Abstract:
:The incidence of thrombotic events is higher in neonates compared to children of other age groups. Perinatal and maternal risk factors, as well as the developing neonatal hemostatic system, are contributing factors in the higher rate of thrombosis in this pediatric population. This review summarizes the available literature to date and gives an updated overview of the systemic venous thrombosis in neonates including clinical presentation, risk factors, recommended treatment modalities and associated outcomes.
journal_name
Thromb Resjournal_title
Thrombosis researchauthors
Yang JY,Chan AKdoi
10.1016/j.thromres.2010.10.009subject
Has Abstractpub_date
2010-12-01 00:00:00pages
471-6issue
6eissn
0049-3848issn
1879-2472pii
S0049-3848(10)00561-Xjournal_volume
126pub_type
杂志文章,评审abstract::Resveratrol (3, 4', 5-trihydroxystilbene), a natural polyphenol, is found in some plants that are used in human nutrition. Grapes are a major source for resveratrol, and a significant amount can also be found in red wine. Several experimental studies have demonstrated biological properties of resveratrol, especially i...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/s0049-3848(02)00273-6
更新日期:2002-08-15 00:00:00
abstract::The loss of sialic acid was determined in human platelets stored during a seven day period in their homologous plasma. Approximately 30% of the sialic acid was lost during the first three days of incubation at room temperature and a total of 73% was lost after seven days. The rapid in vitro loss of sialic acid may mim...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(82)90316-4
更新日期:1982-06-15 00:00:00
abstract:INTRODUCTION:Although the general improvement caused by recombinant human erythropoietin (rHuEPO) in the correction of uraemic anaemia cannot be questioned, some data suggest that the changes in the haemostasis, endothelial function and oxidative stress (SOX) are induced. The aim of the present study was to investigate...
journal_title:Thrombosis research
pub_type: 临床试验,杂志文章
doi:10.1016/j.thromres.2007.02.004
更新日期:2007-01-01 00:00:00
abstract::Isolated rat liver macrophages (Kupffer cells) produce a factor(s) which stimulates fibrinogen synthesis 5-8 fold in hepatocyte cultures. The production of the stimulatory factor reached maximum during the first 24 hours the cells were in culture. When the cell culture medium was chromatographed on a calibrated Sephad...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(83)90025-7
更新日期:1983-10-15 00:00:00
abstract:INTRODUCTION:Thrombomodulin (TM) has been described as a marker of endothelial injury in atherosclerosis. The role of TM as a predictor of PAD severity is to be proven. The goal of the present study is to compare the level of plasmatic (TMp) in patients with intermittent claudication with patients with critical ischemi...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2005.03.010
更新日期:2006-01-01 00:00:00
abstract:INTRODUCTION:No data are available regarding appropriate strategies for the transition of patients undergoing total hip or knee replacement (THR/TKR) surgery from subcutaneous low molecular weight heparin (LMWH) to rivaroxaban. This study determined the pharmacodynamic effects of rivaroxaban on the first day of adminis...
journal_title:Thrombosis research
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1016/j.thromres.2012.07.014
更新日期:2012-11-01 00:00:00
abstract::A simple and reproducible method to induce an occlusive thrombus in rabbit carotid artery is reported. Rabbits were anesthetized and prepared to record arterial pressure, heart rate, and carotid blood flow. A critical stenosis of a damaged carotid artery was obtained using an external plastic cylinder. Complete occlus...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(91)90147-o
更新日期:1991-05-15 00:00:00
abstract::We investigated the alteration of heparan sulfate proteoglycans induced by thrombin in cultured vascular endothelial cells. Heparan sulfate proteoglycans, which were metabolically labeled with [3H] glucosamine and [35S] sulfate, were isolated by DEAE-Sephacel ion-exchange chromatography and characterized by molecular ...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/s0049-3848(97)00257-0
更新日期:1997-11-01 00:00:00
abstract::Changes in the plasma thrombomodulin (TM) level were examined in endotoxin-infused rabbits. The plasma TM level in normal rabbits was 143.8 +/- 8.4 ng/ml (n = 67) and the molecular weight of the major TM was about 55 kd. Endotoxin (lipopolysaccharide, LPS, E. Coli B8:0127) was intravenously infused. LPS infusion incre...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(92)90240-b
更新日期:1992-01-15 00:00:00
abstract::Previous studies indicated that human placental anticoagulant protein, a member of the lipocortin family, prolonged the clotting time of normal plasma when clotting was induced by brain thromboplastin or by kaolin in the presence of cephalin and calcium. Using a two-stage amidolytic assay to assess factor X activation...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(87)90402-6
更新日期:1987-11-15 00:00:00
abstract::Cross reactive antigens to factor VIII have been measured in a range of vertebrate phyla. VIII coagulant antigen (VIII:CAg) measured using a human antibody was in general, much lower than reported values of VIII coagulant activity (VIII:C) except in simians and the guinea pig. The dose response curve for the assay was...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(82)90132-3
更新日期:1982-03-01 00:00:00
abstract:INTRODUCTION:Warfarin is the most widely used oral anticoagulant. It has been suggested that anticoagulation effect of warfarin is significantly associated with the polymorphism of certain genes, including Cytochrome P450 complex subunit 2C9 (CYP2C9), Vitamin K Epoxide Reductase Complex Subunit 1 (VKORC1), Gamma-Glutam...
journal_title:Thrombosis research
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.thromres.2009.10.017
更新日期:2010-04-01 00:00:00
abstract:BACKGROUND:A recent study suggested that the plasminogen activator inhibitor (PAI)-1 4G/5G genotype may play a role in the resolution of deep vein thrombosis (DVT) after surgery. In the present study, we investigated the association between PAI-1 4G/5G genotype and the persistence of venous occlusion after acute idiopa...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2017.03.017
更新日期:2017-05-01 00:00:00
abstract::Hemophilia A is an X-linked recessive bleeding disorder, widely prevalent throughout the world, for which, replacement therapy is the current treatment done by infusion of either recombinant FVIII or human plasma derived FVIII. The expression of FVIII is limited by many aspects, bioengineered FVIII with increased the ...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2011.07.015
更新日期:2011-12-01 00:00:00
abstract::Microheterogeneity of antithrombin III (ATIII) was examined in pooled normal human plasma and serum by IEF/PA and immunoblotting techniques. A pattern consisting of 8 bands varying in isoelectric point from 4.7 to 5.2 was observed in citrated plasma following IEF in a pH range of 4-6. A similar pattern was observed in...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(85)90331-7
更新日期:1985-10-15 00:00:00
abstract:INTRODUCTION:Reports on the prevalence and risk factors of atherothrombotic events (AEs) are conflicting in persons with hemophilia (PWH). METHODS:This study evaluated the prevalence and risk factors of AEs among 1054 male hemophilia patients, using data collected from Taiwan's National Health Insurance Research Datab...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2014.12.027
更新日期:2015-03-01 00:00:00
abstract:BACKGROUND:The Clauss fibrinogen method and thrombin clotting time (TCT) are still routinely used in patients with cirrhosis to define fibrinogen concentration and clotting potential. The thromboelastometric functional fibrinogen FIBTEM assay evaluates the strength of fibrin-based clots in whole blood, providing inform...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2015.04.003
更新日期:2015-06-01 00:00:00
abstract:BACKGROUND:There is a substantial local release of tissue-type plasminogen activator (t-PA) in the splanchnic vascular bed, and this release is increased at high sympathetic tone. Coronary t-PA release is also significant, and this release increases during cardiac nerve stimulation and during reperfusion after 10 min o...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2009.10.004
更新日期:2010-03-01 00:00:00
abstract::Owing to the beneficial health effects on human cardiovascular system, soybeans and soy-related products have been a focus of intensive research. Soy isoflavones are known to be primarily responsible for the soy-related biological effects including anti-platelet activity but its in vivo relevancy has not been fully ve...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2013.01.002
更新日期:2013-03-01 00:00:00
abstract:INTRODUCTION:Diabetes mellitus is characterised by hyperglycaemia that plays an important role in the pathogenesis of diabetic complications including accumulation of methylglyoxal (MG), a highly reactive alpha-dicarbonyl metabolite of glucose degradation pathways and increased generation of advanced glycation end prod...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2007.03.002
更新日期:2007-01-01 00:00:00
abstract::Activation of the coagulation and inflammatory systems are physiologically occurring during pregnancy. However, excess activation of either system is well documented in gestational vascular diseases (GVD). GVD are placenta-mediated pregnancy complications and a major cause of feto-maternal morbidity and mortality. The...
journal_title:Thrombosis research
pub_type: 杂志文章,评审
doi:10.1016/S0049-3848(17)30063-4
更新日期:2017-03-01 00:00:00
abstract:INTRODUCTION:Anedoctal reports suggest that some thrombotic primary antiphospholipid antibody syndrome (PAPS) patients on oral anticoagulation require higher than average doses to achieve given targets international normalized ratios (INR). MATERIALS AND METHODS:To test the hypothesis of relative warfarin resistance i...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2011.01.014
更新日期:2011-06-01 00:00:00
abstract::A direct assay for plasminogen activator (PA) was developed. It employed polyacrylamide gel electrophoresis in the presence of sodium dodecyl sulfate and beta-mercaptoethanol to monitor PA-mediated conversion of single chain, 125I-plasminogen to two chain plasmin. By incorporating Triton X-100, albumin and trasylol in...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(84)90008-2
更新日期:1984-05-01 00:00:00
abstract::The fibrinogen molecule consists of two sets of Aalpha, Bbeta, and gamma chains assembled into a bilateral disulfide linked (Aalpha, Bbeta, gamma)2 structure. Cleavage of the two A-fibrinopeptides (FPA, Aalpha1-16) from normal Aalpha chains with arginine at position 16 (RFPA) by thrombin or the venom enzyme atroxin tr...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/s0049-3848(00)00383-2
更新日期:2001-01-15 00:00:00
abstract:BACKGROUND:Integrin αIIbβ3 mediates platelet adhesion, aggregation and fibrin clot retraction. These processes require activation of αIIbβ3 and post-ligation signaling. Disulfide bond exchanges are involved in αIIbβ3 and αvβ3 activation. METHODS:In order to investigate the role of integrin activation and disulfide bon...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2014.02.001
更新日期:2014-05-01 00:00:00
abstract::Seven compounds having varying affinities for peripheral benzodiazepine (p sites) were evaluated in vitro as inhibitors of arachidonic acid-induced rabbit platelet aggregation and thromboxane B2 (TXB2) synthesis. With the exception of flumazenil, all compounds inhibited both parameters with IC50 values ranging from 0....
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(95)00062-v
更新日期:1995-05-15 00:00:00
abstract::Contact angle measurements, histological examinations and platelet adhesion tests on native and glutaraldehyde-treated porcine aortic valve leaflets, are reported. Contact angles measured with water or saline on native and treated leaflets do not differ appreciably. Values of less than 10 degrees for both the dry and ...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(85)90058-1
更新日期:1985-04-15 00:00:00
abstract::SK, t-PA or APSAC were incubated in human plasma (adjusted to 300,000 platelets/mm3), in vitro, for up to 90 minutes using concentrations which were equivalent to those achieved in the treatment of AMI patients. Aggregation was measured in response to ADP and collagen. SK inhibited platelet aggregation after a 60 minu...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(90)90105-l
更新日期:1990-11-15 00:00:00
abstract::A new type of assay for heparins has been devised, in which the test material competes with 125I-labelled heparin for binding to protamine-Sepharose. The assay is very sensitive and will measure heparin concentrations down to 10 ng ml-1. It responds to both the degree of sulphation and the molecular weight of acidic p...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(82)90056-1
更新日期:1982-08-15 00:00:00
abstract::We evaluate the anti-platelet and anti-thrombotic effects of cilostazol using Multiplate® and PFA-100® in vitro and ex vivo with freshly isolated rat whole blood and in vivo venous and arterial thrombosis models in the same species, in an effort to assess the sensitivity of the whole blood aggregometer assays without ...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2011.02.004
更新日期:2011-06-01 00:00:00