Abstract：
:One of the primary and most serious treatment-related complications in haemophilia A is the formation of anti-factor VIM (FVIII) antibodies, which significantly impacts patient care. For these patients, immunomodulatory therapy becomes important to induce immunological tolerance to FVIII. Immune tolerance induction (ITI) is an efficient therapeutic approach to eliminating inhibitors. Several ITI protocols are currently in use, including the Malmö-, Bonn- and van-Creveld-protocol. Successful utilisation of these protocols enables regular FVIII treatment (in the case of surgery and bleeding), prophylactic treatment (to prevent haemophilic arthropathy and life-threatening bleeding), improvement in quality of life and cost savings. Success rates with ITI may vary depending on patient variables and factors related to the therapeutic regimen, including concentrate purity and von Willebrand factor (VWF) content. Both in vitro and in vivo studies support the clinical observation that the VWF content may have an important role in the success rate of ITI. Over the past 25 years extensive experience has been gained in ITI using the VWF/FVIII product HaemateP/Humate-P. Overall success rates of around 80% have been observed using the Bonn-protocol with plasma-derived VWF/FVIII, whereas the success rates with high-purity or recombinant FVIII products were much lower at 3 German haemophilia centres. Further research is required to better understand the impact of different variables on ITI including the role of VWF, and this is being investigated in several ongoing studies. Meanwhile, current guidelines recommend the use of VWF-FVIII concentrates for ITI where first-line therapy with high-purity FVIII concentrates has failed.
journal_name
Thromb Resjournal_title
Thrombosis researchauthors
Kreuz Wdoi
10.1016/S0049-3848(08)70003-3subject
Has Abstractpub_date
2008-01-01 00:00:00pages
S7-S12eissn
0049-3848issn
1879-2472pii
S0049-3848(08)70003-3journal_volume
122 Suppl 2pub_type
杂志文章,评审abstract：:Platelet concentrates (PC) were prepared by platelet apheresis to obtain a low (< 0.1 x 10(9)/l, PC A) and high (2-9 x 10(9)/l, PC B) concentration of white cells from the same donor. The mean platelet count (+/- SD) of the PC were 1000 +/- 50 x 10(9)/l. During storage 71-96% of the white cells were mononuclear. A por...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(93)90132-8
更新日期：1993-05-01 00:00:00
abstract：:Two isozymes of a native form of human plasminogen (plg), Glu-plg I and II, were isolated. Glu-plg I or II was activated by urokinase (UK) or streptokinase (SK) in the presence of fibrinogen or fibrin. The activation of Glu-plg I was enhanced more than that of Glu-plg II in the presence of fibrin. Fibrin caused better...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(85)90224-5
更新日期：1985-08-01 00:00:00
abstract：BACKGROUND:Plasminogen activator inhibitor type-1 (PAI-1) is considered to be the main inhibitor of fibrinolysis in sepsis. However, the contribution of TAFI to the inhibition of fibrinolysis in sepsis is currently unknown. METHODS:TAFI antigen and PAI-1 levels were measured in severe sepsis (n = 32) and septic shock ...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2005.06.007
更新日期：2006-01-01 00:00:00
abstract：INTRODUCTION:The purpose of the present study was to study the concept of aspirin resistance or non-responsiveness by investigating the response to long-term aspirin therapy in patients with a former acute myocardial infarction (AMI). MATERIALS AND METHODS:Patients with an AMI (n=202) randomly assigned to aspirin 160 ...
journal_title：Thrombosis research
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0049-3848(02)00405-x
更新日期：2002-10-01 00:00:00
abstract：:The pharmacodynamic and pharmacokinetic properties of endpoint-attached N'alkylamine derivatives of low molecular mass heparin (LMMH), low molecular mass heparin (LMMH), low molecular mass heparin-tyramine (LMMH-tyr) and low molecular mass heparin-tyramine-fluorescein-5-isothiocyanate (LMMH-tyr-fitc) were investigated...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(95)00172-n
更新日期：1995-11-01 00:00:00
abstract：:The immunogenic potential of natural and recombinant hirudin was investigated using baboons. Animals received 4 intravenous hirudin injections of 1,000 antithrombin units/kg at certain times (day 1, 3, 8 and 42) and were checked for an immune response. None of the tests performed (in vitro histamine-release, ELISA for...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(91)90167-u
更新日期：1991-01-01 00:00:00
abstract：:The proteinase, brinase (Mr approximately 35000), from Aspergillus oryzae, which has been used in therapeutic attempts as a thrombolytic agent in arterial thrombosis, binds to purified human alpha 2-macroglobulin (alpha 2M) with a stoichiometry of 1.7-1.9 mol of enzyme/mol inhibitor. This binding leads to quantitative...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(88)90359-3
更新日期：1988-01-01 00:00:00
abstract：OBJECTIVE:To date, only a few case studies have reported occurrence of thrombosis in patients with VonWillebrand disease (VWD). No studies have looked at its incidence in this patient population. The aim of this study was to test our hypothesis that decreased VonWillebrand factor (VWF) levels confer a protective effect...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2012.09.005
更新日期：2012-11-01 00:00:00
abstract：INTRODUCTION:Long-term dual antiplatelet therapy (DAPT) has substantially reduced the risk of post-percutaneous coronary intervention (PCI) myocardial infarction and stent thrombosis at the expense of major bleeding. We hypothesized that a short-term DAPT followed by extended P2Y12 inhibitor monotherapy might be approp...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2020.11.038
更新日期：2020-12-07 00:00:00
abstract：INTRODUCTION:In reconstructive head and neck cancer surgery, tissue flaps are transferred to the surgical defect and revascularized by anastomosis of small vessels. Cancer patients are in a hypercoagulable state with high risk of peri- and postoperative thrombotic events. Thrombosis to the tissue flap anastomoses or mi...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/S0049-3848(16)30195-5
更新日期：2016-04-01 00:00:00
abstract：INTRODUCTION:The contact system proteins factor XII (FXII), prekallikrein (PK) and high molecular weight kininogen (HK) have roles in coagulation, fibrinolysis, thrombin-induced platelet activation, cell adhesion and angeogenisis. It has been suggested that inherited or acquired deficiencies of these proteins may be ri...
journal_title：Thrombosis research
pub_type： 临床试验,杂志文章
doi：10.1016/j.thromres.2004.05.005
更新日期：2004-01-01 00:00:00
abstract：:The aim of this study was to compare the efficacy and safety of prolonged (35 days) thromboprophylaxis with a standard length (7 days) regimen of a low molecular weight heparin in patients undergoing total hip arthroplasty. The study was multicentre, randomised, double-blind, and prospective with two groups. Following...
journal_title：Thrombosis research
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0049-3848(98)00018-8
更新日期：1998-03-15 00:00:00
abstract：:The time course and degree of collagen induced platelet shape change, aggregation and ATP-secretion in citrated human platelet rich plasma was monitored with a lumi-aggregometer. Onset of ATP-secretion was measurable within seconds after collagen challenge and always distinctly before onset of shape change. In absence...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(86)90089-7
更新日期：1986-08-15 00:00:00
abstract：:Activation of plasma plasminogen to plasmin is the objective of current strategies for thrombolytic therapy. Although thrombolytic activity in blood involves a large cellular component as well as that in plasma, the contribution of this cellular phase to clinical thrombolysis has not been examined. Using a 125I-fibrin...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(90)90128-y
更新日期：1990-07-15 00:00:00
abstract：:We examined the effects of verapamil on platelet function. Verapamil (0.5 micrograms/ml) in this study inhibited platelet aggregation induced by threshold amounts of ADP, AA, and epinephrine. With higher concentrations of aggregating stimuli, verapamil caused a dose-dependent inhibition of aggregation. Verapamil reduc...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(83)90181-0
更新日期：1983-06-01 00:00:00
abstract：:Chronic thromboembolic pulmonary hypertension (CTEPH) is the most severe long term complication of acute pulmonary embolism (PE). Untreated, CTEPH is associated with a very poor prognosis and high risk of mortality, although curation can be achieved by surgical removal of the obstructive endothelialised thromboemboli ...
journal_title：Thrombosis research
pub_type： 杂志文章,评审
doi：10.1016/j.thromres.2016.12.026
更新日期：2017-03-01 00:00:00
abstract：:Seven males with atherosclerotic disease received daily 1.6 g of the thromboxane antagonist BM 13.177 in two separate oral dosages over a period of four days. The drug significantly reduced elevated plasma levels of thromboxane B2, beta-thromboglobulin and platelet factor 4, whereas thromboxane B2 generation was only ...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(84)90229-9
更新日期：1984-08-15 00:00:00
abstract：INTRODUCTION:Elevated soluble urokinase-type plasminogen activator receptor (suPAR) indicates an inflammatory state caused by conditions such as HIV and cancer. Recently suPAR was identified as an indicator of cardiovascular disease (CVD). CVD is highly prevalent in black South Africans, but the potential role of suPAR...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2011.10.034
更新日期：2012-08-01 00:00:00
abstract：BACKGROUND:Predictors of venous thromboembolism (VTE) after trauma are uncertain. OBJECTIVE:To identify independent predictors of VTE after acute trauma. METHODS:Using Rochester Epidemiology Project (REP) resources, we identified all Olmsted County, MN residents with objectively-diagnosed incident VTE within 92days a...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2016.03.026
更新日期：2016-08-01 00:00:00
abstract：:Two anti-cardiolipin antibody (ACA)-producing cell lines were established, using Epstein-Barr virus transformation followed by a repeated cluster-picking from the same individual with antiphospholipid syndrome who had a history of 8 consecutive fetal losses and deep venous thrombosis. Characterization of the two ACAs ...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(94)90037-x
更新日期：1994-04-01 00:00:00
abstract：:In 1926, Erik von Willebrand, a Finnish physician, published the first manuscript describing a haemorrhagic disorder in people who were living on the Aland islands off the coast of Finland. This disorder is now known by the name of its discoverer. Since this early observation, von Willebrand disease has been extensive...
journal_title：Thrombosis research
pub_type： 传,历史文章,杂志文章
doi：10.1016/j.thromres.2007.03.010
更新日期：2007-01-01 00:00:00
abstract：INTRODUCTION:Patients with stable coronary artery disease (CAD) are at risk of arterial thrombosis causing myocardial infarction. Detection of global haemostatic markers of hypercoagulability and hypofibrinolysis may be important for risk stratification and individualised treatment. We examined overall haemostatic pote...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2013.03.015
更新日期：2013-05-01 00:00:00
abstract：:Coronary artery disease (CAD) continues to be the most frequent cause of death among women in the United States. Although elevated levels of clotting factors have been associated with CAD, few of these studies have been performed in women. Elevated levels of Factor XI have previously been associated with venous thromb...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/s0049-3848(02)00190-1
更新日期：2002-07-15 00:00:00
abstract：:In this study we examined in 100 patients testing positive for Helicobacter pylori infection whether successful eradication therapy with pantoprazole, clarithromycin, and metronidazole alters fibrinogen and other acute phase response markers. Of 100 patients, only 11 showed a fibrinogen level above 300 mg/dL. Successf...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/s0049-3848(99)00230-3
更新日期：2000-03-15 00:00:00
abstract：:The diagnosis of preeclampsia, with all of its consequences, is at times difficult to establish, especially when the patient has underlying chronic hypertension and is not known from prior prenatal care visits. Many screening tests have been proposed. These should be sensitive, relatively specific, easy to perform, of...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(94)90065-5
更新日期：1994-07-15 00:00:00
abstract：BACKGROUND AND PURPOSE:Miniplasmin was a des-kringle variant of plasminogen with potential pharmacological application. We investigated the thrombolytic effect of miniplasmin in a canine model of femoral artery thrombosis. METHODS:In anesthetized dogs, a stable occlusive thrombus was formed by mechanical and electroly...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2008.01.007
更新日期：2008-01-01 00:00:00
abstract：:The three polypeptide chains of fibrinogen, A alpha, B beta and gamma chain, are synthesized on separate polysomes. Fully formed fibrinogen is a six chain, disulfide-linked, dimeric molecule with a molecular weight of 340kDa. Previous pulse-chase studies with L-35 S methionine using the human hepatocellular carcinoma ...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(87)90290-8
更新日期：1987-04-15 00:00:00
abstract：:The cerebral vascular supply is constructed to protect the cerebral hemispheres and brainstem from the consequences of blood flow cessation. Reversal of blood flow around local obstructions is a feature of the microvascular beds of the striatum and cerebral cortex. Cerebral capillaries of these beds consist of endothe...
journal_title：Thrombosis research
pub_type： 杂志文章,评审
doi：10.1016/s0049-3848(00)00218-8
更新日期：2000-05-01 00:00:00
abstract：:Human antithrombin III was demonstrated to bind plasminogen specifically in a time and concentration-dependent manner. The above binding was also confirmed using ligand western blot assays. The interaction of plasminogen was significantly (>90%) inhibited by lysine, indicating the involvement of kringles in binding an...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/s0049-3848(00)00268-1
更新日期：2000-09-15 00:00:00
abstract：:Extended half-life (EHL) products have shown robust efficacy in clinical trials, whilst allowing for less intense treatment regimens when compared with standard half-life products. Regimen optimisation with EHL products could lead to further improvements in bleeding rates, quality of life and reductions in treatment b...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2019.12.012
更新日期：2020-12-01 00:00:00
