Abnormal Ca2+ homeostasis in platelets of patients with myeloproliferative disorders: low levels of Ca2+ influx and efflux across the plasma membrane and increased Ca2+ accumulation into the dense tubular system.

abstract：:A synthetic pentasaccharide, representing the critical sequence required in heparin for binding to antithrombin III (AT III), produces strong anti-factor Xa activity in vitro in the presence of AT III and is devoid of any activity directed towards thrombin. This pentasaccharide provides a unique tool to study the ques...

journal_title：Thrombosis research

authors： Walenga JM,Petitou M,Lormeau JC,Samama M,Fareed J,Choay J

更新日期：1987-04-15 00:00:00

abstract：INTRODUCTION:The Cilostazol Stroke Prevention Study found that cilostazol, a phosphodiesterase 3 inhibitor, can reduce the risk of subsequent stroke in Japanese patients with cerebral infarction. Here, we measured the effects of cilostazol in vitro on shear-induced platelet aggregation, an important mechanism of thromb...

journal_title：Thrombosis research

authors： Nakamura T,Uchiyama S,Yamazaki M,Iwata M

更新日期：2007-01-01 00:00:00

abstract：:Hip joint replacement surgery, using acrylic cement for prosthesis fixation, is associated with intraoperative cardiorespiratory dysfunction, and a high frequency of postoperative proximal deep vein thrombosis (DVT). Levels of prothrombin fragments 1+2 (F1+2), tissue plasminogen activator antigen (t-PA), plasminogen a...

journal_title：Thrombosis research

authors： Dahl OE,Pedersen T,Kierulf P,Westvik AB,Lund P,Arnesen H,Seljeflot I,Abdelnoor M,Lyberg T

更新日期：1993-06-15 00:00:00

abstract：:In the treatment of unstable coronary artery disease, direct thrombin inhibitors have shown no or only limited benefit as compared with heparin, despite theoretical advantages. One explanation may be that the direct thrombin inhibitors to a greater extent than heparin have an inhibiting effect on the generation and ac...

journal_title：Thrombosis research

authors： Linder R,Blombäck M,Egberg N,Grip L

更新日期：1999-07-15 00:00:00

abstract：INTRODUCTION:Metastases are responsible for more than 90% of cancer related mortality. The hematogenous metastatic invasion is a complex process in which the endothelium plays a key role. Extravasation is a dynamic process involving remodeling and change in cell shape and in cytoskeleton whereby a series of strongly de...

journal_title：Thrombosis research

authors： Gilardi M,Bersini S,Calleja AB,Kamm RD,Vanoni M,Moretti M

更新日期：2016-04-01 00:00:00

abstract：:Tissue factor (TF) is a transmembrane protein which, in complex with factor (F)VIIa, initiates blood coagulation. Numerous studies have determined TF epitopes and individual amino acids which play an important role in the TF/FVIIa complex formation and its activity towards natural substrates. However the subject of ce...

journal_title：Thrombosis research

authors： Butenas S,Krudysz-Amblo J

更新日期：2012-05-01 00:00:00

abstract：INTRODUCTION:Though thrombin-activatable fibrinolysis inhibitor (TAFI) may contribute to hypercoagulability during pregnancy, limited data are available on the role of TAFI in women with recurrent fetal loss. MATERIAL/METHODS:We performed a case-control study aimed at evaluating any possible association between TAFI l...

journal_title：Thrombosis research

authors： Legnani C,Bovara M,Valdrè L,Cosmi B,Caniato A,Palareti G

更新日期：2012-08-01 00:00:00

abstract：INTRODUCTION:Lung cancer is the leading cause of cancer-related death worldwide. Small cell lung cancer (SCLC) is thereby a highly aggressive neuroendocrine carcinoma representing about 15% of all lung cancer cases. Due to the highly metastatic behavior and multidrug resistance, the long-term survival of patients is ve...

journal_title：Thrombosis research

authors： Taromi S,Catusse J,Elverfeldt DV,Reichardt W,Ledig B,Zeiser R,Burger M

更新日期：2016-04-01 00:00:00

abstract：:Human platelets contain a single membrane glycoprotein which is susceptible to thrombin proteolysis, glycoprotein V. We have purified 1 mg of glycoprotein V from 10(13) platelets using a combination of gel filtration, hydroxylapatite and ion-exchange chromatographies. Glycoprotein V has a blocked amino-terminus. Follo...

journal_title：Thrombosis research

authors： Zafar RS,Walz DA

更新日期：1989-01-01 00:00:00

abstract：:Using an ACL 300R coagulometer (Instrumentation Laboratory) we assessed the clinical usefulness of a new method to measure PS activity (PS:Act), based on the prolongation of prothrombin time of a mixture of diluted plasma sample, PS depleted plasma previously incubated with Protac for protein C activation, bovine thro...

journal_title：Thrombosis research

authors： Maccaferri M,Legnani C,Preda L,Palareti G

更新日期：1991-12-15 00:00:00

abstract：:Several clinical trials have demonstrated the benefits of thienopyridine monotherapy in ischaemic stroke patients. Non-human primate models of ischaemic stroke have been used for various antithrombotic agents; however, to the best of our knowledge, there is no data on the effects of P2Y12 antagonists in models, such a...

journal_title：Thrombosis research

authors： Tomizawa A,Ohno K,Jakubowski JA,Mizuno M,Sugidachi A

更新日期：2015-12-01 00:00:00

abstract：INTRODUCTION:Cytomegalovirus (CMV)-associated thrombosis has been reported sporadically in the medical literature until now. However, thrombosis incidence and its risk factors have never been studied in a cohort of patients with acute CMV infection. MATERIALS AND METHODS:A retrospective case-control study. Medical cha...

journal_title：Thrombosis research

authors： Atzmony L,Halutz O,Avidor B,Finn T,Zimmerman O,Steinvil A,Zeltser D,Giladi M,Justo D

更新日期：2010-12-01 00:00:00

abstract：INTRODUCTION:Fluid resuscitation after trauma often results in dilutional coagulopathy that may hinder control of bleeding and, once initial hemostasis has been secured, heighten risk of perioperative bleeding when further surgery is required. Since multiple coagulation factor deficiencies typically accompany fluid res...

journal_title：Thrombosis research

authors： Pragst I,Kaspereit F,Dörr B,Dickneite G

更新日期：2010-03-01 00:00:00

abstract：INTRODUCTION:Following the Fontan procedure, children require lifelong anticoagulant therapy to minimise the risk of thrombosis. Factors influencing the management of warfarin therapy in children post-Fontan procedure are poorly understood. This study investigated factors affecting warfarin therapy stability and time t...

journal_title：Thrombosis research

authors： Crone E,Saliba N,George S,Hume E,Newall F,Jones S

更新日期：2013-04-01 00:00:00

abstract：INTRODUCTION:Type 2 diabetes mellitus (T2DM) patients have a variable response profile to the P2Y(12) receptor antagonist clopidogrel. P2Y(12) receptor signalling promotes platelet procoagulant activity. The aim of this study was to determine if T2DM patients with suboptimal clopidogrel response have greater platelet p...

journal_title：Thrombosis research

authors： Angiolillo DJ,Capranzano P,Desai B,Shoemaker SB,Charlton R,Zenni MM,Guzman LA,Bass TA

更新日期：2009-07-01 00:00:00

abstract：INTRODUCTION:Cancer associated thrombosis is a well-recognized phenomenon that results in considerable patient morbidity and mortality. Malignancy conveys an increased risk for thrombosis and chemotherapy further elevates this risk. The pathophysiological mechanisms underlying this process remain poorly defined. MATER...

journal_title：Thrombosis research

authors： Boles JC,Williams JC,Hollingsworth RM,Wang JG,Glover SL,Owens AP 3rd,Barcel DA,Kasthuri RS,Key NS,Mackman N

更新日期：2012-02-01 00:00:00

abstract：:Bleeding is an important complication of heparin therapy. A number of low molecular weight heparin fractions produce less bleeding than standard heparin for an equivalent antithrombotic effect in experimental animals. Low molecular weight heparin fractions and fragments are produced by a number of different procedures...

journal_title：Thrombosis research

authors： Cade JF,Buchanan MR,Boneu B,Ockelford P,Cater CJ,Cerskus AL,Hirsh J

更新日期：1984-09-15 00:00:00

abstract：INTRODUCTION:Randomized clinical trials have demonstrated non-inferiority of rivaroxaban compared with vitamin K antagonists (VKAs) in the treatment of venous thromboembolism (VTE). Our objective was to analyze in real life, tolerance, recurrence, bleeding and adverse events of rivaroxaban in patients with acute sympto...

journal_title：Thrombosis research

authors： Jara-Palomares L,Sanchez-Oro-Gomez R,Elias-Hernandez T,Morillo-Guerrero R,Ferrer-Galvan M,Asensio-Cruz MI,Barrot-Cortes E,Otero-Candelera R

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND:Influencing factors for clopidogrel-mediated platelet inhibition have only been evaluated by one or two different test systems in the same population so far. Since previous studies revealed poor correlations between the various platelet function tests, the identification of influencing variables for clopidog...

journal_title：Thrombosis research

authors： Gremmel T,Steiner S,Seidinger D,Koppensteiner R,Panzer S,Kopp CW

更新日期：2011-10-01 00:00:00

abstract：:Sandwich ELISA systems were developed to measure human von Willebrand factor (vWF). In one system the microtitre plates were coated with goat F(ab')2 to vWF. The F(ab')2 different molecular forms in the soluble phase. VWF antigen bound by the F(ab')2 antibody was subsequently determined by using horse-radish peroxidas...

journal_title：Thrombosis research

authors： Silveira AM,Yamamoto T,Adamson L,Hessel B,Blombäck B

更新日期：1986-07-01 00:00:00

abstract：INTRODUCTION:Inter-individual variability in clopidogrel responsiveness is dependent on genetic polymorphisms. We aimed to investigate the impact of 3 genetic polymorphisms involved in clopidogrel metabolism on a strategy of dose-adjustment according to platelet reactivity (PR) monitoring. MATERIAL AND METHODS:[correc...

journal_title：Thrombosis research

authors： Bonello L,Camoin-Jau L,Mancini J,Bessereau J,Grosdidier C,Alessi MC,Ostorero M,Dignat-George F,Paganelli F

更新日期：2012-07-01 00:00:00

abstract：:The diagnosis of preeclampsia, with all of its consequences, is at times difficult to establish, especially when the patient has underlying chronic hypertension and is not known from prior prenatal care visits. Many screening tests have been proposed. These should be sensitive, relatively specific, easy to perform, of...

journal_title：Thrombosis research

authors： Saleh AA,Bottoms SF,Gerbasi FR,Mammen EF

更新日期：1994-07-15 00:00:00

abstract：BACKGROUND:In patients who are receiving warfarin therapy and require cataract surgery, it may be possible to continue warfarin in the perioperative period but the safety of this management strategy has not been systematically evaluated. METHODS:We performed a systematic review of the literature to assess the safety (...

journal_title：Thrombosis research

authors： Jamula E,Anderson J,Douketis JD

更新日期：2009-07-01 00:00:00

abstract：:Defibrotide (D) is a natural polydeoxyribonucleotide from mammalian lungs with profibrinolytic and antithrombotic activities. D also has PGI2-stimulating and tissue plasminogen activator (TPA)-releasing activities, but has no anticoagulant properties. The protective effects of D were demonstrated very recently in a mo...

journal_title：Thrombosis research

authors： Niada R,Porta R,Pescador R,Mantovani M,Prino G

更新日期：1986-05-01 00:00:00

abstract：INTRODUCTION:Severe thrombocytopenia (≤50×10(9) platelets/L) is often the consequence of hematological malignancies and intensive chemotherapy. The risk of clinically significant bleeding is increased in these patients, despite the use of prophylactic platelet transfusions. The fact that there is no clear correlation b...

journal_title：Thrombosis research

authors： Baaten CC,Moenen FC,Henskens YM,Swieringa F,Wetzels R,van Oerle R,Ten Cate H,Beckers EA,Heemskerk JW,van der Meijden PE

更新日期：2016-04-01 00:00:00

abstract：INTRODUCTION:Profuse postpartum hemorrhage (PPH) and red blood cell (RBC) transfusion have been suggested to be associated with venous thromboembolic events (VTE). However, it is not fully clear if they are independent major risk factors. METHODS:Women who gave birth in the Stockholm area between 1999 and 2002 were th...

journal_title：Thrombosis research

authors： Thurn L,Wikman A,Lindqvist PG

更新日期：2018-05-01 00:00:00

abstract：INTRODUCTION:The activated partial thromboplastin time (APTT) is commonly used to monitor unfractionated heparin (UFH) but may not accurately measure the amount of heparin present. The anti-Xa assay is less susceptible to confounding factors and may be a better assay for this purpose. MATERIALS AND METHODS:The validit...

journal_title：Thrombosis research

authors： Arachchillage DRJ,Kamani F,Deplano S,Banya W,Laffan M

更新日期：2017-09-01 00:00:00

abstract：INTRODUCTION:Global clotting assays may reflect an individual's net hemostatic balance and could contribute to prothrombotic and hemorrhagic risk assessment. In this research, a global assay that measures both coagulation and fibrinolytic capacities was developed and investigated. MATERIALS AND METHODS:In the Clot For...

journal_title：Thrombosis research

authors： Goldenberg NA,Hathaway WE,Jacobson L,Manco-Johnson MJ

更新日期：2005-01-01 00:00:00

abstract：INTRODUCTION:The safety and efficacy of low-molecular-weight heparin (LMWH) treatment in patients with cancer-associated thrombosis (CAT) beyond 6months are unknown. Our aim was to determine the safety of long-term tinzaparin use in patients with CAT. METHODS:We performed a prospective, open, single arm, multicentre s...

journal_title：Thrombosis research

authors： Jara-Palomares L,Solier-Lopez A,Elias-Hernandez T,Asensio-Cruz M,Blasco-Esquivias I,Marin-Barrera L,de la Borbolla-Artacho MR,Praena-Fernandez JM,Montero-Romero E,Navarro-Herrero S,Serrano-Gotarredona MP,Sánchez-Díaz JM,Palacios

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND:Peripheral pulmonary artery thrombus (PPT) is common in the clinic. However, due to the lack of an ideal diagnostic tool, PPT cannot be quickly diagnosed and effectively treated at present. Optical coherence tomography (OCT) is a new intravascular imaging technique that is characterized by high image resolut...

journal_title：Thrombosis research

authors： Hong C,Luo FQ,Liu CL,Zhong NS,Li JY,Wang W

更新日期：2018-01-01 00:00:00