy volunteers: a randomized controlled clinical trial.

abstract：:The ability of the COA-SET Fibrin monomer (COA-SET FM) test to detect soluble fibrin was evaluated by comparing the results of the COA-SET FM test with fibrinopeptide A (FPA) determinations following thrombin incubation of plasma or whole blood. In addition, two semiquantitative tests (erythrocytes-agglutination test ...

journal_title：Thrombosis research

authors： Halvorsen S,Skjønsberg OH,Ruyter R,Godal HC

更新日期：1990-02-15 00:00:00

abstract：:HC II functional assays are generally preferred with respect to immunochemical assays. Nevertheless functional assays can be biased by the antithrombin III (AT III)-heparin complex activity; in fact trace amounts of heparin generally contaminate dermatan sulfate (DS) commercial preparations used as HC II reaction acti...

journal_title：Thrombosis research

authors： Ruzzenente O,Ghidini R,Poli G,Schiavon R,Guidi GC

更新日期：1992-01-15 00:00:00

abstract：INTRODUCTION:Thrombotic storm (TS) presents as a severe, acute thrombotic phenotype, characterized by multiple clotting events and frequently affecting younger adults. Understanding the extensive hypercoagulation of an extreme phenotype as TS will also provide insight into the pathogenesis of a wider spectrum of thromb...

journal_title：Thrombosis research

authors： Nuytemans K,Ortel TL,Gomez L,Hofmann N,Alves N,Dueker N,Beecham A,Whitehead P,Hahn Estabrooks S,Kitchens CS,Erkan D,Brandão LR,James AH,Kulkarni R,Manco-Johnson MJ,Pericak-Vance MA,Vance JM

更新日期：2018-01-01 00:00:00

abstract：:Sulfation of the natural polysaccharide curdlan results in anticoagulantly active beta-1,3-glucan sulfates whose activity depends on various structural parameters. In this study the anticoagulant and antithrombotic effects of one of these beta-1,3-glucan sulfates (GS) were compared with those of a porcine mucosal hepa...

journal_title：Thrombosis research

authors： Alban S,Jeske W,Welzel D,Franz G,Fareed J

更新日期：1995-05-01 00:00:00

abstract：:Fasting plasma homocysteine level and the related clinical findings were analysed in 240 consecutive patients with venous thromboembolism. Hyperhomocysteinemia, defined as a plasma level above 20 micromol/l (corresponding to the percentile 95th in the controls), was present in 11.2% of the patients. Plasma homocystein...

journal_title：Thrombosis research

authors： Hainaut P,Jaumotte C,Verhelst D,Wallemacq P,Gala JL,Lavenne E,Heusterspreute M,Zech F,Moriau M

更新日期：2002-04-15 00:00:00

abstract：:We investigated on how to effectively administer orally factor VIII preparation to two patients with von Willebrand's disease as volunteers, and the following results were obtained: Bleeding time and aPTT were shortened, but no change of PT was observed. Factor VIII:C increased slightly, but no significant increase wa...

journal_title：Thrombosis research

authors： Sakuragawa N,Niiya K,Kondo S

更新日期：1985-06-15 00:00:00

abstract：:This prospective randomized study investigated the influence of normotensive and hypotensive general anesthesia on platelet aggregability, intraoperative blood loss and parameters of plasmatic coagulation during extensive orthognathic surgery. A total of 30 patients were randomly allocated for either normotensive anes...

journal_title：Thrombosis research

authors： Felfernig-Boehm D,Salat A,Kinstner C,Fleck T,Felfernig M,Kimberger O,Andel H,Mueller MR

更新日期：2001-08-01 00:00:00

abstract：:The use of oral contraceptives (OCs) has been associated with vascular complications. The mechanism(s) by which OCs predispose to thrombotic events remains unclear. Recent studies have demonstrated that postmenopausal (PM) women who take estrogen replacement therapy (ERT) have a decreased incidence of myocardial infar...

journal_title：Thrombosis research

authors： Dores GM,Miller ME,Thorpe SL

更新日期：1993-01-15 00:00:00

abstract：:Activation of plasma plasminogen to plasmin is the objective of current strategies for thrombolytic therapy. Although thrombolytic activity in blood involves a large cellular component as well as that in plasma, the contribution of this cellular phase to clinical thrombolysis has not been examined. Using a 125I-fibrin...

journal_title：Thrombosis research

authors： Langleben D,Moroz LA,Schlesinger RD

更新日期：1990-07-15 00:00:00

abstract：INTRODUCTION:Bivalirudin is an alternative to heparin anticoagulation in infants and children in the setting of extracorporeal life support (ECLS). While activated partial thromboplastin time (aPTT) is widely accepted as the standard test to monitor bivalirudin therapy, the usefulness of thromboelastometry (ROTEM) to m...

journal_title：Thrombosis research

authors： Teruya J,Hensch L,Bruzdoski K,Adachi I,Hui SR,Kostousov V

更新日期：2020-02-01 00:00:00

abstract：INTRODUCTION:In contrast to unfractionated heparin (UFH), use of low-molecular weight heparin (LMWH) during pregnancy has not been reported to be associated with a significant decrease in bone mineral density (BMD). The aim of this study was to investigate whether long-term use of LMWH during pregnancy is associated wi...

journal_title：Thrombosis research

authors： Galambosi P,Hiilesmaa V,Ulander VM,Laitinen L,Tiitinen A,Kaaja R

更新日期：2016-07-01 00:00:00

abstract：INTRODUCTION:Cancer associated thrombosis is a well-recognized phenomenon that results in considerable patient morbidity and mortality. Malignancy conveys an increased risk for thrombosis and chemotherapy further elevates this risk. The pathophysiological mechanisms underlying this process remain poorly defined. MATER...

journal_title：Thrombosis research

authors： Boles JC,Williams JC,Hollingsworth RM,Wang JG,Glover SL,Owens AP 3rd,Barcel DA,Kasthuri RS,Key NS,Mackman N

更新日期：2012-02-01 00:00:00

abstract：:The proteinase, brinase (Mr approximately 35000), from Aspergillus oryzae, which has been used in therapeutic attempts as a thrombolytic agent in arterial thrombosis, binds to purified human alpha 2-macroglobulin (alpha 2M) with a stoichiometry of 1.7-1.9 mol of enzyme/mol inhibitor. This binding leads to quantitative...

journal_title：Thrombosis research

authors： Larsson LJ,Frisch EP,Törneke K,Lindblom T,Björk I

更新日期：1988-01-01 00:00:00

abstract：:Rabbit platelets pretreated with CV-3988 had reduced responsiveness to platelet activating factor(PAF) even after the platelets had been washed with a buffer. This was due to its tight binding to receptor sites for PAF, but not conformational changes of the receptor, because the platelets that were pretreated with CV-...

journal_title：Thrombosis research

authors： Tokumura A,Yoshida J,Okasaka N,Fukuzawa K,Tsukatani H

更新日期：1987-04-01 00:00:00

abstract：:Bovine myelin basic protein (BP) induced a shape change and endogenous phosphorylation of a 45,000 (45K) molecular weight protein of intact human platelets. This effect occurred rapidly over an effective concentration range of 5-100 microM BP. BP peptides encompassing residues 1-42, 43-88, and 89-169 from the BP molec...

journal_title：Thrombosis research

authors： Chiang TM,Whitaker JN,Kang AH,Beachey EH

更新日期：1982-03-15 00:00:00

abstract：INTRODUCTION:A fraction of fibrinogen molecules contain an alternatively spliced variant chain called gamma'. Plasma levels of this variant have been associated with both myocardial infarction and venous thrombosis. Because clot structure has been associated with cardiovascular risk, we examined the effect of gamma' ch...

journal_title：Thrombosis research

authors： Gersh KC,Nagaswami C,Weisel JW,Lord ST

更新日期：2009-07-01 00:00:00

abstract：:Selected coagulation and fibrinolytic parameters were assessed in 40 insulin dependent diabetes mellitus patients with varying degrees of metabolic control; 30 healthy subjects matched for age and sex formed the control group. Activated Partial Thromboplastin Time, Prothrombin Time, Fibrinogen, Factor VII, Antithrombi...

journal_title：Thrombosis research

authors： Carmassi F,Morale M,Puccetti R,De Negri F,Monzani F,Navalesi R,Mariani G

更新日期：1992-09-15 00:00:00

abstract：BACKGROUND:Predictors of venous thromboembolism (VTE) after trauma are uncertain. OBJECTIVE:To identify independent predictors of VTE after acute trauma. METHODS:Using Rochester Epidemiology Project (REP) resources, we identified all Olmsted County, MN residents with objectively-diagnosed incident VTE within 92days a...

journal_title：Thrombosis research

authors： Park MS,Perkins SE,Spears GM,Ashrani AA,Leibson CL,Boos CM,Harmsen WS,Jenkins DH,Bailey KR,Ballman KV,Heit JA

更新日期：2016-08-01 00:00:00

abstract：:Forty women undergoing surgery under general anaesthesia for hyperplasia mammae were randomized to treatment with low dose heparin (5000 IU twice daily) or not. Preoperatively, and repeated on the 3. postoperative day, assays of euglobulin clot lysis time (ELT) after venous stasis, tissue plasminogen activator (t-PA) ...

journal_title：Thrombosis research

authors： Arnesen H,Engebretsen LF,Ugland OM,Seljeflot I,Kierulf P

更新日期：1987-03-01 00:00:00

abstract：:Defibrotide (D) was labelled with 125I or with 32P. The radiolabelled compounds ([125I]-Defibrotide ([125I]-D), [32P]-Defibrotide ([32P]-D) retained the same profibrinolytic activity, in vitro, as the parent drug, suggesting that the labelling procedures had not modified the pharmacological properties of D and hence t...

journal_title：Thrombosis research

authors： Fisher J,Holland TK,Pescador R,Porta R,Ferro L

更新日期：1996-01-01 00:00:00

abstract：:Twenty-five men and 26 women were studied to investigate the effects of acute strenuous exercise on hemostasis after obtaining their informed consent. After familiarization, they performed exercise on a bicycle ergometer at 75% of their predetermined maximal workload until exhaustion. Bleeding time, measured by the Si...

journal_title：Thrombosis research

authors： Chen HI,Tang YR,Wu HJ,Jen CJ

更新日期：1989-08-15 00:00:00

abstract：:Highly purified bovine von Willebrand protein (vWP) has been studied with two complementary techniques. Light scattering measurements on different samples give weight average molecular weights in the range from 7 to 13 million, radius of gyration between 75 and 140 nm and diffusion coefficient near 4.15 X 10(-8) cm2/s...

journal_title：Thrombosis research

authors： Binnie C,Wagner RH,Cooper H,Hermans J

更新日期：1985-11-15 00:00:00

abstract：:The zymogen form of circulating Factor VII activating protease (FSAP) is activated by histones that are released as a consequence of tissue damage or excessive inflammation. This is likely to have consequences in a number of disease conditions such as stroke, atherosclerosis, liver fibrosis, thrombosis and cancer. To ...

journal_title：Thrombosis research

authors： Rut W,Nielsen NV,Czarna J,Poreba M,Kanse SM,Drag M

更新日期：2019-10-01 00:00:00

abstract：:G619, a 4-OH-isophthalic acid derivative, was studied for its capacity to inhibit platelet aggregation. G619 dose-dependently inhibited U46619, collagen, ADP, PAF, thrombin and epinephrine-induced platelet aggregation in vitro. The IC50 values for inhibition of U46619-induced human and rabbit platelet aggregation were...

journal_title：Thrombosis research

authors： Yue TL,Smith EF 3rd,Ohlstein EH,Sulpizio A,Slivjak MJ,Rabinovici R,Sellers TS,Lynch KM,Poyser R,Feuerstein G

更新日期：1992-05-15 00:00:00

abstract：:Two functional assays for protein C inhibitor (PCI) were evaluated in parallel for the same plasma samples. One assay is specific for active PCI and measures its ability to form complexes with activated protein C (APC) in the presence of heparin (España et al, Thromb Res 64, 309, 1991) (Method A). After incubation of ...

journal_title：Thrombosis research

authors： España F,Hendl S,Gilabert J,Estellés A,Aznar J

更新日期：1993-06-01 00:00:00

abstract：:Using high-resolution real-time two-dimensional ultrasound, we have investigated the role of red cells in the growth of already established platelet aggregates under controlled flow conditions. Platelet rich plasma (PRP) was circulated in vitro in horizontally and vertically arranged tubing at mean shear rate ranging ...

journal_title：Thrombosis research

authors： Machi J,Sigel B,Ramos JR,Justin JR,Feinberg H,LeBreton GC,Robertson AL Jr

更新日期：1984-10-01 00:00:00

abstract：UNLABELLED:We undertook a survey of French university hospital hematological laboratories to ascertain the clinical characteristics of patients with suspected HIT, the laboratory tests performed, and the therapeutic strategy adopted in current practice. METHODS:A standardized medical records database for patients with...

journal_title：Thrombosis research

authors： Bidet A,Tardy Poncet B,Desprez D,de Maistre E,Presles E,Lecompte T,Lavenu-Bombled C,Huisse MG,Wolf M,Morange P,Racadot E,Mouton C,Grunebaum L,Pouplard C,Tardy B,GEHT-HIT study group.

更新日期：2010-06-01 00:00:00

abstract：INTRODUCTION:Type 2 diabetes mellitus (T2DM) patients have a variable response profile to the P2Y(12) receptor antagonist clopidogrel. P2Y(12) receptor signalling promotes platelet procoagulant activity. The aim of this study was to determine if T2DM patients with suboptimal clopidogrel response have greater platelet p...

journal_title：Thrombosis research

authors： Angiolillo DJ,Capranzano P,Desai B,Shoemaker SB,Charlton R,Zenni MM,Guzman LA,Bass TA

更新日期：2009-07-01 00:00:00

abstract：:A new method, based on the observation that leukocytes contain PGI2-synthetase activity, was used to measure the effect of pharmacological levels of sulphinpyrazone on the TXA2 and PGI2 production in whole blood. Four human volunteers took 400 mg sulphinpyrazone twice daily for 5 1/2 days. Blood was drawn before the s...

journal_title：Thrombosis research

authors： Badenhorst PN,Deckmyn H,Vermylen J

更新日期：1982-10-01 00:00:00

abstract：:A platelet storage pool deficiency (SPD) is present in platelets from cattle with the Chediak-Higashi syndrome (CHS). The most plausible hypothesis for the SPD is that dense granule precursors are simply not formed in CHS megakaryocytes. There is, however, evidence that some recently acquired 5-hydroxytryptamine (5HT)...

journal_title：Thrombosis research

authors： Meyers KM,Costa JL,Magnuson J

更新日期：1990-05-01 00:00:00