Platelet clearance by the hepatic Ashwell-Morrell receptor: mechanisms and biological significance.

abstract：:Fibrinogen has been reported to interact with phospholipid; however, the properties of this binding interaction have not been characterized. Purified preparations of human fibrinogen bound to small unilamellar vesicles containing phosphatidylserine (PS) as measured by light scattering and radioisotope filtration. Bind...

journal_title：Thrombosis research

authors： Cunningham MT,Citron BA,Koerner TA

更新日期：1999-09-15 00:00:00

abstract：INTRODUCTION:There is some controversy regarding the effect of CYP2C19 polymorphism on clinical outcome in patients with dual antiplatelet therapy. Chronic kidney disease (CKD) is associated with increased risk of cardiovascular event, but the association between the possession of CYP2C19 loss-of-function (LOF) alleles...

journal_title：Thrombosis research

authors： Tabata N,Hokimoto S,Akasaka T,Arima Y,Kaikita K,Kumagae N,Morita K,Miyazaki H,Oniki K,Nakagawa K,Matsui K,Ogawa H

更新日期：2014-11-01 00:00:00

abstract：:The Fab fragment of a polyclonal antibody against platelet factor XIII inhibited the collagen-induced platelet aggregation in a dose-dependent manner. This inhibitory effect was specific for collagen, and it had no effect on arachidonic acid-, ADP-, and serotonin-induced aggregations. This finding strengthens our noti...

journal_title：Thrombosis research

authors： Kasahara K,Takagi J,Sekiya F,Inada Y,Saito Y

更新日期：1988-04-15 00:00:00

abstract：:Ovarian hyperstimulation syndrome (OHSS) affects 5% of IVF cycles and incurs a 100-fold increase in risk of venous thrombosis over natural conceptions. Identification of women at risk of OHSS can be achieved using antral follicle count (AFC) and anti-Müllerian hormone (AMH). For those women with a high AFC or AMH comb...

journal_title：Thrombosis research

authors： Nelson SM

更新日期：2013-01-01 00:00:00

abstract：:Indirect genetic diagnosis using polymorphic DNA markers can be useful in large-scale screening programs, which is technically simpler, more rapid and amenable. The main objective of this study was to test the informativeness of two common intragenic markers (TaqI and XmnI) in Iranian haemophilia B families to detect ...

journal_title：Thrombosis research

authors： Ghandil P,Ghadiri A,Farhud D,Zeinali S

更新日期：2004-01-01 00:00:00

abstract：INTRODUCTION:A close association exists between oral health and cardiovascular disease. Periodontal disease induces early vascular changes while oral pathogens have been detected in sub gingival and atheromatous plaques. We examined the interrelationship between Periodontal disease, oral bacteria, surrogate sub-clinica...

journal_title：Thrombosis research

authors： Shanker J,Setty P,Arvind P,Nair J,Bhasker D,Balakrishna G,Kakkar VV

更新日期：2013-07-01 00:00:00

abstract：:The release of arachidonic acid, and its subsequent conversion to thromboxane A2, is an important component of platelet activation. The precise mechanism of arachidonic acid release is unknown although cytosolic phospholipase A2 (cPLA2) has been implicated. In the present study the effects of three agonists, the serin...

journal_title：Thrombosis research

authors： McNicol A,Shibou TS

更新日期：1998-10-01 00:00:00

abstract：:Several sex-related differences in the incidence rate, clinical presentation and outcomes of VTE were recently investigated. Gender-related risk factors, such as the use of oral contraceptives (OC) and pregnancy, in particular in women with a thrombophilic state, are associated with an increased risk of venous thrombo...

journal_title：Thrombosis research

authors： Romualdi E,Ageno W

更新日期：2011-02-01 00:00:00

abstract：:The loss of sialic acid was determined in human platelets stored during a seven day period in their homologous plasma. Approximately 30% of the sialic acid was lost during the first three days of incubation at room temperature and a total of 73% was lost after seven days. The rapid in vitro loss of sialic acid may mim...

journal_title：Thrombosis research

authors： Soslau G,Giles J

更新日期：1982-06-15 00:00:00

abstract：:Severe bleeding took place in a patient when abdominal aneurysm was removed by operation. Bleeding continued after infusion of heparin, antithrombin III (ATIII), fresh platelets and fresh blood. Infusion of tranexamic acid resulted in an immediate cessation of bleeding and improvement of his general condition. Sometim...

journal_title：Thrombosis research

authors： Takada A,Takada Y,Mori T,Sakaguchi S

更新日期：1990-04-15 00:00:00

abstract：:It has become customary to regard the various glycerophospholipids as quite similar, and the acyl groups are considered to have little influence on the behaviour of the lipids in membranes or metabolism. Nevertheless, a number of recent observations by the authors and others indicate a high degree of metabolic compart...

journal_title：Thrombosis research

authors： Holmsen H,Hindenes JO,Fukami M

更新日期：1992-08-01 00:00:00

abstract：INTRODUCTION:Recombinant members of the vitamin K-dependent protein family (factors IX and VII and protein C) have become important pharmaceuticals in treatment of bleeding disorders and sepsis. However, because the in vivo gamma-carboxylation system in stable cell lines used for transfection has a limited capacity of ...

journal_title：Thrombosis research

authors： Wajih N,Owen J,Wallin R

更新日期：2008-01-01 00:00:00

abstract：INTRODUCTION:Information regarding any possible additional effect of genetic variants other than CYP2C19*2 on platelet reactivity in patients undergoing percutaneous coronary intervention (PCI), while on dual antiplatelet therapy, is sparse. MATERIALS AND METHODS:Genotyping for CYP2C19*2, CYP2C19*17, CYP2C9*3, CYP2B6*...

journal_title：Thrombosis research

authors： Kassimis G,Davlouros P,Xanthopoulou I,Stavrou EF,Athanassiadou A,Alexopoulos D

更新日期：2012-04-01 00:00:00

abstract：INTRODUCTION:Type 2 diabetes mellitus (T2DM) patients have a variable response profile to the P2Y(12) receptor antagonist clopidogrel. P2Y(12) receptor signalling promotes platelet procoagulant activity. The aim of this study was to determine if T2DM patients with suboptimal clopidogrel response have greater platelet p...

journal_title：Thrombosis research

authors： Angiolillo DJ,Capranzano P,Desai B,Shoemaker SB,Charlton R,Zenni MM,Guzman LA,Bass TA

更新日期：2009-07-01 00:00:00

abstract：INTRODUCTION:After major liver surgery, there are risks of both postoperative bleeding and thrombosis. Routine coagulation monitoring is indicated, but may not provide adequate clinical guidance. Thus, we described the clotting status in a pilot study using broader coagulation testing. We analysed the temporal pattern ...

journal_title：Thrombosis research

authors： Dumitrescu G,Januszkiewicz A,Ågren A,Magnusson M,Isaksson B,Wernerman J

更新日期：2015-08-01 00:00:00

abstract：:Antithrombin III (AT III) is increased in situations where there is increased platelet turnover. Plasma AT III levels measured in 39 renal transplant recipients were significantly higher than in 20 healthy subjects (p less than 0.001) and 20 patient controls (p less than 0.025). AT III levels were significantly correl...

journal_title：Thrombosis research

authors： Woo KT,Lee EJ,Lau YK,Lim CH

更新日期：1985-05-01 00:00:00

abstract：BACKGROUND:Although patients with idiopathic VTE are at higher than normal risk of asymptomatic atherosclerosis and of cardiovascular events, the impact of cardiovascular risk factors on VTE is poorly understood. OBJECTIVE:To assess the prevalence of the metabolic syndrome and of its components in patients with early-...

journal_title：Thrombosis research

authors： Di Minno MN,Tufano A,Guida A,Di Capua M,De Gregorio AM,Cerbone AM,Tarantino G,Di Minno G

更新日期：2011-03-01 00:00:00

abstract：INTRODUCTION:Thrombomodulin (TM) has been described as a marker of endothelial injury in atherosclerosis. The role of TM as a predictor of PAD severity is to be proven. The goal of the present study is to compare the level of plasmatic (TMp) in patients with intermittent claudication with patients with critical ischemi...

journal_title：Thrombosis research

authors： Nasser M,Wolosker N,Uint L,Rosoky RA,Lobato M,Wajngarten M,Puech-Leao P

更新日期：2006-01-01 00:00:00

abstract：:The purpose of this study was to determine if the results obtained in platelet function tests and whole blood perfusions are associated with those in platelet function analyser (PFA)-100. We used collagen type I monomers and fibrils to analyse the distinct roles of glycoprotein (GP) Ia/IIa and other collagen receptors...

journal_title：Thrombosis research

authors： Lepäntalo A,Beer JH,Siljander P,Syrjälä M,Lassila R

更新日期：2001-07-15 00:00:00

abstract：:The role of thrombin in vascular physiology and pathophysiology continues to impact our understanding of many cellular processes and systems including the function of platelets, endothelial cells, smooth muscle cells, leukocytes and the regulation of the coagulation cascade. Recent acute coronary syndrome clinical tri...

journal_title：Thrombosis research

authors： Giri S,Jennings LK

更新日期：2015-05-01 00:00:00

abstract：:Resistance to Activated Protein C (APC) was evaluated using 3 different methods: two of them were based on the prolongation of the Activated Partial Thromboplastin Time (APTT) using 2 different APTT reagents in the presence of APC, whereas the third method was based on the prolongation of prothrombin time when APC is ...

journal_title：Thrombosis research

authors： Vasse M,Leduc O,Borg JY,Chrétien MH,Monconduit M

更新日期：1994-10-01 00:00:00

abstract：UNLABELLED:Suboptimal gastrointestinal absorption is a problem for many direct thrombin inhibitors. The studies presented herein describe the new oral direct thrombin inhibitor H 376/95, a prodrug with two protecting residues added to the direct thrombin inhibitor melagatran. Absorption properties in vitro: H 376/95 is...

journal_title：Thrombosis research

authors： Gustafsson D,Nyström J,Carlsson S,Bredberg U,Eriksson U,Gyzander E,Elg M,Antonsson T,Hoffmann K,Ungell A,Sörensen H,Någård S,Abrahamsson A,Bylund R

更新日期：2001-02-01 00:00:00

abstract：INTRODUCTION:Antithrombin (AT), protein C (PC) and protein S (PS) deficiencies are risk factors for venous thromboembolism. Overlapping values between heterozygous carriers and normal individuals often make a correct classification of a deficiency difficult. The aim of this study was to investigate the effect of sex, a...

journal_title：Thrombosis research

authors： Franchi F,Biguzzi E,Martinelli I,Bucciarelli P,Palmucci C,D'Agostino S,Peyvandi F

更新日期：2013-08-01 00:00:00

abstract：:The two objectives of the study were to determine whether a procedure could be developed for measuring cancer procoagulant (CP) activity in human serum and if this procedure provided a method for distinguishing people with cancer from those without cancer. A procedure was developed for processing human serum such that...

journal_title：Thrombosis research

authors： Gordon SG,Benson B

更新日期：1989-11-01 00:00:00

abstract：:Cell lysates of the human monoblastic leukemia cell line, THP-1, have procoagulant activity (PCA) that is Ca++-dependent and not demonstrable in either Factor VII-, or Factor X-deficient plasma. The PCA of THP-1 cells was enhanced by human recombinant tumor necrosis factor-alpha (TNF-alpha) up to five fold. There was ...

journal_title：Thrombosis research

authors： Tanaka M

更新日期：1989-10-15 00:00:00

abstract：INTRODUCTION:Congenital factor V (FV) deficiency is a rare inherited disorder. Three compound heterozygous missense mutations, Asp68His, His147Arg, and Arg2074Cys, were observed in a Taiwanese patient with moderately severe FV deficiency. METHOD:The novel His147Arg mutation in the A1 domain was investigated by protein...

journal_title：Thrombosis research

authors： Liu HC,Lin TM,Eng HL,Lin YT,Shen MC

更新日期：2014-07-01 00:00:00

abstract：:Stimulation of rat platelets with U46619 induced Ca2+ mobilization and platelet shape change, but aggregation and secretion were induced when platelets were stimulated with U46619 plus phorbol 12-myristate 13-acetate (PMA). However, stimulation of rabbit platelets with U46619 induced all the three platelet responses. ...

journal_title：Thrombosis research

authors： Nakano T,Hanasaki K,Arita H

更新日期：1989-10-15 00:00:00

abstract：:The fibrinolytic system contains a proenzyme plasminogen (Plg) which is converted to plasmin (Plm) by the action of Plg activators. Physiological Plg activators are: tissue-type plasminogen activator (t-PA) and urokinase-type plasminogen activator. Plg was shown to be further cleaved by leukocyte elastase producing se...

journal_title：Thrombosis research

authors： Duboscq C,Genoud V,Parborell MF,Kordich LC

更新日期：1997-06-15 00:00:00

abstract：INTRODUCTION:Caesarean section (CS) is a significant risk factor for venous thromboembolism.. Low molecular weight heparin (LMWH) is commonly used for thromboprophylaxis post emergency caesarean delivery. However, no consensus exists regarding LMWH thromboprophylaxis following elective caesarean section. Measures of th...

journal_title：Thrombosis research

authors： Ismail SK,Norris L,Muttukrishna S,Higgins JR

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:Direct oral anticoagulants (DOACs) are high risk medications with short half-lives making adherence vitally important. Global measures for adherence have been described; however, there is a lack of patient-level data on adherence. METHODS:This prospective, single-center study in an interdisciplinary interna...

journal_title：Thrombosis research

authors： Talana AS,Huber K,Sorin M,Stalvey C,Davis K,Dietrich E

更新日期：2019-07-01 00:00:00