Abstract：
:We investigated the age-related changes in blood coagulation, fibrinolysis, and platelet aggregation in male WBN/Kob rats, animals that exhibit spontaneously diabetes mellitus at more than 6 months of age. The rats aged 6 months or more showed significant hyperglycemia, hypoinsulinemia, and hyperlipidemia. As changes in coagulation parameters, the data indicated significant increases in factors II, V, VII, VIII, IX, X, and XII activities; a significant decrease in antithrombin III activity in rats more than 6 months of age; significant increases in fibrinogen level and factor XI activity; and significant decreases in prothrombin time and activated partial thromboplastin time in those more than 9 months of age. As changes in fibrinolytic parameters, the animals showed significant decreases in plasminogen and tissue-type plasminogen activator, and significant increases in alpha2-plasmin inhibitor and plasminogen activator inhibitor at more than 6 months of age. In addition, there were significant correlations between the plasma levels of coagulation/fibrinolytic markers and the 4-hour fasting glucose or lipids. Furthermore, they displayed significant increases in ADP- or collagen-induced platelet aggregation and in cholesterol/phospholipid molar ratio in platelets at more than 9 months of age. The increase in cholesterol/phospholipid ratio may be responsible for hyperaggregation of platelets in diabetic animals. These findings suggest that WBN/Kob rats are suitable for research on blood coagulation abnormalities in diabetes. However, further studies are needed to clarify the details of the mechanisms involved.
journal_name
Thromb Resjournal_title
Thrombosis researchauthors
Nobukata H,Ishikawa T,Obata M,Shibutani Ydoi
10.1016/s0049-3848(00)00196-1subject
Has Abstractpub_date
2000-06-15 00:00:00pages
507-16issue
6eissn
0049-3848issn
1879-2472pii
S0049-3848(00)00196-1journal_volume
98pub_type
杂志文章abstract：:Studies of the factors affecting the first recurrence of ischemic stroke have reported inconsistent findings. Types of initial stroke and the racial differences in study samples are among the explanations that may account for this inconsistency. The aims of this study were to estimate the cumulative recurrence rates o...
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journal_title：Thrombosis research
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pub_type： 杂志文章
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pub_type： 杂志文章
doi：10.1016/0049-3848(96)00004-7
更新日期：1996-02-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.thromres.2006.12.004
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pub_type： 杂志文章,随机对照试验
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pub_type： 临床试验,杂志文章,随机对照试验
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pub_type： 杂志文章,评审
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pub_type： 杂志文章
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更新日期：2015-12-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/0049-3848(83)90093-2
更新日期：1983-11-15 00:00:00
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pub_type： 临床试验,杂志文章
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journal_title：Thrombosis research
pub_type： 杂志文章
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更新日期：1999-07-15 00:00:00
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journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(92)90081-k
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pub_type： 杂志文章
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pub_type： 杂志文章,多中心研究
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