Current insights into thrombotic microangiopathies: Thrombotic thrombocytopenic purpura and pregnancy.

abstract：:The role of Protein C in combined factor V/VIII deficiency was examined by reducing the Protein C concentration using warfarin therapy in a patient with the combined deficiency. The factor VIII deficiency was like Hemophilia-A, with deficiency of VIII:C and VIII:C(Ag), but normal VIIIR:Ag and VIIIR:cof. The factor V d...

journal_title：Thrombosis research

authors： Bern MM,Suzuki K,Mann K,Tracy P,Hoyer L,Jensen W,Gallivan M,Arkin C,Davis G

更新日期：1984-12-15 00:00:00

abstract：:Disadvantages of current bleeding time methods include poor reproducibility, limited repeatability, and at times scar formation. We report a new, in vitro technique which circumvents these problems. Venous blood is collected in sodium citrate, stored capped in a siliconized tube at 37 degrees C until use, and made to ...

journal_title：Thrombosis research

authors： Uchiyama S,Stropp JQ,Claypool DA,Didisheim P,Dewanjee MK

更新日期：1983-07-01 00:00:00

abstract：:Both venous thromboembolism and intracranial metastases are common complications in the setting of primary brain tumors and metastatic malignancies. Anticoagulation is indicated in the presence of cancer-associated thrombosis in order to limit the risk of pulmonary embolism; however, there is reluctance to initiate an...

journal_title：Thrombosis research

authors： Weinstock MJ,Uhlmann EJ,Zwicker JI

更新日期：2016-04-01 00:00:00

abstract：:Diabetes mellitus (DM) is associated with platelet and leukocyte dysfunction. Previous observations with regard to insulin effects on platelet and leukocyte function are less than consistent. We thus investigated the effects of insulin on platelets and leukocytes, as well as on platelet-leukocyte interactions in whole...

journal_title：Thrombosis research

authors： Hu H,Hjemdahl P,Li N

更新日期：2002-09-01 00:00:00

abstract：:Generally, the rules of good practice in transfusion medicine apply also to the pediatric age group. However, the frequency of specific diseases that might necessitate the administration of fresh frozen plasma (FFP) differs from that in adults. Physiologic differences to the later age exist in the neonatal period and ...

journal_title：Thrombosis research

authors： Muntean W

更新日期：2002-10-31 00:00:00

abstract：:We have investigated fibrinolytic parameters in 33 patients with peripheral arterial occlusive disease (PAOD) before and 6, 24, and 48 hours after percutaneous transluminal angioplasty (PTA) as well as in 35 gender-matched healthy controls, whose mean age was not significantly different from the mean age of the patien...

journal_title：Thrombosis research

authors： Roller RE,Janisch S,Carroll V,Kvas E,Pilger E,Binder BR,Wojta J

更新日期：1999-05-15 00:00:00

abstract：:A prolongation of the thrombin clotting time by at least 25% was found in the presence of 8 of 26 IgG myeloma proteins, 2 of 5 IgA proteins and 1 of 10 macroglobulins, in a concentration of 10 mg/ml. Normal pooled immunoglobulin in concentrations up to 83 mg/ml were inactive. 2 IgG and 2 IgM monoclonal immunoglobulins...

journal_title：Thrombosis research

authors： Wisløff F,Michaelsen TE,Godal HC

更新日期：1984-07-01 00:00:00

abstract：INTRODUCTION:Hip fracture is common among the elderly and is associated with increased morbidity and mortality, particularly when surgery is delayed. Direct oral anticoagulants (DOACs) use might increase bleeding and postpone hip repair surgery. We aimed to assess the association between preoperative DOACs use and adve...

journal_title：Thrombosis research

authors： Saliba W,Arbel A,Abu-Full Z,Cohen S,Rennert G,Preis M

更新日期：2020-05-01 00:00:00

abstract：INTRODUCTION:Increased levels of circulating tissue factor (TF)-positive microvesicles (MVs) may increase the risk of thrombosis. Indeed, TF-positive MVs are detected in plasma of patients with various types of diseases. In this study, we measured levels of MV TF activity in non-cancer severely ill patients and cancer ...

journal_title：Thrombosis research

authors： Hisada Y,Thålin C,Lundström S,Wallén H,Mackman N

更新日期：2018-05-01 00:00:00

abstract：:We have previously described a stimulus-specific defect in platelet aggregation in polycythaemia vera (PV) after stimulation with surface receptor dependent agonists such as platelet activating factor (PAF). In contrast, responses to phorbol myristate acetate (PMA) were normal. We now report that after PAF stimulation...

journal_title：Thrombosis research

authors： Le Blanc K,Lindahl T,Rosendahl K,Samuelsson J

更新日期：1998-09-15 00:00:00

abstract：:Capsaicin was found to be a potent inhibitor of platelet aggregation and release reaction. It inhibited the aggregation of rat platelet induced by collagen and thrombin, but only slightly reduced those of AA and A23187. The IC50 on collagen-induced platelet aggregation was about 85 micrograms/ml. Less inhibition was o...

journal_title：Thrombosis research

authors： Wang JP,Hsu MF,Teng CM

更新日期：1984-12-15 00:00:00

abstract：:Activation of plasma plasminogen to plasmin is the objective of current strategies for thrombolytic therapy. Although thrombolytic activity in blood involves a large cellular component as well as that in plasma, the contribution of this cellular phase to clinical thrombolysis has not been examined. Using a 125I-fibrin...

journal_title：Thrombosis research

authors： Langleben D,Moroz LA,Schlesinger RD

更新日期：1990-07-15 00:00:00

abstract：BACKGROUND/AIM:It is believed that the amniotic fluid-derived TF, in the case of amniotic fluid embolism (AFE), contributes to acute disseminated intravascular coagulation (DIC) and obstetric shock in the mother. However, the role of amniotic fluid-derived contact phase coagulation factors that irrupt into the bloodstr...

journal_title：Thrombosis research

authors： Uszyński W,Żekanowska E,Uszyński M,Kieszkowski P

更新日期：2015-04-01 00:00:00

abstract：:The effects of extracellular sodium on platelet aggregation and calcium mobilization in platelets stimulated with either rattlesnake (Crotalus atrox) lectin (RSL) or alpha-thrombin were compared. The absence of extracellular sodium had no effect on platelet aggregation or calcium mobilization in response to all levels...

journal_title：Thrombosis research

authors： Wilson-Byl JA,Dockter ME,Gartner TK

更新日期：1991-11-01 00:00:00

abstract：:RheothRx Injection, an aqueous solution of a nonionic block copolymer (poloxamer 188) formulated for intravenous administration, was investigated as an inhibitor of red blood cell (RBC)-induced platelet aggregation at plasma concentrations of 0.05-5mgmL-1. Platelet aggregation was determined by measuring the fall in s...

journal_title：Thrombosis research

authors： Armstrong JK,Meiselman HJ,Fisher TC

更新日期：1995-09-15 00:00:00

abstract：:The extrinsic pathway of coagulation is initiated when zymogen factor VII binds to its cell surface receptor tissue factor. Recently recombinant human tissue factor has become available and therefore in this study the direct binding of human factor VII in plasma to recombinant tissue factor was explored. Factor VII bi...

journal_title：Thrombosis research

authors： Sridhara S,Clarke BJ,Ofosu FA,High KA,Blajchman MA

更新日期：1993-05-15 00:00:00

abstract：INTRODUCTION:Anedoctal reports suggest that some thrombotic primary antiphospholipid antibody syndrome (PAPS) patients on oral anticoagulation require higher than average doses to achieve given targets international normalized ratios (INR). MATERIALS AND METHODS:To test the hypothesis of relative warfarin resistance i...

journal_title：Thrombosis research

authors： Ames PR,Margaglione M,Ciampa A,Colaizzo D,Ferrara F,Iannaccone L,Vincenzobrancaccio

更新日期：2011-06-01 00:00:00

abstract：:We have studied the synthesis and subcellular distribution of the glycosylated membrane protein tissue factor (TF) in human blood monocytes and the inducible monocyte like cell line, HL-60. Following induction with endotoxin or the phorbol ester, TPA, tissue factor specific activity was measured in intact cells, sonic...

journal_title：Thrombosis research

authors： Bona R,Lee E,Rickles F

更新日期：1987-11-15 00:00:00

abstract：INTRODUCTION:Endothelial dysfunction plays an essential role in the pathogenesis of sepsis. The study aimed to illustrate the associations between the dynamic change (from day 1 to day 7) in biomarker concentration of endothelial dysfunction and outcomes in severe sepsis and septic shock in the intensive care unit (ICU...

journal_title：Thrombosis research

authors： Fang Y,Li C,Shao R,Yu H,Zhang Q

更新日期：2018-11-01 00:00:00

abstract：INTRODUCTION:Thrombomodulin (TM) has been described as a marker of endothelial injury in atherosclerosis. The role of TM as a predictor of PAD severity is to be proven. The goal of the present study is to compare the level of plasmatic (TMp) in patients with intermittent claudication with patients with critical ischemi...

journal_title：Thrombosis research

authors： Nasser M,Wolosker N,Uint L,Rosoky RA,Lobato M,Wajngarten M,Puech-Leao P

更新日期：2006-01-01 00:00:00

abstract：INTRODUCTION:A close association exists between oral health and cardiovascular disease. Periodontal disease induces early vascular changes while oral pathogens have been detected in sub gingival and atheromatous plaques. We examined the interrelationship between Periodontal disease, oral bacteria, surrogate sub-clinica...

journal_title：Thrombosis research

authors： Shanker J,Setty P,Arvind P,Nair J,Bhasker D,Balakrishna G,Kakkar VV

更新日期：2013-07-01 00:00:00

abstract：:The protease inhibitor, aprotinin, has been examined for its ability to inhibit urokinase and tissue-type plasminogen activators at pH 7.4 in assays utilizing pyroGlu-Gly-Arg-p-nitroanilide and H-D-Ile-Pro-Arg-p-nitroanilide as substrates, respectively. Aprotinin inhibited both two-chain low molecular weight urokinase...

journal_title：Thrombosis research

authors： Lottenberg R,Sjak-Shie N,Fazleabas AT,Roberts RM

更新日期：1988-03-15 00:00:00

abstract：:Chronic thromboembolic pulmonary hypertension (CTEPH) is the most severe long term complication of acute pulmonary embolism (PE). Untreated, CTEPH is associated with a very poor prognosis and high risk of mortality, although curation can be achieved by surgical removal of the obstructive endothelialised thromboemboli ...

journal_title：Thrombosis research

authors： Ende-Verhaar YM,Huisman MV,Klok FA

更新日期：2017-03-01 00:00:00

abstract：:An in vitro test system was developed to examine the effects of red blood cells (RBC) on shear-induced platelet adhesion (SIPAD) and platelet aggregation (SIPAG). Suspensions of human platelets labeled with Mepacrine and suspended in citrated plasma were exposed to single, continuous or repetitive (120-300x) one secon...

journal_title：Thrombosis research

authors： Joist JH,Bauman JE,Sutera SP

更新日期：1998-12-15 00:00:00

abstract：:The use of oral contraceptives (OCs) has been associated with vascular complications. The mechanism(s) by which OCs predispose to thrombotic events remains unclear. Recent studies have demonstrated that postmenopausal (PM) women who take estrogen replacement therapy (ERT) have a decreased incidence of myocardial infar...

journal_title：Thrombosis research

authors： Dores GM,Miller ME,Thorpe SL

更新日期：1993-01-15 00:00:00

abstract：:Megakaryocytes (MKs) are widely known as the progenitor cells of platelets. These large, polyploid cells are a derivative of the hematopoietic stem cell (HSC), and reside in the bone marrow, lining blood vessel walls where they release their platelet progeny into circulation. Although little is known about how MKs dif...

journal_title：Thrombosis research

authors： Couldwell G,Machlus KR

更新日期：2019-07-01 00:00:00

abstract：:An abnormal prothrombin has been detected in a 26-year-old female, who had no history of excessive bleeding. Prothrombin activity was approximately 10% when measured using either the classical one-stage assay or the assay with Echis carinatus venom, whereas prothrombin antigen level was normal. In keeping with current...

journal_title：Thrombosis research

authors： Morishita E,Saito M,Asakura H,Jokaji H,Uotani C,Kumabashiri I,Yamazaki M,Hachiya H,Okamura M,Matsuda T

更新日期：1991-06-15 00:00:00

abstract：INTRODUCTION:Microparticles (MPs) are small fragments of apoptotic or activated cells that may contribute to pathological processes in cardiovascular diseases. In studies of MPs in clinical cohorts, it is unclear if observed changes in MP composition are a cause or a result of the cardiovascular disease being studied. ...

journal_title：Thrombosis research

authors： Watts JA,Lee YY,Gellar MA,Fulkerson MB,Hwang SI,Kline JA

更新日期：2012-07-01 00:00:00

abstract：:The concentration of the glycoprotein (GP) IIb-IIIa complex in thrombasthenic platelets of 8 patients of 6 families has been estimated. In the thrombasthenic platelets of 3 patients this complex is absent (thrombasthenia type I and subtype I). In 2 patients only traces are detectable and in 3 patients GP IIb-IIIa comp...

journal_title：Thrombosis research

authors： Herrmann FH,Meyer M,Gogstad GO,Solum NO

更新日期：1983-12-15 00:00:00

abstract：:In 1926, Erik von Willebrand, a Finnish physician, published the first manuscript describing a haemorrhagic disorder in people who were living on the Aland islands off the coast of Finland. This disorder is now known by the name of its discoverer. Since this early observation, von Willebrand disease has been extensive...

journal_title：Thrombosis research

authors： Berntorp E

更新日期：2007-01-01 00:00:00