Abstract:
:A prolongation of the thrombin clotting time by at least 25% was found in the presence of 8 of 26 IgG myeloma proteins, 2 of 5 IgA proteins and 1 of 10 macroglobulins, in a concentration of 10 mg/ml. Normal pooled immunoglobulin in concentrations up to 83 mg/ml were inactive. 2 IgG and 2 IgM monoclonal immunoglobulins caused an acceleration of the thrombin time by at least 20%; this phenomenon has not been reported before. Corresponding results were obtained with these proteins when the polymerization of des-AA and des-AABB fibrin monomers were investigated in a light scattering system. Studies with enzymatically produced Fab, F(ab')2 and Fc fragments from normal and monoclonal immunoglobulin suggested that the polymerization inhibitory activity resides in the Fab portion of the immunoglobulin molecule. While the ability to inhibit fibrin polymerization may be an immunoglobulin specific effect, the acceleration caused by certain other monoclonal immunoglobulins may be an unspecific effect similar to that seen with dextran or albumin.
journal_name
Thromb Resjournal_title
Thrombosis researchauthors
Wisløff F,Michaelsen TE,Godal HCdoi
10.1016/0049-3848(84)90315-3subject
Has Abstractpub_date
1984-07-01 00:00:00pages
81-90issue
1eissn
0049-3848issn
1879-2472journal_volume
35pub_type
杂志文章abstract:INTRODUCTION:Plasma viscosity (PV) constitutes an independent important predictor of initial and recurrent cardiac events and mortality. It has been suggested that there is a geographical variation in PV values related to coronary event rates. Little information exists regarding PV in Spain. Therefore, our objective wa...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2006.11.009
更新日期:2007-01-01 00:00:00
abstract::Epidemiologic data have indicated that the intake of polyphenols is inversely associated with mortality from cardiovascular disease. Mitogen-activated protein kinases (MAPKs) are ubiquitous signaling proteins that have been associated with gene regulation. This study determined whether polyphenols (catechin and querce...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2007.02.001
更新日期:2007-01-01 00:00:00
abstract::The candidate-gene approach can be used to locate and identify genetic variations that are associated with a particular phenotype. This gene-centric approach assumes that there exists important genetic variation within genes that can influence health. Identifying known genes which are candidates for the phenotype of i...
journal_title:Thrombosis research
pub_type: 杂志文章,评审
doi:10.1016/S0049-3848(09)70139-2
更新日期:2009-01-01 00:00:00
abstract::Bone marrow transplantation (BMT) is the only curable option for thalassemia major, β-thalassemia/HbE. However, some patients still have the risk of hypercoagulable complications. We used a whole blood flow cytometric analysis to measure the circulating microparticle (MP) levels, activated platelets, and leukocyte-pla...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2018.07.007
更新日期:2018-09-01 00:00:00
abstract::DMP 728 is a potent and specific platelet GPIIb/IIIa antagonist. Like all GPIIb/IIIa antagonists, DMP 728 has a steep dose-response relationship in inhibiting platelet aggregation. In this study the relationships between receptor occupancy, platelet aggregation and bleeding time was determined in anesthetized dogs aft...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(95)00029-1
更新日期:1995-03-15 00:00:00
abstract::Pergularain e I, a cysteine protease with thrombin-like activity, was purified by ion exchange chromatography from the latex of Pergularia extensa. Its homogeneity was characterized by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE), native PAGE and reverse-phase high-performance liquid chromatogr...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2009.10.002
更新日期:2010-03-01 00:00:00
abstract:BACKGROUND AND AIM:Recent studies have documented that elevation of C-reactive protein (CRP) levels after percutaneous coronary intervention (PCI) have been predictive of adverse outcome. This study was performed to test the hypothesis that preprocedural use of naproxen sodium is associated with a reduction in the exte...
journal_title:Thrombosis research
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.thromres.2006.11.003
更新日期:2007-01-01 00:00:00
abstract:INTRODUCTION:Pelvic deep vein thrombosis (DVT) is difficult to diagnose during pregnancy. In a two-center trial, we evaluated the agreement between ultrasonography and magnetic resonance imaging (MRI) in diagnosing the extent of DVT into the pelvic veins during pregnancy. MATERIALS AND METHODS:Pregnant women with prox...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2010.05.011
更新日期:2010-08-01 00:00:00
abstract:BACKGROUND:Clopidogrel, cilostazol, and aspirin were compared in terms of efficacy and safety for primary prevention of stroke in peripheral artery disease (PAD) patients. METHODS:This retrospective cohort study analyzed data contained in the Taiwan National Health Insurance Bureau database for patients treated for PA...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2013.01.036
更新日期:2013-08-01 00:00:00
abstract::In the treatment of unstable coronary artery disease, direct thrombin inhibitors have shown no or only limited benefit as compared with heparin, despite theoretical advantages. One explanation may be that the direct thrombin inhibitors to a greater extent than heparin have an inhibiting effect on the generation and ac...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/s0049-3848(99)00029-8
更新日期:1999-07-15 00:00:00
abstract:INTRODUCTION:The A-subunit of blood coagulation factor XIII is a pro-transglutaminase, which cross-links α- and γ-fibrin-chains in its activated form. Selective inhibitors against FXIII-A may be desirable drugs to prevent the development of thromboses. Animal models are generally used for proof of principle and for tox...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2013.02.008
更新日期:2013-05-01 00:00:00
abstract:INTRODUCTION:Excessive platelet activation fundamentally contributes to cardiovascular events and mortality in patients with diabetes mellitus. Functional resistance has been described for current antiplatelet therapies in broad populations that include patients with diabetes. We investigated acute and chronic effects ...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2009.09.025
更新日期:2010-03-01 00:00:00
abstract:INTRODUCTION:Changes in platelet count and function contribute to thrombo-hemorrhagic episodes in chronic myeloproliferative syndromes (MPS). We used flow cytometry to study platelet-leukocyte conjugates and markers of platelet activation in patients with MPS. METHODS:Whole blood from patients with chronic myelogenous...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/s0049-3848(02)00354-7
更新日期:2002-11-01 00:00:00
abstract::Pharmacovigilance is an essential element of any drug treatment and considering the history of adverse events due to products used to treat inherited bleeding disorders, it should be an integral component of modern haemophilia treatment. Because inherited bleeding disorders and adverse events are rare, a multicentre, ...
journal_title:Thrombosis research
pub_type: 杂志文章,多中心研究
doi:10.1016/S0049-3848(10)70150-X
更新日期:2011-01-01 00:00:00
abstract::Cancer is frequently associated with activation of blood coagulation, which in turn has been suggested to promote tumor growth and metastasis. Indeed, low molecular weight heparin treatment significantly prolongs the survival of a wide variety of patients with cancer. Based on this notion that anticoagulant treatment ...
journal_title:Thrombosis research
pub_type: 杂志文章,评审
doi:10.1016/S0049-3848(12)70022-1
更新日期:2012-04-01 00:00:00
abstract:INTRODUCTION:High concentrations of N-terminal-pro-brain natriuretic peptide (NT-proBNP) are found in patients with right ventricular overload. Right ventricular overload may be the result of large perfusion defects in patients with pulmonary embolism (PE). NT-proBNP levels are associated with poorer outcome in patient...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2011.02.014
更新日期:2011-06-01 00:00:00
abstract:BACKGROUND:The immediate administration of oral antiplatelet therapy in the form of aspirin plus a P2Y12 inhibitor is the universally recognised standard of care for patients who present with acute myocardial infarction. Despite strong recommendations for their use, there are a paucity of data describing their onset of...
journal_title:Thrombosis research
pub_type: 杂志文章,评审
doi:10.1016/j.thromres.2016.05.019
更新日期:2016-07-01 00:00:00
abstract:BACKGROUND:The level of platelet reactivity (PR) inhibition obtained after P2Y12-ADP receptor antagonist loading dose (LD) is associated with the ischemic and bleeding risk following percutaneous coronary intervention (PCI) in acute coronary syndromes (ACS). OBJECTIVE:We aimed to evaluate the level of PR inhibition ac...
journal_title:Thrombosis research
pub_type: 杂志文章,多中心研究
doi:10.1016/j.thromres.2013.04.030
更新日期:2013-07-01 00:00:00
abstract:BACKGROUND:Upon platelet stimulation with agonists, reactive oxygen species (ROS) generation enhances platelet activation and granule release. Whether ROS generation during platelet storage could be directly correlated with the expression of proinflammatory molecules and granule release has been investigated in this st...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2017.06.016
更新日期:2017-08-01 00:00:00
abstract:INTRODUCTION:Data regarding the clinical relevance of pulmonary infarction (PI) in patients with pulmonary embolism (PE) are lacking. The aim of this study was to investigate the clinical features of PE patients with PI and the prognostic role of PI for PE patients. MATERIALS AND METHODS:Based on computed tomography s...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2012.03.012
更新日期:2012-09-01 00:00:00
abstract::The placenta is the highly specialised organ of pregnancy that supports the normal growth and development of the fetus. Growth and function of the placenta are precisely regulated and coordinated to ensure the exchange of nutrients and waste products between the maternal and fetal circulatory systems operates at maxim...
journal_title:Thrombosis research
pub_type: 杂志文章,评审
doi:10.1016/j.thromres.2004.06.038
更新日期:2004-01-01 00:00:00
abstract:BACKGROUND:HELLP (Hemolysis, elevated liver enzymes and low platelets) syndrome is a severe and acute pregnancy-related disorder that occurs in approximately 2.5 per 1000 deliveries and represents a major cause of maternal and perinatal morbidity and mortality. This syndrome has been suggested to be a microangiopathy a...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2020.08.038
更新日期:2020-12-01 00:00:00
abstract::Endothelial cells synthesize and release different proteins involved in their function, and some of these proteins may play important roles in the cellular response to injury, infection, or glucocorticoids. We have examined the profile of proteins released from rabbit coronary microvascular endothelial (RCME) and huma...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(90)90202-n
更新日期:1990-01-01 00:00:00
abstract:INTRODUCTION:Warfarin is the most widely used oral anticoagulant. It has been suggested that anticoagulation effect of warfarin is significantly associated with the polymorphism of certain genes, including Cytochrome P450 complex subunit 2C9 (CYP2C9), Vitamin K Epoxide Reductase Complex Subunit 1 (VKORC1), Gamma-Glutam...
journal_title:Thrombosis research
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.thromres.2009.10.017
更新日期:2010-04-01 00:00:00
abstract:INTRODUCTION:Cytomegalovirus (CMV)-associated thrombosis has been reported sporadically in the medical literature until now. However, thrombosis incidence and its risk factors have never been studied in a cohort of patients with acute CMV infection. MATERIALS AND METHODS:A retrospective case-control study. Medical cha...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2010.09.006
更新日期:2010-12-01 00:00:00
abstract:INTRODUCTION:The effects of multiple inherited and acquired thrombophilic defects on the outcome of in-vitro fertilization (IVF) remain unexplored. The aim of this study was to evaluate the association between multiple thrombophilia and clinical outcomes in a large prospective cohort of women undergoing IVF. MATERIALS...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2018.05.006
更新日期:2018-07-01 00:00:00
abstract::The time course and degree of collagen induced platelet shape change, aggregation and ATP-secretion in citrated human platelet rich plasma was monitored with a lumi-aggregometer. Onset of ATP-secretion was measurable within seconds after collagen challenge and always distinctly before onset of shape change. In absence...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(86)90089-7
更新日期:1986-08-15 00:00:00
abstract:BACKGROUND:The recanalization rate in patients with deep venous thrombosis (DVT) of the legs treated with the direct oral anticoagulants (DOAC) is unknown. METHODS:In an Italian cohort, we investigated the rate of residual vein thrombosis (RVT) after three and/or six months in 352 patients with proximal DVT who had be...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2017.03.022
更新日期:2017-05-01 00:00:00
abstract:INTRODUCTION:Recombinant members of the vitamin K-dependent protein family (factors IX and VII and protein C) have become important pharmaceuticals in treatment of bleeding disorders and sepsis. However, because the in vivo gamma-carboxylation system in stable cell lines used for transfection has a limited capacity of ...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2007.11.002
更新日期:2008-01-01 00:00:00
abstract:INTRODUCTION:Tissue factor (TF) is abnormally expressed in many cancers including colorectal and is associated with a poor cancer prognosis. Colorectal cancer cell lines expressing TF produce faster growing tumours. In lung cancer, TF inhibition has been shown to reduce proliferation AIM:We aimed to determine if TF ex...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/S0049-3848(16)30183-9
更新日期:2016-04-01 00:00:00