Effect of a collagen derived octapeptide on different steps of the platelet/collagen interaction.

abstract：:Platelet aggregation in platelet-rich plasma (PRP) is more sensitive to agonists and more resistant to antagonists than that in whole blood. In this study, we show that the presence of neutrophils in whole blood accounts at least in part for diminished platelet aggregation in whole blood. The platelet-inhibitory effec...

journal_title：Thrombosis research

authors： Nicolini FA,Mehta JL

更新日期：1990-12-01 00:00:00

abstract：INTRODUCTION:Inherited thrombophilia has been associated with unexplained recurrent pregnancy loss (RPL) and stillbirth. This thrombotic tendency can manifest as thrombotic lesions in the placenta, and may lead to abortion and stillbirth. The aim of our case-control study was to investigate the prevalence of FVL and FI...

journal_title：Thrombosis research

authors： Sottilotta G,Oriana V,Latella C,Luise F,Piromalli A,Ramirez F,Mammì C,Santoro R,Iannaccaro P,Muleo G,Lombardo VT

更新日期：2006-01-01 00:00:00

abstract：:Cross reactive antigens to factor VIII have been measured in a range of vertebrate phyla. VIII coagulant antigen (VIII:CAg) measured using a human antibody was in general, much lower than reported values of VIII coagulant activity (VIII:C) except in simians and the guinea pig. The dose response curve for the assay was...

journal_title：Thrombosis research

authors： Rotblat F,Hawkey C,O'Brien DP,Tuddenham EG

更新日期：1982-03-01 00:00:00

abstract：:The role of thrombin in vascular physiology and pathophysiology continues to impact our understanding of many cellular processes and systems including the function of platelets, endothelial cells, smooth muscle cells, leukocytes and the regulation of the coagulation cascade. Recent acute coronary syndrome clinical tri...

journal_title：Thrombosis research

authors： Giri S,Jennings LK

更新日期：2015-05-01 00:00:00

abstract：:Time response curves of the anti-thrombotic effects, bleeding enhancing effects, effects on APTT, anti-Xa activities, anti-thrombin activities and thrombin generation inhibitory activities of the low molecular weight heparinoid Org 10172 and heparin have been compared in rats. The time courses of these effects were si...

journal_title：Thrombosis research

authors： Hobbelen PM,Vogel GM,Meuleman DG

更新日期：1987-12-01 00:00:00

abstract：INTRODUCTION:Unicompartmental knee arthroplasty (UKA) has increased due to potential favourable complication rates when compared to total knee arthroplasty (TKA). Although venous thromboembolism (VTE) is a well-documented complication after TKA limited data is available after UKA and mostly presented as secondary findi...

journal_title：Thrombosis research

authors： Petersen PB,Jørgensen CC,Gromov K,Kehlet H,Lundbeck Foundation Centre for Fast-track Hip and Knee Replacement Collaborative Group.

更新日期：2020-11-01 00:00:00

abstract：INTRODUCTION:Thrombomodulin (TM) has been described as a marker of endothelial injury in atherosclerosis. The role of TM as a predictor of PAD severity is to be proven. The goal of the present study is to compare the level of plasmatic (TMp) in patients with intermittent claudication with patients with critical ischemi...

journal_title：Thrombosis research

authors： Nasser M,Wolosker N,Uint L,Rosoky RA,Lobato M,Wajngarten M,Puech-Leao P

更新日期：2006-01-01 00:00:00

abstract：INTRODUCTION:Coagulation factor XIII (FXIII) is a fibrin-stabilizing factor, which contributes to hemostasis, wound healing, and maintenance of pregnancy. Accordingly, patients with congenital FXIII deficiency manifest a life-long bleeding tendency, abnormal wound healing and recurrent miscarriage. In order to understa...

journal_title：Thrombosis research

authors： Souri M,Yee VC,Fujii N,Ichinose A

更新日期：2012-09-01 00:00:00

abstract：:A direct assay for plasminogen activator (PA) was developed. It employed polyacrylamide gel electrophoresis in the presence of sodium dodecyl sulfate and beta-mercaptoethanol to monitor PA-mediated conversion of single chain, 125I-plasminogen to two chain plasmin. By incorporating Triton X-100, albumin and trasylol in...

journal_title：Thrombosis research

authors： Mussoni L,Lawrence D,Loskutoff DJ

更新日期：1984-05-01 00:00:00

abstract：:Prothrombin fragments (F1+2), thrombin-antithrombin complexes (TAT) and D-dimers, markers of hemostatic system activation, were measured in 59 consecutive patients with deep vein thrombosis (DVT). Patients were randomly treated either with subcutaneous unfractionated heparin (UH) administered in two to three subcutane...

journal_title：Thrombosis research

authors： Peternel P,Terbizan M,Tratar G,Bozic M,Horvat D,Salobir B,Stegnar M

更新日期：2002-02-01 00:00:00

abstract：:In a double-blind, placebo-controlled trial of 40 patients requiring aortocoronary vene transplant surgery, prostacyclin (PGI2) was infused in a dose of 8 ng/kg/min throughout cardiopulmonary bypass. When compared with the placebo-group, the patients treated with PGI2 were found to have significantly higher platelet c...

journal_title：Thrombosis research

authors： Heinrich D,Schleussner E,Wagner WL,Sellmann-Richter R,Hehrlein FW

更新日期：1983-11-15 00:00:00

abstract：BACKGROUND:Although excess platelet activation, as indicated by increased plasma beta thromboglobulin (beta-TG), has been shown in pregnancy-induced hypertension (PIH), platelet adhesion, platelet morphology and a comparison of platelet and soluble (plasma) levels of the adhesion molecules P-selectin (pPsel and sPsel, ...

journal_title：Thrombosis research

authors： Karalis I,Nadar SK,Al Yemeni E,Blann AD,Lip GY

更新日期：2005-01-01 00:00:00

abstract：:Tissue factor (TF) is an integral membrane glycoprotein that serves as a cofactor for blood coagulation factor VIIa. The induction of TF on the surface of endothelial cells is initiated by various kinds of stimuli including lipopolysaccharide (LPS), interleukin-1 beta (IL-1 beta), and tumor necrosis factor alpha (TNF ...

journal_title：Thrombosis research

authors： Wakita K,Stearns-Kurosawa DJ,Marumoto Y

更新日期：1994-04-15 00:00:00

abstract：:The effects and mechanism of action of a phospholipase C (PLC) from Pseudomonas aeruginosa on human platelet rich plasma were examined to better understand the interaction of PLC with human platelets. PLC caused platelet aggregation in a concentration-dependent manner. Enzymatic activity of PLC was necessary for aggre...

journal_title：Thrombosis research

authors： Coutinho IR,Berk RS,Mammen E

更新日期：1988-09-01 00:00:00

abstract：INTRODUCTION:Pulmonary embolism (PE) is a common cause of morbidity and mortality. In this study, we investigated patterns of morbidity and mortality from PE in Australia. MATERIALS & METHODS:Australian government databases were used to extract data on age and sex specific rates of mortality between 1997 and 2007, and...

journal_title：Thrombosis research

authors： Shiraev TP,Omari A,Rushworth RL

更新日期：2013-07-01 00:00:00

abstract：:We investigated the effects of Defibrotide (D), a natural polydeoxyribonucleotide, on acute myocardial ischemia (AMI) in anesthetized cats. A permanent ligature was placed around the left anterior descending coronary artery (LAD) 12-14 mm from its origin. Ventricular fibrillation and death were exceptional and when th...

journal_title：Thrombosis research

authors： Niada R,Porta R,Pescador R,Mantovani M,Prino G

更新日期：1985-04-01 00:00:00

abstract：PURPOSE:A poor implementation of VTE prophylactic measures recommended for critically ill patients has been observed in several epidemiological studies. The clinical factors associated with this have not been clearly established. The objective of our study was to identify which factors could be related to the inappropr...

journal_title：Thrombosis research

authors： García-Olivares P,Guerrero JE,Keough E,Galdos P,Carriedo D,Murillo F,Rivera A,PROF-ETEV study investigators.

更新日期：2016-07-01 00:00:00

abstract：:Ticlopidine (100 mg/kg/day or 400 mg/kg/day) was administered to rats and rabbits for 48 hr before and during the experiments. Aggregation studies of twice-washed platelets resuspended in Tyrode solution containing apyrase and 0.35% albumin showed that inhibition by ticlopidine of aggregation induced by ADP, collagen,...

journal_title：Thrombosis research

authors： Cattaneo M,Winocour PD,Somers DA,Groves HM,Kinlough-Rathbone RL,Packham MA,Mustard JF

更新日期：1985-01-01 00:00:00

abstract：INTRODUCTION:Ultrasound can accelerate clot dissolution in vitro and in vivo. We used an ex vivo canine shunt to investigate low frequency ultrasound effects on platelet-rich stent thrombosis. METHODS AND RESULTS:Nitinol stents were expanded to 2 mm in diameter in two perfusion chambers in a parallel shunt and exposed...

journal_title：Thrombosis research

authors： Neuman Y,Rukshin V,Tsang V,Atar S,Miyamoto T,Luo H,Kobal S,Thompson T,Birnbaum Y,Horzewski M,Siegel RJ,Kaul S

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:Atherosclerosis occurs as a result of a chronic inflammatory response in the arterial wall associated with an increased uptake of low-density lipoprotein by macrophages and the subsequent transformation of this lipoprotein into foam cells. It has been found that miR-188-3p can suppress autophagy and myocardi...

journal_title：Thrombosis research

authors： Zhang XF,Yang Y,Yang XY,Tong Q

更新日期：2018-11-01 00:00:00

abstract：:Aggregation responses of platelet-rich plasma (PRP) from monocrotaline pyrrole (MCTP)-treated rats were examined to help elucidate the role of platelets in MCTP-induced pulmonary hypertension. PRP from rats treated one or four days earlier with MCTP (5 mg/kg, i.v.) or vehicle exhibited the same slope and maximum aggre...

journal_title：Thrombosis research

authors： Hilliker KS,Deyo JA,Bell TG,Roth RA

更新日期：1983-11-01 00:00:00

abstract：BACKGROUND:Factor XIII (FXIII), a plasma pro-transglutaminase, consists of two A subunits and two B subunits (FXIIIA2B2). Following activation by thrombin, it cross-links fibrin chains at the final step of coagulation. We previously reported that FXIII subunit A (FXIIIA) serves as a protein disulfide isomerase (PDI), a...

journal_title：Thrombosis research

authors： Lahav J,Tvito A,Bagoly Z,Dardik R,Inbal A

更新日期：2013-04-01 00:00:00

abstract：INTRODUCTION:Antithrombin (AT), protein C (PC) and protein S (PS) deficiencies are risk factors for venous thromboembolism. Overlapping values between heterozygous carriers and normal individuals often make a correct classification of a deficiency difficult. The aim of this study was to investigate the effect of sex, a...

journal_title：Thrombosis research

authors： Franchi F,Biguzzi E,Martinelli I,Bucciarelli P,Palmucci C,D'Agostino S,Peyvandi F

更新日期：2013-08-01 00:00:00

abstract：:The ability of the COA-SET Fibrin monomer (COA-SET FM) test to detect soluble fibrin was evaluated by comparing the results of the COA-SET FM test with fibrinopeptide A (FPA) determinations following thrombin incubation of plasma or whole blood. In addition, two semiquantitative tests (erythrocytes-agglutination test ...

journal_title：Thrombosis research

authors： Halvorsen S,Skjønsberg OH,Ruyter R,Godal HC

更新日期：1990-02-15 00:00:00

abstract：:Epidemiologic data have indicated that the intake of polyphenols is inversely associated with mortality from cardiovascular disease. Mitogen-activated protein kinases (MAPKs) are ubiquitous signaling proteins that have been associated with gene regulation. This study determined whether polyphenols (catechin and querce...

journal_title：Thrombosis research

authors： Pasten C,Olave NC,Zhou L,Tabengwa EM,Wolkowicz PE,Grenett HE

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:SARS-CoV-2 infection has noted derangements in coagulation markers along with significant thrombotic complications. Post-mortem examinations show severe endothelial injury and widespread thrombotic microangiopathy in the pulmonary vasculature. Early reports describing the use of prophylactic anticoagulation ...

journal_title：Thrombosis research

authors： Hsu A,Liu Y,Zayac AS,Olszewski AJ,Reagan JL

更新日期：2020-12-01 00:00:00

abstract：:The aim was to describe the phlebographic pattern of asymptomatic and symptomatic deep vein thrombosis (DVT) after total hip replacement by the use of a scoring system in 102 consecutive patients (54 asymptomatic, 48 symptomatic). The DVTs were scored from 1 to 3, and registered in a scoring system dividing the deep v...

journal_title：Thrombosis research

authors： Björgell O,Nilsson PE,Benoni G,Bergqvist D

更新日期：2000-09-01 00:00:00

abstract：:Factor Xa-catalyzed prothrombin activation occurs on cellular surfaces, including those of vascular endothelial cells. In a reconstituted model, endothelial cells and platelets acted synergistically to maximally activate prothrombin in the presence of Factor Xa. Synergism was observed at platelet concentrations less t...

journal_title：Thrombosis research

authors： Rodgers GM,Shuman MA

更新日期：1987-01-15 00:00:00

abstract：INTRODUCTION:The standard dabigatran etexilate dosage for prevention of venous thromboembolism (VTE) after elective total hip or knee replacement (THR/TKR) is 220mg once daily (qd), with 150mg qd for patients with moderate renal impairment. As clinical trial experience in patients with moderate renal impairment was lim...

journal_title：Thrombosis research

authors： Samama CM,Rosencher N,Kleine E,Feuring M,Brueckmann M,Clemens A,Gullberg J,Frostick SP

更新日期：2016-07-01 00:00:00

abstract：INTRODUCTION:Anedoctal reports suggest that some thrombotic primary antiphospholipid antibody syndrome (PAPS) patients on oral anticoagulation require higher than average doses to achieve given targets international normalized ratios (INR). MATERIALS AND METHODS:To test the hypothesis of relative warfarin resistance i...

journal_title：Thrombosis research

authors： Ames PR,Margaglione M,Ciampa A,Colaizzo D,Ferrara F,Iannaccone L,Vincenzobrancaccio

更新日期：2011-06-01 00:00:00