Human platelet aggregation is not altered by Shiga toxins 1 or 2.

abstract：:We provide a centralised thrombophilia screening service with sample transfer by courier or first class mail, a practice common to many centres. Sample quality is of prime importance, thus we have assessed the effect of delayed sample handling upon the haemostatic variables within our thrombophilia profile. This compr...

journal_title：Thrombosis research

authors： Luddington R,Peters J,Baker P,Baglin T

更新日期：1997-09-15 00:00:00

abstract：:Thrombin-activatable fibrinolysis inhibitor (TAFI), also known as procarboxypeptidase U or plasma procarboxypeptidase B, is a relatively recently described plasma glycoprotein synthesised in the liver. It can be activated into active enzyme TAFIa (carboxypeptidase U or plasma carboxypeptidase B) by a complex of thromb...

journal_title：Thrombosis research

authors： Antovic JP,Blombäck M

更新日期：2002-04-01 00:00:00

abstract：:In this study we examined in 100 patients testing positive for Helicobacter pylori infection whether successful eradication therapy with pantoprazole, clarithromycin, and metronidazole alters fibrinogen and other acute phase response markers. Of 100 patients, only 11 showed a fibrinogen level above 300 mg/dL. Successf...

journal_title：Thrombosis research

authors： Schweeger I,Fitscha P,Sinzinger H

更新日期：2000-03-15 00:00:00

abstract：:An in vitro test system was developed to examine the effects of red blood cells (RBC) on shear-induced platelet adhesion (SIPAD) and platelet aggregation (SIPAG). Suspensions of human platelets labeled with Mepacrine and suspended in citrated plasma were exposed to single, continuous or repetitive (120-300x) one secon...

journal_title：Thrombosis research

authors： Joist JH,Bauman JE,Sutera SP

更新日期：1998-12-15 00:00:00

abstract：:Anticoagulants are effective for preventing both venous and arterial thrombosis. Although antithrombotic agents have been reported to reduce thrombin formation, to our knowledge, the relation between blood viscosity (BV) and antithrombotic agents has not been examined. We examined the effects on whole BV of various do...

journal_title：Thrombosis research

authors： Hitosugi M,Niwa M,Takatsu A

更新日期：2001-12-01 00:00:00

abstract：:Since the 19(th) century an association between cancer and thromboembolic events has been described, with a poorer survival prognosis. Production and secretion of procoagulant factors affect tumor biology and cancer-associated thrombosis. Tissue factor (TF) exerts coagulant and protease activated receptor (PAR)-depend...

journal_title：Thrombosis research

authors： Ünlü B,Versteeg HH

更新日期：2014-05-01 00:00:00

abstract：:The procoagulant cellular activity (PCA) of leukemic cells was evaluated, before and after endotoxin stimulation, in 38 patients with acute leukemia at presentation subdivided according to the FAB classification. In the M4 and M5 subgroups the stimulated leukemic cells showed a significant increase in the production o...

journal_title：Thrombosis research

authors： Guarini A,Gugliotta L,Catani L,Chetti L,Macchi S,Tura S

更新日期：1987-03-01 00:00:00

abstract：:It has been found in our laboratory that compression induces disaggregation and decompression induces aggregation of human platelets. The experimental design was based on the premise that oppositely charged amino acid residues of fibrinogen are juxtaposed in the specific adhesive site(s). This can be explained by the ...

journal_title：Thrombosis research

authors： Murayama M

更新日期：1987-03-15 00:00:00

abstract：INTRODUCTION:To evaluate the pathogenetic role of tissue factor (TF), tissue factor pathway inhibitor (TFPI), and neutrophil elastase in acute respiratory distress syndrome (ARDS), as well as to test the hypothesis that TFPI levels modified by neutrophil activation are not sufficient to prevent TF-dependent intravascul...

journal_title：Thrombosis research

authors： Gando S,Kameue T,Matsuda N,Hayakawa M,Morimoto Y,Ishitani T,Kemmotsu O

更新日期：2003-01-25 00:00:00

abstract：:An in vivo rabbit model of venous thrombosis which includes physiological blood flow was used to compare the efficacy of the potent and specific factor Xa inhibitor recombinant tick anticoagulant peptide (rTAP) with standard heparin in the prevention of venous thrombus formation. In anesthetized rabbits, an autologous...

journal_title：Thrombosis research

authors： Fioravanti C,Burkholder D,Francis B,Siegl PK,Gibson RE

更新日期：1993-08-15 00:00:00

abstract：:Flavocetin-A is a strong platelet aggregation inhibitor isolated from the venom of Trimeresurus flavoviridis. It binds specifically to platelet glycoprotein Ib with high affinity and inhibits von Willebrand factor-dependent platelet aggregation. The apparent molecular weight of flavocetin-A is 149 kDa. It consists of ...

journal_title：Thrombosis research

authors： Shin Y,Okuyama I,Hasegawa J,Morita T

更新日期：2000-08-01 00:00:00

abstract：:Carotid artery dissections are the second leading cause of stroke in young adults. The hemostatic response to a dissection involves exposure of the subendothelium to the intravascular environment. Platelet activation/aggregation superimposed by secondary coagulation cascade activity attempts to heal the injury. Failur...

journal_title：Thrombosis research

authors： Stevic I,Chan HH,Chan AK

更新日期：2011-10-01 00:00:00

abstract：:The study of the interaction between activated protein C (APC) and non-plasmatic inhibitors allowed us to demonstrate that aprotinin is a potent competitive inhibitor of APC with a Ki of 1.35 mumol/L. It was possible to adsorb immunopurified protein C (PC) activated by venom activator to insolubilized aprotinin and to...

journal_title：Thrombosis research

authors： Taby O,Chabbat J,Steinbuch M

更新日期：1990-07-01 00:00:00

abstract：:This study investigates the effect on human platelet function of two sesquiterpene lactones from Arnica montana L., helenalin (H) and 11 alpha,13-dihydrohelenalin (DH). Both compounds inhibited collagen-induced platelet aggregation, thromboxane formation and 5-hydroxytryptamine secretion in a concentration-dependent m...

journal_title：Thrombosis research

authors： Schröder H,Lösche W,Strobach H,Leven W,Willuhn G,Till U,Schrör K

更新日期：1990-03-15 00:00:00

abstract：:The experiments in this work were focused on determination of the extent to which fibrinogen component of fibrin glue (Hemaseel HMN, Haemacure Biotech.) retained the conformation of the parent molecule after dry heat antiviral treatment (one hour at 100 degrees C). For this purpose antigenic structure of the fibrinoge...

journal_title：Thrombosis research

authors： Cierniewski CS,Pluskota E,Cieslak M,Brodniewicz T,Nowotarski M

更新日期：1996-05-15 00:00:00

abstract：:Porcine and human umbilical vein and adult blood vessels were studied for the presence and synthesis of factor VIII related antigen (VIIIR:Ag) and fibronectin (Fn) by immunofluorescence histology and immunoautoradiography. Investigation of human tissue confirmed the widespread distribution of VIIIR:Ag on the endotheli...

journal_title：Thrombosis research

authors： Giddings JC,Jarvis AL,Bloom AL

更新日期：1983-02-01 00:00:00

abstract：:The antithrombotic actions of selective factor Xa (FXa) inhibitors, recombinant tick anticoagulant peptide (rTAP) and DX-9065a, were evaluated in experimental thrombosis models in anesthetized rats. In the first model, thrombosis was induced by exposing flowing blood to a silk thread anchored in an arteriovenous (AV) ...

journal_title：Thrombosis research

authors： Wong PC,Crain EJ Jr,Nguan O,Watson CA,Racanelli A

更新日期：1996-07-15 00:00:00

abstract：:Defibrotide (D) is a natural polydeoxyribonucleotide from mammalian lungs with profibrinolytic and antithrombotic activities. D also has PGI2-stimulating and tissue plasminogen activator (TPA)-releasing activities, but has no anticoagulant properties. The protective effects of D were demonstrated very recently in a mo...

journal_title：Thrombosis research

authors： Niada R,Porta R,Pescador R,Mantovani M,Prino G

更新日期：1986-05-01 00:00:00

abstract：:Experience with tranexamic acid, an indirect fibrinolytic inhibitor, started as soon as it was released from Shosuke Okamoto's lab in the early 1960s. It was first prescribed to females with heavy menstrual blood loss and to patients with hereditary bleeding disorders. Soon the indications were widened to elective sur...

journal_title：Thrombosis research

authors： Tengborn L,Blombäck M,Berntorp E

更新日期：2015-02-01 00:00:00

abstract：INTRODUCTION:The use of oral anticoagulant therapy is increasing in children. Managing anticoagulant therapy in children presents unique challenges, including poor venous access. The advent of point-of-care (POC) monitoring of anticoagulant therapy offers a potential solution to this challenge. This paper reviews the p...

journal_title：Thrombosis research

authors： Newall F,Bauman M

更新日期：2006-01-01 00:00:00

abstract：:We previously found evidence (based on the use of 5HT as a marker) that i.v. injection of a lipopolysaccharide (LPS) into mice induces a rapid accumulation of platelets in liver and lung. Our previous studies lacked measurement of the platelet count itself, but we have now compared the LPS-induced changes in 5HT level...

journal_title：Thrombosis research

authors： Ohtaki Y,Shimauchi H,Yokochi T,Takada H,Endo Y

更新日期：2002-12-15 00:00:00

abstract：INTRODUCTION:Aspirin inhibits the cyclooxygenase-1 (COX-1) mediated thromboxane A2 synthesis. Despite COX-1 inhibition, in patients with coronary artery disease (CAD), platelets can be activated through other mechanisms, like activation by thrombin. MATERIALS AND METHODS:At baseline in this cross-sectional substudy of...

journal_title：Thrombosis research

authors： Pettersen AÅ,Arnesen H,Opstad TB,Bratseth V,Seljeflot I

更新日期：2012-09-01 00:00:00

abstract：:Diabetes mellitus (DM) is associated with platelet and leukocyte dysfunction. Previous observations with regard to insulin effects on platelet and leukocyte function are less than consistent. We thus investigated the effects of insulin on platelets and leukocytes, as well as on platelet-leukocyte interactions in whole...

journal_title：Thrombosis research

authors： Hu H,Hjemdahl P,Li N

更新日期：2002-09-01 00:00:00

abstract：OBJECTIVES:Screening of patients with sepsis for disseminated intravascular coagulation (DIC) has been recommended in several guidelines. However, DIC screening is still not widely accepted as an essential component of sepsis management, partly because of a lack of evidence that DIC screening has an effect on mortality...

journal_title：Thrombosis research

authors： Umemura Y,Yamakawa K,Hayakawa M,Hamasaki T,Fujimi S,Japan Septic Disseminated Intravascular Coagulation (J-Septic DIC) study group.

更新日期：2018-01-01 00:00:00

abstract：:We have investigated fibrinolytic parameters in 33 patients with peripheral arterial occlusive disease (PAOD) before and 6, 24, and 48 hours after percutaneous transluminal angioplasty (PTA) as well as in 35 gender-matched healthy controls, whose mean age was not significantly different from the mean age of the patien...

journal_title：Thrombosis research

authors： Roller RE,Janisch S,Carroll V,Kvas E,Pilger E,Binder BR,Wojta J

更新日期：1999-05-15 00:00:00

abstract：INTRODUCTION:Whether clinical prediction rules for pulmonary embolism are accepted and used among general internal medicine residents remains uncertain. We therefore evaluated the frequency of use and acceptability of the Revised Geneva Score (RGS) and the Pulmonary Embolism Severity Index (PESI), and explored which fa...

journal_title：Thrombosis research

authors： Faller N,Stalder O,Limacher A,Bassetti S,Beer JH,Genné D,Battegay E,Hayoz D,Leuppi J,Mueller B,Perrier A,Waeber G,Rodondi N,Aujesky D

更新日期：2017-12-01 00:00:00

abstract：INTRODUCTION:Rivaroxaban is an oral, selective direct factor Xa inhibitor approved for several indications in patients at risk of thrombotic events. One limitation of its clinical use is the lack of data pertaining to its reversal in situations where urgent response is critical (e.g. acute bleeding events or emergency ...

journal_title：Thrombosis research

authors： Herzog E,Kaspereit F,Krege W,Mueller-Cohrs J,Doerr B,Niebl P,Dickneite G

更新日期：2015-03-01 00:00:00

abstract：INTRODUCTION:Though thrombin-activatable fibrinolysis inhibitor (TAFI) may contribute to hypercoagulability during pregnancy, limited data are available on the role of TAFI in women with recurrent fetal loss. MATERIAL/METHODS:We performed a case-control study aimed at evaluating any possible association between TAFI l...

journal_title：Thrombosis research

authors： Legnani C,Bovara M,Valdrè L,Cosmi B,Caniato A,Palareti G

更新日期：2012-08-01 00:00:00

abstract：INTRODUCTION:There is an exponential rise of thromboembolic risk with age because of co-morbidities, immobility and pharmacotherapy. We aimed to investigate the benefits and risks of heparin prophylaxis in very elderly patients ≥80 years and the type of heparin used in a subgroup analysis of the CERTIFY trial. PATIENT...

journal_title：Thrombosis research

authors： Schellong SM,Gerlach HE,Tebbe U,Haas S,Melzer N,Abletshauser C,Sieder C,Bramlage P,Riess H,Bauersachs R

更新日期：2011-11-01 00:00:00

abstract：:Rabbit platelets pretreated with CV-3988 had reduced responsiveness to platelet activating factor(PAF) even after the platelets had been washed with a buffer. This was due to its tight binding to receptor sites for PAF, but not conformational changes of the receptor, because the platelets that were pretreated with CV-...

journal_title：Thrombosis research

authors： Tokumura A,Yoshida J,Okasaka N,Fukuzawa K,Tsukatani H

更新日期：1987-04-01 00:00:00