Immunologic studies of factor VIII coagulant activity (VIII:C). 2. Factor VIII in selected vertebrates.

Abstract:

:Cross reactive antigens to factor VIII have been measured in a range of vertebrate phyla. VIII coagulant antigen (VIII:CAg) measured using a human antibody was in general, much lower than reported values of VIII coagulant activity (VIII:C) except in simians and the guinea pig. The dose response curve for the assay was parallel in all cases. Factor VIII-related antigen (VIIIR:Ag) measured using rabbit antibody to human VIIIR:Ag was low or absent in most species except simians and the dose response curve was non-parallel to the human standard except with goat plasma. Avians lacked cross-reactive material.

journal_name

Thromb Res

journal_title

Thrombosis research

authors

Rotblat F,Hawkey C,O'Brien DP,Tuddenham EG

doi

10.1016/0049-3848(82)90132-3

subject

Has Abstract

pub_date

1982-03-01 00:00:00

pages

423-31

issue

5

eissn

0049-3848

issn

1879-2472

pii

0049-3848(82)90132-3

journal_volume

25

pub_type

杂志文章
  • Low PAI-1 activity in relation to the risk for perioperative bleeding complications in transurethral resection of the prostate.

    abstract:INTRODUCTION:Low levels of plasminogen activator inhibitor type 1 (PAI-1) have been associated with increased risk for perioperative bleeding in some case reports. The aim of this study was to investigate prospectively whether low PAI-1 activity increases the risk for perioperative bleeding in patients undergoing trans...

    journal_title:Thrombosis research

    pub_type: 杂志文章

    doi:10.1016/j.thromres.2006.06.014

    authors: Agren A,Kolmert T,Wiman B,Schulman S

    更新日期:2007-01-01 00:00:00

  • Recombinant γT305A fibrinogen indicates severely impaired fibrin polymerization due to the aberrant function of hole 'A' and calcium binding sites.

    abstract:INTRODUCTION:We examined a 6-month-old girl with inherited fibrinogen abnormality and no history of bleeding or thrombosis. Routine coagulation screening tests showed a markedly low level of plasma fibrinogen determined by functional measurement and also a low level by antigenic measurement (functional/antigenic ratio=...

    journal_title:Thrombosis research

    pub_type: 杂志文章

    doi:10.1016/j.thromres.2014.06.002

    authors: Ikeda M,Kobayashi T,Arai S,Mukai S,Takezawa Y,Terasawa F,Okumura N

    更新日期:2014-08-01 00:00:00

  • Evaluation of annexin V as a platelet-directed thrombus targeting agent.

    abstract::Annexin V is a human phospholipid binding protein (M(r) 36,000) that binds with high affinity to activated platelets in vitro. We studied the biodistribution and thrombus binding of annexin V in rabbit and swine models of fully occlusive arterial thrombi formed 1-2 h prior to injection of annexin V. Iodinated annexin ...

    journal_title:Thrombosis research

    pub_type: 杂志文章

    doi:10.1016/0049-3848(94)90224-0

    authors: Tait JF,Cerqueira MD,Dewhurst TA,Fujikawa K,Ritchie JL,Stratton JR

    更新日期:1994-09-01 00:00:00

  • Increased levels of platelet-derived microparticles in pulmonary hypertension.

    abstract:INTRODUCTION:Thrombosis and coagulation abnormalities are thought to be involved in disease progression of pulmonary hypertension. Platelet-derived microparticles (PDMP) are released from platelets following stimulation and have recently been demonstrated to play an important role in pathogenesis of various diseases. T...

    journal_title:Thrombosis research

    pub_type: 杂志文章

    doi:10.1016/j.thromres.2020.07.030

    authors: Ogawa A,Matsubara H

    更新日期:2020-11-01 00:00:00

  • Catheter-directed ultrasound-accelerated thrombolysis for the treatment of acute pulmonary embolism.

    abstract:BACKGROUND:Systemic thrombolysis rapidly improves right ventricular (RV) dysfunction in patients with acute pulmonary embolism (PE) but is associated with major bleeding complications in up to 20%. The efficacy of low-dose, catheter-directed ultrasound-accelerated thrombolysis (USAT) on the reversal of RV dysfunction i...

    journal_title:Thrombosis research

    pub_type: 杂志文章

    doi:10.1016/j.thromres.2011.05.014

    authors: Engelhardt TC,Taylor AJ,Simprini LA,Kucher N

    更新日期:2011-08-01 00:00:00

  • Lack of correlation between "in vitro" and "in vivo" antithrombotic activity of heparin fractions and related compounds. Heparan sulfate as an antithrombotic agent "in vivo".

    abstract::The anticoagulant (U.S.P., APTT; "in vitro" and "in vivo") antithrombotic (aXa; Yin and Wessler and chromogenic), antilipemic (LPL) activities of heparin, heparin fractions and fragments, heparinoids, heparan sulfate and other sulfated glycosaminoglycans were compared with the activities of these compounds as antithro...

    journal_title:Thrombosis research

    pub_type: 杂志文章

    doi:10.1016/0049-3848(85)90298-1

    authors: Bianchini P,Osima B,Parma B,Nader HB,Dietrich CP

    更新日期:1985-12-01 00:00:00

  • Detection of procoagulant phospholipid interfering in tests for lupus anticoagulant.

    abstract::Excess platelets shorten most clotting tests for lupus anticoagulant (LA). Often it is not clear if a shortened, normal or slightly prolonged result in a test masks a weak LA in combination with activated platelets, which express procoagulant phospholipid (PPL). Our aim was to investigate a new LA-insensitive factor X...

    journal_title:Thrombosis research

    pub_type: 杂志文章,评审

    doi:10.1016/j.thromres.2004.06.001

    authors: Exner T,Low J

    更新日期:2004-01-01 00:00:00

  • Release of lipoprotein lipase and hepatic triglyceride lipase in rats by heparin and other sulphated polysaccharides.

    abstract::The ability of parenteral heparin to release the capillary-bound enzymes lipoprotein lipase (LPL) and hepatic triglyceride lipase (HTGL) into the circulation is shared by several other sulphated polysaccharides. The lipase-releasing activity in rats of two unfractionated heparins has been compared with that of charact...

    journal_title:Thrombosis research

    pub_type: 杂志文章

    doi:10.1016/0049-3848(89)90068-6

    authors: Williams SP,Johnson EA

    更新日期:1989-08-01 00:00:00

  • Pharmacodynamics assessment of Bemiparin after multiple prophylactic and single therapeutic doses in adult and elderly healthy volunteers and in subjects with varying degrees of renal impairment.

    abstract:INTRODUCTION:Aging and renal impairment may prolong the half-life and lead to accumulation of low molecular weight heparins. Correct dosing is critical to prevent bleeding or thrombosis. MATERIALS AND METHODS:Open, parallel study. Healthy adult [n=13] and elderly (>65yrs) [n=12] volunteers; and subjects with mild (ClC...

    journal_title:Thrombosis research

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.thromres.2014.03.038

    authors: Rico S,Antonijoan RM,Ballester MR,Gutierro I,Ayani I,Martinez-Gonzalez J,Borrell M,Fontcuberta J,Gich I

    更新日期:2014-06-01 00:00:00

  • Neutrophil extracellular traps exacerbate coagulation and endothelial damage in patients with essential hypertension and hyperhomocysteinemia.

    abstract::Patients with essential hypertension (EH) and hyperhomocysteinemia (HHCY) suffer from more increased thrombotic events than those in EH alone. However, the underlying mechanisms for this effect are not well understood. This study hypothesized that neutrophil extracellular trap (NET) releasing may be triggered by HHCY ...

    journal_title:Thrombosis research

    pub_type: 杂志文章

    doi:10.1016/j.thromres.2020.10.028

    authors: Li JH,Tong DX,Wang Y,Gao L,Liu Y,Zhang XH,Chen WJ,Chi JY,Liu N,Yang K,Wang SP,Xu Y,Li Y,Yin XH,Liu WX

    更新日期:2021-01-01 00:00:00

  • Intravascular cysteinyl-leukotriene formation by clotting whole human blood. Evidence from clamped umbilical vein segments and thrombus specimens.

    abstract::We have recently demonstrated that contact activation of the intrinsic coagulation cascade in vitro is accompanied not only by thromboxane (TX) B2 generation but also by the formation of 5-lipoxygenase-derived cysteinyl-leukotrienes (LT). In our present study we have investigated the effects of the vascular wall on th...

    journal_title:Thrombosis research

    pub_type: 杂志文章

    doi:10.1016/0049-3848(93)90175-n

    authors: Weide I,Winking M,Simmet T

    更新日期:1993-10-01 00:00:00

  • Intracranial hemorrhage in cancer patients treated with anticoagulation.

    abstract::Both venous thromboembolism and intracranial metastases are common complications in the setting of primary brain tumors and metastatic malignancies. Anticoagulation is indicated in the presence of cancer-associated thrombosis in order to limit the risk of pulmonary embolism; however, there is reluctance to initiate an...

    journal_title:Thrombosis research

    pub_type: 杂志文章,评审

    doi:10.1016/S0049-3848(16)30100-1

    authors: Weinstock MJ,Uhlmann EJ,Zwicker JI

    更新日期:2016-04-01 00:00:00

  • Warfarin-induced factor VII deficiency and the bleeding time.

    abstract::The effect of warfarin-induced factor VII deficiency on the skin bleeding time was investigated in 10 consecutive patients with mean prothrombin times of 33 sec and factor VII levels of 7%. Bleeding times in all but one subject were entirely within the normal range. We conclude that warfarin administration, even to th...

    journal_title:Thrombosis research

    pub_type: 杂志文章

    doi:10.1016/0049-3848(83)90243-8

    authors: Green D,Ts'ao CH

    更新日期:1983-02-15 00:00:00

  • The action of thrombin on peptide p-nitroanilide substrates: hydrolysis of Tos-Gly-Pro-Arg-pNA and D-Phe-Pip-Arg-pNA by human alpha and gamma and bovine alpha and beta-thrombins.

    abstract::Human and bovine alpha-thrombins (greater than 90% alpha form) with high fibrinogen clotting activities (approximately 3,000 U.S. units/mg protein) exhibit similar Michaelis menten kinetics with the p-nitroanilide tripeptide substrates Tos-Gly-Pro-arg-pNA (Chromozym-TH) and D-Phe-Pip-Arg-pNA (S-2238). The kinetic para...

    journal_title:Thrombosis research

    pub_type: 杂志文章

    doi:10.1016/0049-3848(82)90114-1

    authors: Lottenberg R,Hall JA,Fenton JW 2nd,Jackson CM

    更新日期:1982-11-01 00:00:00

  • Anti-human factor IX monoclonal antibodies specific for calcium ion-induced conformations.

    abstract::Four monoclonal antibodies have been produced, which are specific for the Ca2+ or Sr2(+)-induced conformation of human factor IX. Certain, but not all, gamma-carboxy-glutamic acid residues in factor IX are involved in the epitope expression together with the conformation stabilized by the adjacent region of Gla-domain...

    journal_title:Thrombosis research

    pub_type: 杂志文章

    doi:10.1016/0049-3848(90)90306-w

    authors: Sugo T,Mizuguchi J,Kamikubo Y,Matsuda M

    更新日期:1990-06-15 00:00:00

  • Treatment of venous thromboembolism in patients with cancer: from clinical trials to real life.

    abstract::Approximately one-fifth of all cases of venous thromboembolism (VTE) are related to cancer. VTE complications may have a substantial impact on prognosis, quality of life and care in patients with cancer. Patients with cancer-related VTE are at increased risk of developing recurrent VTE compared to patients without can...

    journal_title:Thrombosis research

    pub_type: 杂志文章

    doi:10.1016/S0049-3848(20)30409-6

    authors: Verso M,Agnelli G

    更新日期:2020-07-01 00:00:00

  • Factor VIII coagulant moiety binds to platelets by binding to phospholipids of the platelet membrane.

    abstract::Washed human platelets were incubated with commercial factor VIII concentrate, or with purified factor VIII coagulant moiety. Platelets were then washed again and lysed by sonication. VIII:Ag and vWf:Ag were measured in the platelet lysate prior to and after incubation of the lysate with phospholipase C (PL-C). Platel...

    journal_title:Thrombosis research

    pub_type: 杂志文章

    doi:10.1016/0049-3848(87)90223-4

    authors: Muntean W,Leschnik B,Haas J

    更新日期:1987-02-15 00:00:00

  • Factors affecting the first recurrence of noncardioembolic ischemic stroke.

    abstract::Studies of the factors affecting the first recurrence of ischemic stroke have reported inconsistent findings. Types of initial stroke and the racial differences in study samples are among the explanations that may account for this inconsistency. The aims of this study were to estimate the cumulative recurrence rates o...

    journal_title:Thrombosis research

    pub_type: 杂志文章

    doi:10.1016/s0049-3848(99)00146-2

    authors: Wu TH,Chen HH,Lee TK

    更新日期:2000-02-01 00:00:00

  • Blood rheology during chemotherapy in patients with ovarian cancer.

    abstract::The use of platinum based chemotherapy in ovarian malignancy and other cancer types is known to be associated with deep vein thrombosis. In a prospective study of 47 patients with ovarian cancer of International Federation of Gynecology and Obstetrics stage Ib-IV, serial rheological parameters were determined (plasma ...

    journal_title:Thrombosis research

    pub_type: 杂志文章

    doi:10.1016/s0049-3848(98)00022-x

    authors: von Tempelhoff GF,Niemann F,Schneider DM,Kirkpatrick CJ,Hommel G,Heilmann L

    更新日期:1998-04-15 00:00:00

  • Thermally induced conformational changes in fibrin film.

    abstract::Fibrin film is prepared by compaction in one dimension of a fibrin clot (pH 6.3, ionic strength 0.15, fibrin concentration about 0.5%) by expulsion of fluid to reach a fibrin concentration of about 15%. Strips of film, equilibrated in the same buffer with very slowly increasing temperature, shrink in length in a narro...

    journal_title:Thrombosis research

    pub_type: 杂志文章

    doi:10.1016/0049-3848(88)90020-5

    authors: Nakatani AI,Ferry JD

    更新日期:1988-12-01 00:00:00

  • Collagen derived octapeptide inhibits platelet procoagulant activity induced by the combined action of collagen and thrombin.

    abstract::Platelet prothrombin converting activity was measured in a system using washed human platelets and purified coagulation factors Xa, Va and prothrombin. Exposure of platelet prothrombin converting activity evoked by collagen or the combined action of collagen and thrombin was effectively inhibited when a collagen deriv...

    journal_title:Thrombosis research

    pub_type: 杂志文章

    doi:10.1016/0049-3848(85)90065-9

    authors: Bevers EM,Karniguian A,Legrand YJ,Zwaal RF

    更新日期:1985-02-01 00:00:00

  • A two-step approach (Enzyme-linked immunosorbent assay and confirmation assay) to detect antibodies against von Willebrand factor in patients with Acquired von Willebrand Syndrome.

    abstract:BACKGROUND:Acquired von Willebrand Syndrome is a rare bleeding disorder, which arises in individuals with no personal or family history of bleeding, associated with lymphoproliferative and myeloproliferative disorders or other diseases. AIM:To develop a two-step approach assay to detect autoantibodies against VWF and ...

    journal_title:Thrombosis research

    pub_type: 杂志文章

    doi:10.1016/j.thromres.2014.09.020

    authors: Franchi F,Biguzzi E,Stufano F,Siboni SM,Baronciani L,Peyvandi F

    更新日期:2014-12-01 00:00:00

  • Procoagulant cellular activity (PCA) in the classification of acute leukemia.

    abstract::The procoagulant cellular activity (PCA) of leukemic cells was evaluated, before and after endotoxin stimulation, in 38 patients with acute leukemia at presentation subdivided according to the FAB classification. In the M4 and M5 subgroups the stimulated leukemic cells showed a significant increase in the production o...

    journal_title:Thrombosis research

    pub_type: 杂志文章

    doi:10.1016/0049-3848(87)90317-3

    authors: Guarini A,Gugliotta L,Catani L,Chetti L,Macchi S,Tura S

    更新日期:1987-03-01 00:00:00

  • Treatment of haemophilia patients in East Germany prior to and after reunification in 1990.

    abstract::The reunification of Germany in 1990 brought with it major challenges in terms of unifying the care offered to haemophilia patients. At that time, most of the treatment centres belonged to the largest regional hospitals. The centre for paediatric haemophilia patients in Leipzig was at the University Hospital. In this ...

    journal_title:Thrombosis research

    pub_type: 历史文章,杂志文章,评审

    doi:10.1016/j.thromres.2013.10.018

    authors: Lenk H

    更新日期:2014-11-01 00:00:00

  • Impaired platelet binding of fibrinogen due to a lower number of GPIIB/IIIA receptors in polycythemia vera.

    abstract::We have previously described a stimulus-specific defect in platelet aggregation in polycythaemia vera (PV) after stimulation with surface receptor dependent agonists such as platelet activating factor (PAF). In contrast, responses to phorbol myristate acetate (PMA) were normal. We now report that after PAF stimulation...

    journal_title:Thrombosis research

    pub_type: 杂志文章

    doi:10.1016/s0049-3848(98)00096-6

    authors: Le Blanc K,Lindahl T,Rosendahl K,Samuelsson J

    更新日期:1998-09-15 00:00:00

  • Thrombosis in hematological malignancies: mechanisms and implications.

    abstract::A B S T R A C T Thrombotic events are a major cause of morbidity and mortality in cancer. While the association of venous thromboembolic events with cancer is well documented, in recent years arterial events (i.e. acute myocardial infarction and ischemic strokes) have also emerged as relatively common complications am...

    journal_title:Thrombosis research

    pub_type: 杂志文章

    doi:10.1016/S0049-3848(20)30398-4

    authors: Horowitz NA,Brenner B

    更新日期:2020-07-01 00:00:00

  • Markers of endothelial dysfunction differ between subphenotypes in children with sickle cell disease.

    abstract::In adult patients with sickle cell disease two distinct subphenotypes have previously been defined: patients with the viscosity-vaso-occlusion subphenotype (VVO) suffer mainly from vaso-occlusive pain crises and have a relatively high hemoglobin concentration. Patients classified as the hemolysis-endothelial dysfuncti...

    journal_title:Thrombosis research

    pub_type: 杂志文章

    doi:10.1016/j.thromres.2013.10.006

    authors: van der Land V,Peters M,Biemond BJ,Heijboer H,Harteveld CL,Fijnvandraat K

    更新日期:2013-01-01 00:00:00

  • A randomized management study of impedance plethysmography vs. contrast venography in patients with a first episode of clinically suspected deep vein thrombosis.

    abstract:OBJECTIVES:In this randomized management study, we examined the safety of withholding anticoagulation on the basis of negative impedance plethysmography (IPG) compared to negative contrast venography (CV) in symptomatic patients with a first episode of clinically suspected deep vein thrombosis (DVT), and we determined ...

    journal_title:Thrombosis research

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0049-3848(01)00222-5

    authors: Kahn SR,Joseph L,Grover SA,Leclerc JR

    更新日期:2001-04-01 00:00:00

  • Preoperative direct oral anticoagulants treatment and all-cause mortality in elderly patients with hip fracture: A retrospective cohort study.

    abstract:INTRODUCTION:Hip fracture is common among the elderly and is associated with increased morbidity and mortality, particularly when surgery is delayed. Direct oral anticoagulants (DOACs) use might increase bleeding and postpone hip repair surgery. We aimed to assess the association between preoperative DOACs use and adve...

    journal_title:Thrombosis research

    pub_type: 杂志文章

    doi:10.1016/j.thromres.2020.03.002

    authors: Saliba W,Arbel A,Abu-Full Z,Cohen S,Rennert G,Preis M

    更新日期:2020-05-01 00:00:00

  • Management of heparin-induced thrombocytopenia: a critical comparison of lepirudin and argatroban.

    abstract::Heparin-induced thrombocytopenia (HIT) is a transient hypercoagulability state initiated, paradoxically, by the anticoagulant, heparin. It is characterized by antibody-induced activation of platelets, leading to thrombin generation. Many patients with HIT develop thrombosis; even when heparin is stopped because of "is...

    journal_title:Thrombosis research

    pub_type: 杂志文章,评审

    doi:10.1016/s0049-3848(03)00336-0

    authors: Warkentin TE

    更新日期:2003-05-01 00:00:00