Abstract:
:The purpose of this study was to determine whether plasma von Willebrand factor concentrations are correlated with the degree of intestinal ischaemia-reperfusion injury. Forty-six anaesthetised adult Wistar rats were divided into five groups. The sham-operated group (S, n=10) had laparotomy and isolation of the superior mesenteric artery without clamping. Three ischaemia-reperfusion groups (n=10 in each) had clamping of the superior mesenteric artery for 15, 30, and 45 minutes, respectively, and reperfusion for 15 minutes. A control group (C, n=6) had direct puncture of the heart to sample blood. Mean arterial pressure was measured continuously. Blood was collected at the end of the study to measure von Willebrand factor. The small bowel injury was graded histologically. There was a significant systemic hypotension after declamping in all ischaemia-reperfusion groups, which had a high negative correlation with the histological score (R=-0.46, F=10.1, p<0.003, simple linear regression). Plasma von Willebrand factor was significantly elevated in the three ischaemia-reperfusion groups compared with the control group but not significantly different from the sham-operated group (mean von Willebrand factor concentration (SEM): 156 (29), 283 (29), 295 (25), 381 (44), and 366 (40)% in C, S, ischaemia-reperfusion 15, ischaemia-reperfusion 30, and ischaemia-reperfusion 45 groups, respectively). The concentration of von Willebrand factor was not correlated to the histological score (R=0.22, F=1.83, p<0.2) or the degree of hypotension after the removal of the clamp (R=-0.22, F=1.8, p<0.2, simple linear regression). This study shows that von Willebrand factor concentration does not correlate with the degree of intestinal ischaemia-reperfusion injury. It is unlikely that von Willebrand factor can be used as a predictor of disease severity.
journal_name
Thromb Resjournal_title
Thrombosis researchauthors
Abu-Zidan FM,Farrant G,Zwi LJ,Simovic MO,Day T,Bonham MJ,Windsor JAdoi
10.1016/s0049-3848(99)00013-4subject
Has Abstractpub_date
1999-06-15 00:00:00pages
353-8issue
6eissn
0049-3848issn
1879-2472pii
S0049-3848(99)00013-4journal_volume
94pub_type
杂志文章abstract::The two objectives of the study were to determine whether a procedure could be developed for measuring cancer procoagulant (CP) activity in human serum and if this procedure provided a method for distinguishing people with cancer from those without cancer. A procedure was developed for processing human serum such that...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(89)90256-9
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journal_title:Thrombosis research
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doi:10.1016/0049-3848(84)90152-x
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doi:10.1016/0049-3848(92)90263-a
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journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(89)90042-x
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doi:10.1016/0049-3848(95)99610-k
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journal_title:Thrombosis research
pub_type: 杂志文章,meta分析
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journal_title:Thrombosis research
pub_type: 杂志文章
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journal_title:Thrombosis research
pub_type: 杂志文章
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journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(83)90227-x
更新日期:1983-05-15 00:00:00
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journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(86)90133-7
更新日期:1986-10-15 00:00:00
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journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/s0049-3848(00)00191-2
更新日期:2000-06-01 00:00:00
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journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(87)90102-2
更新日期:1987-09-15 00:00:00
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journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2007.08.004
更新日期:2008-01-01 00:00:00
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journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/s0049-3848(01)00242-0
更新日期:2001-05-01 00:00:00
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journal_title:Thrombosis research
pub_type: 杂志文章
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更新日期:2018-04-01 00:00:00
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journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2018.05.016
更新日期:2018-07-01 00:00:00
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journal_title:Thrombosis research
pub_type: 杂志文章,评审
doi:10.1016/j.thromres.2012.08.281
更新日期:2012-10-01 00:00:00
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journal_title:Thrombosis research
pub_type: 杂志文章,评审
doi:10.1016/j.thromres.2007.03.014
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journal_title:Thrombosis research
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doi:10.1016/j.thromres.2012.05.003
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journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2019.01.016
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journal_title:Thrombosis research
pub_type: 临床试验,杂志文章
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更新日期:2002-09-01 00:00:00
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journal_title:Thrombosis research
pub_type: 临床试验,杂志文章,多中心研究
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更新日期:2012-07-01 00:00:00
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journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2016.01.025
更新日期:2016-04-01 00:00:00
abstract::Change in the density of circulating platelets in monkeys was studied by using a method that removed greater than 90% of the platelet population from whole blood. These were labelled with 51-Cr and reinjected, having been protected by prostacyclin while in vitro. Platelets were separated into density subpopulations th...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(83)90238-4
更新日期:1983-04-15 00:00:00
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journal_title:Thrombosis research
pub_type: 临床试验,杂志文章
doi:10.1016/j.thromres.2011.07.022
更新日期:2012-04-01 00:00:00
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journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2015.04.003
更新日期:2015-06-01 00:00:00
abstract:INTRODUCTION:The epidemiology of tamoxifen and venous thromboembolism (VTE) is not well understood, and most data on tamoxifen toxicity are from adjuvant clinical trials. This study examined the relationship between the duration of tamoxifen use in female patients with breast cancer and the risk of VTE in a large popul...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2011.11.025
更新日期:2012-07-01 00:00:00
abstract:INTRODUCTION:Systemic embolism is the most serious complication of cardioversion of atrial fibrillation (AF) and the immediate post-cardioversion period is associated with increased risk for thrombus formation. For this reason, treatment with vitamin K antagonist (VKA) is recommended for patients with AF. No informatio...
journal_title:Thrombosis research
pub_type: 杂志文章,多中心研究
doi:10.1016/j.thromres.2011.08.031
更新日期:2012-05-01 00:00:00
abstract::Tissue factor (TF) is an integral membrane glycoprotein that serves as a cofactor for blood coagulation factor VIIa. The induction of TF on the surface of endothelial cells is initiated by various kinds of stimuli including lipopolysaccharide (LPS), interleukin-1 beta (IL-1 beta), and tumor necrosis factor alpha (TNF ...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(94)90002-7
更新日期:1994-04-15 00:00:00