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Prothrombin complex concentrate (Beriplex P/N) for control of bleeding after kidney trauma in a rabbit dilutional coagulopathy model.

Abstract：

INTRODUCTION:Fluid resuscitation after trauma often results in dilutional coagulopathy that may hinder control of bleeding and, once initial hemostasis has been secured, heighten risk of perioperative bleeding when further surgery is required. Since multiple coagulation factor deficiencies typically accompany fluid resuscitation, prothrombin complex concentrate (PCC) containing factors II, VII, IX and X may potentially offer greater hemostatic efficacy than coagulation factor monotherapy. MATERIALS AND METHODS:Anesthetized normothermic rabbits were hemodiluted 50-60% by phased blood withdrawal and infusion of hydroxyethyl starch and erythrocytes. The animals were randomly assigned to receive saline placebo, 25 IU x kg(-1) PCC (Beriplex P/N) or 180 microg x kg(-1) activated recombinant factor VII (rFVIIa; NovoSeven). Immediately thereafter, bleeding was precipitated by a standardized kidney incision. RESULTS:PCC accelerated hemostasis compared both with saline and rFVIIa (p=0.002 for both comparisons). The median times to hemostasis in the PCC, saline and rFVIIa groups were 12, 19 and 28 min, respectively. PCC reduced blood loss by a median of 43 mL with a 95% confidence interval (CI) of 8.0-67.5 mL vs. saline and 82 mL (CI, 35.0-110.0 mL) vs. rFVIIa. PCC augmented peak thrombin generation by a median of 104.1 nM (CI, 78.3-142.3 nM) compared with saline and 105.8 nM (CI, 70.7-139.5 nM ) relative to rFVIIa. At the respective 180 microg x kg(-1) and 25 IU x kg(-1) doses tested, rFVIIa displayed thrombogenicity in the Wessler stasis model, while PCC did not. CONCLUSIONS:In an animal model of dilutional coagulopathy and kidney trauma, PCC accelerated hemostasis and diminished blood loss compared with rFVIIa monotherapy.

journal_name

Thromb Res

journal_title

Thrombosis research

authors

Pragst I,Kaspereit F,Dörr B,Dickneite G

doi

10.1016/j.thromres.2009.10.011

subject

Has Abstract

pub_date

2010-03-01 00:00:00

pages

272-7

issue

3

eissn

0049-3848

issn

1879-2472

pii

S0049-3848(09)00488-5

journal_volume

125

pub_type

杂志文章

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