Antithrombotic effects of aspirin based on PLA1/A2 glycoprotein IIIa polymorphism in patients with coronary artery disease.

abstract：INTRODUCTION:Maximal exercise may be a trigger for cardiovascular events. The aim of the study was to investigate changes in blood coagulation and fibrinolysis following maximal short-term exercises with different durations up to 90 s. METHODS:A total of 15 healthy nonsmokers underwent three isokinetic maximal tests o...

journal_title：Thrombosis research

authors： Hilberg T,Prasa D,Stürzebecher J,Gläser D,Schneider K,Gabriel HH

更新日期：2003-03-15 00:00:00

abstract：:In spite of numerous studies on the involvement of fibrinogen in transendothelial migration of leukocytes and thereby inflammation, there is still no clear understanding of which fibrin(ogen) species can stimulate leukocyte transmigration. Although we have previously proposed that interaction of fibrin with the VLDL r...

journal_title：Thrombosis research

authors： Yakovlev S,Medved L

更新日期：2018-02-01 00:00:00

abstract：:The candidate-gene approach can be used to locate and identify genetic variations that are associated with a particular phenotype. This gene-centric approach assumes that there exists important genetic variation within genes that can influence health. Identifying known genes which are candidates for the phenotype of i...

journal_title：Thrombosis research

authors： Smith NL,Rice KM,Lumley T,Heckbert SR,Psaty BM

更新日期：2009-01-01 00:00:00

abstract：OBJECTIVE:To investigate the mechanism underlying the hypercoagulable state in severe pre-eclampsia. METHODS:Plasma tissue factor (TF) and tissue factor pathway inhibitor (TFPI) expression from pre-eclampsia patients and healthy pregnant controls were determined by ELISA. Placental TF and TFPI gene and protein express...

journal_title：Thrombosis research

authors： Teng Y,Jiang R,Lin Q,Ding C,Ye Z

更新日期：2010-07-01 00:00:00

abstract：:Using the standard turbidimetric method of platelet aggregation and quantitation of platelet secretion with 14C-Serotonin, we have examined the responsiveness of the platelets of mongrel dogs to arachidonic acid (AA), and the thromboxane agonist U46619 in the presence and absence of a subthreshold concentration of epi...

journal_title：Thrombosis research

authors： McGoff MA,Allen BT,Der T,Sicard GA,Santoro SA

更新日期：1989-09-15 00:00:00

abstract：:A B S T R A C T Thrombotic events are a major cause of morbidity and mortality in cancer. While the association of venous thromboembolic events with cancer is well documented, in recent years arterial events (i.e. acute myocardial infarction and ischemic strokes) have also emerged as relatively common complications am...

journal_title：Thrombosis research

authors： Horowitz NA,Brenner B

更新日期：2020-07-01 00:00:00

abstract：:The aim was to describe the phlebographic pattern of asymptomatic and symptomatic deep vein thrombosis (DVT) after total hip replacement by the use of a scoring system in 102 consecutive patients (54 asymptomatic, 48 symptomatic). The DVTs were scored from 1 to 3, and registered in a scoring system dividing the deep v...

journal_title：Thrombosis research

authors： Björgell O,Nilsson PE,Benoni G,Bergqvist D

更新日期：2000-09-01 00:00:00

abstract：:Lipoprotein(a) [Lp(a)] has been demonstrated to be an independent risk factor for coronary heart disease. However, the precise mechanism by which it contributes to the development of atherosclerosis remains unclear. P-selectin is one of the major adhesion molecules to mediate the interaction between monocytes, platele...

journal_title：Thrombosis research

authors： Zhao SP,Xu DY

更新日期：2000-12-15 00:00:00

abstract：:In rabbits, a clear microscopic image of individual, fluorescent blood platelets flowing in a mesenteric microvessel could be obtained over the whole cross-sectional area of the vessel, following an intravenous injection of a solution containing 5-15 mg of the fluorochrome Acridine Red. Most of the circulating platele...

journal_title：Thrombosis research

authors： Tangelder GJ,Slaaf DW,Reneman RS

更新日期：1982-12-15 00:00:00

abstract：AIM:Postprandial platelet activation was related to postprandial insulin rather than glucose levels in a previous meal insulin study in type 2 diabetes mellitus (T2DM). We therefore compared postprandial platelet activation in type 1 (T1DM) patients without insulin secretion and T2DM patients with high postprandial ins...

journal_title：Thrombosis research

authors： Spectre G,Stålesen R,Östenson CG,Hjemdahl P

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND:Ambient particulate matter (PM) is associated with cardiovascular morbidity and mortality. It has been proposed that PM induces a pro-thrombotic process, increasing the risk of cardiovascular events, with some support from epidemiological and laboratory-based models. Diesel exhaust is a major contributor to ...

journal_title：Thrombosis research

authors： Carlsten C,Kaufman JD,Peretz A,Trenga CA,Sheppard L,Sullivan JH

更新日期：2007-01-01 00:00:00

abstract：INTRODUCTION:Tissue Factor Pathway Inhibitor-2 (TFPI-2) is a Kunitz-type serine proteinase inhibitor whose expression is up-regulated by VEGF in microvascular and umbilical vein endothelial cells (EC). Despite this, TFPI-2 has been suggested as anti-angiogenic molecule, due to its ability to inhibit the migration/proli...

journal_title：Thrombosis research

authors： Ghilardi C,Anastasia A,Avigni R,Lupi M,Giavazzi R,Bani MR

更新日期：2016-04-01 00:00:00

abstract：:The potency for the inhibition of 5-hydroxytryptamine (5-HT)-induced human platelet aggregation by ketanserin, pipamperone, spiperone, cyproheptadine and BW 501 in vitro decreased as the reaction pH increased progressively from 7.4 to 8.6, the largest shift (X 1125) in IC50 value (pH 7.4: 4 X 10(-9) M; pH 8.6: 4.5 X 1...

journal_title：Thrombosis research

authors： De Clerck F,Xhonneux B,Tollenaere JP,Janssen PA

更新日期：1985-12-01 00:00:00

abstract：INTRODUCTION:Venous thromboembolism (VTE) occurs frequently in at-risk hospitalized patients, and prophylaxis of VTE is significantly underused. We sought to preliminarily assess the validity of Caprini risk assessment model, a famous individual VTE risk assessment model, in Chinese hospitalized patients with VTE. MAT...

journal_title：Thrombosis research

authors： Zhou HX,Peng LQ,Yan Y,Yi Q,Tang YJ,Shen YC,Feng YL,Wen FQ

更新日期：2012-11-01 00:00:00

abstract：:Ten studies of the effect of cryoprecipitate infusion in four patients with von Willebrand's Disease (vWD) are reported. The doses studied (4, 8 and in one case 10 bags of cryoprecipitate) were based on previous reports of correction of the bleeding time (BT) with such doses. A modest shortening of the BT was observed...

journal_title：Thrombosis research

authors： Smiley RK,Tittley P,Rock G

更新日期：1989-03-01 00:00:00

abstract：INTRODUCTION:In reconstructive head and neck cancer surgery, tissue flaps are transferred to the surgical defect and revascularized by anastomosis of small vessels. Cancer patients are in a hypercoagulable state with high risk of peri- and postoperative thrombotic events. Thrombosis to the tissue flap anastomoses or mi...

journal_title：Thrombosis research

authors： Krag AE,Kiil BJ,Hvas CL,Eschen GT,Hvas AM

更新日期：2016-04-01 00:00:00

abstract：INTRODUCTION:Pre-eclampsia is an important cause of maternal morbidity and mortality. Its etiology is still unknown. Clinical symptoms correlate with activation of coagulation and inherited thrombophilia has been associated with pre-eclampsia. ABO blood group has been associated with thrombotic disorders and pre-eclamp...

journal_title：Thrombosis research

authors： Hiltunen LM,Laivuori H,Rautanen A,Kaaja R,Kere J,Krusius T,Paunio M,Rasi V

更新日期：2009-06-01 00:00:00

abstract：:This study evaluates the role of neutrophil granulocytes in mediating acute phase stimulation of fibrinogen synthesis. Turpentine was administered to neutropenic and non-neutropenic rats and fibrinogen synthetic rates measured in an isolated liver perfusion system. Using the (14C) carbonate technique for the measureme...

journal_title：Thrombosis research

authors： Kernoff L,Colman J

更新日期：1982-10-01 00:00:00

abstract：:The thrombin inhibitory role of antithrombin III (ATIII) and heparin cofactor II (HCII) was studied in vitro using intact and injured rabbit aortae. When intact vessels were loaded with thrombin and then exposed to either heat defibrinogenated human plasma (HDHP) or ATIII the same degree of thrombin inhibition was ach...

journal_title：Thrombosis research

authors： Pasche B,Swedenborg J,Frebelius S,Olsson P

更新日期：1991-06-01 00:00:00

abstract：:The immunogenic potential of natural and recombinant hirudin was investigated using baboons. Animals received 4 intravenous hirudin injections of 1,000 antithrombin units/kg at certain times (day 1, 3, 8 and 42) and were checked for an immune response. None of the tests performed (in vitro histamine-release, ELISA for...

journal_title：Thrombosis research

authors： Bichler J,Gemmerli R,Fritz H

更新日期：1991-01-01 00:00:00

abstract：:It has previously been observed that aspirin diminishes the increase in blood fibrinolytic activity during arm venous occlusion. We studied the duration of this inhibitory effect on fibrinolytic response during 20 minutes arm venous occlusion and its effect on fibrinolytic response during acute physical activity (stan...

journal_title：Thrombosis research

authors： Keber I,Jereb M,Keber D

更新日期：1987-04-15 00:00:00

abstract：:The effect of the combined oral administration of pentoxifylline (pof) and low dose acetylsalicylic acid (ASA) was evaluated with the help of the laser-induced thrombosis in rat mesenteric arterioles. Laser-induced thrombosis is inhibited in a dose-dependent way by both drugs. The administration of ASA, either simulta...

journal_title：Thrombosis research

authors： Seiffge D,Weithmann KU

更新日期：1987-04-15 00:00:00

abstract：:Isolated rat liver macrophages (Kupffer cells) produce a factor(s) which stimulates fibrinogen synthesis 5-8 fold in hepatocyte cultures. The production of the stimulatory factor reached maximum during the first 24 hours the cells were in culture. When the cell culture medium was chromatographed on a calibrated Sephad...

journal_title：Thrombosis research

authors： Sanders KD,Fuller GM

更新日期：1983-10-15 00:00:00

abstract：INTRODUCTION:Profuse postpartum hemorrhage (PPH) and red blood cell (RBC) transfusion have been suggested to be associated with venous thromboembolic events (VTE). However, it is not fully clear if they are independent major risk factors. METHODS:Women who gave birth in the Stockholm area between 1999 and 2002 were th...

journal_title：Thrombosis research

authors： Thurn L,Wikman A,Lindqvist PG

更新日期：2018-05-01 00:00:00

abstract：:Adenosine is an endogenous antiaggregating substance that influences the platelet responses through specific A-type receptors that activate adenylate cyclase increasing the levels of 3',5'-cyclic adenosine monophosphate (cAMP). In this study, we investigated whether adenosine can also influence the levels of 3',5'-cyc...

journal_title：Thrombosis research

authors： Anfossi G,Russo I,Massucco P,Mattiello L,Cavalot F,Balbo A,Trovati M

更新日期：2002-01-01 00:00:00

abstract：:Prothrombin fragments (F1+2), thrombin-antithrombin complexes (TAT) and D-dimers, markers of hemostatic system activation, were measured in 59 consecutive patients with deep vein thrombosis (DVT). Patients were randomly treated either with subcutaneous unfractionated heparin (UH) administered in two to three subcutane...

journal_title：Thrombosis research

authors： Peternel P,Terbizan M,Tratar G,Bozic M,Horvat D,Salobir B,Stegnar M

更新日期：2002-02-01 00:00:00

abstract：:Severe rejection crises occurred in 13 out of 20 cadaver kidney recipients; removal of the graft was inevitable in 10 cases. The plasminogen levels were found to be lower (76.5 +/- 2.9%) in the 13 patients with impaired graft acceptance (group B) than in the 7 patients experiencing only moderate rejection (group A, 93...

journal_title：Thrombosis research

authors： Seitz R,Michalik R,Karges HE,Lange H,Egbring R

更新日期：1986-05-01 00:00:00

abstract：:The antithrombotic effect of aspirin (ASA) and dipyridamole (DIP) was evaluated in rabbits in which platelet thromboxane A2 (TXA2) and arterial prostacyclin (PGI2) were measured. An intracarotid cannula thrombosis model previously shown to be sensitive to antiplatelet agents was used. Prostaglandins were determined by...

journal_title：Thrombosis research

authors： Louie S,Gurewich V

更新日期：1983-05-15 00:00:00

abstract：:Full-length Tissue Factor (flTF) - the obligatory co-factor for the serine protease (factor) VII/VIIa - serves as the initiator of blood coagulation. The flTF/VIIa complex triggers a sequence of proteolytic events that lead to the formation of a hemostatic plug. Aside from hemostatic maintenance, flTF can contribute t...

journal_title：Thrombosis research

authors： Srinivasan R,Bogdanov VY

更新日期：2012-05-01 00:00:00

abstract：:Fibrin film is prepared by compaction in one dimension of a fibrin clot (pH 6.3, ionic strength 0.15, fibrin concentration about 0.5%) by expulsion of fluid to reach a fibrin concentration of about 15%. Strips of film, equilibrated in the same buffer with very slowly increasing temperature, shrink in length in a narro...

journal_title：Thrombosis research

authors： Nakatani AI,Ferry JD

更新日期：1988-12-01 00:00:00