A new model of arterial thrombosis.

abstract：:Recombinant forms of human antithrombin (AT) were expressed in COS-1 cells, and their interaction with human thrombin characterized by comparing the reactivity of two engineered mutant forms of AT with the wild-type recombinant. Both mutant forms contained single amino acid substitutions of Asp (G392D) or Pro (G392P) ...

journal_title：Thrombosis research

authors： Sheffield WP,Blajchman MA

更新日期：1994-08-01 00:00:00

abstract：INTRODUCTION:Management of pregnant women at risk for venous thromboembolism (VTE) remains complex. Guidelines do not definitively fix optimal strategies due to limited trial data. Our objective was to build an easy-to-use tool allowing individualised, risk-adapted prophylaxis. MATERIALS AND METHODS:A Delphi exercise ...

journal_title：Thrombosis research

authors： Chauleur C,Gris JC,Laporte S,Rancon F,Varlet MN,Decousus H,Mismetti P,STRATHEGE Group.

更新日期：2010-08-01 00:00:00

abstract：:We investigated the alteration of heparan sulfate proteoglycans induced by thrombin in cultured vascular endothelial cells. Heparan sulfate proteoglycans, which were metabolically labeled with [3H] glucosamine and [35S] sulfate, were isolated by DEAE-Sephacel ion-exchange chromatography and characterized by molecular ...

journal_title：Thrombosis research

authors： Fujii N,Kaji T,Akai T,Koizumi F

更新日期：1997-11-01 00:00:00

abstract：:Although effective therapies for haemophilia have been available for decades, the prevention and treatment of joint disease remain major clinical concerns for all haemophilia patients. Early identification of joint disease is vital to initiate or modify treatment, and prevent arthropathy. However, there remains a need...

journal_title：Thrombosis research

authors： Lambert T,Auerswald G,Benson G,Hedner U,Jiménez-Yuste V,Ljung R,Morfini M,Remor E,Santagostino E,Zupančić Šalek S

更新日期：2014-06-01 00:00:00

abstract：:Prothrombin fragments (F1+2), thrombin-antithrombin complexes (TAT) and D-dimers, markers of hemostatic system activation, were measured in 59 consecutive patients with deep vein thrombosis (DVT). Patients were randomly treated either with subcutaneous unfractionated heparin (UH) administered in two to three subcutane...

journal_title：Thrombosis research

authors： Peternel P,Terbizan M,Tratar G,Bozic M,Horvat D,Salobir B,Stegnar M

更新日期：2002-02-01 00:00:00

abstract：:The effect of warfarin-induced factor VII deficiency on the skin bleeding time was investigated in 10 consecutive patients with mean prothrombin times of 33 sec and factor VII levels of 7%. Bleeding times in all but one subject were entirely within the normal range. We conclude that warfarin administration, even to th...

journal_title：Thrombosis research

authors： Green D,Ts'ao CH

更新日期：1983-02-15 00:00:00

abstract：:Clot lysis induced by streptokinase has been studied and the influences of pH and the concentrations of plasminogen, fibrinogen and buffer composition investigated. Variations in the concentrations of plasminogen strongly effect the SK apparent activity, maxima being obtained at different plasminogen concentrations li...

journal_title：Thrombosis research

authors： Westlund LE,Andersson LO

更新日期：1991-12-15 00:00:00

abstract：:Two monoclonal antibodies against plasminogen and two against alpha-2-antiplasmin were characterized regarding their binding properties towards their respective native and modified antigens and towards the plasmin-alpha-2-antiplasmin complex. Using an ELISA system, the two monoclonal antibodies against plasminogen (MP...

journal_title：Thrombosis research

authors： Hattey E,Wojta J,Binder BR

更新日期：1987-03-01 00:00:00

abstract：:We purified the urinary procoagulant from frozen human urine by introducing phenyl-Sepharose hydrophobic chromatography. By this method, the apoprotein of the procoagulant and the lipid-like substance were separately recovered. Upon reassociation with the lipid-like substance or exogenous crude phospholipids, the apop...

journal_title：Thrombosis research

authors： Kurosawa S,Matsuda M,Aoki N

更新日期：1984-03-15 00:00:00

abstract：:Studies of the factors affecting the first recurrence of ischemic stroke have reported inconsistent findings. Types of initial stroke and the racial differences in study samples are among the explanations that may account for this inconsistency. The aims of this study were to estimate the cumulative recurrence rates o...

journal_title：Thrombosis research

authors： Wu TH,Chen HH,Lee TK

更新日期：2000-02-01 00:00:00

abstract：:Activation of plasma plasminogen to plasmin is the objective of current strategies for thrombolytic therapy. Although thrombolytic activity in blood involves a large cellular component as well as that in plasma, the contribution of this cellular phase to clinical thrombolysis has not been examined. Using a 125I-fibrin...

journal_title：Thrombosis research

authors： Langleben D,Moroz LA,Schlesinger RD

更新日期：1990-07-15 00:00:00

abstract：:In this study, we investigated the effects of a 3-min insulin incubation both at physiological and at supraphysiological concentrations on platelet aggregation and intraplatelet cyclic guanosine monophosphate (cGMP) levels both in the absence and in the presence of phosphodiesterase inhibition. We observed that insuli...

journal_title：Thrombosis research

authors： Anfossi G,Massucco P,Mattiello L,Piretto V,Mularoni E,Cavalot F,Paoletti G,Trovati M

更新日期：1996-04-01 00:00:00

abstract：INTRODUCTION:Guidelines recommend the assessment of stroke and bleeding risk before initiating warfarin anticoagulation in patients with atrial fibrillation. Many of the elements used to predict stroke also overlap with bleeding risk in atrial fibrillation patients and it is tempting to use stroke risk scores to effici...

journal_title：Thrombosis research

authors： Barnes GD,Gu X,Haymart B,Kline-Rogers E,Almany S,Kozlowski J,Besley D,Krol GD,Froehlich JB,Kaatz S

更新日期：2014-08-01 00:00:00

abstract：INTRODUCTION:Edoxaban is an oral, once-daily direct factor Xa (FXa) inhibitor. Although rapidly cleared, strategies to reverse edoxaban-mediated effects on anticoagulation are needed in cases of excessive bleeding or emergency. This study evaluated the effect of two prohemostatic agents, recombinant factor VIIa (rFVIIa...

journal_title：Thrombosis research

authors： Halim AB,Samama MM,Mendell J

更新日期：2014-10-01 00:00:00

abstract：INTRODUCTION:Thrombosis and coagulation abnormalities are thought to be involved in disease progression of pulmonary hypertension. Platelet-derived microparticles (PDMP) are released from platelets following stimulation and have recently been demonstrated to play an important role in pathogenesis of various diseases. T...

journal_title：Thrombosis research

authors： Ogawa A,Matsubara H

更新日期：2020-11-01 00:00:00

abstract：:The fibrinolytic potential of tissue-type plasminogen activator (t-PA) either incorporated in a clot (endogenous) or added to the surrounding plasma (exogenous), was studied in an in vitro system consisting of 125I-labeled human plasma clots (200 microliters) immersed in human plasma (2 ml). Clot lysis was measured as...

journal_title：Thrombosis research

authors： Zamarron C,Lijnen HR,Collen D

更新日期：1984-08-01 00:00:00

abstract：:The Coa-set Fibrin Monomer test (CFM-test) is a quantitative method for determination of soluble fibrin in plasma. The fibrin standard of the CFM-test is produced by bathroxobin conversion of purified fibrinogen to fibrin. Plasma treated with minute amounts of thrombin may be considered as a more physiological way of ...

journal_title：Thrombosis research

authors： Halvorsen S,Skjønsberg OH,Godal HC

更新日期：1993-11-15 00:00:00

abstract：BACKGROUND:Few studies investigated the relationship between fibrinolysis abnormalities and residual pulmonary perfusion defects after acute pulmonary embolism (PE). OBJECTIVE:To assess the fibrinolytic profile in patients with prior PE in relation to the extent of scintigraphically detectable residual perfusion abnor...

journal_title：Thrombosis research

authors： Lami D,Cellai AP,Antonucci E,Fiorillo C,Becatti M,Grifoni E,Cenci C,Marcucci R,Mannini L,Miniati M,Abbate R,Prisco D

更新日期：2014-09-01 00:00:00

abstract：:Extended half-life (EHL) products have shown robust efficacy in clinical trials, whilst allowing for less intense treatment regimens when compared with standard half-life products. Regimen optimisation with EHL products could lead to further improvements in bleeding rates, quality of life and reductions in treatment b...

journal_title：Thrombosis research

authors： Chowdary P

更新日期：2020-12-01 00:00:00

abstract：:Change in the density of circulating platelets in monkeys was studied by using a method that removed greater than 90% of the platelet population from whole blood. These were labelled with 51-Cr and reinjected, having been protected by prostacyclin while in vitro. Platelets were separated into density subpopulations th...

journal_title：Thrombosis research

authors： Martin JF,Penington DG

更新日期：1983-04-15 00:00:00

abstract：:Antithrombin III (AT III) is increased in situations where there is increased platelet turnover. Plasma AT III levels measured in 39 renal transplant recipients were significantly higher than in 20 healthy subjects (p less than 0.001) and 20 patient controls (p less than 0.025). AT III levels were significantly correl...

journal_title：Thrombosis research

authors： Woo KT,Lee EJ,Lau YK,Lim CH

更新日期：1985-05-01 00:00:00

abstract：:Platelet prothrombin converting activity was measured in a system using washed human platelets and purified coagulation factors Xa, Va and prothrombin. Exposure of platelet prothrombin converting activity evoked by collagen or the combined action of collagen and thrombin was effectively inhibited when a collagen deriv...

journal_title：Thrombosis research

authors： Bevers EM,Karniguian A,Legrand YJ,Zwaal RF

更新日期：1985-02-01 00:00:00

abstract：:Severe prekallikrein (Fletcher factor) deficiency was diagnosed in a 49-year-old woman and in 3 of her siblings. Functional prekallikrein (PKK) activity was found below 1% by clotting assay and 20% by amidolytic assay in all the affected subjects; PKK cross-reacting material (CRM) was present in all the patients (anti...

journal_title：Thrombosis research

authors： De Stefano V,Leone G,Teofili L,De Marinis L,Micalizzi P,Fiumara C,Bizzi B

更新日期：1990-12-01 00:00:00

abstract：:Flavocetin-A is a strong platelet aggregation inhibitor isolated from the venom of Trimeresurus flavoviridis. It binds specifically to platelet glycoprotein Ib with high affinity and inhibits von Willebrand factor-dependent platelet aggregation. The apparent molecular weight of flavocetin-A is 149 kDa. It consists of ...

journal_title：Thrombosis research

authors： Shin Y,Okuyama I,Hasegawa J,Morita T

更新日期：2000-08-01 00:00:00

abstract：INTRODUCTION:Fibrin structure and cellular composition of thrombi profoundly affect the clinical outcomes in ischemic coronary and peripheral artery disease. Our study addressed the interrelations of structural features of thrombi and routinely measured laboratory parameters. MATERIALS AND METHODS:Thrombi removed by t...

journal_title：Thrombosis research

authors： Kovács A,Sótonyi P,Nagy AI,Tenekedjiev K,Wohner N,Komorowicz E,Kovács E,Nikolova N,Szabó L,Kovalszky I,Machovich R,Szelid Z,Becker D,Merkely B,Kolev K

更新日期：2015-04-01 00:00:00

abstract：:Separation of plasma, erythrocytes, and platelets was studied in T-shaped bifurcations prepared by a casting technique. The diameters of the side and main channel were 100 microns and 200 microns, respectively. Small blood samples (about 20 microliters) were collected from the side channel for determination of erythro...

journal_title：Thrombosis research

authors： Perkkiö J,Wurzinger LJ,Schmid-Schönbein H

更新日期：1987-03-01 00:00:00

abstract：:Lysophosphatidic acid (LPA) is a lipid mediator generated by activated platelets and having various effects on numerous cell types. We investigated some effects of 1-oleyl LPA on vascular smooth muscle cells cultured from adult human normal arteries. At micromolar concentrations, LPA induced a mitogenic effect ([3H]-t...

journal_title：Thrombosis research

authors： Gennero I,Xuereb JM,Simon MF,Girolami JP,Bascands JL,Chap H,Boneu B,Sié P

更新日期：1999-06-01 00:00:00

abstract：:Time response curves of the anti-thrombotic effects, bleeding enhancing effects, effects on APTT, anti-Xa activities, anti-thrombin activities and thrombin generation inhibitory activities of the low molecular weight heparinoid Org 10172 and heparin have been compared in rats. The time courses of these effects were si...

journal_title：Thrombosis research

authors： Hobbelen PM,Vogel GM,Meuleman DG

更新日期：1987-12-01 00:00:00

abstract：INTRODUCTION:The A-subunit of blood coagulation factor XIII is a pro-transglutaminase, which cross-links α- and γ-fibrin-chains in its activated form. Selective inhibitors against FXIII-A may be desirable drugs to prevent the development of thromboses. Animal models are generally used for proof of principle and for tox...

journal_title：Thrombosis research

authors： Heil A,Weber J,Büchold C,Pasternack R,Hils M

更新日期：2013-05-01 00:00:00

abstract：:Two types of LMW heparin were prepared by gel filtration of standard heparin (LMW fraction) and by degradation of heparin by nitrous acid (LMW fragment), respectively. The effects on factor Xa inhibition (XaI), APTT, platelet aggregation and AT III level of these preparations were studied after subcutaneous administra...

journal_title：Thrombosis research

authors： Bergqvist D,Hedner U,Sjörin E,Holmer E

更新日期：1983-11-15 00:00:00