N' alkylamine low molecular mass heparins (LMM-heparin-tyramine and LMM-heparin-tyramine-fitc) exhibit long lasting anticoagulant effects.

abstract：BACKGROUND:Deep vein thrombosis (DVT) is a common multi-factorial disease with a partially understood aetiology. Although the roles of high factor (F)VIII and von Willebrand factor (VWF) levels are recognized, that of ADAMTS13 is still unclear. AIM:To assess the association between ADAMTS13 activity levels, VWF antige...

journal_title：Thrombosis research

authors： Pagliari MT,Boscarino M,Cairo A,Mancini I,Martinelli I,Bucciarelli P,Rossi F,Rosendaal FR,Peyvandi F

更新日期：2021-01-01 00:00:00

abstract：INTRODUCTION:Although recurrent venous thromboembolism is a known risk factor for chronic thromboembolic pulmonary hypertension (CTEPH), the prevalence of CTEPH after recurrent pulmonary embolism (PE) is not clear. MATERIALS AND METHODS:A cohort screening study was performed to clarify the prevalence of echocardiograp...

journal_title：Thrombosis research

authors： Berghaus TM,Barac M,von Scheidt W,Schwaiblmair M

更新日期：2011-12-01 00:00:00

abstract：:Venous thromboembolism remains an important cause of maternal mortality. For women at risk during pregnancy, the recommended venous thromboembolismprophylaxis is unfractionated heparin. Low molecular weight heparins, such as dalteparin, also may be suitable, but randomised trials have not been performed. Pregnant wome...

journal_title：Thrombosis research

authors： Pettilä V,Kaaja R,Leinonen P,Ekblad U,Kataja M,Ikkala E

更新日期：1999-11-15 00:00:00

abstract：:Defibrotide (D) is a natural polydeoxyribonucleotide from mammalian lungs with profibrinolytic and antithrombotic activities. D also has PGI2-stimulating and tissue plasminogen activator (TPA)-releasing activities, but has no anticoagulant properties. The protective effects of D were demonstrated very recently in a mo...

journal_title：Thrombosis research

authors： Niada R,Porta R,Pescador R,Mantovani M,Prino G

更新日期：1986-05-01 00:00:00

abstract：:Properties of a new concentrate of FVII/FVIIa, obtained by adsorption onto an inorganic adsorbent followed by a chromatographic step onto Q-Sepharose using a by-product of routine fractionation as starting material, are described. This fraction contains only small amounts of the other components of the prothrombin com...

journal_title：Thrombosis research

authors： Chabbat J,Hampikian-Lenin S,Toully V,Gaillandre A,Péjaudier L,Steinbuch M

更新日期：1989-06-15 00:00:00

abstract：INTRODUCTION:Fibrin structure and cellular composition of thrombi profoundly affect the clinical outcomes in ischemic coronary and peripheral artery disease. Our study addressed the interrelations of structural features of thrombi and routinely measured laboratory parameters. MATERIALS AND METHODS:Thrombi removed by t...

journal_title：Thrombosis research

authors： Kovács A,Sótonyi P,Nagy AI,Tenekedjiev K,Wohner N,Komorowicz E,Kovács E,Nikolova N,Szabó L,Kovalszky I,Machovich R,Szelid Z,Becker D,Merkely B,Kolev K

更新日期：2015-04-01 00:00:00

abstract：INTRODUCTION:Although the general improvement caused by recombinant human erythropoietin (rHuEPO) in the correction of uraemic anaemia cannot be questioned, some data suggest that the changes in the haemostasis, endothelial function and oxidative stress (SOX) are induced. The aim of the present study was to investigate...

journal_title：Thrombosis research

authors： Pawlak K,Pawlak D,Mysliwiec M

更新日期：2007-01-01 00:00:00

abstract：:Coronary artery disease (CAD) continues to be the most frequent cause of death among women in the United States. Although elevated levels of clotting factors have been associated with CAD, few of these studies have been performed in women. Elevated levels of Factor XI have previously been associated with venous thromb...

journal_title：Thrombosis research

authors： Berliner JI,Rybicki AC,Kaplan RC,Monrad ES,Freeman R,Billett HH

更新日期：2002-07-15 00:00:00

abstract：INTRODUCTION:Nitric oxide (NO) plays an important role in the regulation of the cardiovascular system. It is produced by endothelial nitric oxide synthase (eNOS), which exhibits genetic polymorphisms. Although the clinically relevant polymorphism T(+IhI-786)C reduces eNOS-promoter activity, it is not clear whether circ...

journal_title：Thrombosis research

authors： Nagassaki S,Metzger IF,Souza-Costa DC,Marroni AS,Uzuelli JA,Tanus-Santos JE

更新日期：2005-01-01 00:00:00

abstract：:Reliable information on what patients with venous thromboembolism (VTE) are at increased risk to die of pulmonary embolism (PE) or bleeding (and the time course of the two fatal events) could likely help to better use anticoagulant therapy by improving selection of patients in whom its benefit will likely outweigh the...

journal_title：Thrombosis research

authors： Monreal M

更新日期：2019-09-01 00:00:00

abstract：INTRODUCTION:Prediction of venous thromboembolism (VTE) occurrence in cancer patients using individual risk factors may contribute to preventing the burden of disease associated with VTE. Congestive heart failure in patients with cancer may increase the risk of VTE and worsen the prognosis. AIM:We sought to investigat...

journal_title：Thrombosis research

authors： Königsbrügge O,Riedl J,Grilz E,Wiltschke C,Zielinski C,Pabinger I,Ay C

更新日期：2016-04-01 00:00:00

abstract：INTRODUCTION:Hip fracture is common among the elderly and is associated with increased morbidity and mortality, particularly when surgery is delayed. Direct oral anticoagulants (DOACs) use might increase bleeding and postpone hip repair surgery. We aimed to assess the association between preoperative DOACs use and adve...

journal_title：Thrombosis research

authors： Saliba W,Arbel A,Abu-Full Z,Cohen S,Rennert G,Preis M

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:Many heparin-induced thrombocytopenia (HIT) antibodies cause platelet activation in the serotonin release assay (SRA) in the absence of heparin. This in vitro observation may help unravel the mechanism of delayed-onset HIT, where seropositive patients develop thrombocytopenia and associated thrombosis after ...

journal_title：Thrombosis research

authors： Prechel MM,Jeske WP,Walenga JM

更新日期：2010-04-01 00:00:00

abstract：:We have studied the synthesis and subcellular distribution of the glycosylated membrane protein tissue factor (TF) in human blood monocytes and the inducible monocyte like cell line, HL-60. Following induction with endotoxin or the phorbol ester, TPA, tissue factor specific activity was measured in intact cells, sonic...

journal_title：Thrombosis research

authors： Bona R,Lee E,Rickles F

更新日期：1987-11-15 00:00:00

abstract：INTRODUCTION:Venous thromboembolism (VTE) occurs frequently in at-risk hospitalized patients, and prophylaxis of VTE is significantly underused. We sought to preliminarily assess the validity of Caprini risk assessment model, a famous individual VTE risk assessment model, in Chinese hospitalized patients with VTE. MAT...

journal_title：Thrombosis research

authors： Zhou HX,Peng LQ,Yan Y,Yi Q,Tang YJ,Shen YC,Feng YL,Wen FQ

更新日期：2012-11-01 00:00:00

abstract：INTRODUCTION:Recombinant members of the vitamin K-dependent protein family (factors IX and VII and protein C) have become important pharmaceuticals in treatment of bleeding disorders and sepsis. However, because the in vivo gamma-carboxylation system in stable cell lines used for transfection has a limited capacity of ...

journal_title：Thrombosis research

authors： Wajih N,Owen J,Wallin R

更新日期：2008-01-01 00:00:00

abstract：:Prothrombin fragments (F1+2), thrombin-antithrombin complexes (TAT) and D-dimers, markers of hemostatic system activation, were measured in 59 consecutive patients with deep vein thrombosis (DVT). Patients were randomly treated either with subcutaneous unfractionated heparin (UH) administered in two to three subcutane...

journal_title：Thrombosis research

authors： Peternel P,Terbizan M,Tratar G,Bozic M,Horvat D,Salobir B,Stegnar M

更新日期：2002-02-01 00:00:00

abstract：BACKGROUND:The immediate administration of oral antiplatelet therapy in the form of aspirin plus a P2Y12 inhibitor is the universally recognised standard of care for patients who present with acute myocardial infarction. Despite strong recommendations for their use, there are a paucity of data describing their onset of...

journal_title：Thrombosis research

authors： Khan N,Cox AR,Cotton JM

更新日期：2016-07-01 00:00:00

abstract：:A prolongation of the thrombin clotting time by at least 25% was found in the presence of 8 of 26 IgG myeloma proteins, 2 of 5 IgA proteins and 1 of 10 macroglobulins, in a concentration of 10 mg/ml. Normal pooled immunoglobulin in concentrations up to 83 mg/ml were inactive. 2 IgG and 2 IgM monoclonal immunoglobulins...

journal_title：Thrombosis research

authors： Wisløff F,Michaelsen TE,Godal HC

更新日期：1984-07-01 00:00:00

abstract：:Cancer-associated arterial thrombotic events (ATEs) are increasingly recognized in specific malignancies and in association with the expanding armamentarium of novel chemotherapeutic agents. The improved cancer survival led to cardiovascular complications becoming clinically relevant many years after cancer diagnosis....

journal_title：Thrombosis research

authors： Aronson D,Brenner B

更新日期：2018-04-01 00:00:00

abstract：:Mass-Length ratio of fibrin fibres (microT and microP) derived independently from turbidity and permeability respectively, in networks made in fibrinogen solution and plasma, have been compared under similar conditions of clotting. Amount of fibrinogen conversion to fibrin was similar in both systems when high thrombi...

journal_title：Thrombosis research

authors： Shah GA,Nair CH,Dhall DP

更新日期：1987-02-01 00:00:00

abstract：:The present study has evaluated the effect of some newly synthesized triphenylethylene (TPE) analogs on platelet arachidonic acid metabolism and function. All compounds tested inhibited arachidonic acid induced platelet aggregation and several were superior to aspirin in their relative potency. Introduction of a carbo...

journal_title：Thrombosis research

authors： Rao GH,John V,Hill TD,Vennerstrom JL,White JG,Holmes TJ Jr

更新日期：1986-11-15 00:00:00

abstract：INTRODUCTION:Apoptotic cell death is a highly regulated genetic program, which has been observed in mature megakaryocytes fragmenting into platelets. The clock gene Per2, a key component of core clock oscillator, was involved in affecting both cell cycle control and apoptosis. Thus, loss of Per2 function may be conside...

journal_title：Thrombosis research

authors： Zhao Y,Zhang Y,Wang S,Hua Z,Zhang J

更新日期：2011-02-01 00:00:00

abstract：:This work demonstrates that after bolus intravenous injection standard heparin (SH) disappearance results from the combination of a saturable and a non saturable mechanism. Pharmacokinetics and pharmacodynamics of SH were studied by measuring the disappearance of increasing doses (5 - 500 anti-factor Xa U/kg) of 125I-...

journal_title：Thrombosis research

authors： Boneu B,Caranobe C,Gabaig AM,Dupouy D,Sie P,Buchanan MR,Hirsh J

更新日期：1987-06-15 00:00:00

abstract：INTRODUCTION:Metastases are responsible for more than 90% of cancer related mortality. The hematogenous metastatic invasion is a complex process in which the endothelium plays a key role. Extravasation is a dynamic process involving remodeling and change in cell shape and in cytoskeleton whereby a series of strongly de...

journal_title：Thrombosis research

authors： Gilardi M,Bersini S,Calleja AB,Kamm RD,Vanoni M,Moretti M

更新日期：2016-04-01 00:00:00

abstract：:The effect of extracellular matrix components on lipopolysaccharide-induced vascular endothelial cell injury was studied by using lipopolysaccharide-susceptible bovine aortic endothelial cells. For evaluation of lipopolysaccharide-induced injury, we estimated DNA synthesis and cell detachment of bovine aortic endothel...

journal_title：Thrombosis research

authors： Chakravortty D,Kato Y,Koide N,Sugiyama T,Kawai M,Fukada M,Yoshida T,Yokochi T

更新日期：2000-04-15 00:00:00

abstract：INTRODUCTION:Sepsis is frequently complicated by disseminated intravascular coagulation (DIC), which promotes multiple organ dysfunctions and significantly increase the mortality of patients with sepsis. How bacteria cause DIC is not fully understood. Outer membrane vesicles (OMVs) are membrane-enclosed microvesicles r...

journal_title：Thrombosis research

authors： Wang E,Liu Y,Qiu X,Tang Y,Wang H,Xiao X,Chen F,Lu B

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND:Cardiovascular mortality is especially low in southwest France (the French Paradox). In previous experimental studies, we found that alcohol-free extracts of armagnac could inhibit human platelet function in vitro and experimental thrombosis in vivo. To test the possible relevance of these findings, we teste...

journal_title：Thrombosis research

authors： Umar A,Depont F,Jacquet A,Lignot S,Segur MC,Boisseau M,Bégaud B,Moore N

更新日期：2005-01-01 00:00:00

abstract：:Thromboangiitis obliterans (TAO), or Buerger's disease, is a segmental occlusive inflammatory disorder of the arteries and veins, and etiopathogenesis is still obscure. In the present study we investigated the prevalence of prothrombin 20210 G-->A, factor V 1691 G-->A (Factor V Leiden), and factor V 4070 A-->G (His 12...

journal_title：Thrombosis research

authors： Avcu F,Akar E,Demirkiliç U,Yilmaz E,Akar N,Yalçin A

更新日期：2000-11-01 00:00:00

abstract：:Initiation of clotting cascade by tissue factor (TF): Factor VII (FVII) complex is essential for hemostasis however pathologic expression of TF leads to thrombosis. In contrast, the contact pathway factor XII, and to the smaller extent FXI are dispensable for normal hemostasis but still contribute to pathologic thromb...

journal_title：Thrombosis research

authors： Hoffman M,Pawlinski R

更新日期：2014-05-01 00:00:00