Abstract:
:Venous thromboembolism (VTE), including deep vein thrombosis (DVT) and pulmonary embolism (PE), is the third most common cardiovascular disease after coronary artery disease and cerebrovascular disease and is responsible for significant morbidity and mortality in the general population. Full dose anticoagulation is the standard therapy for VTE, both for the acute and the long-term phase. The latest guidelines of the American College of Chest Physicians recommend treatment with a full-dose of unfractioned heparin (UFH), low-molecular-weight-heparin (LMWH), fondaparinux, vitamin K antagonist (VKA) or thrombolysis for most patients with objectively confirmed VTE. Catheter-guided thrombolysis and trombosuction are interventional approaches that should be used only in selected populations; interruption of the inferior vena cava (IVC) with a filter can be performed to prevent life-threatening PE in patients with VTE and contraindications to anticoagulant treatment, bleeding complications during antithrombotic treatment, or VTE recurrences despite optimal anticoagulation. In this review we summarize the currently available literature regarding interventional approaches for VTE treatment (vena cava filters, catheter-guided thrombolysis, thrombosuction) and we discuss current evidences on their efficacy and safety. Moreover, the appropriate indications for their use in daily clinical practice are reviewed.
journal_name
Thromb Resjournal_title
Thrombosis researchauthors
Imberti D,Ageno W,Manfredini R,Fabbian F,Salmi R,Duce R,Gallerani Mdoi
10.1016/j.thromres.2011.11.003subject
Has Abstractpub_date
2012-04-01 00:00:00pages
418-25issue
4eissn
0049-3848issn
1879-2472pii
S0049-3848(11)00579-2journal_volume
129pub_type
杂志文章,评审abstract:INTRODUCTION:Animal models of thrombosis and hemostasis are critical for target validation in pharmaceutical research. Guinea pig haemostatic mechanisms, such as the platelet thrombin receptor repertoire, resemble those of humans. Measuring the performance characteristics of marketed antithrombotic drugs in guinea pig ...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2008.03.010
更新日期:2008-01-01 00:00:00
abstract::Endothelial cells synthesize and release different proteins involved in their function, and some of these proteins may play important roles in the cellular response to injury, infection, or glucocorticoids. We have examined the profile of proteins released from rabbit coronary microvascular endothelial (RCME) and huma...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(90)90202-n
更新日期:1990-01-01 00:00:00
abstract::The thrombin inhibitory role of antithrombin III (ATIII) and heparin cofactor II (HCII) was studied in vitro using intact and injured rabbit aortae. When intact vessels were loaded with thrombin and then exposed to either heat defibrinogenated human plasma (HDHP) or ATIII the same degree of thrombin inhibition was ach...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(91)90014-n
更新日期:1991-06-01 00:00:00
abstract::Two types of LMW heparin were prepared by gel filtration of standard heparin (LMW fraction) and by degradation of heparin by nitrous acid (LMW fragment), respectively. The effects on factor Xa inhibition (XaI), APTT, platelet aggregation and AT III level of these preparations were studied after subcutaneous administra...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(83)90091-9
更新日期:1983-11-15 00:00:00
abstract:INTRODUCTION:Thrombin or tryptase cleavage of protease-activated receptors (PAR) on human coronary artery endothelial cells (HCAEC) results in activation of a membrane-associated, calcium-independent phospholipase A2 (iPLA2) that selectively hydrolyzes plasmalogen phospholipids. Atherosclerotic plaque rupture results i...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2006.11.007
更新日期:2007-01-01 00:00:00
abstract::Activated factor X (FXa) and thrombin can up-regulate gene expression of connective tissue growth factor (CTGF/CCN2) on fibroblasts. Since tissue factor (TF) is expressed on these cells, we hypothesized that they may assemble the prothrombinase complex leading to CTGF/CCN2 upregulation. In addition, the effect of thro...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2011.08.009
更新日期:2012-06-01 00:00:00
abstract::The fibrinolytic system contains a proenzyme plasminogen (Plg) which is converted to plasmin (Plm) by the action of Plg activators. Physiological Plg activators are: tissue-type plasminogen activator (t-PA) and urokinase-type plasminogen activator. Plg was shown to be further cleaved by leukocyte elastase producing se...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/s0049-3848(97)00099-6
更新日期:1997-06-15 00:00:00
abstract::Binding of 3H-labeled 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet-activating factor; PAF) to the intact, washed canine platelet has been defined and characterized as being specific and receptor-mediated. Under the conditions described, specific binding to 2 X 10(7) canine platelets reached saturation with...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(88)90339-8
更新日期:1988-06-15 00:00:00
abstract::Reproducible disseminated intravascular coagulation in rabbits was provoked by two intravenous injections 24 hours apart of endotoxin from Salmonella enteritidis. There were mild symptoms of DIC before the second injection which considerably increased thereafter. In detail there was a sharp drop of the platelet count ...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(93)90029-n
更新日期:1993-02-01 00:00:00
abstract::Heparin cofactor II (HCII) is a specific thrombin inhibitor; its inhibitory activity is stimulated by heparin (Hep) and dermatan sulfate (DS). Vitronectin (VN), a heparin binding adhesive glycoprotein present in plasma and extracellular matrix, has been shown to decrease the stimulatory effect of Hep but not of DS on ...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(92)90310-7
更新日期:1992-06-01 00:00:00
abstract:INTRODUCTION:Rivaroxaban is an oral, selective direct factor Xa inhibitor approved for several indications in patients at risk of thrombotic events. One limitation of its clinical use is the lack of data pertaining to its reversal in situations where urgent response is critical (e.g. acute bleeding events or emergency ...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2015.01.007
更新日期:2015-03-01 00:00:00
abstract::Advances in antithrombotic therapy began when traditional anticoagulant agents such as heparin and the vitamin K antagonists like Coumadin became commercially available in the 1940s and 1950s. Inherent limitations of these compounds, including the need for monitoring and multiple food and drug interactions (with couma...
journal_title:Thrombosis research
pub_type: 杂志文章,评审
doi:10.1016/j.thromres.2008.08.010
更新日期:2008-01-01 00:00:00
abstract::Diagnosis and risk stratification of patients with acute coronary syndromes remain extremely important in order to avoid unnecessary hospitalizations on the one hand, and to improve prognosis of these patients on the other. For diagnosis of acute coronary syndromes, an ECG should be obtained at rest, troponin T and I ...
journal_title:Thrombosis research
pub_type: 杂志文章,评审
doi:10.1016/s0049-3848(01)00298-5
更新日期:2001-09-30 00:00:00
abstract::The coumarin derivative AD6 is known to inhibit platelet aggregation and release and it possesses vasodilatory properties on coronary arteries of laboratory animals. Furthermore, the inhibition of the production of TxB2 from endogenous substrates after stimulation of human platelets with collagen has been demonstrated...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(87)90236-2
更新日期:1987-07-01 00:00:00
abstract:BACKGROUND:Abdominal obesity has been found to be associated with an increased risk of deep vein thrombosis (DVT). Whether patients with abdominal obesity have an increased risk of recurrence is currently unknown. METHODS:Patients with objective diagnosis of DVT and a life expectancy of greater than 6 months underwent...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2006.05.013
更新日期:2007-01-01 00:00:00
abstract:INTRODUCTION:Atypical hemolytic uremic syndrome (aHUS) is a rare thrombotic microangiopathy (TMA), characterized by micro-angiopathic hemolytic anemia, thrombocytopenia, and renal failure. In more than half of cases, genetic defects leading to overactivation of the alternative complement system have been identified. In...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2020.06.016
更新日期:2020-10-01 00:00:00
abstract::Severe bleeding took place in a patient when abdominal aneurysm was removed by operation. Bleeding continued after infusion of heparin, antithrombin III (ATIII), fresh platelets and fresh blood. Infusion of tranexamic acid resulted in an immediate cessation of bleeding and improvement of his general condition. Sometim...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(90)90167-b
更新日期:1990-04-15 00:00:00
abstract::Two isozymes of a native form of human plasminogen (plg), Glu-plg I and II, were isolated. Glu-plg I or II was activated by urokinase (UK) or streptokinase (SK) in the presence of fibrinogen or fibrin. The activation of Glu-plg I was enhanced more than that of Glu-plg II in the presence of fibrin. Fibrin caused better...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(85)90224-5
更新日期:1985-08-01 00:00:00
abstract::We examined the effects of verapamil on platelet function. Verapamil (0.5 micrograms/ml) in this study inhibited platelet aggregation induced by threshold amounts of ADP, AA, and epinephrine. With higher concentrations of aggregating stimuli, verapamil caused a dose-dependent inhibition of aggregation. Verapamil reduc...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(83)90181-0
更新日期:1983-06-01 00:00:00
abstract:BACKGROUND:Postthrombotic intraluminal tissue causing postthrombotic syndrome (PTS) has not been well described. This study defines its histological characteristics and assess whether tissue function evolves over time. METHODS:Specimens from 18 common femoral veins (CFV) from 16 patients obtained during CFV endovenect...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2015.02.026
更新日期:2015-05-01 00:00:00
abstract::Hemorrhagic tendency is frequent in uremic patients and is often associated with prolonged bleeding time and decreased platelet functions in vitro. Similarly, in multiple myeloma, platelet functions are affected, mainly by the inhibitory effect of paraprotein. We have studied patients with renal insufficiency and mult...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/s0049-3848(02)00003-8
更新日期:2002-02-15 00:00:00
abstract::The perfusion technique to measure the relative adhesive and thrombogenic indices of vascular prostheses by a quantitative scanning electron microscopy has been described. To normalize the experiments with different samples of plasma we compared the adhesive and thrombogenic properties of the analyzed prostheses with ...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(83)90038-5
更新日期:1983-02-01 00:00:00
abstract:BACKGROUND:Thrombosis and complement activation are pathogenic features of antiphospholipid syndrome (APS). Their molecular link is Plasma carboxypeptidase-B, also known as thrombin activatable fibrinolysis inhibitor (TAFIa), which plays a dual role: anti-fibrinolytic, by cleaving carboxyl-terminal lysine residues from...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2017.06.028
更新日期:2017-10-01 00:00:00
abstract::Porcine and human umbilical vein and adult blood vessels were studied for the presence and synthesis of factor VIII related antigen (VIIIR:Ag) and fibronectin (Fn) by immunofluorescence histology and immunoautoradiography. Investigation of human tissue confirmed the widespread distribution of VIIIR:Ag on the endotheli...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(83)90042-7
更新日期:1983-02-01 00:00:00
abstract:BACKGROUND:It has been reported that statin therapy produces additional effects including impaired activation of blood coagulation. It is not clear whether statins can affect hemostasis in patients with acute coronary syndrome. The aim of this study was to investigate the effect of prior statin treatment on thrombin ge...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2009.06.021
更新日期:2010-05-01 00:00:00
abstract::The effects of sodium salicylate (SS) on ADP-induced platelet aggregation and on a metabolism of calcium in platelets were studied, using gel-filtrated platelets (GFP). SS inhibited dose-responsively ADP-induced aggregation in the presence of fibrinogen and Ca2+. It was found that extracellular 45Ca2+ was rapidly take...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(85)90232-4
更新日期:1985-08-01 00:00:00
abstract::Highly purified bovine von Willebrand protein (vWP) has been studied with two complementary techniques. Light scattering measurements on different samples give weight average molecular weights in the range from 7 to 13 million, radius of gyration between 75 and 140 nm and diffusion coefficient near 4.15 X 10(-8) cm2/s...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(85)90289-0
更新日期:1985-11-15 00:00:00
abstract::Cardiovascular diseases are one of the leading causes of morbidity and mortality in industrialized countries, and although many processes play a role in the development of vascular disease, thrombosis is the primary event that precipitates stroke and acute coronary syndromes. The blood platelets are of significant imp...
journal_title:Thrombosis research
pub_type: 杂志文章,评审
doi:10.1016/j.thromres.2011.09.026
更新日期:2012-02-01 00:00:00
abstract::We have developed a new bioassay for endothelium-derived relaxing factor (EDRF) or nitric oxide (NO) using human [3H]guanosine triphosphate (GTP)-labeled platelets. The labeled platelets were preincubated with isobutyl-methylxanthine and co-cultured with endothelial cells and the [3H]cyclic guanosine monophosphate (cG...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(95)00082-3
更新日期:1995-06-15 00:00:00
abstract::The effect of suloctidil (600 mg/day) on platelet survival time (PST) and plasma and urine betathromboglobulin (BTG) was studied in a double-blind, placebo-controlled six-week crossover trial in 13 patients with shortened PST (less than 110 hrs, exponential model). Mean PST after suloctidil (110.6 hrs) was significant...
journal_title:Thrombosis research
pub_type: 临床试验,杂志文章
doi:10.1016/0049-3848(84)90231-7
更新日期:1984-08-15 00:00:00