Antithrombotic activity of a symmetrical triglyceride with eicosapentaenoic acid and gamma-linolenic acid in guinea pig mesenteric microvasculature.

abstract：:Blood platelets have recently been shown to express PYK2, a nonreceptor tyrosine kinase belonging to the FAK gene family. In this study, we examined the involvement of protein kinase C (PKC) in PYK2-related responses in human platelets. While PYK2 tyrosine phosphorylation induced by thrombin was inhibited by preincuba...

journal_title：Thrombosis research

authors： Ohmori T,Yatomi Y,Asazuma N,Satoh K,Ozaki Y

更新日期：1999-03-15 00:00:00

abstract：:Among central Europeans polymorphisms of GPIIIa, GPIb, GPIIb, and GPIa named human platelet antigen-1 (HPA-1), -2, -3, and -5 are the clinically most relevant systems in which alloimmunization occurs. These genetically determined polymorphisms of glycoproteins may render platelets sensible for plaque formation and thu...

journal_title：Thrombosis research

authors： Sperr WR,Huber K,Roden M,Janisiw M,Lang T,Graf S,Maurer G,Mayr WR,Panzer S

更新日期：1998-05-01 00:00:00

abstract：INTRODUCTION:The contribution of platelet activation to the pathogenesis of sickle cell disease (SCD) remains uncertain. We evaluated the safety and efficacy of eptifibatide, a synthetic peptide inhibitor of the αIIbβ3 receptor, in SCD patients during acute painful episodes. MATERIALS AND METHODS:In this single site, ...

journal_title：Thrombosis research

authors： Desai PC,Brittain JE,Jones SK,McDonald A,Wilson DR,Dominik R,Key NS,Parise LV,Ataga KI

更新日期：2013-09-01 00:00:00

abstract：INTRODUCTION:Recombinant members of the vitamin K-dependent protein family (factors IX and VII and protein C) have become important pharmaceuticals in treatment of bleeding disorders and sepsis. However, because the in vivo gamma-carboxylation system in stable cell lines used for transfection has a limited capacity of ...

journal_title：Thrombosis research

authors： Wajih N,Owen J,Wallin R

更新日期：2008-01-01 00:00:00

abstract：:Fibrillar collagen endows the normal aortic wall with significant stiffness and strength and similarly plays important roles in many disease processes. For example, because of the marked loss of elastic fibers and functional smooth cells in aortic aneurysms, collagen plays a particularly important role in controlling ...

journal_title：Thrombosis research

authors： Schriefl AJ,Collins MJ,Pierce DM,Holzapfel GA,Niklason LE,Humphrey JD

更新日期：2012-09-01 00:00:00

abstract：:The Coa-set Fibrin Monomer test (CFM-test) is a quantitative method for determination of soluble fibrin in plasma. The fibrin standard of the CFM-test is produced by bathroxobin conversion of purified fibrinogen to fibrin. Plasma treated with minute amounts of thrombin may be considered as a more physiological way of ...

journal_title：Thrombosis research

authors： Halvorsen S,Skjønsberg OH,Godal HC

更新日期：1993-11-15 00:00:00

abstract：:It has been suggested that unstable angina at rest, like acute myocardial infarction, might be associated with a thrombotic process. In order to study the hypothesis that myocardial ischemia during exercise could also be associated with an activation of blood coagulation and/or fibrinolysis, we investigated the presen...

journal_title：Thrombosis research

authors： Bounameaux H,Righetti A,de Moerloose P,Bongard O,Reber G

更新日期：1992-01-01 00:00:00

abstract：:To demonstrate that human alpha-thrombin is effectively inactivated by human antithrombin III (AT) during the production of a fibrin clot we measured the amount of alpha-thrombin activity which can be recovered from a clot generated from purified human proteins. We discovered that 0.05-0.07% of the original alpha-thro...

journal_title：Thrombosis research

authors： Naski MC,Shafer JA

更新日期：1993-03-01 00:00:00

abstract：:Platelet adherence and aggregation are important in the development of ischemic sequelae in atherosclerosis. To directly examine platelet interaction with plaque, everted, deendothelialized aortic fibrous plaques from Watanabe-heritable hyperlipidemic rabbits were exposed to flowing human blood in an annular perfusion...

journal_title：Thrombosis research

authors： Lawrence JB,Prevosti LG,Kramer WS,Lu DY,Leon MB

更新日期：1989-04-15 00:00:00

abstract：:Isolated rat liver macrophages (Kupffer cells) produce a factor(s) which stimulates fibrinogen synthesis 5-8 fold in hepatocyte cultures. The production of the stimulatory factor reached maximum during the first 24 hours the cells were in culture. When the cell culture medium was chromatographed on a calibrated Sephad...

journal_title：Thrombosis research

authors： Sanders KD,Fuller GM

更新日期：1983-10-15 00:00:00

abstract：INTRODUCTION:Circulating levels of fibrinogen are associated with atherosclerosis and predict future coronary heart disease and stroke. Levels of fibrinogen are correlated among family members, suggesting a heritable component. Variants of the beta-fibrinogen gene subunit on 4q28 are associated with fibrinogen levels b...

journal_title：Thrombosis research

authors： Yang Q,Tofler GH,Cupples LA,Larson MG,Feng D,Lindpaintner K,Levy D,D'Agostino RB,O'Donnell CJ

更新日期：2003-04-15 00:00:00

abstract：:Stimulation of rat platelets with U46619 induced Ca2+ mobilization and platelet shape change, but aggregation and secretion were induced when platelets were stimulated with U46619 plus phorbol 12-myristate 13-acetate (PMA). However, stimulation of rabbit platelets with U46619 induced all the three platelet responses. ...

journal_title：Thrombosis research

authors： Nakano T,Hanasaki K,Arita H

更新日期：1989-10-15 00:00:00

abstract：:Hemorrhagic tendency is frequent in uremic patients and is often associated with prolonged bleeding time and decreased platelet functions in vitro. Similarly, in multiple myeloma, platelet functions are affected, mainly by the inhibitory effect of paraprotein. We have studied patients with renal insufficiency and mult...

journal_title：Thrombosis research

authors： Cieslar P,Másová L,Scheiner T,Rysavá J,Krízová P,Danzigová Z,Spicka I,Tesar V

更新日期：2002-02-15 00:00:00

abstract：:Aim of this study was to evaluate rapid D-Dimer tests for their utility in diagnosis of acute pulmonary embolism (PE). Tests were performed in 183 consecutive pats referred for lung scanning because of clinically suspected PE. According to lung scans and the clinical course of disease 19 pats were classified to have P...

journal_title：Thrombosis research

authors： Veitl M,Hamwi A,Kurtaran A,Virgolini I,Vukovich T

更新日期：1996-06-01 00:00:00

abstract：:The effects of ticlopidine treatment (250 mg b.i.d. for 21 months) on fibrinogen and other rheological variables, as compared to placebo, were studied in 44 patients with intermittent claudication due to peripheral arterial occlusive disease. Blood samples were collected every 3 months during this double-blind, random...

journal_title：Thrombosis research

authors： Palareti G,Poggi M,Torricelli P,Balestra V,Coccheri S

更新日期：1988-12-15 00:00:00

abstract：BACKGROUND:The AMPLIFY trial found significantly lower major bleeding (MB) and similar recurrent venous thromboembolism (VTE) risks associated with apixaban vs warfarin among patients with VTE. OBJECTIVES:To compare MB, clinically-relevant non-major (CRNM) bleeding, and recurrent VTE risks among clinically-relevant su...

journal_title：Thrombosis research

authors： Guo JD,Hlavacek P,Rosenblatt L,Keshishian A,Russ C,Mardekian J,Ferri M,Poretta T,Yuce H,McBane R

更新日期：2020-12-08 00:00:00

abstract：INTRODUCTION:Only sparse information exists on the use of direct oral anticoagulant (DOAC) testing and the impact on clinical management. Here, we evaluated the clinical impact of DOAC measurements in a real-life clinical setting. Moreover, number of tests performed in relation to number of DOAC-treated patients was ev...

journal_title：Thrombosis research

authors： Winther-Larsen A,Hvas AM

更新日期：2019-03-01 00:00:00

abstract：:The immunogenic potential of natural and recombinant hirudin was investigated using baboons. Animals received 4 intravenous hirudin injections of 1,000 antithrombin units/kg at certain times (day 1, 3, 8 and 42) and were checked for an immune response. None of the tests performed (in vitro histamine-release, ELISA for...

journal_title：Thrombosis research

authors： Bichler J,Gemmerli R,Fritz H

更新日期：1991-01-01 00:00:00

abstract：:Thrombocytopenia is a common finding in cancer patients and can have different and/or multifactorial pathogenesis. While in solid tumors it occurs often as a consequence of chemotherapy treatment, it is frequently observed at diagnosis in patients with hematological malignancies being aggravated to a potentially life-...

journal_title：Thrombosis research

authors： Castaman G,Pieri L

更新日期：2018-04-01 00:00:00

abstract：:The two objectives of the study were to determine whether a procedure could be developed for measuring cancer procoagulant (CP) activity in human serum and if this procedure provided a method for distinguishing people with cancer from those without cancer. A procedure was developed for processing human serum such that...

journal_title：Thrombosis research

authors： Gordon SG,Benson B

更新日期：1989-11-01 00:00:00

abstract：:When activated in vitro, thrombin-activatable fibrinolysis inhibitor (TAFI) slows clot lysis by cleaving the C-terminal lysine and arginine residues from partially degraded fibrin. An inhibitor of carboxypeptidase isolated from potato (CPI) reverses prolongation of clot lysis by inhibiting activated TAFI. We investiga...

journal_title：Thrombosis research

authors： Nagashima M,Werner M,Wang M,Zhao L,Light DR,Pagila R,Morser J,Verhallen P

更新日期：2000-05-15 00:00:00

abstract：:We evaluate the anti-platelet and anti-thrombotic effects of cilostazol using Multiplate® and PFA-100® in vitro and ex vivo with freshly isolated rat whole blood and in vivo venous and arterial thrombosis models in the same species, in an effort to assess the sensitivity of the whole blood aggregometer assays without ...

journal_title：Thrombosis research

authors： Kim CW,Yun JW,Bae IH,Park YH,Jeong YS,Park JW,Chung JH,Park YH,Lim KM

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND:Multiple sclerosis (MS) often causes progressive loss of mobility, leading to limb paralysis. Venous and lymphatic stasis is a risk condition for venous thromboembolism (VTE). There is, however, no data on the frequency of VTE complicating the progression of MS. The aim of this study was to assess the freque...

journal_title：Thrombosis research

authors： Arpaia G,Bavera PM,Caputo D,Mendozzi L,Cavarretta R,Agus GB,Milani M,Ippolito E,Cimminiello C

更新日期：2010-04-01 00:00:00

abstract：:Mass-Length ratio of fibrin fibres (microT and microP) derived independently from turbidity and permeability respectively, in networks made in fibrinogen solution and plasma, have been compared under similar conditions of clotting. Amount of fibrinogen conversion to fibrin was similar in both systems when high thrombi...

journal_title：Thrombosis research

authors： Shah GA,Nair CH,Dhall DP

更新日期：1987-02-01 00:00:00

abstract：BACKGROUND:Plasminogen activator inhibitor type-1 (PAI-1) is considered to be the main inhibitor of fibrinolysis in sepsis. However, the contribution of TAFI to the inhibition of fibrinolysis in sepsis is currently unknown. METHODS:TAFI antigen and PAI-1 levels were measured in severe sepsis (n = 32) and septic shock ...

journal_title：Thrombosis research

authors： Zeerleder S,Schroeder V,Hack CE,Kohler HP,Wuillemin WA

更新日期：2006-01-01 00:00:00

abstract：INTRODUCTION:We conducted this prospective study in order to investigate the hypotheses that an alternative pathway for fibrinolysis is activated in patients who have undergone cardiopulmonary bypass (CPB) surgery and major abdominal surgery and that the levels of fibrin degradation products digested by polymorphonucle...

journal_title：Thrombosis research

authors： Gando S,Kameue T,Sawamura A,Hayakawa M,Hoshino H,Kubota N

更新日期：2007-01-01 00:00:00

abstract：:Ticlopidine (100 mg/kg/day or 400 mg/kg/day) was administered to rats and rabbits for 48 hr before and during the experiments. Aggregation studies of twice-washed platelets resuspended in Tyrode solution containing apyrase and 0.35% albumin showed that inhibition by ticlopidine of aggregation induced by ADP, collagen,...

journal_title：Thrombosis research

authors： Cattaneo M,Winocour PD,Somers DA,Groves HM,Kinlough-Rathbone RL,Packham MA,Mustard JF

更新日期：1985-01-01 00:00:00

abstract：:Hemostatic challenges occur throughout the period of stem cell transplantation (SCT). Endothelial cells injury due to chemotherapy, growth factors, intravenous catheter, and graft-versus-host disease and profound thrombocytopenia are the major components involved in the hemostatic complications. Diffuse alveolar hemor...

journal_title：Thrombosis research

authors： Nadir Y,Brenner B

更新日期：2007-01-01 00:00:00

abstract：INTRODUCTION:Retinal vein occlusion is a major cause of ocular morbidity. The precise mechanism leading to thrombosis in retinal vein occlusion has not yet been clearly elucidated. Several risk factors have been identified, including hypertension diabetes, history of cardiovascular disease, hypercholesterolemia, hyperh...

journal_title：Thrombosis research

authors： Leoncini G,Signorello MG,Segantin A,Giacobbe E,Armani U,Piana A,Camicione P

更新日期：2009-12-01 00:00:00

abstract：:The ultrastructure of the platelet contacts with collagen fibrils (CF) as well as the course taken by CF on the platelet surface were studied on ultrathin sections of platelets and CF. Platelets from normal donors and from a patient with thrombasthenia were incubated in citrated plasma with collagen. For electron micr...

journal_title：Thrombosis research

authors： Ruf A,Morgenstern E,Janzarik H,Lüscher EF

更新日期：1986-11-15 00:00:00