Abstract:
:Fasting plasma homocysteine level and the related clinical findings were analysed in 240 consecutive patients with venous thromboembolism. Hyperhomocysteinemia, defined as a plasma level above 20 micromol/l (corresponding to the percentile 95th in the controls), was present in 11.2% of the patients. Plasma homocysteine level was similar in patients presenting with either deep venous thrombosis, pulmonary embolism or both conditions. It was significantly higher in patients with primary (unprovoked) VTE than in patients with secondary disease (associated with at least one risk factor): 12.3 vs. 9.55 micromol/l (p < 0.005). Mean homocysteine was higher in male than in female patients (14.51 vs. 12.9 micromol/l, p < 0.05) and increased significantly with age. Hyperhomocysteinemia was more frequent in patients with relapsing disease (14 of 76, 18.4%) than in those presenting with a single episode (13 of 164, 7.9%) (p = 0.034). Furthermore, hyperhomocysteinemia was correlated with reduced protein C level (p = 0.013). In a multivariate analysis, two factors were significantly associated with hyperhomocysteinemia: older age (p < 0.0001) and idiopathic occurrence (p < 0.02). Since the frequency of homozygous MTHFR thermolabile variant was rather similar in patients and controls, testing for C677T mutation was not helpful in screening VTE patients. However, the homozygous mutation was significantly more prevalent among hyperhomocysteinemia patients, confirming its role in the genesis of hyperhomocysteinemia. According to its prevalence, to the putative role in venous and arterial disease and the availability of an effective and low-cost corrective therapy, hyperhomocysteinemia deserves interest, especially in the elderly and in the patients with idiopathic VTE disease.
journal_name
Thromb Resjournal_title
Thrombosis researchauthors
Hainaut P,Jaumotte C,Verhelst D,Wallemacq P,Gala JL,Lavenne E,Heusterspreute M,Zech F,Moriau Mdoi
10.1016/s0049-3848(02)00096-8subject
Has Abstractpub_date
2002-04-15 00:00:00pages
121-5issue
2eissn
0049-3848issn
1879-2472pii
S0049384802000968journal_volume
106pub_type
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journal_title:Thrombosis research
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更新日期:2011-02-01 00:00:00
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更新日期:1988-04-01 00:00:00
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更新日期:2000-02-01 00:00:00
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更新日期:1993-01-15 00:00:00
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更新日期:1992-11-01 00:00:00
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更新日期:2011-06-01 00:00:00
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journal_title:Thrombosis research
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doi:10.1016/j.thromres.2017.01.007
更新日期:2017-03-01 00:00:00
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journal_title:Thrombosis research
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pub_type: 杂志文章,评审
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更新日期:2008-01-01 00:00:00
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更新日期:2001-03-15 00:00:00
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更新日期:2020-01-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2008-01-01 00:00:00
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journal_title:Thrombosis research
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doi:10.1016/j.thromres.2012.08.001
更新日期:2012-11-01 00:00:00
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journal_title:Thrombosis research
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doi:10.1016/j.thromres.2019.09.005
更新日期:2019-11-01 00:00:00