当前位置： SCI文献检索 > THROMBOSIS RESEARCH期刊下所有文献 > PO-62 - Remote ischemic preconditioning in head and neck cancer reconstruction - a randomized controlled trial.

PO-62 - Remote ischemic preconditioning in head and neck cancer reconstruction - a randomized controlled trial.

Abstract：

INTRODUCTION:In reconstructive head and neck cancer surgery, tissue flaps are transferred to the surgical defect and revascularized by anastomosis of small vessels. Cancer patients are in a hypercoagulable state with high risk of peri- and postoperative thrombotic events. Thrombosis to the tissue flap anastomoses or microcirculation is the main reason for total flap necrosis with potential fatal consequences for the patient. Remote ischemic preconditioning (RIPC), where brief cycles of upper extremity ischemia are induced with an inflatable tourniquet, triggers a global protection of tissues subjected to ischemia-reperfusion injury. RIPC has also been shown to impact the coagulation system. AIM:The aim of the trial is to investigate, if RIPC attenuates platelet aggregation during reconstructive head and neck cancer surgery. MATERIALS AND METHODS:Sixty patients with head and neck cancer will be included in the trial. The subjects will be randomized to RIPC or sham during surgery. RIPC is administered by four 5-minute cycles of upper extremity ischemia, each separated by five minutes of reperfusion. Blood samples will be drawn preoperatively, before RIPC/sham, 3 hours after RIPC/ sham, 6 hours after RIPC/sham, and on the first postoperative day. Platelet aggregation will be measured with the Multiplate® analyzer using collagen, ADP and TRAP as agonists. Furthermore, platelet count, mean platelet volume, immature platelet fraction, and von Willebrand factor antigen are determined. RESULTS:The trial is ongoing. Preliminary results will be presented at ICTHIC 2016. CONCLUSIONS:If RIPC proves to attenuate platelet aggregation, it could become a novel antithrombotic treatment in oncologic reconstructive surgery. Hence, morbidity and mortality related to surgery is reduced, and adjuvant oncologic therapy can be initiated in timely fashion.

journal_name

Thromb Res

journal_title

Thrombosis research

authors

Krag AE,Kiil BJ,Hvas CL,Eschen GT,Hvas AM

doi

10.1016/S0049-3848(16)30195-5

subject

Has Abstract

pub_date

2016-04-01 00:00:00

pages

S199

eissn

0049-3848

issn

1879-2472

pii

S0049-3848(16)30195-5

journal_volume

140 Suppl 1

pub_type

杂志文章

相关文献

THROMBOSIS RESEARCH文献大全
  • Effects of tranexamic acid and local fibrin deposition of fibrinolysis and granulation tissue formation in preformed cavities.

    abstract：:The effects of locally deposited fibrin and of tranexamic acid-induced antifibrinolysis on forming granulation tissue were studied in the light of a recently developed method for treatment of postoperative fistulas by occlusion with a fibrin clot. Perforated teflon cylinders, either empty or fibrin-filled, were implan...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(84)90152-x

    authors： Hedelin H,Teger-Nilsson AC,Peterson HI,Pettersson S

    更新日期：1984-01-01 00:00:00

  • A pilot study of eptifibatide for treatment of acute pain episodes in sickle cell disease.

    abstract：INTRODUCTION:The contribution of platelet activation to the pathogenesis of sickle cell disease (SCD) remains uncertain. We evaluated the safety and efficacy of eptifibatide, a synthetic peptide inhibitor of the αIIbβ3 receptor, in SCD patients during acute painful episodes. MATERIALS AND METHODS:In this single site, ...

    journal_title：Thrombosis research

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.thromres.2013.08.002

    authors： Desai PC,Brittain JE,Jones SK,McDonald A,Wilson DR,Dominik R,Key NS,Parise LV,Ataga KI

    更新日期：2013-09-01 00:00:00

  • Fibrinogen does not protect von Willebrand factor against proteolysis by human cathepsin G.

    abstract：:The susceptibility of von Willebrand factor /vWF/ to digestion by human neutrophil cathepsin G in highly purified FVIII/vWF concentrate /BHS/ and in cryoprecipitate has been studied. In contrast to human neutrophil elastase, cathepsin G inactivates and degrades vWF not only in BHS but also in cryoprecipitate. Fibrinog...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(91)90657-i

    authors： Jeleńska M,Kopeć M,Sopata I,Vigh Z,Scharrer I,Breddin K

    更新日期：1991-02-15 00:00:00

  • High levels of endothelial and platelet microvesicles in patients with type 1 diabetes irrespective of microvascular complications.

    abstract：INTRODUCTION:Patients with type 1 diabetes have high risk of developing microvascular complications, and microangiopathy contributes to premature cardiovascular disease in this population. The role that microvesicles (MVs) may play in the development of microangiopathy in type 1 diabetes remains unclear. MATERIALS AND...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2020.08.012

    authors： Bergen K,Mobarrez F,Jörneskog G,Wallén H,Tehrani S

    更新日期：2020-12-01 00:00:00

  • Solubilized ketanserin binding sites from pig platelet membranes.

    abstract：:Plasma membranes of pig platelets were isolated and subjected to solubilization with digitonin. Binding of [3H]ketanserin to the solubilized membrane fraction, optimal at pH 7.5, was time and protein dependent and was greatly reduced by increasing ionic strength of the incubation buffer. Saturation analysis and inhibi...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(85)90253-1

    authors： Wesemann W,Hoffmann D

    更新日期：1985-09-15 00:00:00

  • A retrospective cohort study of venous thromboembolism(VTE) in 1035 Japanese myeloma patients treated with thalidomide; lower incidence without statistically significant association between specific risk factors and development of VTE and effects of throm

    abstract：BACKGROUND:Rate of thalidomide-related VTE and risk factors in Japanese myeloma patients are not clear and effects of thromboprophylaxis remain controvertial. PATIENTS AND METHODS:We retrospectively analyzed a cohort data of registered Japanese myeloma patients treated with thalidomide-based regimens between 2009 and ...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2012.11.014

    authors： Kato A,Takano H,Ichikawa A,Koshino M,Igarashi A,Hattori K,Nagata K

    更新日期：2013-02-01 00:00:00

  • Inhibitory effect of fibronectin on the fibrin formation.

    abstract：:125I-fibronectin is incorporated into fibrin when blood plasma is clotted with thrombin. This process is dependent upon fibronectin concentration, temperature, and the presence of calcium ions. Fibronectin appears to be a very strong inhibitor of fibrin formation and influences both the thrombin clotting time and fibr...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(82)90308-5

    authors： Niewiarowska J,Cierniewski CS

    更新日期：1982-09-01 00:00:00

  • Postpartum blood transfusion and hemorrhage as independent risk factors for venous thromboembolism.

    abstract：INTRODUCTION:Profuse postpartum hemorrhage (PPH) and red blood cell (RBC) transfusion have been suggested to be associated with venous thromboembolic events (VTE). However, it is not fully clear if they are independent major risk factors. METHODS:Women who gave birth in the Stockholm area between 1999 and 2002 were th...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2018.03.002

    authors： Thurn L,Wikman A,Lindqvist PG

    更新日期：2018-05-01 00:00:00

  • Functional characterization of a novel missense mutation, His147Arg, in A1 domain of FV protein causing type II deficiency.

    abstract：INTRODUCTION:Congenital factor V (FV) deficiency is a rare inherited disorder. Three compound heterozygous missense mutations, Asp68His, His147Arg, and Arg2074Cys, were observed in a Taiwanese patient with moderately severe FV deficiency. METHOD:The novel His147Arg mutation in the A1 domain was investigated by protein...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2014.04.005

    authors： Liu HC,Lin TM,Eng HL,Lin YT,Shen MC

    更新日期：2014-07-01 00:00:00

  • Assembly of the prothrombinase complex on the surface of human foreskin fibroblasts: Implications for connective tissue growth factor.

    abstract：:Activated factor X (FXa) and thrombin can up-regulate gene expression of connective tissue growth factor (CTGF/CCN2) on fibroblasts. Since tissue factor (TF) is expressed on these cells, we hypothesized that they may assemble the prothrombinase complex leading to CTGF/CCN2 upregulation. In addition, the effect of thro...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2011.08.009

    authors： Rico MC,Rough JJ,Manns JM,Del Carpio-Cano F,Safadi FF,Kunapuli SP,DeLa Cadena RA

    更新日期：2012-06-01 00:00:00

  • Evidence for serotonin binding in vitro by platelet factor 4 and beta-thromboglobulin.

    abstract：:Evidence is presented for in vitro high affinity binding of serotonin (5-HT) by beta-thromboglobulin (beta TG) and platelet factor 4 (PF4) from human blood. Results include: 1) identification by radioimmunoassay of PF4 in specifically bound material obtained by 5-HT affinity chromatography of human platelet extracts; ...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(83)90044-0

    authors： Heemstra VL

    更新日期：1983-02-01 00:00:00

  • Blood clotting factor IX Nagoya 3: the molecular defect of zymogen activation caused by an arginine-145 to histidine substitution.

    abstract：:Factor IX Nagoya 3 (IX Nagoya 3) is a natural mutant of factor IX recognized in a patient with moderately severe hemophilia B. The patient had 0.60 units/ml of factor IX antigen and 2-5% of clotting activity. IX Nagoya 3 was purified from the patient's plasma by immunoaffinity chromatography with an anti-factor IX mon...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(90)90109-p

    authors： Suehiro K,Miyata T,Takeya H,Takamatsu J,Saito H,Murakawa M,Okamura T,Niho Y,Iwanaga S

    更新日期：1990-11-15 00:00:00

  • Characterization of antithrombin levels in pregnancy.

    abstract：OBJECTIVE:To characterize antithrombin (AT) levels in normal pregnancy. METHODS:We performed secondary analyses with data from 3 studies. Using a single measurement from each subject in the first analysis (cross-sectional), we correlated AT levels with gestational age from the middle of the second trimester throughout...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2014.07.025

    authors： James AH,Rhee E,Thames B,Philipp CS

    更新日期：2014-09-01 00:00:00

  • Effects of increased sulfation of dermatan sulfate on its in vitro and in vivo pharmacological properties.

    abstract：:The in vitro and in vivo pharmacological properties of two oversulfated dermatan sulfate (DS) derivatives, S-DS1 and S-DS2, containing 2 and 3.7 sulfate groups/disaccharide unit respectively were compared to those of the parent DS (1 sulfate group/disaccharide unit). In a purified system the ability of S-DS1 and of S-...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(88)90094-1

    authors： Dol F,Caranobe C,Dupouy D,Petitou M,Lormeau JC,Choay J,Sié P,Boneu B

    更新日期：1988-10-15 00:00:00

  • Gastrointestinal bleeding in von Willebrand disease.

    abstract：:Gastrointestinal bleeding due to colonic angiodysplasia is a well-recognised complication of von Willebrand disease (vWD), occurring almost exclusively in subtypes of the disease associated with a reduction in high-molecular-weight (HMW) multimers of von Willebrand factor (vWF). A deficiency of vWF HMW multimers also ...

    journal_title：Thrombosis research

    pub_type： 杂志文章,评审

    doi：10.1016/j.thromres.2006.01.022

    authors： Makris M

    更新日期：2006-01-01 00:00:00

  • To screen or not to screen for chronic thromboembolic pulmonary hypertension after acute pulmonary embolism.

    abstract：:Chronic thromboembolic pulmonary hypertension (CTEPH) is the most severe long term complication of acute pulmonary embolism (PE). Untreated, CTEPH is associated with a very poor prognosis and high risk of mortality, although curation can be achieved by surgical removal of the obstructive endothelialised thromboemboli ...

    journal_title：Thrombosis research

    pub_type： 杂志文章,评审

    doi：10.1016/j.thromres.2016.12.026

    authors： Ende-Verhaar YM,Huisman MV,Klok FA

    更新日期：2017-03-01 00:00:00

  • The skin bleeding time test as a predictor of brain bleeding time in a rat model.

    abstract：:Previous studies have indicated that the skin bleeding time test does not accurately reflect visceral bleeding time (BT). The present study examines the predictive value of the skin bleeding time for brain bleeding tendency. Sixteen Sprague-Dawley rats were divided into equal groups. The first group (controls) underwe...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(94)90282-8

    authors： MacDonald JD,Remington BJ,Rodgers GM

    更新日期：1994-12-15 00:00:00

  • From laboratory to clinical practice: Dabigatran effects on thrombin generation and coagulation in patient samples.

    abstract：INTRODUCTION:Dabigatran (Dabi) is not routinely monitored. However, in emergency cases quantitative assessment is required and laboratories must provide suitable tests at all hours. Little is known about Dabi effects on thrombin generation. MATERIALS AND METHODS:Patient samples (n=241) were analyzed for functional Dab...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2015.04.032

    authors： Helin TA,Lemponen M,Hjemdahl P,Rönquist-Nii Y,Lassila R,Joutsi-Korhonen L

    更新日期：2015-07-01 00:00:00

  • Quantification of kininogens in plasma. A functional method based on the cysteine proteinase inhibitor activity.

    abstract：:We have previously reported on a microassay based on human kininogens as cysteine proteinase inhibitors (CPIs), which could quantify partially purified kininogens from different biological fluids (J Pharmacol Meth 26, 113-124, 1991). In the present study we describe a functional method that, when assuming a 1:1 stoich...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(96)00073-4

    authors： Karlsrud TS,Buø L,Aasen AO,Johansen HT

    更新日期：1996-05-01 00:00:00

  • Evidence that heparin but not hirudin reduces PAI-1 expression in cultured human endothelial cells.

    abstract：:Heparin and other antithrombotic drugs besides their anticoagulant action could have a profibrinolytic effect. We have analyzed the effect of unfractionated heparin (UFH) and hirudin on PAI-1 gene expression in human umbilical vein endothelial cells (HUVEC). Cells were stimulated with UFH (1 and 10 IU/ml) and hirudin ...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/s0049-3848(98)00203-5

    authors： Orbe J,Montes R,Zabalegui N,Pérez-Ruiz A,Páramo JA

    更新日期：1999-05-01 00:00:00

  • Inhibition of thiol isomerase activity diminishes endothelial activation of plasminogen, but not of protein C.

    abstract：INTRODUCTION:Cell surface thiol isomerase enzymes, principally protein disulphide isomerase (PDI), have emerged as important regulators of platelet function and tissue factor activation via their action on allosteric disulphide bonds. Allosteric disulphides are present in other haemostasis-related proteins, and we have...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2015.01.034

    authors： Smith CL,Shah CM,Kamaludin N,Gordge MP

    更新日期：2015-04-01 00:00:00

  • Genetic and molecular evidence for complement dysregulation in patients with HELLP syndrome.

    abstract：BACKGROUND:HELLP (Hemolysis, elevated liver enzymes and low platelets) syndrome is a severe and acute pregnancy-related disorder that occurs in approximately 2.5 per 1000 deliveries and represents a major cause of maternal and perinatal morbidity and mortality. This syndrome has been suggested to be a microangiopathy a...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2020.08.038

    authors： Bazzan M,Todros T,Tedeschi S,Ardissino G,Cardaropoli S,Stella S,Montaruli B,Marchese C,Roccatello D,Cugno M

    更新日期：2020-12-01 00:00:00

  • Augmentation of 1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphocholine (PAF)-induced human platelet activation by C-reactive protein.

    abstract：:Activation of human platelets by PAF was augmented by C-reactive protein, an acute phase plasma protein. The concentration of PAF required for irreversible activation (secondary aggregation of platelet and release of serotonin) was decreased to 1/10 in the presence of C-reactive protein (CRP). The presence of CRP stim...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(86)90361-0

    authors： Kohayakawa M,Inoue K

    更新日期：1986-03-01 00:00:00

  • An ultrastructural study of Porphyromonas gingivalis-induced platelet aggregation.

    abstract：:One of the major pathogens of periodontitis, Porphyromonas gingivalis (P. gingivalis), has the ability to aggregate human platelets. To investigate the interaction between P. gingivalis and human platelets in platelet rich plasma (PRP), platelet aggregation was measured by an aggregometer based on laser light scatteri...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2008.03.011

    authors： Li X,Iwai T,Nakamura H,Inoue Y,Chen Y,Umeda M,Suzuki H

    更新日期：2008-01-01 00:00:00

  • Identification of the 1.4 kb and 4.0 kb messages for the lipoprotein associated coagulation inhibitor and expression of the encoded protein.

    abstract：:Lipoprotein-Associated Coagulation Inhibitor (LACI) is a factor Xa dependent inhibitor of the factor VII(a)/Tissue Factor catalytic complex. Deduced from partial cDNA sequence, LACI's amino acid sequence has recently been reported. Northern blot analysis showed LACI cDNA hybridizes to RNAs of 1.4 and 4.0 kb in size. T...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(89)90454-4

    authors： Girard TJ,Warren LA,Novotny WF,Bejcek BE,Miletich JP,Broze GJ Jr

    更新日期：1989-07-01 00:00:00

  • Assessment of rotation thromboelastometry (ROTEM) parameters in patients with multiple myeloma at diagnosis.

    abstract：INTRODUCTION:Patients with multiple myeloma (MM) have an increased risk of thromboembolic events (TEE). Due to the complex nature of the prothrombotic state in MM, no single laboratory test has been designed to identify patients with the highest risk of developing TEE. Hence, this study is intended to assess the feasib...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2014.01.011

    authors： Treliński J,Misiewicz M,Robak M,Smolewski P,Chojnowski K

    更新日期：2014-04-01 00:00:00

  • Usefulness of high-concentration calcium chloride solution for correction of activated partial thromboplastin time (APTT) in patients with high-hematocrit value.

    abstract：INTRODUCTION:Pseudoprolongation of activated partial thromboplastin time (APTT) is a serious problem in anticoagulation therapy for patients with high hematocrit, such as cyanotic congenital heart diseases. APTT pseudoprolongation occurs when APTT assay is performed using routinely used vacuum sampling tubes containing...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2007.08.004

    authors： Kanahara M,Kai H,Okamura T,Wada T,Suda K,Imaizumi T,Sagawa K

    更新日期：2008-01-01 00:00:00

  • Congenital afibrinogenemia: Identification and characterization of two novel homozygous fibrinogen Aα and Bβ chain mutations in two Tunisian families.

    abstract：INTRODUCTION:Inherited abnormalities of fibrinogen (FG) are rare coagulation disorders divided into two types: quantitative abnormalities (afibrinogenemia and hypofibrinogenemia) or qualitative abnormalities (dysfibrinogenemia and hypo-dysfibrinogenemia) of circulating fibrinogen. In particular, congenital afibrinogene...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2016.04.016

    authors： Amri Y,Toumi Nel H,Hadj Fredj S,de Moerloose P

    更新日期：2016-07-01 00:00:00

  • Coagulation and fibrinolytic system impairment in insulin dependent diabetes mellitus.

    abstract：:Selected coagulation and fibrinolytic parameters were assessed in 40 insulin dependent diabetes mellitus patients with varying degrees of metabolic control; 30 healthy subjects matched for age and sex formed the control group. Activated Partial Thromboplastin Time, Prothrombin Time, Fibrinogen, Factor VII, Antithrombi...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(92)90068-l

    authors： Carmassi F,Morale M,Puccetti R,De Negri F,Monzani F,Navalesi R,Mariani G

    更新日期：1992-09-15 00:00:00

  • Low endogenous thrombin potential in trained subjects.

    abstract：INTRODUCTION:A paradox seems to exist: exercising leads to clotting activation in conventional clotting tests, but exercising persons have a low risk of thrombosis. In this study we tried to evaluate the effect of exercise performance status on in vitro plasma thrombin generation, which represents an overall function t...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2013.04.009

    authors： Cimenti C,Schlagenhauf A,Leschnik B,Schretter M,Tschakert G,Gröschl W,Seibert FJ,Hofmann P,Muntean WE

    更新日期：2013-06-01 00:00:00