当前位置： SCI文献检索 > THROMBOSIS RESEARCH期刊下所有文献 > Certoparin versus UFH to prevent venous thromboembolic events in the very elderly patient: an analysis of the CERTIFY study.

Certoparin versus UFH to prevent venous thromboembolic events in the very elderly patient: an analysis of the CERTIFY study.

Abstract：

INTRODUCTION:There is an exponential rise of thromboembolic risk with age because of co-morbidities, immobility and pharmacotherapy. We aimed to investigate the benefits and risks of heparin prophylaxis in very elderly patients ≥80 years and the type of heparin used in a subgroup analysis of the CERTIFY trial. PATIENTS/METHODS:3,239 patients were randomized to 3,000 U aXa o.d. certoparin or 5,000 IU t.i.d. unfractionated heparin (UFH) for 8-20 days. RESULTS:Patients ≥80 years (n=1,365) were more likely to be female, had a lower mean bodyweight, were more frequently using antiplatelets and had a GFR below 30 ml/min/1.73 m(2) more often than patients <80 years (n=1,875). The combined endpoint of proximal DVT, symptomatic non-fatal PE and VTE related death was experience by 5.26% of patients ≥80 years versus 3.51% in younger patients (OR 1.53; 95%CI 1.05-2.21; p=0.03). There were no significant differences in both minor (OR 1.11; 95%CI 0.75-1.62) and major (OR 2.53; 95%CI 0.93-6.86) bleeding risks. Certoparin and UFH were equally effective in reducing thromboembolic risk in either age group. The risk of any (OR 0.45; 95%CI 0.26-0.79) and minor bleeding (OR 0.42; 95%CI 0.23-0.78) was reduced with certoparin in the very elderly only. There were more adverse events in elderly patients (OR 1.26; 95%CI 1.1-1.46), but rates were otherwise comparable. CONCLUSIONS:The analysis confirmed the increased thromboembolic risk in very elderly patients, but demonstrated no increased bleeding risk. Certoparin and UFH were equally effective and safe with a reduced risk of minor bleeding complications with certoparin in the very elderly.

journal_name

Thromb Res

journal_title

Thrombosis research

authors

Schellong SM,Gerlach HE,Tebbe U,Haas S,Melzer N,Abletshauser C,Sieder C,Bramlage P,Riess H,Bauersachs R

doi

10.1016/j.thromres.2011.05.002

subject

Has Abstract

pub_date

2011-11-01 00:00:00

pages

417-21

issue

5

eissn

0049-3848

issn

1879-2472

pii

S0049-3848(11)00227-1

journal_volume

128

pub_type

杂志文章,随机对照试验

相关文献

THROMBOSIS RESEARCH文献大全
  • Efficacy and safety of the use of heparin as thromboprophylaxis in patients with liver cirrhosis: a systematic review and meta-analysis.

    abstract：INTRODUCTION:Venous thromboembolism is a common cause of morbidity and mortality. Although cirrhosis has classically been considered as an acquired bleeding diathesis, there is increasing evidence that rejects the traditional belief that these patients are naturally protected against venous thromboembolism. However, an...

    journal_title：Thrombosis research

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.thromres.2013.08.001

    authors： Gómez Cuervo C,Bisbal Pardo O,Pérez-Jacoiste Asín MA

    更新日期：2013-10-01 00:00:00

  • Antigenic properties of fibrinogen component of Hemaseel HMN subjected to the antiviral severe dry heat treatment.

    abstract：:The experiments in this work were focused on determination of the extent to which fibrinogen component of fibrin glue (Hemaseel HMN, Haemacure Biotech.) retained the conformation of the parent molecule after dry heat antiviral treatment (one hour at 100 degrees C). For this purpose antigenic structure of the fibrinoge...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(96)00084-9

    authors： Cierniewski CS,Pluskota E,Cieslak M,Brodniewicz T,Nowotarski M

    更新日期：1996-05-15 00:00:00

  • Effect of NaC1 on inactivation of bovine thrombin by antithrombin III in the presence of low affinity-heparin or dextran sulfate.

    abstract：:Heparin with low affinity (LA-heparin) to antithrombin III (AT III) enhanced the rate of inactivation of thrombin by AT III. The enhancement of the rate was saturable with AT III and was proportional to the LA-heparin concentration. Although the rate-enhancement in the presence of LA-heparin decreased with increase in...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(86)90247-1

    authors： Oshima G,Nagasawa K

    更新日期：1986-02-01 00:00:00

  • Antithrombotic effects of aspirin based on PLA1/A2 glycoprotein IIIa polymorphism in patients with coronary artery disease.

    abstract：OBJECTIVE:The diallelic glycoprotein IIIa polymorphism P1A1/A2 was attributed to be an inherited risk factor for coronary events. Whether this polymorphism affects response to aspirin in patients with coronary artery disease is not known. METHODS:We assessed thrombin generation (prothrombin fragment F1+2) in consecuti...

    journal_title：Thrombosis research

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.thromres.2006.03.005

    authors： Dropinski J,Musial J,Sanak M,Wegrzyn W,Nizankowski R,Szczeklik A

    更新日期：2007-01-01 00:00:00

  • Clinical relevance of pulmonary infarction in patients with pulmonary embolism.

    abstract：INTRODUCTION:Data regarding the clinical relevance of pulmonary infarction (PI) in patients with pulmonary embolism (PE) are lacking. The aim of this study was to investigate the clinical features of PE patients with PI and the prognostic role of PI for PE patients. MATERIALS AND METHODS:Based on computed tomography s...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2012.03.012

    authors： Cha SI,Shin KM,Lee J,Hwangbo Y,Yoo SS,Lee J,Lee SY,Kim CH,Park JY,Jung TH

    更新日期：2012-09-01 00:00:00

  • Pharmacokinetics of Defibrotide and of its profibrinolytic activity in the rabbit.

    abstract：:An extensive study of the pharmacokinetics and the pharmacokinetics of the profibrinolytic activity of Defibrotide (D) in the rabbit has been made. a two compartment model was used to describe D's pharmacokinetics. The parameters of drug disposition and the rate constant of release from tissues to central compartment ...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(83)90391-2

    authors： Pescador R,Mantovani M,Prino G,Madonna M

    更新日期：1983-04-01 00:00:00

  • Expression and characterization of recombinant protein S with the Ser 460 Pro mutation.

    abstract：:To characterize the putative biochemical modifications induced by the Ser 460 to Pro (Heerlen) mutation in protein S (PS), we expressed both wild-type (wt) and mutated recombinant PS in HEK cells. In SDS-polyacrylamide gels, r-PS Heerlen migrated at 71 kDa whereas r-wt PS migrated at 73 kDa, a difference abolished aft...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/s0049-3848(00)00296-6

    authors： Morboeuf O,Borgel D,Aiach M,Kaabache T,Gandrille S,Gaussem P

    更新日期：2000-10-01 00:00:00

  • Substitution of antithrombin III in shock and DIC: a randomized study.

    abstract：:In 51 shock patients with DIC Antithrombin III (AT III) substitution, heparin or a combination of both substances respectively was administered. In the two groups which had been given AT III substitution the concentration of AT III rose considerably higher than the activity. There was a drop of the platelet count in b...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(85)90123-9

    authors： Blauhut B,Kramar H,Vinazzer H,Bergmann H

    更新日期：1985-07-01 00:00:00

  • Prothrombin complex concentrate (Beriplex P/N) for control of bleeding after kidney trauma in a rabbit dilutional coagulopathy model.

    abstract：INTRODUCTION:Fluid resuscitation after trauma often results in dilutional coagulopathy that may hinder control of bleeding and, once initial hemostasis has been secured, heighten risk of perioperative bleeding when further surgery is required. Since multiple coagulation factor deficiencies typically accompany fluid res...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2009.10.011

    authors： Pragst I,Kaspereit F,Dörr B,Dickneite G

    更新日期：2010-03-01 00:00:00

  • Preparation and characterization of anionic oligopeptide-modified tissue plasminogen activator for triggered delivery: an approach for localized thrombolysis.

    abstract：PURPOSE:The study sought to synthesize anionic peptide-conjugated tissue plasminogen activator (tPA) for its targeted/triggered delivery, where tPA's activity would be masked in the circulation and regenerated at the thrombus site by a commonly used anticoagulant, heparin, to minimize tPA associated bleeding complicati...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2012.11.030

    authors： Absar S,Choi S,Ahsan F,Cobos E,Yang VC,Kwon YM

    更新日期：2013-03-01 00:00:00

  • The concomitant augmentation of urokinase-type plasminogen activator and collagenase-like proteinase activities in X-ray irradiated cells of a human metastatic carcinomatous line.

    abstract：:The enzymatic activities of uPA, and a collagenase-like proteinase in the post-nuclear fraction of cell homogenates of a metastatic carcinomatous cell line following X-ray irradiation were examined by the use of chromogenic substrates and by casein- or gelatin-containing zymographies and electrophoretic gel stained wi...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(94)90214-3

    authors： Uchida N,Takahashi K,Kasai T,Ishida T,Kwaan HC

    更新日期：1994-06-15 00:00:00

  • Intratumoral tissue factor expression and risk of venous thromboembolism in brain tumor patients.

    abstract：BACKGROUND:Brain tumor patients have an increased risk of venous thromboembolism (VTE). An important role in cancer-related VTE has been suggested for tissue factor (TF), the main initiator of the coagulation cascade. We conducted a prospective cohort study to determine whether expression levels of TF in brain tumors a...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2012.09.020

    authors： Thaler J,Preusser M,Ay C,Kaider A,Marosi C,Zielinski C,Pabinger I,Hainfellner JA

    更新日期：2013-02-01 00:00:00

  • Kupffer cell regulation of fibrinogen synthesis in hepatocytes.

    abstract：:Isolated rat liver macrophages (Kupffer cells) produce a factor(s) which stimulates fibrinogen synthesis 5-8 fold in hepatocyte cultures. The production of the stimulatory factor reached maximum during the first 24 hours the cells were in culture. When the cell culture medium was chromatographed on a calibrated Sephad...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(83)90025-7

    authors： Sanders KD,Fuller GM

    更新日期：1983-10-15 00:00:00

  • The C677T polymorphism of the methylenetetrahydrofolate reductase gene is associated with the level of decrease on diastolic blood pressure in essential hypertension patients treated by angiotensin-converting enzyme inhibitor.

    abstract：OBJECTIVES:Elevated plasma homocysteine has been implicated as a risk factor for hypertension. C677T polymorphism in methylenetetrahydrofolate reductase gene (MTHFR) is a major determinant of hyperhomocysteinemia, which results in endothelial dysfunction. Angiotensin-converting enzyme (ACE) inhibitors appear to remedy ...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2004.04.005

    authors： Jiang S,Hsu YH,Xu X,Xing H,Chen C,Niu T,Zhang Y,Peng S,Xu X

    更新日期：2004-01-01 00:00:00

  • Elevated levels of Factor XI are associated with cardiovascular disease in women.

    abstract：:Coronary artery disease (CAD) continues to be the most frequent cause of death among women in the United States. Although elevated levels of clotting factors have been associated with CAD, few of these studies have been performed in women. Elevated levels of Factor XI have previously been associated with venous thromb...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/s0049-3848(02)00190-1

    authors： Berliner JI,Rybicki AC,Kaplan RC,Monrad ES,Freeman R,Billett HH

    更新日期：2002-07-15 00:00:00

  • Impaired platelet binding of fibrinogen due to a lower number of GPIIB/IIIA receptors in polycythemia vera.

    abstract：:We have previously described a stimulus-specific defect in platelet aggregation in polycythaemia vera (PV) after stimulation with surface receptor dependent agonists such as platelet activating factor (PAF). In contrast, responses to phorbol myristate acetate (PMA) were normal. We now report that after PAF stimulation...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/s0049-3848(98)00096-6

    authors： Le Blanc K,Lindahl T,Rosendahl K,Samuelsson J

    更新日期：1998-09-15 00:00:00

  • The effect of delayed analysis or freeze-thawing on the measurement of natural anticoagulants, resistance to activated protein C and markers of activation of the haemostatic system.

    abstract：:We provide a centralised thrombophilia screening service with sample transfer by courier or first class mail, a practice common to many centres. Sample quality is of prime importance, thus we have assessed the effect of delayed sample handling upon the haemostatic variables within our thrombophilia profile. This compr...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/s0049-3848(97)00187-4

    authors： Luddington R,Peters J,Baker P,Baglin T

    更新日期：1997-09-15 00:00:00

  • Determinants of left atrial thrombus or spontaneous echo contrast in nonvalvular atrial fibrillation.

    abstract：BACKGROUND:The CHADS2 and CHA2DS2-VASc scores are well-established clinical scales to estimate the risk of stroke in patients with atrial fibrillation (AF). However, the predictive power of the two scales concerning left atrial thrombus (LAT) or spontaneous echo contrast (SEC) has not been well investigated. Therefore,...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2020.07.055

    authors： Han D,Chu Y,Wu Y,Wang X

    更新日期：2020-11-01 00:00:00

  • The influencing factors for clopidogrel-mediated platelet inhibition are assay-dependent.

    abstract：BACKGROUND:Influencing factors for clopidogrel-mediated platelet inhibition have only been evaluated by one or two different test systems in the same population so far. Since previous studies revealed poor correlations between the various platelet function tests, the identification of influencing variables for clopidog...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2011.05.008

    authors： Gremmel T,Steiner S,Seidinger D,Koppensteiner R,Panzer S,Kopp CW

    更新日期：2011-10-01 00:00:00

  • Prolonged low-molecular-weight heparin use during pregnancy and subsequent bone mineral density.

    abstract：INTRODUCTION:In contrast to unfractionated heparin (UFH), use of low-molecular weight heparin (LMWH) during pregnancy has not been reported to be associated with a significant decrease in bone mineral density (BMD). The aim of this study was to investigate whether long-term use of LMWH during pregnancy is associated wi...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2016.05.016

    authors： Galambosi P,Hiilesmaa V,Ulander VM,Laitinen L,Tiitinen A,Kaaja R

    更新日期：2016-07-01 00:00:00

  • AGEs and methylglyoxal induce apoptosis and expression of Mac-1 on neutrophils resulting in platelet-neutrophil aggregation.

    abstract：INTRODUCTION:Diabetes mellitus is characterised by hyperglycaemia that plays an important role in the pathogenesis of diabetic complications including accumulation of methylglyoxal (MG), a highly reactive alpha-dicarbonyl metabolite of glucose degradation pathways and increased generation of advanced glycation end prod...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2007.03.002

    authors： Gawlowski T,Stratmann B,Stirban AO,Negrean M,Tschoepe D

    更新日期：2007-01-01 00:00:00

  • Anemia in patients with acute coronary syndromes treated with prasugrel or ticagrelor: Insights from the RENAMI registry.

    abstract：INTRODUCTION:Ticagrelor and prasugrel are recommended as first line therapy in patients with acute coronary syndromes (ACS). However, patients with anemia are commonly treated with clopidogrel in routine clinical practice. The RENAMI registry (REgistry of New Antiplatelet therapy in patients with acute Myocardial Infar...

    journal_title：Thrombosis research

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.thromres.2018.05.024

    authors： Guerrero C,Garay A,Ariza-Solé A,Formiga F,Raposeiras-Roubín S,Abu-Assi E,D'Ascenzo F,Kinnaird T,Manzano-Fernández S,Alegre O,Sánchez-Salado JC,Lorente V,Templin C,Velicki L,Xanthopoulou I,Cerrato E,Rognoni A,Boccuzzi G

    更新日期：2018-07-01 00:00:00

  • Excessive expressions of T cell activation markers in pediatric immune thrombocytopenia.

    abstract：BACKGROUND:Immune thrombocytopenia (ITP) is an immune-mediated bleeding disorder in children. Activated T cells have been shown to play important roles in ITP. The aims of this study were to evaluate whether these T cell activation markers could be used as indicators to differentiate ITP patients from controls, and to ...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2019.05.010

    authors： Chen Y,Zhou Y,Chen P,Zhang P,Jia M,Tang Y

    更新日期：2019-08-01 00:00:00

  • A new variant of von Willebrand disease (type II I) with a normal degree of proteolytic cleavage of von Willebrand factor.

    abstract：:A variant of type II von Willebrand disease (vWd) is described in a young woman and her mother with severe lifelong bleeding histories. On electrophoresis with low-resolution agarose gels the plasma of the proband lacked large and intermediate-size multimers of von Willebrand factor (vWF) but the platelet multimeric s...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(92)90165-7

    authors： Castaman G,Rodeghiero F,Lattuada A,Mannucci PM

    更新日期：1992-02-01 00:00:00

  • Plasma and platelet skimming at T-junctions.

    abstract：:Separation of plasma, erythrocytes, and platelets was studied in T-shaped bifurcations prepared by a casting technique. The diameters of the side and main channel were 100 microns and 200 microns, respectively. Small blood samples (about 20 microliters) were collected from the side channel for determination of erythro...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(87)90314-8

    authors： Perkkiö J,Wurzinger LJ,Schmid-Schönbein H

    更新日期：1987-03-01 00:00:00

  • Effects of BM 13.177, a new antiplatelet drug in patients with atherosclerotic disease.

    abstract：:Seven males with atherosclerotic disease received daily 1.6 g of the thromboxane antagonist BM 13.177 in two separate oral dosages over a period of four days. The drug significantly reduced elevated plasma levels of thromboxane B2, beta-thromboglobulin and platelet factor 4, whereas thromboxane B2 generation was only ...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(84)90229-9

    authors： Riess H,Hiller E,Reinhardt B,Bräuning C

    更新日期：1984-08-15 00:00:00

  • Heparin cofactor II significance for the inhibition of thrombin at the injured vessel wall.

    abstract：:The thrombin inhibitory role of antithrombin III (ATIII) and heparin cofactor II (HCII) was studied in vitro using intact and injured rabbit aortae. When intact vessels were loaded with thrombin and then exposed to either heat defibrinogenated human plasma (HDHP) or ATIII the same degree of thrombin inhibition was ach...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(91)90014-n

    authors： Pasche B,Swedenborg J,Frebelius S,Olsson P

    更新日期：1991-06-01 00:00:00

  • Clinical evaluation of a pasteurized factor XIII concentrate administration in Henoch-Schönlein purpura. Japanese Pediatric Group.

    abstract：:Arthral, abdominal and renal symptoms in Henoch-Schönlein purpura (HSP) were scored. Coagulation factor XIII (F XIII) activity was determined in fifty-six children with HSP and the correlation with the severity score of the clinical symptoms was investigated. As a result, it was found that the decrease in F XIII level...

    journal_title：Thrombosis research

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1016/0049-3848(89)90284-3

    authors： Fukui H,Kamitsuji H,Nagao T,Yamada K,Akatsuka J,Inagaki M,Shike S,Kobayashi Y,Yoshioka K,Maki S

    更新日期：1989-12-15 00:00:00

  • Platelet procoagulant activity induced in vivo by muromonab-CD3 infusion in uremic patients.

    abstract：BACKGROUND:Muromonab-CD3 is a murine monoclonal antibody (MoAb) that is used in the prophylaxis and treatment of acute graft rejection. Activation of coagulation and fibrinolysis following anti-CD3 administration have been reported in some patients to lead to irreversible intragraft thrombosis. DESIGN AND METHODS:We h...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/s0049-3848(01)00396-6

    authors： Lozano M,Oppenheimer F,Cofan F,Rosinyol L,Mazzara R,Escolar G,Ordinas A

    更新日期：2001-12-15 00:00:00

  • Effect of aspirin and clopidogrel on platelet-dependent tissue factor expression in endothelial cells.

    abstract：:Tissue factor is an ubiquitous membrane-anchored glycoprotein that initiates blood coagulation by forming a complex with circulating factors VII and VIIa. Under normal circumstances, endothelial cells do not express tissue factor but, in some pathological situations, when the endothelium or the monocytes are exposed t...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(94)90086-8

    authors： Savi P,Bernat A,Dumas A,Aït-Chek L,Herbert JM

    更新日期：1994-01-15 00:00:00