Effects of verapamil on platelet aggregation, ATP release and thromboxane generation.

abstract：:The interaction of platelets with collagen involves short aminoacid sequences which recur along the fibres. Platelet aggregation by collagen and serotonin release is inhibited by a synthetic octapeptide LYS-PRO-GLY-GLU- PRO-GLY-PRO-LYS- derived from type III collagen. In contrast, this octapeptide inhibits only weakly...

journal_title：Thrombosis research

authors： Karniguian A,Legrand YJ,Lefrancier P,Caen JP

更新日期：1983-12-15 00:00:00

abstract：:Dextran sulfate and polybrene were immobilized on polypropylene tubes with plastic adhesive. Serum albumin was also immobilized on the tube by heat-denaturation. In the those tubes thrombin was protected from inactivation in the presence of 0.1 M NaCl remarkably. Cholesterol coated on the tube also protected the enzym...

journal_title：Thrombosis research

authors： Oshima G

更新日期：1988-07-01 00:00:00

abstract：:The present investigation has used an aggregation-disaggregation-reaggregation model to determine if exposure to potent aggregating agents causing a refractory state in deaggregated platelets results in down-regulation and clearance of GPIb/IX, the receptor for von willebrand factor. Thrombin, the thrombin receptor ac...

journal_title：Thrombosis research

authors： White JG,Rao GH

更新日期：1996-11-15 00:00:00

abstract：:Factor IX Nagoya 3 (IX Nagoya 3) is a natural mutant of factor IX recognized in a patient with moderately severe hemophilia B. The patient had 0.60 units/ml of factor IX antigen and 2-5% of clotting activity. IX Nagoya 3 was purified from the patient's plasma by immunoaffinity chromatography with an anti-factor IX mon...

journal_title：Thrombosis research

authors： Suehiro K,Miyata T,Takeya H,Takamatsu J,Saito H,Murakawa M,Okamura T,Niho Y,Iwanaga S

更新日期：1990-11-15 00:00:00

abstract：:Platelet alpha adrenoceptor status was examined using the radioligands 3H-yohimbine (3H-YOH) and 3H-dihydroergocryptine (3H-DHE) in 14 patients with myeloproliferative disorder (MPD) and 10 normal controls. Platelets from normal controls and MPD patients sensitive to adrenaline induced aggregation exhibited approximat...

journal_title：Thrombosis research

authors： Swart SS,Wood JK,Barnett DB

更新日期：1985-12-01 00:00:00

abstract：:The efficacy and the safety of a new urokinase dosage regimen (loading dose 250,000 IU, initial maintenance dosage 2,000 IU/kg/h in combination with heparin) was studied in ten cases of deep vein thrombosis with regard to the changes of the blood coagulation and fibrinolytic enzyme system. The coagulation analyses dem...

journal_title：Thrombosis research

authors： Schöffel G,Zimmermann R,Harenberg J,Mörl H

更新日期：1982-01-01 00:00:00

abstract：:Platelet aggregate size was determined with a newly-developed platelet aggregometer, PA-100 (KOWA), which can quantitatively evaluate the size and number of platelet aggregates by means of the particle counting method based upon light scattering. Epinephrine-induced platelet aggregation consists of two phases, the for...

journal_title：Thrombosis research

authors： Satoh K,Ozaki Y,Qi R,Yang L,Asazuma N,Yatomi Y,Kume S

更新日期：1996-03-01 00:00:00

abstract：BACKGROUND:Postthrombotic intraluminal tissue causing postthrombotic syndrome (PTS) has not been well described. This study defines its histological characteristics and assess whether tissue function evolves over time. METHODS:Specimens from 18 common femoral veins (CFV) from 16 patients obtained during CFV endovenect...

journal_title：Thrombosis research

authors： Comerota AJ,Oostra C,Fayad Z,Gunning W,Henke P,Luke C,Lynn A,Lurie F

更新日期：2015-05-01 00:00:00

abstract：:D-dimer is an indicator for in vivo fibrin formation, reflecting the formation of fibrin crosslinked by factor XIIIa. D-dimer assays are frequently used in emergency situations, such as diagnosis of venous thrombosis and pulmonary embolism, or disseminated intravascular coagulation. In these conditions, short sample t...

journal_title：Thrombosis research

authors： Dempfle CE,Suvajac N,Elmas E,Borggrefe M

更新日期：2007-01-01 00:00:00

abstract：:Tissue factor is an ubiquitous membrane-anchored glycoprotein that initiates blood coagulation by forming a complex with circulating factors VII and VIIa. Under normal circumstances, endothelial cells do not express tissue factor but, in some pathological situations, when the endothelium or the monocytes are exposed t...

journal_title：Thrombosis research

authors： Savi P,Bernat A,Dumas A,Aït-Chek L,Herbert JM

更新日期：1994-01-15 00:00:00

abstract：:Two monoclonal antibodies against plasminogen and two against alpha-2-antiplasmin were characterized regarding their binding properties towards their respective native and modified antigens and towards the plasmin-alpha-2-antiplasmin complex. Using an ELISA system, the two monoclonal antibodies against plasminogen (MP...

journal_title：Thrombosis research

authors： Hattey E,Wojta J,Binder BR

更新日期：1987-03-01 00:00:00

abstract：:Prothrombin time is a standard screening test to monitor patients treated with oral anticoagulants. We hypothesize that INR measurements will not vary a lot within a given day in a given patient. The present study was thus conducted to compare the change of the international normalized ratio (INR) of prothrombin time ...

journal_title：Thrombosis research

authors： Ho CH,Lin MW,You JY,Chen CC,Yu TJ

更新日期：2002-09-01 00:00:00

abstract：:Coagulation is initiated by tissue factor (TF). Coagulant TF is constitutively expressed by extravascular cells, but there is increasing evidence that TF can also be present within the blood, in particular during pathological conditions. Such TF is exposed on circulating cell-derived vesicles, and its presence has bee...

journal_title：Thrombosis research

authors： Kleinjan A,Böing AN,Sturk A,Nieuwland R

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND:The purpose of this study was to determine whether the administration of multiple boluses of oral and intravenous tranexamic acid (TXA) postoperatively was equivalent in reducing blood loss in primary THA. METHODS:A total of 108 patients were randomized into two groups: oral TXA group (54 patients receiving...

journal_title：Thrombosis research

authors： Cao G,Huang Z,Xie J,Huang Q,Xu B,Zhang S,Pei F

更新日期：2018-04-01 00:00:00

abstract：:Von Willebrand disease (VWD) is classified into three primary subtypes; type 1 includes partial quantitative deficiency, type 2 (A, B, M and N) includes qualitative defects and type 3 includes virtually complete deficiency of von Willebrand factor (VWF). Type 2A includes variants with decreased platelet adhesion cause...

journal_title：Thrombosis research

authors： Lillicrap D

更新日期：2007-01-01 00:00:00

abstract：:The complex relation between thrombotic thrombocytopenic purpura (TTP) and pregnancy is concisely reviewed. Pregnancy is a very strong trigger for acute disease manifestation in patients with hereditary TTP caused by double heterozygous or homozygous mutations of ADAMTS13 (ADisintegrin And Metalloprotease with Thrombo...

journal_title：Thrombosis research

authors： von Auer C,von Krogh AS,Kremer Hovinga JA,Lämmle B

更新日期：2015-02-01 00:00:00

abstract：:Human gel-filtered platelets or platelet-rich plasma were stimulated by sodium arachidonate or by ADP in the presence of two compounds known to inhibit ADP mediated aggregation and secretion - ATP and N-ethylmaleimide. Using gel-filtered platelets and the lowest concentration of agonist necessary to elicit maximum agg...

journal_title：Thrombosis research

authors： Burch JW,Lamb RJ

更新日期：1983-09-01 00:00:00

abstract：:An issue of great importance and continuing concern with regard to all products derived from human plasma is their safety from potential contaminants in the source material from which they are purified. Since viral contaminants are a major safety consideration with these products, a number of different methods, includ...

journal_title：Thrombosis research

authors： Chandra S,Groener A,Feldman F

更新日期：2002-03-01 00:00:00

abstract：:Generation of active Factor XII (FXIIa) triggers blood clotting on artificial surfaces and may also enhance intravascular thrombosis. We developed a patterned kaolin (0 to 0.3 pg/μm(2))/type 1 collagen fibril surface for controlled microfluidic clotting assays. Perfusion of whole blood (treated only with a low level o...

journal_title：Thrombosis research

authors： Zhu S,Diamond SL

更新日期：2014-12-01 00:00:00

abstract：INTRODUCTION:No data are available regarding appropriate strategies for the transition of patients undergoing total hip or knee replacement (THR/TKR) surgery from subcutaneous low molecular weight heparin (LMWH) to rivaroxaban. This study determined the pharmacodynamic effects of rivaroxaban on the first day of adminis...

journal_title：Thrombosis research

authors： Mills RM,Berkowitz RD,Damaraju CV,Jennings LK,Wildgoose P

更新日期：2012-11-01 00:00:00

abstract：:A new method, based on the observation that leukocytes contain PGI2-synthetase activity, was used to measure the effect of pharmacological levels of sulphinpyrazone on the TXA2 and PGI2 production in whole blood. Four human volunteers took 400 mg sulphinpyrazone twice daily for 5 1/2 days. Blood was drawn before the s...

journal_title：Thrombosis research

authors： Badenhorst PN,Deckmyn H,Vermylen J

更新日期：1982-10-01 00:00:00

abstract：:The proteinase, brinase (Mr approximately 35000), from Aspergillus oryzae, which has been used in therapeutic attempts as a thrombolytic agent in arterial thrombosis, binds to purified human alpha 2-macroglobulin (alpha 2M) with a stoichiometry of 1.7-1.9 mol of enzyme/mol inhibitor. This binding leads to quantitative...

journal_title：Thrombosis research

authors： Larsson LJ,Frisch EP,Törneke K,Lindblom T,Björk I

更新日期：1988-01-01 00:00:00

abstract：BACKGROUND:Predictors of venous thromboembolism (VTE) after trauma are uncertain. OBJECTIVE:To identify independent predictors of VTE after acute trauma. METHODS:Using Rochester Epidemiology Project (REP) resources, we identified all Olmsted County, MN residents with objectively-diagnosed incident VTE within 92days a...

journal_title：Thrombosis research

authors： Park MS,Perkins SE,Spears GM,Ashrani AA,Leibson CL,Boos CM,Harmsen WS,Jenkins DH,Bailey KR,Ballman KV,Heit JA

更新日期：2016-08-01 00:00:00

abstract：:Incubation of platelets with pronase or chymotrypsin results in the exposure of fibrinogen receptors. We determined that these enzymes did not affect the membrane fluidity as evaluated by the depolarization of the fluorescence of 1,6-diphenyl-1,3,5 hexatriene (DPH). There was no significant difference in either the de...

journal_title：Thrombosis research

authors： Simons E,Whitin JC,Morinelli TA,Stewart GJ,Niewiarowski S

更新日期：1985-07-01 00:00:00

abstract：BACKGROUND:It is well demonstrated that obesity is an independent risk factor for cardiovascular diseases. Recent studies have shown that obesity, insulin resistance and atherosclerosis are closely related phenomena in which low-grade inflammatory state and prothrombotic condition has pivotal roles. It has been shown t...

journal_title：Thrombosis research

authors： Guldiken S,Demir M,Arikan E,Turgut B,Azcan S,Gerenli M,Tugrul A

更新日期：2007-01-01 00:00:00

abstract：:Endothelial cells in biopsied blood vessels from von Willebrand factor (vWf)-deficient Doberman pinscher dogs contain immunologically detectable vWf. These dogs and normal dogs were treated with DDAVP (0.6 microgram/kg) and epinephrine (0.5 microgram/kg/min for 30 minutes) and were exercised, using 5 different exercis...

journal_title：Thrombosis research

authors： Meyers KM,Wardrop KJ,Dodds WJ,Brassard J

更新日期：1990-01-01 00:00:00

abstract：INTRODUCTION:D-dimer, a fibrin degradation product, is related to risk of cardiovascular disease and venous thromboembolism. Genetic determinants of D-dimer are not well characterized; notably, few data have been reported for African American (AA), Asian, and Hispanic populations. MATERIALS AND METHODS:We conducted a ...

journal_title：Thrombosis research

authors： Weng LC,Tang W,Rich SS,Smith NL,Redline S,O'Donnell CJ,Basu S,Reiner AP,Delaney JA,Tracy RP,Palmer CD,Young T,Yang Q,Folsom AR,Cushman M

更新日期：2014-08-01 00:00:00

abstract：:Endothelial cells from human umbilical vein were incubated in vitro with thrombin in the absence or presence of unfractionated heparin (UFH), low molecular weight heparin (LMWH) or dermatan sulfate (DS) to clarify the effect of these glycosaminoglycans on thrombin-stimulated prostaglandin I2 (PGI2) production. Althoug...

journal_title：Thrombosis research

authors： Itoh F,Kaji T,Hayakawa Y,Oguma Y,Sakuragawa N

更新日期：1990-02-15 00:00:00

abstract：:The pharmacodynamic and pharmacokinetic properties of endpoint-attached N'alkylamine derivatives of low molecular mass heparin (LMMH), low molecular mass heparin (LMMH), low molecular mass heparin-tyramine (LMMH-tyr) and low molecular mass heparin-tyramine-fluorescein-5-isothiocyanate (LMMH-tyr-fitc) were investigated...

journal_title：Thrombosis research

authors： Malsch R,Piazolo L,Harenberg J,Heene DL

更新日期：1995-11-01 00:00:00

abstract：:The serotonin transporter (SERT) is found in neuron and platelet membranes. Selective serotonin-reuptake inhibitors (SSRIs) are widely prescribed for severe depression. They may at least partly counteract the effects of serotonin on the vascular biology system, can lower agonists-induced platelet activation, aggregati...

journal_title：Thrombosis research

authors： Hoirisch-Clapauch S,Nardi AE,Gris JC,Brenner B

更新日期：2014-07-01 00:00:00