Elevated lipid peroxide levels in platelets of chronic ischemic heart disease patients.

abstract：:The effects of sodium salicylate (SS) on ADP-induced platelet aggregation and on a metabolism of calcium in platelets were studied, using gel-filtrated platelets (GFP). SS inhibited dose-responsively ADP-induced aggregation in the presence of fibrinogen and Ca2+. It was found that extracellular 45Ca2+ was rapidly take...

journal_title：Thrombosis research

authors： Irino O,Saitoh K,Ohkubo K,Hashimoto S

更新日期：1985-08-01 00:00:00

abstract：:The complex relation between thrombotic thrombocytopenic purpura (TTP) and pregnancy is concisely reviewed. Pregnancy is a very strong trigger for acute disease manifestation in patients with hereditary TTP caused by double heterozygous or homozygous mutations of ADAMTS13 (ADisintegrin And Metalloprotease with Thrombo...

journal_title：Thrombosis research

authors： von Auer C,von Krogh AS,Kremer Hovinga JA,Lämmle B

更新日期：2015-02-01 00:00:00

abstract：INTRODUCTION:The purpose of the present study was to study the concept of aspirin resistance or non-responsiveness by investigating the response to long-term aspirin therapy in patients with a former acute myocardial infarction (AMI). MATERIALS AND METHODS:Patients with an AMI (n=202) randomly assigned to aspirin 160 ...

journal_title：Thrombosis research

authors： Andersen K,Hurlen M,Arnesen H,Seljeflot I

更新日期：2002-10-01 00:00:00

abstract：:Postoperative chylothorax is a frequently encountered pathology occurring in up to 4% of patients undergoing surgery for repair of congenital heart disease. Symptomatic thrombosis is associated with chylothorax and may contribute to its severity and duration. Furthermore, vessel thrombosis resulting in persistent vess...

journal_title：Thrombosis research

authors： Bauman ME,Moher C,Bruce AK,Kuhle S,Kaur S,Massicotte MP

更新日期：2013-08-01 00:00:00

abstract：:Cell lysates of the human monoblastic leukemia cell line, THP-1, have procoagulant activity (PCA) that is Ca++-dependent and not demonstrable in either Factor VII-, or Factor X-deficient plasma. The PCA of THP-1 cells was enhanced by human recombinant tumor necrosis factor-alpha (TNF-alpha) up to five fold. There was ...

journal_title：Thrombosis research

authors： Tanaka M

更新日期：1989-10-15 00:00:00

abstract：:The loss of sialic acid was determined in human platelets stored during a seven day period in their homologous plasma. Approximately 30% of the sialic acid was lost during the first three days of incubation at room temperature and a total of 73% was lost after seven days. The rapid in vitro loss of sialic acid may mim...

journal_title：Thrombosis research

authors： Soslau G,Giles J

更新日期：1982-06-15 00:00:00

abstract：:The pharmacodynamic and pharmacokinetic properties of endpoint-attached N'alkylamine derivatives of low molecular mass heparin (LMMH), low molecular mass heparin (LMMH), low molecular mass heparin-tyramine (LMMH-tyr) and low molecular mass heparin-tyramine-fluorescein-5-isothiocyanate (LMMH-tyr-fitc) were investigated...

journal_title：Thrombosis research

authors： Malsch R,Piazolo L,Harenberg J,Heene DL

更新日期：1995-11-01 00:00:00

abstract：:A platelet storage pool deficiency (SPD) is present in platelets from cattle with the Chediak-Higashi syndrome (CHS). The most plausible hypothesis for the SPD is that dense granule precursors are simply not formed in CHS megakaryocytes. There is, however, evidence that some recently acquired 5-hydroxytryptamine (5HT)...

journal_title：Thrombosis research

authors： Meyers KM,Costa JL,Magnuson J

更新日期：1990-05-01 00:00:00

abstract：BACKGROUND:Many heparin-induced thrombocytopenia (HIT) antibodies cause platelet activation in the serotonin release assay (SRA) in the absence of heparin. This in vitro observation may help unravel the mechanism of delayed-onset HIT, where seropositive patients develop thrombocytopenia and associated thrombosis after ...

journal_title：Thrombosis research

authors： Prechel MM,Jeske WP,Walenga JM

更新日期：2010-04-01 00:00:00

abstract：INTRODUCTION:Peripheral artery disease (PAD) affects 8.5 million Americans and thus improving our understanding of PAD is critical to developing strategies to reduce disease burden. The objective of the study was to determine the association of ABO blood type with ankle brachial index (ABI) as well as prevalent and inc...

journal_title：Thrombosis research

authors： Pike MM,Larson NB,Wassel CL,Cohoon KP,Tsai MY,Pankow JS,Hanson NQ,Decker PA,Berardi C,Alexander KS,Cushman M,Zakai NA,Bielinski SJ

更新日期：2017-05-01 00:00:00

abstract：:Practice variation, the differences in clinical management between physicians, is one reason why patient outcomes may differ. Identifying factors that contribute to practice variation in areas of clinical uncertainty or equipoise may have implications for understanding and improving patient care. To discern what facto...

journal_title：Thrombosis research

authors： Skeith L,Gonsalves C

更新日期：2017-11-01 00:00:00

abstract：:The release of arachidonic acid, and its subsequent conversion to thromboxane A2, is an important component of platelet activation. The precise mechanism of arachidonic acid release is unknown although cytosolic phospholipase A2 (cPLA2) has been implicated. In the present study the effects of three agonists, the serin...

journal_title：Thrombosis research

authors： McNicol A,Shibou TS

更新日期：1998-10-01 00:00:00

abstract：UNLABELLED:Suboptimal gastrointestinal absorption is a problem for many direct thrombin inhibitors. The studies presented herein describe the new oral direct thrombin inhibitor H 376/95, a prodrug with two protecting residues added to the direct thrombin inhibitor melagatran. Absorption properties in vitro: H 376/95 is...

journal_title：Thrombosis research

authors： Gustafsson D,Nyström J,Carlsson S,Bredberg U,Eriksson U,Gyzander E,Elg M,Antonsson T,Hoffmann K,Ungell A,Sörensen H,Någård S,Abrahamsson A,Bylund R

更新日期：2001-02-01 00:00:00

abstract：:Severe rejection crises occurred in 13 out of 20 cadaver kidney recipients; removal of the graft was inevitable in 10 cases. The plasminogen levels were found to be lower (76.5 +/- 2.9%) in the 13 patients with impaired graft acceptance (group B) than in the 7 patients experiencing only moderate rejection (group A, 93...

journal_title：Thrombosis research

authors： Seitz R,Michalik R,Karges HE,Lange H,Egbring R

更新日期：1986-05-01 00:00:00

abstract：:Platelet aggregation induced by ADP and collagen was monitored in 25 patients with increased serum levels of triglycerides (7 HLPs type IIb, 14 type IV, 4 type V patients) and compared with a group of 10 normolipidaemic control persons. Platelet aggregation was studied simultaneously in platelet rich plasma (PRP) by b...

journal_title：Thrombosis research

authors： Riess H,Merk W,Falkner C,Hiller E

更新日期：1986-02-01 00:00:00

abstract：:Human tissue plasminogen activator (t-PA) was shown to bind specifically to human osteosarcoma cells (HOS), and human epidermoid carcinoma cells (A-431 cells). Crosslinking studies with DTSSP demonstrated high molecular weight complexes (130,000) between 125I-t-PA and cell membrane protein on human umbilical vein endo...

journal_title：Thrombosis research

authors： Beebe DP,Wood LL,Moos M

更新日期：1990-07-15 00:00:00

abstract：INTRODUCTION:The TF-FVIIa complex is the primary activator of coagulation. Elevated levels of microvesicle (MV) bearing tissue factor (TF)-dependent procoagulant activity are detectable in patients with an increased risk of thrombosis. Several methods have been described to measure MV TF activity but they are hampered ...

journal_title：Thrombosis research

authors： Vallier L,Bouriche T,Bonifay A,Judicone C,Bez J,Franco C,Guervilly C,Hisada Y,Mackman N,Houston R,Poncelet P,Dignat-George F,Lacroix R

更新日期：2019-10-01 00:00:00

abstract：:Mice were implanted subcutaneously with a pellet containing 0.5 mg estradiol or with a placebo. Eight to 12 days later platelet aggregation was produced in mesenteric arterioles by injuring their endothelium in vivo with a noxious light/dye stimulus. The time between the onset of the noxious stimulus and the appearanc...

journal_title：Thrombosis research

authors： Rosenblum WI,el-Sabban F,Allen AD,Nelson GH,Bhatnagar AS,Choi S

更新日期：1985-08-01 00:00:00

abstract：BACKGROUND:The treatment of venous thromboembolism (VTE) in cancer patients remains controversial. PURPOSE:The Italian Society for Thrombosis and Haemostasis (SISET) commissioned a project to develop clinical practice guidelines for the therapy of VTE in patients with malignancies. METHODS:Key questions about the tre...

journal_title：Thrombosis research

authors： Imberti D,Di Nisio M,Donati MB,Falanga A,Ghirarduzzi A,Guarneri D,Piovella F,Santoro RC,Baldini E,Zampogna S,Italian Society for Thrombosis and Haemostasis.

更新日期：2009-11-01 00:00:00

abstract：:A prolongation of the thrombin clotting time by at least 25% was found in the presence of 8 of 26 IgG myeloma proteins, 2 of 5 IgA proteins and 1 of 10 macroglobulins, in a concentration of 10 mg/ml. Normal pooled immunoglobulin in concentrations up to 83 mg/ml were inactive. 2 IgG and 2 IgM monoclonal immunoglobulins...

journal_title：Thrombosis research

authors： Wisløff F,Michaelsen TE,Godal HC

更新日期：1984-07-01 00:00:00

abstract：:SK, t-PA or APSAC were incubated in human plasma (adjusted to 300,000 platelets/mm3), in vitro, for up to 90 minutes using concentrations which were equivalent to those achieved in the treatment of AMI patients. Aggregation was measured in response to ADP and collagen. SK inhibited platelet aggregation after a 60 minu...

journal_title：Thrombosis research

authors： Fears R,Ferres H,Greenwood HC

更新日期：1990-11-15 00:00:00

abstract：:Heat treatment is employed to diminish the transmission of hepatitis when blood products are administered. It is possible that such a procedure could reduce the biological activity of the proteins and induce changes in structure and aggregation state. We have therefore made in vitro and pharmacokinetic studies of heat...

journal_title：Thrombosis research

authors： Tengborn L,Frohm B,Nilsson LE,Johansson L,Andersson LO

更新日期：1987-12-15 00:00:00

abstract：BACKGROUND:To investigate the impact of atrial fibrillation/flutter (AF) on adverse in-hospital outcomes in hospitalized surgical patients. METHODS:The nationwide German inpatient sample of the years 2005-2018 was used for this analysis. Surgical patients were stratified by AF and compared. Logistic regression models ...

journal_title：Thrombosis research

authors： Keller K,Hobohm L,Engelhardt M

更新日期：2020-12-01 00:00:00

abstract：:We constructed a new factor IX expression vector containing a full length factor IX cDNA. The Moloney Murine Leukemia Virus (MoMLV)-based retroviral vector pLRNL was cloned with the entire coding region of human factor IX down stream of the promoter of Rous sarcoma virus, giving rise to the construct pL9RNL. The GP+E ...

journal_title：Thrombosis research

authors： Matsushita T,Emi N,Takahashi I,Takamatsu J,Saito H

更新日期：1993-02-15 00:00:00

abstract：:Platelet alpha adrenoceptor status was examined using the radioligands 3H-yohimbine (3H-YOH) and 3H-dihydroergocryptine (3H-DHE) in 14 patients with myeloproliferative disorder (MPD) and 10 normal controls. Platelets from normal controls and MPD patients sensitive to adrenaline induced aggregation exhibited approximat...

journal_title：Thrombosis research

authors： Swart SS,Wood JK,Barnett DB

更新日期：1985-12-01 00:00:00

abstract：:Advances in antithrombotic therapy began when traditional anticoagulant agents such as heparin and the vitamin K antagonists like Coumadin became commercially available in the 1940s and 1950s. Inherent limitations of these compounds, including the need for monitoring and multiple food and drug interactions (with couma...

journal_title：Thrombosis research

authors： Spyropoulos AC

更新日期：2008-01-01 00:00:00

abstract：:The fibrin sleeve of venous catheters (VC) and parietal thrombi represent frequent and dangerous side-effects of central venous catheterization (CVC), due to the risk of embolism. Reduced levels of coagulation clotting factors inhibitors (such as Antithrombin III) are known to be associated with increased thrombogenic...

journal_title：Thrombosis research

authors： De Cicco M,Matovic M,Balestreri L,De Angelis V,Fracasso A,Morassut S,Coran F,Babare R,Buonadonna A,Testa V

更新日期：1995-04-15 00:00:00

abstract：INTRODUCTION:D-dimer, a fibrin degradation product, is related to risk of cardiovascular disease and venous thromboembolism. Genetic determinants of D-dimer are not well characterized; notably, few data have been reported for African American (AA), Asian, and Hispanic populations. MATERIALS AND METHODS:We conducted a ...

journal_title：Thrombosis research

authors： Weng LC,Tang W,Rich SS,Smith NL,Redline S,O'Donnell CJ,Basu S,Reiner AP,Delaney JA,Tracy RP,Palmer CD,Young T,Yang Q,Folsom AR,Cushman M

更新日期：2014-08-01 00:00:00

abstract：INTRODUCTION:Inherited thrombophilia has been associated with unexplained recurrent pregnancy loss (RPL) and stillbirth. This thrombotic tendency can manifest as thrombotic lesions in the placenta, and may lead to abortion and stillbirth. The aim of our case-control study was to investigate the prevalence of FVL and FI...

journal_title：Thrombosis research

authors： Sottilotta G,Oriana V,Latella C,Luise F,Piromalli A,Ramirez F,Mammì C,Santoro R,Iannaccaro P,Muleo G,Lombardo VT

更新日期：2006-01-01 00:00:00

abstract：:Bleeding events are a common adverse effect in oral anticoagulation that frequently depend on the duration and intensity of treatment. Major bleeding events, particularly intracerebral hemorrhages, are a serious complication in cases that require the rapid reversal of anticoagulation. Urgent correction of the coagulat...

journal_title：Thrombosis research

authors： Pindur G,Mörsdorf S

更新日期：1999-08-15 00:00:00