当前位置： SCI文献检索 > THROMBOSIS RESEARCH期刊下所有文献 > Development of a new risk score for hospital-associated venous thromboembolism in critically-ill children not undergoing cardiothoracic surgery.

Development of a new risk score for hospital-associated venous thromboembolism in critically-ill children not undergoing cardiothoracic surgery.

Abstract：

BACKGROUND:Although risk of hospital-associated venous thromboembolism (HA-VTE) differs between critically and non-critically ill children, studies to date have not led to distinct, pragmatic risk scores. OBJECTIVE:To determine risk factors for HA-VTE in critically ill children not undergoing cardiothoracic surgery, in order to derive a novel HA-VTE risk score for this population. METHODS:We conducted a retrospective analysis from January 2006 through April 2013 at All Children's Hospital Johns Hopkins Medicine. HA-VTE cases were identified using ICD-9 discharge diagnosis codes, with subsequent validation via radiologic record review. Cases were restricted to Pediatric Intensive Care Unit (PICU) admissions. Patients who underwent cardiothoracic surgery were excluded; cardiac catheterization per se was not exclusionary. For each case, three non-HA-VTE PICU controls were randomly selected. Data were abstracted on putative risk factors, and associations between risk factors and HA-VTE were estimated using odds ratios (ORs) and 95% confidence intervals (95%CIs). RESULTS:There were 57 HA-VTE cases and 171 controls. HA-VTE occurrence was 3 per 1000 PICU admissions (0.3%). Central venous catheter (CVC) (OR:26.64; 95%CI:7.46-95.13), length of stay (LOS) ≥4days (OR:20.22; 95%CI:2.27-180.07), and significant infection (OR:3.41; 95%CI:1.13-10.29) were independent, statistically-significant risk factors for HA-VTE in a multivariate model. A risk score was derived in which HA-VTE risk exceeded 2% (threshold for anticoagulant thromboprophylaxis in hospitalized adults) with a score of 15, and was >1% but <2% (risk zone for mechanical thromboprophylaxis in hospitalized adults) with scores of 7-14. CONCLUSION:The presence of a CVC, LOS≥4days and infection are significant risk factors for HA-VTE in critically ill children not undergoing cardiothoracic surgery, forming the basis for a new risk score that warrants prospective validation.

journal_name

Thromb Res

journal_title

Thrombosis research

authors

Arlikar SJ,Atchison CM,Amankwah EK,Ayala IA,Barrett LA,Branchford BR,Streiff MB,Takemoto CM,Goldenberg NA

doi

10.1016/j.thromres.2015.04.036

subject

Has Abstract

pub_date

2015-10-01 00:00:00

pages

717-22

issue

4

eissn

0049-3848

issn

1879-2472

pii

S0049-3848(15)00208-X

journal_volume

136

pub_type

杂志文章

相关文献

THROMBOSIS RESEARCH文献大全
  • Frequency of use and acceptability of clinical prediction rules for pulmonary embolism among Swiss general internal medicine residents.

    abstract：INTRODUCTION:Whether clinical prediction rules for pulmonary embolism are accepted and used among general internal medicine residents remains uncertain. We therefore evaluated the frequency of use and acceptability of the Revised Geneva Score (RGS) and the Pulmonary Embolism Severity Index (PESI), and explored which fa...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2017.09.028

    authors： Faller N,Stalder O,Limacher A,Bassetti S,Beer JH,Genné D,Battegay E,Hayoz D,Leuppi J,Mueller B,Perrier A,Waeber G,Rodondi N,Aujesky D

    更新日期：2017-12-01 00:00:00

  • Plasma anti-FXa level as a surrogate marker of the adequacy of thromboprophylaxis in critically ill patients: A systematic review.

    abstract：BACKGROUND:Critical care patients are prone to venous thromboembolism (VTE) and, thus, pharmacological thromboprophylaxis is generally advised. Low-molecular weight heparins (LMWHs) have become the drug of choice in ICU patients, since their predictable and reproducible dose response. Monitoring their pharmacological e...

    journal_title：Thrombosis research

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.thromres.2015.12.016

    authors： Vahtera A,Vaara S,Pettilä V,Kuitunen A

    更新日期：2016-03-01 00:00:00

  • Placental transfer of Org 10172, a low-molecular weight heparinoid, in the awake late-pregnant guinea pig.

    abstract：:The placental transfer of Org 10172, a low-molecular weight heparinoid, was determined in 12 awake late-pregnant guinea pigs. Nine animals receiving placebo served as controls. After 5 days i.v. treatment with Org 10172 (2 x 300 anti-Xa U/kg/day), anti-Xa activity in fetal plasma amounted to 2.4% of the maternal conce...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(86)90002-2

    authors： Peeters LL,Hobbelen PM,Verkeste CM,Vogel GM,Hasenack HG,Meuleman DG,Wallenburg HC

    更新日期：1986-11-01 00:00:00

  • Periodontopathogens induce expression of CD40L on human platelets via TLR2 and TLR4.

    abstract：INTRODUCTION:The outstanding importance of (soluble) CD40L to cardiovascular disease (CVD) is becoming increasingly apparent as CD40L is an important mediator of thrombotic and inflammatory processes. Platelets are the main source for CD40 ligand, linking platelet stimulatory events to inflammation and adverse adaptive...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2012.04.017

    authors： Assinger A,Laky M,Badrnya S,Esfandeyari A,Volf I

    更新日期：2012-09-01 00:00:00

  • Platelet reactivity evaluated with the VASP assay following ticagrelor loading dose in acute coronary syndrome patients undergoing percutaneous coronary intervention.

    abstract：BACKGROUND:The level of platelet reactivity (PR) inhibition obtained after P2Y12-ADP receptor antagonist loading dose (LD) is associated with the ischemic and bleeding risk following percutaneous coronary intervention (PCI) in acute coronary syndromes (ACS). OBJECTIVE:We aimed to evaluate the level of PR inhibition ac...

    journal_title：Thrombosis research

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.thromres.2013.04.030

    authors： Laine M,Toesca R,Berbis J,Frere C,Barnay P,Pansieri M,Peyre JP,Michelet P,Bessereau J,Camilleri E,Helaf O,Camaleonte M,Paganelli F,Dignat-George F,Bonello L

    更新日期：2013-07-01 00:00:00

  • Antithrombotic and anticomplementary properties of a very low molecular mass dermatan sulfate.

    abstract：INTRODUCTION:Dermatan sulfate, a sulfated glycosaminoglycan, acts as an anticoagulant by accelerating the inhibition of thrombin by heparin cofactor II. MATERIALS AND METHODS:A low molecular mass dermatan sulfate was obtained by peroxy-radical depolymerization from a parent dermatan sulfate. Chemical characterization ...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2007.09.001

    authors： Fabiana Alberto M,Giaquinta Romero D,Lazzari M,Calabrese GC

    更新日期：2008-01-01 00:00:00

  • Platelet adhesion at low shear rate: study of a normal population.

    abstract：:The use of oral contraceptives (OCs) has been associated with vascular complications. The mechanism(s) by which OCs predispose to thrombotic events remains unclear. Recent studies have demonstrated that postmenopausal (PM) women who take estrogen replacement therapy (ERT) have a decreased incidence of myocardial infar...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(93)90043-n

    authors： Dores GM,Miller ME,Thorpe SL

    更新日期：1993-01-15 00:00:00

  • Fibrin gel structure and clotting time.

    abstract：:Liquid permeation studies of fibrin gels, which were formed in the presence of thrombin (Fibrin II) and in the presence of Batroxobin (Fibrin I), showed that those gels have distinctly different flow properties. For both gels the permeability coefficient (Ks) and average pore size varied depending on the conditions fo...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(82)90214-6

    authors： Blombäck B,Okada M

    更新日期：1982-01-01 00:00:00

  • The Extracellular Matrix Metalloproteinase Inducer (EMMPRIN, CD147) - a potential novel target in atherothrombosis prevention?

    abstract：:The immunoglobulin superfamily member EMMPRIN (CD147) plays an important role in a number of organ systems, including the cardiovascular system. Here we review the contemporary understanding of EMMPRIN and EMMPRIN-associated sequelae in the course of atherosclerosis. A significant body of data documents the pivotal ro...

    journal_title：Thrombosis research

    pub_type： 杂志文章,评审

    doi：10.1016/j.thromres.2013.04.017

    authors： Joghetaei N,Stein A,Byrne RA,Schulz C,King L,May AE,Schmidt R

    更新日期：2013-06-01 00:00:00

  • Recombinant γT305A fibrinogen indicates severely impaired fibrin polymerization due to the aberrant function of hole 'A' and calcium binding sites.

    abstract：INTRODUCTION:We examined a 6-month-old girl with inherited fibrinogen abnormality and no history of bleeding or thrombosis. Routine coagulation screening tests showed a markedly low level of plasma fibrinogen determined by functional measurement and also a low level by antigenic measurement (functional/antigenic ratio=...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2014.06.002

    authors： Ikeda M,Kobayashi T,Arai S,Mukai S,Takezawa Y,Terasawa F,Okumura N

    更新日期：2014-08-01 00:00:00

  • Mechanisms of vascular graft thrombosis: role of altered canine platelet sensitivity to thromboxane.

    abstract：:Using the standard turbidimetric method of platelet aggregation and quantitation of platelet secretion with 14C-Serotonin, we have examined the responsiveness of the platelets of mongrel dogs to arachidonic acid (AA), and the thromboxane agonist U46619 in the presence and absence of a subthreshold concentration of epi...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(89)90300-9

    authors： McGoff MA,Allen BT,Der T,Sicard GA,Santoro SA

    更新日期：1989-09-15 00:00:00

  • The effect of red wine on the fibrinolytic system and the cellular activation reactions before and after exercise.

    abstract：:The effect of red wine drinking was tested on fibrinolytic parameters and blood cells in nine healthy students at rest and after acute exercise. The subjects were randomly assigned in a crossover design to one of three treatment regimes: control situation, low-dose wine group, and high-dose wine group. Blood samples w...

    journal_title：Thrombosis research

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0049-3848(99)00120-6

    authors： Johansen KM,Skorpe S,Olsen JO,Osterud B

    更新日期：1999-12-01 00:00:00

  • Functional characterization of a novel missense mutation, His147Arg, in A1 domain of FV protein causing type II deficiency.

    abstract：INTRODUCTION:Congenital factor V (FV) deficiency is a rare inherited disorder. Three compound heterozygous missense mutations, Asp68His, His147Arg, and Arg2074Cys, were observed in a Taiwanese patient with moderately severe FV deficiency. METHOD:The novel His147Arg mutation in the A1 domain was investigated by protein...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2014.04.005

    authors： Liu HC,Lin TM,Eng HL,Lin YT,Shen MC

    更新日期：2014-07-01 00:00:00

  • High haematocrit in cyanotic congenital heart disease affects how fibrinogen activity is determined by rotational thromboelastometry.

    abstract：INTRODUCTION:Viscoelastometry enables rapid evaluation of coagulopathy in settings such as cardiac surgery but may be influenced by red cell concentration. METHODS:In order to study the effects of supra-physiological red cell concentrations on viscoelastometry, we compared ROTEM® viscoelastometry and plasma coagulatio...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2013.07.006

    authors： Westbury SK,Lee K,Reilly-Stitt C,Tulloh R,Mumford AD

    更新日期：2013-08-01 00:00:00

  • A mathematical model for the spatio-temporal dynamics of intrinsic pathway of blood coagulation. II. Results.

    abstract：:This paper continues our study (see Part I) where we modeled the spatio-temporal dynamics of the intrinsic pathway of blood coagulation. Here, we analyzed this model and showed that it describes the threshold behavior of coagulation. When activation is subthreshold (which produces not more than 0.07 nM factor XIa at s...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/s0049-3848(96)00197-1

    authors： Zarnitsina VI,Pokhilko AV,Ataullakhanov FI

    更新日期：1996-12-01 00:00:00

  • Two monoclonal antibodies to D-dimer-specific inhibitors of fibrin polymerization.

    abstract：:D-dimer of human fibrin was used as antigen to obtain monoclonal antibodies (mAbs). We have obtained 16 hybridomas producing mAbs of different specificity. Only two of these mAbs inhibited fibrin polymerization. They are of the IgG-class. One mAb (II-4d) inhibited fibrin polymerization to 100% and another (II-3b) to 6...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2004.03.005

    authors： Lugovskoy EV,Gritsenko PG,Kolesnikova IN,Zolotarova EN,Chernishov VI,Nieuwenhuizen W,Komisarenko SV

    更新日期：2004-01-01 00:00:00

  • Quality of individual INR control and the risk of stroke and bleeding events in atrial fibrillation patients: a nested case control analysis of the ACTIVE W study.

    abstract：INTRODUCTION:Time in therapeutic range (TTR) for international normalized ratio (INR) is an accepted quality measure of anticoagulation control in patient populations, but its usefulness for predicting stroke and bleeding in individuals is not well understood. MATERIALS AND METHODS:In a nested case control analysis am...

    journal_title：Thrombosis research

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.thromres.2011.08.024

    authors： Nieuwlaat R,Connolly BJ,Hubers LM,Cuddy SM,Eikelboom JW,Yusuf S,Connolly SJ,ACTIVE Investigators.

    更新日期：2012-06-01 00:00:00

  • Discovering novel risk factors for venous thrombosis: a candidate-gene approach.

    abstract：:The candidate-gene approach can be used to locate and identify genetic variations that are associated with a particular phenotype. This gene-centric approach assumes that there exists important genetic variation within genes that can influence health. Identifying known genes which are candidates for the phenotype of i...

    journal_title：Thrombosis research

    pub_type： 杂志文章,评审

    doi：10.1016/S0049-3848(09)70139-2

    authors： Smith NL,Rice KM,Lumley T,Heckbert SR,Psaty BM

    更新日期：2009-01-01 00:00:00

  • The value of tomographic ventilation/perfusion scintigraphy (V/PSPECT) for follow-up and prediction of recurrence in pulmonary embolism.

    abstract：BACKGROUND:Pulmonary embolism (PE) is diagnosed with imaging techniques such as ventilation/perfusion (V/P) lung scintigraphy or multidetector computed tomography of the pulmonary arteries (MDCT). Lung scintigraphy can be performed with planar (V/P PLANAR) and tomographic (V/P SPECT) techniques. V/P SPECT has higher se...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2012.09.002

    authors： Alhadad A,Miniati M,Alhadad H,Gottsäter A,Bajc M

    更新日期：2012-12-01 00:00:00

  • The skin bleeding time test as a predictor of brain bleeding time in a rat model.

    abstract：:Previous studies have indicated that the skin bleeding time test does not accurately reflect visceral bleeding time (BT). The present study examines the predictive value of the skin bleeding time for brain bleeding tendency. Sixteen Sprague-Dawley rats were divided into equal groups. The first group (controls) underwe...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(94)90282-8

    authors： MacDonald JD,Remington BJ,Rodgers GM

    更新日期：1994-12-15 00:00:00

  • Prothrombin Himi; an abnormal prothrombin characterized by a defective thrombin activity.

    abstract：:An abnormal prothrombin has been detected in a 26-year-old female, who had no history of excessive bleeding. Prothrombin activity was approximately 10% when measured using either the classical one-stage assay or the assay with Echis carinatus venom, whereas prothrombin antigen level was normal. In keeping with current...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(91)90373-5

    authors： Morishita E,Saito M,Asakura H,Jokaji H,Uotani C,Kumabashiri I,Yamazaki M,Hachiya H,Okamura M,Matsuda T

    更新日期：1991-06-15 00:00:00

  • Thrombomodulin and ristocetincofactor in homocystinuria: a study in two siblings.

    abstract：:Homocystinuria due to cystathionine-beta-synthase deficiency (CBS-def-HOCY) initially often presents with vascular disorders, e.g. thromboembolic events. The measurement of vascular endothelial markers in plasma could help to assess endothelial damage. We determined von Willebrand factor (measured as Ristocetincofacto...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(95)90867-f

    authors： Schienle HW,Seitz R,Nawroth P,Rohner I,Lerch L,Krumpholz B,Krauss G,Fowler B,Baumgartner R,Willenbockel U

    更新日期：1995-01-01 00:00:00

  • Impact of mutations at the P4 and P5 positions on the reaction of antithrombin with thrombin and elastase.

    abstract：:Antithrombin (AT) is a serpin capable of trapping thrombin (IIa) in a stable and covalent complex. Complex formation is prevented by leukocyte elastase (LE) cleavage near the AT reactive centre. We mutated the known LE cleavage sites of AT to explore the possibility of producing an LE-resistant AT molecule. Initially,...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/s0049-3848(97)00228-4

    authors： Cunningham MA,Blajchman MA,Sheffield WP

    更新日期：1997-10-15 00:00:00

  • Hypermucoviscous Klebsiella pneumoniae infections induce platelet aggregation and apoptosis and inhibit maturation of megakaryocytes.

    abstract：INTRODUCTION:Different Klebsiella pneumoniae strains carry different virulence factors and antibiotic resistance and may cause thrombocytopenia. This study aimed to investigate the effects of different infections caused by K. pneumoniae on platelets. METHODS:Two hypermucoviscous K. pneumoniae strains and two classic s...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2018.09.053

    authors： Wang Z,Ren J,Liu Q,Li J,Wu X,Wang W,Wu J,Wang G,Li J

    更新日期：2018-11-01 00:00:00

  • Safety of virus inactivated antithrombin III concentrate antithrombin III immuno (AT III).

    abstract：:In a prospective clinical trial the risk of infection after application of virus inactivated antithrombin III concentrate ANTITHROMBIN III IMMUNO (AT III) was investigated in patients undergoing cardiovascular surgery. The study was conducted according to the recommendations of the International Committee on Thrombosi...

    journal_title：Thrombosis research

    pub_type： 临床试验,杂志文章

    doi：10.1016/0049-3848(92)90107-l

    authors： Preiss DU,Abdullah D,Eberspächer B,Wilhelm K

    更新日期：1992-03-15 00:00:00

  • Effects of exercise test on plasma markers of an activation of coagulation and/or fibrinolysis in patients with symptomatic or silent myocardial ischemia.

    abstract：:It has been suggested that unstable angina at rest, like acute myocardial infarction, might be associated with a thrombotic process. In order to study the hypothesis that myocardial ischemia during exercise could also be associated with an activation of blood coagulation and/or fibrinolysis, we investigated the presen...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(92)90222-v

    authors： Bounameaux H,Righetti A,de Moerloose P,Bongard O,Reber G

    更新日期：1992-01-01 00:00:00

  • A sensitive competitive binding assay for exogenous and endogenous heparins.

    abstract：:A new type of assay for heparins has been devised, in which the test material competes with 125I-labelled heparin for binding to protamine-Sepharose. The assay is very sensitive and will measure heparin concentrations down to 10 ng ml-1. It responds to both the degree of sulphation and the molecular weight of acidic p...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(82)90056-1

    authors： Dawes J,Pepper DS

    更新日期：1982-08-15 00:00:00

  • Abdominal obesity and the risk of recurrent deep vein thrombosis.

    abstract：BACKGROUND:Abdominal obesity has been found to be associated with an increased risk of deep vein thrombosis (DVT). Whether patients with abdominal obesity have an increased risk of recurrence is currently unknown. METHODS:Patients with objective diagnosis of DVT and a life expectancy of greater than 6 months underwent...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2006.05.013

    authors： Romualdi E,Squizzato A,Ageno W

    更新日期：2007-01-01 00:00:00

  • Use of purified dermatan sulfate for heparin cofactor II (HC II) assay.

    abstract：:HC II functional assays are generally preferred with respect to immunochemical assays. Nevertheless functional assays can be biased by the antithrombin III (AT III)-heparin complex activity; in fact trace amounts of heparin generally contaminate dermatan sulfate (DS) commercial preparations used as HC II reaction acti...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(92)90248-9

    authors： Ruzzenente O,Ghidini R,Poli G,Schiavon R,Guidi GC

    更新日期：1992-01-15 00:00:00

  • The treatment of venous thromboembolism in special populations.

    abstract：:Anticoagulant therapy for the typical venous thromboembolism patient is straightforward with predictably favorable outcomes. However, for certain patients with venous thromboembolism, there remains uncertainty and controversy about optimal treatment. These controversial areas include venous thromboembolism patients wi...

    journal_title：Thrombosis research

    pub_type： 杂志文章,评审

    doi：10.1016/j.thromres.2006.05.015

    authors： Rondina MT,Pendleton RC,Wheeler M,Rodgers GM

    更新日期：2007-01-01 00:00:00