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Microparticles in vascular disorders: how tissue factor-exposing vesicles contribute to pathology and physiology.

Abstract：

:Coagulation is initiated by tissue factor (TF). Coagulant TF is constitutively expressed by extravascular cells, but there is increasing evidence that TF can also be present within the blood, in particular during pathological conditions. Such TF is exposed on circulating cell-derived vesicles, and its presence has been associated with development of disseminated intravascular coagulation and venous thrombosis. For example, the presence of TF-exposing vesicles in the blood of cancer patients may be associated with their high risk of developing venous thromboembolism. Remarkably, high levels of coagulant TF-exposing vesicles are present in other body fluids such as saliva and urine of healthy persons, suggesting that these vesicles play a physiological role. We postulate that the presence of TF-exposing vesicles in body fluids as saliva and urine provides an additional source of coagulant TF that promotes coagulation, thereby reducing blood loss and contributing to host defence by reducing the risk of microorganisms entering the "milieu intérieur".

journal_name

Thromb Res

journal_title

Thrombosis research

authors

Kleinjan A,Böing AN,Sturk A,Nieuwland R

doi

10.1016/j.thromres.2012.08.281

subject

Has Abstract

pub_date

2012-10-01 00:00:00

pages

S71-3

eissn

0049-3848

issn

1879-2472

pii

S0049-3848(12)00653-6

journal_volume

130 Suppl 1

pub_type

杂志文章,评审

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