Platelet activation and endogenous thrombin potential in pre-eclampsia.

Abstract:

INTRODUCTION:Platelets and the coagulation system may be involved in the pathogenesis of pre-eclampsia. We investigated whether platelet and coagulation activation markers, are elevated in pre-eclampsia. MATERIALS/METHODS:Case-control study in which activated platelets, platelet-monocyte/ neutrophil aggregates, platelet microparticles (measured by flow cytometry) and four markers of thrombin generation capacity (endogenous thrombin potential (ETP), peak height, lag time and time to peak) using the Calibrated Automated Thrombogram system were assessed in pregnant women of similar gestational age with (n=46) and without (n=46) pre-eclampsia, and in healthy non-pregnant women (n=42). RESULTS:The percentage of, CD62P+ platelets (p=0.013), CD62P+ platelet microparticles (p=0.029) and platelet-monocyte aggregates (p=0.019) were significantly higher in women with pre-eclampsia than the pregnant controls. Both groups of pregnant women had significantly higher ETP and peak height (p <0.001) than the healthy non pregnant group and the women with pre-eclampsia had significantly higher ETP and peak height (p<0.001) than the normotensive pregnant controls. CONCLUSION:In the most comprehensive laboratory analysis to date, we found evidence of both platelet and coagulation activation in women with pre-eclampsia.

journal_name

Thromb Res

journal_title

Thrombosis research

authors

Macey MG,Bevan S,Alam S,Verghese L,Agrawal S,Beski S,Thuraisingham R,MacCallum PK

doi

10.1016/j.thromres.2009.09.013

subject

Has Abstract

pub_date

2010-03-01 00:00:00

pages

e76-81

issue

3

eissn

0049-3848

issn

1879-2472

pii

S0049-3848(09)00406-X

journal_volume

125

pub_type

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