当前位置： SCI文献检索 > THROMBOSIS RESEARCH期刊下所有文献 > Association between insurance status, anticoagulation quality, and clinical outcomes in patients with acute venous thromboembolism.

Association between insurance status, anticoagulation quality, and clinical outcomes in patients with acute venous thromboembolism.

Abstract：

INTRODUCTION:A higher level of health insurance coverage may be related to better quality of care and outcomes. Whether insurance status is associated with anticoagulation quality and clinical outcomes in patients with venous thromboembolism (VTE) is unknown. METHODS:We studied 819 elderly patients treated with vitamin K antagonists for VTE in a Swiss prospective multicenter cohort (09/2009-12/2013). The study outcomes were the anticoagulation quality, defined as the time spent in the therapeutic INR range, and clinical events, i.e. the time to a first VTE recurrence, major bleeding, and mortality. We assessed the association between insurance status (private vs. general), anticoagulation quality, and clinical outcomes using regression models, adjusting for potential confounders. RESULTS:Although the unadjusted mean percentage of time spent in the therapeutic INR range (2.0-3.0) was slightly higher in patients with private vs. general insurance (65% vs. 61%; p = 0.030), the adjusted difference was not statistically significant (1.53%, 95% CI -1.97 to 5.04). Patients with private insurance had a lower 36-month cumulative incidence of major bleeding (9.7% vs. 15.7%; p = 0.018). After adjustment, privately insured patients had a lower risk of major bleeding compared to patients with general insurance (sub-hazard ratio 0.57, 95% CI 0.32 to 0.98). Insurance status was not associated with recurrent VTE or mortality. CONCLUSION:Privately insured patients spent somewhat more time in therapeutic INR range and had a lower rate of major bleeding than generally insured patients. Basic (general) health insurance may be a marker of lower anticoagulation quality and higher risk of major bleeding.

journal_name

Thromb Res

journal_title

Thrombosis research

authors

Zumbrunn B,Stalder O,Méan M,Limacher A,Tritschler T,Rodondi N,Aujesky D

doi

10.1016/j.thromres.2018.11.011

subject

Has Abstract

pub_date

2019-01-01 00:00:00

pages

124-130

eissn

0049-3848

issn

1879-2472

pii

S0049-3848(18)30604-2

journal_volume

173

pub_type

杂志文章,多中心研究

相关文献

THROMBOSIS RESEARCH文献大全
  • Next-generation DNA sequencing to identify novel genetic risk factors for cerebral vein thrombosis.

    abstract：BACKGROUND:Cerebral vein thrombosis (CVT) is a rare, life-threatening disease affecting one adult per 100,000 per year. Genetic risk factors are deficiencies of the natural anticoagulant proteins antithrombin, protein C, protein S or single nucleotide polymorphisms such as factor V Leiden and prothrombin 20210A. In 20%...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2018.06.011

    authors： Gorski MM,de Haan HG,Mancini I,Lotta LA,Bucciarelli P,Passamonti SM,Cairo A,Pappalardo E,van Hylckama Vlieg A,Martinelli I,Rosendaal FR,Peyvandi F

    更新日期：2018-09-01 00:00:00

  • Prevalence of factor V Leiden, FII G20210A, FXIII Val34Leu and MTHFR C677T polymorphisms in cancer patients with and without venous thrombosis.

    abstract：:Venous thromboembolism (VTE) is a common complication in patients with malignant disease. In addition to well-established acquired risk factors for VTE, several genetic risk factors, mainly related to the haemostatic system, are known to influence thrombotic risk. However, the contribution of gene abnormalities to thr...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/s0049-3848(03)00179-8

    authors： Ramacciotti E,Wolosker N,Puech-Leao P,Zeratti EA,Gusson PR,del Giglio A,Franco RF

    更新日期：2003-02-15 00:00:00

  • Fibrinolysis as a feature of disseminated intravascular coagulation (DIC) after Pseudonaja textilis textilis envenomation.

    abstract：:Blood was obtained from four patients envenomated by the Australian common brown snake, Pseudonaja textilis textilis. This elapid snake has one of the most toxic venoms in the world, containing extremely potent neurotoxic and coagulant components. The latter is a potent complete prothrombinase, converting prothrombin ...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(90)90399-w

    authors： Masci PP,Rowe EA,Whitaker AN,de Jersey J

    更新日期：1990-09-01 00:00:00

  • Premature arterial and venous events in three families. Effect of folate levels and MTHFR mutation mediated by family/generation and homocysteine levels.

    abstract：:Plasma homocysteine levels result from the effect of genetic and environmental factors. We investigated the hypothesis of familial association between folates, methylenetetrahydrofolate reductase (MTHFR) and hyperhomocysteinemia with acute events, studying three families through pedigree analysis and log-linear graphi...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/s0049-3848(01)00408-x

    authors： Assanelli D,Grassi M,Bonanome A,Salvadori G,Bonetti P,Boldini A,Archetti S,Ruggeri G,Pezzini A,Pagnan A

    更新日期：2002-01-15 00:00:00

  • Purification and some properties of a protein obtained from normal human plasma which inhibits the platelet aggregation induced by thrombotic thrombocytopenic purpura plasma.

    abstract：:Plasma from patients with thrombotic thrombocytopenic purpura (TTP) caused the aggregation of washed human platelets, which was inhibited by preincubation with normal plasma. Using salt fractionation, ion exchange chromatography, and preparative agarose gel electrophoresis, we purified a protein from normal plasma whi...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(84)90155-5

    authors： Lian EC,Mui PT,Siddiqui FA,Chiu LL

    更新日期：1984-01-01 00:00:00

  • Soluble fibrinogen derivatives generated by thrombin: affinity for elastin.

    abstract：:When human citrated plasma is dialysed against a phosphate buffer containing Ca++, citrate anions are removed, thrombin is generated and soluble fibrinogen derivatives (fibrin monomers and/or soluble fibrin polymers) are formed. These derivatives are able to combine with human or bovine elastin to form a very stable a...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(86)90061-7

    authors： Rabaud M,Lefebvre F,Piquet Y,Belloc F,Chevaleyre J,Roudaut MF,Bricaud H

    更新日期：1986-07-15 00:00:00

  • The activation of plasminogen by T-PA-PAI-1 complex in the absence of fibrin.

    abstract：:The activity of tissue plasminogen activator-plasminogen activator inhibitor-1 (t-PA-PAI-1) complex to convert plasminogen to plasmin was examined by using fibrin autography and casein zymography where plasminogen was added or removed for casein layer. Fibrin autography was more sensitive to the activity of t-PA even ...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(91)90279-6

    authors： Takada Y,Takada A

    更新日期：1991-07-01 00:00:00

  • Prognostic role of heart-type fatty acid binding protein in pulmonary embolism: a meta-analysis.

    abstract：INTRODUCTION:Pulmonary embolism (PE) has a high morbidity and mortality. Hence it is important to recognize factors associated with higher risk of adverse outcomes in hemodynamically stable patients. Heart-type fatty acid binding protein (H-FABP) is a novel marker evaluated in recent years for prognosis in acute PE. Ou...

    journal_title：Thrombosis research

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.thromres.2014.10.007

    authors： Liu M,Yuan X,Qiu X,Shan X,Lin D,Zhu L

    更新日期：2015-01-01 00:00:00

  • A microarray study on the effect of four hormone therapy regimens on gene transcription in whole blood from healthy postmenopausal women.

    abstract：BACKGROUND:Postmenopausal hormone therapy is associated with many diseases and conditions, e.g., cardiovascular diseases and asthma, but the underlying molecular mechanisms are incompletely understood. The aim of the current study was to investigate the effect of four different postmenopausal hormone therapy regimens o...

    journal_title：Thrombosis research

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.thromres.2011.12.009

    authors： Dahm AE,Eilertsen AL,Goeman J,Olstad OK,Ovstebø R,Kierulf P,Mowinckel MC,Skretting G,Sandset PM

    更新日期：2012-07-01 00:00:00

  • Elevated levels of platelet microparticles in carotid atherosclerosis and during the postprandial state.

    abstract：BACKGROUND:Platelet microparticles (PMPs) possess proatherogenic and procoagulant properties which may play a role in atherogenesis and subsequent thromboembolic complications. The present study was conducted to investigate the possible relationship between carotid atherosclerosis and plasma concentrations of PMPs, and...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2008.10.016

    authors： Michelsen AE,Notø AT,Brodin E,Mathiesen EB,Brosstad F,Hansen JB

    更新日期：2009-04-01 00:00:00

  • Quantification of kininogens in plasma. A functional method based on the cysteine proteinase inhibitor activity.

    abstract：:We have previously reported on a microassay based on human kininogens as cysteine proteinase inhibitors (CPIs), which could quantify partially purified kininogens from different biological fluids (J Pharmacol Meth 26, 113-124, 1991). In the present study we describe a functional method that, when assuming a 1:1 stoich...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(96)00073-4

    authors： Karlsrud TS,Buø L,Aasen AO,Johansen HT

    更新日期：1996-05-01 00:00:00

  • The C677T polymorphism of the methylenetetrahydrofolate reductase gene is associated with the level of decrease on diastolic blood pressure in essential hypertension patients treated by angiotensin-converting enzyme inhibitor.

    abstract：OBJECTIVES:Elevated plasma homocysteine has been implicated as a risk factor for hypertension. C677T polymorphism in methylenetetrahydrofolate reductase gene (MTHFR) is a major determinant of hyperhomocysteinemia, which results in endothelial dysfunction. Angiotensin-converting enzyme (ACE) inhibitors appear to remedy ...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2004.04.005

    authors： Jiang S,Hsu YH,Xu X,Xing H,Chen C,Niu T,Zhang Y,Peng S,Xu X

    更新日期：2004-01-01 00:00:00

  • Mechanisms of vascular graft thrombosis: role of altered canine platelet sensitivity to thromboxane.

    abstract：:Using the standard turbidimetric method of platelet aggregation and quantitation of platelet secretion with 14C-Serotonin, we have examined the responsiveness of the platelets of mongrel dogs to arachidonic acid (AA), and the thromboxane agonist U46619 in the presence and absence of a subthreshold concentration of epi...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(89)90300-9

    authors： McGoff MA,Allen BT,Der T,Sicard GA,Santoro SA

    更新日期：1989-09-15 00:00:00

  • The vascular plasminogen activator as source of the fibrinolytic potential observed during cardiopulmonary bypass.

    abstract：:Increased fibrinolytic activity is a well recognized constant finding observed during cardiopulmonary bypass (CPB). The purpose of the present work was to study and estimate the factors involved in the plasminogen activation and prekallikrein-kallikrein systems in a population of adult patients undergoing open heart s...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(92)90018-6

    authors： Baños G,de la Peña A,Izaguirre R

    更新日期：1992-09-01 00:00:00

  • Adhesion between neutrophils and platelets: a modulator of thrombotic and inflammatory events?

    abstract：:Recent studies have demonstrated that neutrophilic granulocytes and platelets have the capability to interact with each other. Either type of cell may release soluble factors, which either activate the other or increase its response to separate stimulating agents. Direct contact between the two types of cell generally...

    journal_title：Thrombosis research

    pub_type： 杂志文章,评审

    doi：10.1016/s0049-3848(10)80002-7

    authors： Nash GB

    更新日期：1994-01-01 00:00:00

  • Thrombogenetic studies of bioprosthetic heart valve surfaces. I. In vitro platelet adhesion in a static system.

    abstract：:Contact angle measurements, histological examinations and platelet adhesion tests on native and glutaraldehyde-treated porcine aortic valve leaflets, are reported. Contact angles measured with water or saline on native and treated leaflets do not differ appreciably. Values of less than 10 degrees for both the dry and ...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(85)90058-1

    authors： Hum OS,Ghista DN,Brash JL

    更新日期：1985-04-15 00:00:00

  • The anti-thrombotic effect of hydrogen sulfide is partly mediated by an upregulation of nitric oxide synthases.

    abstract：INTRODUCTION:Hydrogen sulfide (H2S) known as a gasotransmitter is increasingly recognized for its anti-adhesive, anti-inflammatory and vasoactive properties. Due to these properties, we analysed anti-thrombotic effects of H2S and the participation of the nitric oxide synthase (NOS)-pathway. MATERIALS AND METHODS:In in...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2013.07.010

    authors： Kram L,Grambow E,Mueller-Graf F,Sorg H,Vollmar B

    更新日期：2013-08-01 00:00:00

  • Anticoagulant and antithrombotic actions of a semisynthetic beta-1,3-glucan sulfate.

    abstract：:Sulfation of the natural polysaccharide curdlan results in anticoagulantly active beta-1,3-glucan sulfates whose activity depends on various structural parameters. In this study the anticoagulant and antithrombotic effects of one of these beta-1,3-glucan sulfates (GS) were compared with those of a porcine mucosal hepa...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(95)00049-w

    authors： Alban S,Jeske W,Welzel D,Franz G,Fareed J

    更新日期：1995-05-01 00:00:00

  • The use of aspirin for primary and secondary prevention in venous thromboembolism and other cardiovascular disorders.

    abstract：:Cardiovascular disease (CVD) includes a number of conditions such as myocardial infarction, coronary heart disease, stroke, and venous thromboembolism. CVD is a leading health problem worldwide and a major cause of mortality, morbidity, and disability; it is also associated with high healthcare costs. The incidence of...

    journal_title：Thrombosis research

    pub_type： 杂志文章,评审

    doi：10.1016/j.thromres.2014.11.036

    authors： Cohen AT,Imfeld S,Markham J,Granziera S

    更新日期：2015-02-01 00:00:00

  • Increased expression of thrombomodulin on the cultured human umbilical vein endothelial cells and mouse hemangioma cells by cyclic AMP.

    abstract：:We previously reported that the expression of thrombomodulin on the MEG-01, a cell line from human megakaryoblastic leukemia, was increased by agents that increase intracellular cAMP. In this paper we examine the effect of these agents on cultured human umbilical vein endothelial cells (HUVEC) and mouse hemangioma cel...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(91)90107-8

    authors： Maruyama I,Soejima Y,Osame M,Ito T,Ogawa K,Yamamoto S,Dittman WA,Saito H

    更新日期：1991-02-01 00:00:00

  • Effects of desmopressin and dextran on coagulation and fibrinolysis in healthy volunteers.

    abstract：:The effects of desmopressin and dextran on haemostasis and fibrinolysis were studied in four healthy volunteers. Both drugs were compared to placebo, each volunteer being subject to four experiments. Dextran 70 (30 g i.v.) moderately decreased VIII:C and vWF:Ag and slightly increased antithrombin III, also when haemod...

    journal_title：Thrombosis research

    pub_type： 临床试验,杂志文章

    doi：10.1016/0049-3848(91)90009-l

    authors： Flordal PA,Svensson J,Ljungström KG

    更新日期：1991-06-01 00:00:00

  • Iloprost and tissue-type plasminogen activator differentially affect platelet aggregation in platelet-rich plasma and in whole blood.

    abstract：:Platelet aggregation in platelet-rich plasma (PRP) is more sensitive to agonists and more resistant to antagonists than that in whole blood. In this study, we show that the presence of neutrophils in whole blood accounts at least in part for diminished platelet aggregation in whole blood. The platelet-inhibitory effec...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(90)90216-y

    authors： Nicolini FA,Mehta JL

    更新日期：1990-12-01 00:00:00

  • Factors affecting the first recurrence of noncardioembolic ischemic stroke.

    abstract：:Studies of the factors affecting the first recurrence of ischemic stroke have reported inconsistent findings. Types of initial stroke and the racial differences in study samples are among the explanations that may account for this inconsistency. The aims of this study were to estimate the cumulative recurrence rates o...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/s0049-3848(99)00146-2

    authors： Wu TH,Chen HH,Lee TK

    更新日期：2000-02-01 00:00:00

  • Platelet-leukocyte interactions in thrombosis.

    abstract：:Activated platelets may adhere to leukocytes and form circulating mixed aggregates. The latter are considered a reliable marker of a prothrombotic state and are associated with several cardiovascular conditions. The molecular mechanisms responsible of this cellular interaction include a central role of platelet P-sele...

    journal_title：Thrombosis research

    pub_type： 杂志文章,评审

    doi：10.1016/j.thromres.2011.10.010

    authors： Cerletti C,Tamburrelli C,Izzi B,Gianfagna F,de Gaetano G

    更新日期：2012-03-01 00:00:00

  • Combined occurrence of a heterozygous missense mutation in the protein C gene and allelic exclusion of one protein S allele leading to severe venous thrombosis.

    abstract：:Individuals with more than one defect in the natural anticoagulant system exhibit an increased risk for thrombosis. We report on a family with two cases of combined protein C (PROC) and protein S (PROS) deficiency, five cases of isolated PROC deficiency Type I, and two cases of isolated PROS deficiency Type I. PROC an...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/s0049-3848(01)00232-8

    authors： Knoll B,Hach-Wunderle V,Rieger S,Häring D,Mannhalter C

    更新日期：2001-07-01 00:00:00

  • From laboratory to clinical practice: Dabigatran effects on thrombin generation and coagulation in patient samples.

    abstract：INTRODUCTION:Dabigatran (Dabi) is not routinely monitored. However, in emergency cases quantitative assessment is required and laboratories must provide suitable tests at all hours. Little is known about Dabi effects on thrombin generation. MATERIALS AND METHODS:Patient samples (n=241) were analyzed for functional Dab...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2015.04.032

    authors： Helin TA,Lemponen M,Hjemdahl P,Rönquist-Nii Y,Lassila R,Joutsi-Korhonen L

    更新日期：2015-07-01 00:00:00

  • Proteolysis of bovine and human prothrombin and of bovine factor X by rat mast cell proteinase.

    abstract：:The alpha-chymotrypsin-like proteinase from rat peritoneal mast cells (RMCP I) rapidly destroyed the normal clotting activity of purified, calcium-free, bovine prothrombin, human prothrombin and bovine factor X and simultaneously removed similar N-terminal peptides (Mr approximately 5,000) from both prothrombin and th...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(86)90007-1

    authors： Wylie AR,Lonsdale-Eccles JD,Blumsom NL,Elmore DT

    更新日期：1986-11-01 00:00:00

  • Activation of human prothrombin by the venom of Lonomia achelous (Cramer) caterpillars.

    abstract：:In this paper, we demonstrated that the procoagulant action of Lonomia achelous (Cramer) is due in part to a component that activates prothrombin. The activation by crude venom and Fractions obtained by gel filtration on Sephadex G-75 is not dependent of phospholipid, Ca++ or Factor V. The activation of prothrombin by...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(92)90187-f

    authors： Guerrero B,Arocha-Piñango CL

    更新日期：1992-05-01 00:00:00

  • Platelets as immune mediators: their role in host defense responses and sepsis.

    abstract：:Platelets occupy a central role at the interface between thrombosis and inflammation. At sites of vascular damage, adherent platelets physically and functionally interact with circulating leukocytes. Activated platelets release soluble factors into circulation that may have local and systemic effects on blood and vasc...

    journal_title：Thrombosis research

    pub_type： 杂志文章,评审

    doi：10.1016/j.thromres.2010.10.010

    authors： Li Z,Yang F,Dunn S,Gross AK,Smyth SS

    更新日期：2011-03-01 00:00:00

  • Fever as a risk factor for increased response to vitamin K antagonists: a review of the evidence and potential mechanisms.

    abstract：:Numerous factors affect the response to vitamin K antagonists (VKA) including age, dietary vitamin K, other drugs, pharmacogenetics, and disease states. In antithrombotic guidelines, fever is mentioned as a factor that may increase response to VKA. The purpose of this article is to review the available evidence regard...

    journal_title：Thrombosis research

    pub_type： 杂志文章,评审

    doi：10.1016/j.thromres.2014.10.015

    authors： Self TH,Oliphant CS,Reaves AB,Richardson AM,Sands CW

    更新日期：2015-01-01 00:00:00