Antithrombotic activity of a symmetrical triglyceride with eicosapentaenoic acid and gamma-linolenic acid in guinea pig mesenteric microvasculature.


:The antithrombotic effect of a synthetic symmetrical triglyceride having eicosapentaenoic acid (EPA) at positions 1 and 3, and gamma-linolenic acid (GLA) at position 2 was investigated. Administration of the triglyceride significantly increased thrombus formation time and thrombotic occlusion time induced by light irradiation and a fluorescent dye in guinea pigs after 14 days administration compared to that of soybean oil. The antithrombotic effect of the triglyceride was similar to that of EPA ethyl ester. Administration of the triglyceride increased GLA, dihomo-gamma-linolenic acid (DGLA) and EPA contents in plasma and the liver, and the ratio of DGLA to arachidonic acid. These results might be responsible for this antithrombotic effect.


Thromb Res


Thrombosis research


Akahane N,Ohba S,Suzuki J,Wakabayashi T,Nakahara T,Yanagi K,Ohshima N




Has Abstract


1995-06-01 00:00:00














  • Prevalence and clinical history of incidental, asymptomatic pulmonary embolism: a meta-analysis.

    abstract:CONTEXT:Recently, there has been an increasing number of reports of incidental pulmonary embolism (PE) in patients undergoing chest computer tomography (CT) for reasons other than the research of suspected PE. Natural history of incidental PE remains unclear. OBJECTIVES:To estimate the prevalence of incidental PE, to ...

    journal_title:Thrombosis research

    pub_type: 杂志文章,meta分析


    authors: Dentali F,Ageno W,Becattini C,Galli L,Gianni M,Riva N,Imberti D,Squizzato A,Venco A,Agnelli G

    更新日期:2010-06-01 00:00:00

  • Purification and some properties of a protein obtained from normal human plasma which inhibits the platelet aggregation induced by thrombotic thrombocytopenic purpura plasma.

    abstract::Plasma from patients with thrombotic thrombocytopenic purpura (TTP) caused the aggregation of washed human platelets, which was inhibited by preincubation with normal plasma. Using salt fractionation, ion exchange chromatography, and preparative agarose gel electrophoresis, we purified a protein from normal plasma whi...

    journal_title:Thrombosis research

    pub_type: 杂志文章


    authors: Lian EC,Mui PT,Siddiqui FA,Chiu LL

    更新日期:1984-01-01 00:00:00

  • Biodistribution of the recombinant fusion protein linking coagulation factor IX with albumin (rIX-FP) in rats.

    abstract:INTRODUCTION:The recombinant fusion protein linking coagulation factor IX with albumin (rIX-FP) is undergoing clinical trials for prophylaxis and on-demand treatment of haemophilia B patients. The aim of this study was to investigate the pharmacokinetics, whole-body and knee joint distribution of rIX-FP following intra...

    journal_title:Thrombosis research

    pub_type: 杂志文章


    authors: Herzog E,Harris S,Henson C,McEwen A,Schenk S,Nolte MW,Pragst I,Dickneite G,Schulte S,Zollner S

    更新日期:2014-05-01 00:00:00

  • Blood coagulation and fibrinolysis after extreme short-term exercise.

    abstract:INTRODUCTION:Maximal exercise may be a trigger for cardiovascular events. The aim of the study was to investigate changes in blood coagulation and fibrinolysis following maximal short-term exercises with different durations up to 90 s. METHODS:A total of 15 healthy nonsmokers underwent three isokinetic maximal tests o...

    journal_title:Thrombosis research

    pub_type: 杂志文章


    authors: Hilberg T,Prasa D,Stürzebecher J,Gläser D,Schneider K,Gabriel HH

    更新日期:2003-03-15 00:00:00

  • Catheter-directed ultrasound-accelerated thrombolysis for the treatment of acute pulmonary embolism.

    abstract:BACKGROUND:Systemic thrombolysis rapidly improves right ventricular (RV) dysfunction in patients with acute pulmonary embolism (PE) but is associated with major bleeding complications in up to 20%. The efficacy of low-dose, catheter-directed ultrasound-accelerated thrombolysis (USAT) on the reversal of RV dysfunction i...

    journal_title:Thrombosis research

    pub_type: 杂志文章


    authors: Engelhardt TC,Taylor AJ,Simprini LA,Kucher N

    更新日期:2011-08-01 00:00:00

  • Inhibitory effects of TFPI on thrombin and factor Xa generation in vitro--modulatory action of glycosaminoglycans.

    abstract::The effect of tissue factor pathway inhibitor (TFPI) on thrombin and factor Xa generation was studied in an in vitro system using a prothrombin complex concentrate. It was found that TFPI, via the direct inhibition of factor Xa and the tissue factor/factor VIIa complex, inhibited both the further generation of factor ...

    journal_title:Thrombosis research

    pub_type: 杂志文章


    authors: Kaiser B,Hoppensteadt DA,Jeske W,Wun TC,Fareed J

    更新日期:1994-09-15 00:00:00

  • Risk of bleeding in low-risk atrial fibrillation patients on warfarin waiting for elective cardioversion.

    abstract:INTRODUCTION:Systemic embolism is the most serious complication of cardioversion of atrial fibrillation (AF) and the immediate post-cardioversion period is associated with increased risk for thrombus formation. For this reason, treatment with vitamin K antagonist (VKA) is recommended for patients with AF. No informatio...

    journal_title:Thrombosis research

    pub_type: 杂志文章,多中心研究


    authors: Poli D,Antonucci E,Grifoni E,Paoletti O,Rancan E,Dentali F,Testa S

    更新日期:2012-05-01 00:00:00

  • Successful eradication of Helicobacter pylori as determined by ((13))C-urea breath test does not alter fibrinogen and acute phase response markers.

    abstract::In this study we examined in 100 patients testing positive for Helicobacter pylori infection whether successful eradication therapy with pantoprazole, clarithromycin, and metronidazole alters fibrinogen and other acute phase response markers. Of 100 patients, only 11 showed a fibrinogen level above 300 mg/dL. Successf...

    journal_title:Thrombosis research

    pub_type: 杂志文章


    authors: Schweeger I,Fitscha P,Sinzinger H

    更新日期:2000-03-15 00:00:00

  • Chronic kidney disease status modifies the association of CYP2C19 polymorphism in predicting clinical outcomes following coronary stent implantation.

    abstract:INTRODUCTION:There is some controversy regarding the effect of CYP2C19 polymorphism on clinical outcome in patients with dual antiplatelet therapy. Chronic kidney disease (CKD) is associated with increased risk of cardiovascular event, but the association between the possession of CYP2C19 loss-of-function (LOF) alleles...

    journal_title:Thrombosis research

    pub_type: 杂志文章


    authors: Tabata N,Hokimoto S,Akasaka T,Arima Y,Kaikita K,Kumagae N,Morita K,Miyazaki H,Oniki K,Nakagawa K,Matsui K,Ogawa H

    更新日期:2014-11-01 00:00:00

  • Relationship between maternal and cord blood hemostatic disturbances in preeclamptic pregnancies.

    abstract::Endothelial cell activation or damage is believed to play a key role in preeclampsia (PE) and may underlie the hemostatic changes observed in this syndrome. The aim of this study was to evaluate a relationship between maternal and cord blood hemostatic disturbances in preeclamptic pregnancies. We measured the plasma l...

    journal_title:Thrombosis research

    pub_type: 杂志文章


    authors: Catarino C,Rebelo I,Belo L,Rocha S,Castro EB,Patricio B,Quintanilha A,Santos-Silva A

    更新日期:2008-01-01 00:00:00

  • OC-08 - Multiple functional defects in platelets from thrombocytopenic cancer patients undergoing chemotherapy.

    abstract:INTRODUCTION:Severe thrombocytopenia (≤50×10(9) platelets/L) is often the consequence of hematological malignancies and intensive chemotherapy. The risk of clinically significant bleeding is increased in these patients, despite the use of prophylactic platelet transfusions. The fact that there is no clear correlation b...

    journal_title:Thrombosis research

    pub_type: 杂志文章


    authors: Baaten CC,Moenen FC,Henskens YM,Swieringa F,Wetzels R,van Oerle R,Ten Cate H,Beckers EA,Heemskerk JW,van der Meijden PE

    更新日期:2016-04-01 00:00:00

  • Aspirin non-responsiveness as measured by PFA-100 in patients with coronary artery disease.

    abstract:INTRODUCTION:The purpose of the present study was to study the concept of aspirin resistance or non-responsiveness by investigating the response to long-term aspirin therapy in patients with a former acute myocardial infarction (AMI). MATERIALS AND METHODS:Patients with an AMI (n=202) randomly assigned to aspirin 160 ...

    journal_title:Thrombosis research

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Andersen K,Hurlen M,Arnesen H,Seljeflot I

    更新日期:2002-10-01 00:00:00

  • Markers of endothelial and platelet activation are associated with high on-aspirin platelet reactivity in patients with stable coronary artery disease.

    abstract:INTRODUCTION:Aspirin inhibits the cyclooxygenase-1 (COX-1) mediated thromboxane A2 synthesis. Despite COX-1 inhibition, in patients with coronary artery disease (CAD), platelets can be activated through other mechanisms, like activation by thrombin. MATERIALS AND METHODS:At baseline in this cross-sectional substudy of...

    journal_title:Thrombosis research

    pub_type: 杂志文章


    authors: Pettersen AÅ,Arnesen H,Opstad TB,Bratseth V,Seljeflot I

    更新日期:2012-09-01 00:00:00

  • Comparison of antithrombin activity of the polysulphate chitosan derivatives in in vivo and in vitro system.

    abstract::In order to choose the proper method for evaluating the antithrombin activity in samples of chitosan polysulphate (CP) with different polymerization degrees and sulphation degrees, we estimated the ability of direct anticoagulants to depress the coagulability of recalcified sheep blood using the third international he...

    journal_title:Thrombosis research

    pub_type: 杂志文章


    authors: Drozd NN,Sher AI,Makarov VA,Galbraikh LS,Vikhoreva GA,Gorbachiova IN

    更新日期:2001-06-01 00:00:00

  • Effect of fucoidan during activation of human plasminogen.

    abstract::Fucoidan [sulfated poly (L-fucopyranose)] was compared with 6-aminohexanoic acid (6-AH) or CNBr-cleaved fibrinogen (CNBr-Fbg) alone or in combination in enhancing the activation of glutamic plasminogen (Glu-Plg) or lysine plasminogen (Lys-Plg) by two-chain tissue plasminogen activator (t-PA) or LMwt-urokinase or by st...

    journal_title:Thrombosis research

    pub_type: 杂志文章


    authors: Doctor VM,Hill C,Jackson GJ

    更新日期:1995-08-01 00:00:00

  • Pharmacological profile of G619, a new platelet aggregation inhibitor.

    abstract::G619, a 4-OH-isophthalic acid derivative, was studied for its capacity to inhibit platelet aggregation. G619 dose-dependently inhibited U46619, collagen, ADP, PAF, thrombin and epinephrine-induced platelet aggregation in vitro. The IC50 values for inhibition of U46619-induced human and rabbit platelet aggregation were...

    journal_title:Thrombosis research

    pub_type: 杂志文章


    authors: Yue TL,Smith EF 3rd,Ohlstein EH,Sulpizio A,Slivjak MJ,Rabinovici R,Sellers TS,Lynch KM,Poyser R,Feuerstein G

    更新日期:1992-05-15 00:00:00

  • Diagnosis and risk stratification in patients with acute coronary syndromes according to ESC guidelines.

    abstract::Diagnosis and risk stratification of patients with acute coronary syndromes remain extremely important in order to avoid unnecessary hospitalizations on the one hand, and to improve prognosis of these patients on the other. For diagnosis of acute coronary syndromes, an ECG should be obtained at rest, troponin T and I ...

    journal_title:Thrombosis research

    pub_type: 杂志文章,评审


    authors: Klein W,Hödl R,Kraxner W

    更新日期:2001-09-30 00:00:00

  • Outcome of central venous catheter associated upper extremity deep vein thrombosis in cancer patients.

    abstract:INTRODUCTION:Data on efficacy and safety of using low molecular weight heparin in cancer patients with catheter-related upper extremity deep vein thrombosis is scarce and the risk of recurrent venous thromboembolism after discontinuation of anticoagulation is unknown. MATERIAL AND METHODS:We conducted a retrospective ...

    journal_title:Thrombosis research

    pub_type: 杂志文章


    authors: Delluc A,Le Gal G,Scarvelis D,Carrier M

    更新日期:2015-02-01 00:00:00

  • Long-term erythropoietin therapy does not affect endothelial markers, coagulation activation and oxidative stress in haemodialyzed patients.

    abstract:INTRODUCTION:Although the general improvement caused by recombinant human erythropoietin (rHuEPO) in the correction of uraemic anaemia cannot be questioned, some data suggest that the changes in the haemostasis, endothelial function and oxidative stress (SOX) are induced. The aim of the present study was to investigate...

    journal_title:Thrombosis research

    pub_type: 临床试验,杂志文章


    authors: Pawlak K,Pawlak D,Mysliwiec M

    更新日期:2007-01-01 00:00:00

  • Chronic kidney disease is associated with increased risk of venous thromboembolism recurrence.

    abstract:INTRODUCTION:It is currently unclear whether chronic kidney disease (CKD) and the decrease in renal function can influence the risk of venous thromboembolism (VTE) recurrence. MATERIALS AND METHODS:We performed an ambispective observational study on 409 patients with a previous episode of VTE. All the patients were in...

    journal_title:Thrombosis research

    pub_type: 杂志文章


    authors: Rattazzi M,Villalta S,De Lucchi L,Sponchiado A,Galliazzo S,Faggin E,Pagliara V,Zilli C,Callegari E,Caberlotto L,Puato M,Pauletto P

    更新日期:2017-12-01 00:00:00

  • The loss of sialic acid and its prevention in stored human platelets.

    abstract::The loss of sialic acid was determined in human platelets stored during a seven day period in their homologous plasma. Approximately 30% of the sialic acid was lost during the first three days of incubation at room temperature and a total of 73% was lost after seven days. The rapid in vitro loss of sialic acid may mim...

    journal_title:Thrombosis research

    pub_type: 杂志文章


    authors: Soslau G,Giles J

    更新日期:1982-06-15 00:00:00

  • Enhanced functional recombinant factor VII production by HEK 293 cells stably transfected with VKORC1 where the gamma-carboxylase inhibitor calumenin is stably suppressed by shRNA transfection.

    abstract:INTRODUCTION:Recombinant members of the vitamin K-dependent protein family (factors IX and VII and protein C) have become important pharmaceuticals in treatment of bleeding disorders and sepsis. However, because the in vivo gamma-carboxylation system in stable cell lines used for transfection has a limited capacity of ...

    journal_title:Thrombosis research

    pub_type: 杂志文章


    authors: Wajih N,Owen J,Wallin R

    更新日期:2008-01-01 00:00:00

  • Turnover of tPA in rabbits: influence of carbohydrate moieties.

    abstract::The turnover of tissue plasminogen activator (tPA) was studied in rabbits using a double-label technique which allowed the comparison of various tPA derivatives with a standard tPA in individual animals. Purified recombinant tPA (Alteplase) was labelled with 125I and used as a standard for each experiment. Various tPA...

    journal_title:Thrombosis research

    pub_type: 杂志文章


    authors: Beebe DP,Aronson DL

    更新日期:1988-07-01 00:00:00

  • Adenosine increases human platelet levels of cGMP through nitric oxide: possible role in its antiaggregating effect.

    abstract::Adenosine is an endogenous antiaggregating substance that influences the platelet responses through specific A-type receptors that activate adenylate cyclase increasing the levels of 3',5'-cyclic adenosine monophosphate (cAMP). In this study, we investigated whether adenosine can also influence the levels of 3',5'-cyc...

    journal_title:Thrombosis research

    pub_type: 杂志文章


    authors: Anfossi G,Russo I,Massucco P,Mattiello L,Cavalot F,Balbo A,Trovati M

    更新日期:2002-01-01 00:00:00

  • ATP-secretion occurs as an initial response in collagen induced platelet activation.

    abstract::The time course and degree of collagen induced platelet shape change, aggregation and ATP-secretion in citrated human platelet rich plasma was monitored with a lumi-aggregometer. Onset of ATP-secretion was measurable within seconds after collagen challenge and always distinctly before onset of shape change. In absence...

    journal_title:Thrombosis research

    pub_type: 杂志文章


    authors: Malmgren R

    更新日期:1986-08-15 00:00:00

  • The relationship between the age and density of circulating 51-Cr labelled platelets in the sub-human primate.

    abstract::Change in the density of circulating platelets in monkeys was studied by using a method that removed greater than 90% of the platelet population from whole blood. These were labelled with 51-Cr and reinjected, having been protected by prostacyclin while in vitro. Platelets were separated into density subpopulations th...

    journal_title:Thrombosis research

    pub_type: 杂志文章


    authors: Martin JF,Penington DG

    更新日期:1983-04-15 00:00:00

  • Impaired flow mediated dilatation as evidence of endothelial dysfunction in chronic atrial fibrillation: relationship to plasma von Willebrand factor and soluble E-selectin levels.

    abstract:BACKGROUND:Impaired endothelial-dependent flow-mediated dilatation (FMD) has been used to demonstrate endothelial dysfunction in a wide variety of cardiovascular disease, but previous studies have excluded patients with atrial fibrillation(AF). We therefore hypothesised that endothelial dysfunction exists in AF and tha...

    journal_title:Thrombosis research

    pub_type: 杂志文章


    authors: Freestone B,Chong AY,Nuttall S,Lip GY

    更新日期:2008-01-01 00:00:00

  • Safety of virus inactivated antithrombin III concentrate antithrombin III immuno (AT III).

    abstract::In a prospective clinical trial the risk of infection after application of virus inactivated antithrombin III concentrate ANTITHROMBIN III IMMUNO (AT III) was investigated in patients undergoing cardiovascular surgery. The study was conducted according to the recommendations of the International Committee on Thrombosi...

    journal_title:Thrombosis research

    pub_type: 临床试验,杂志文章


    authors: Preiss DU,Abdullah D,Eberspächer B,Wilhelm K

    更新日期:1992-03-15 00:00:00

  • Thromboprophylaxis in acutely ill medical patients: results of a survey among Italian physicians.

    abstract:AIMS:acutely ill medical patients are at increased risk of venous thromboembolism (VTE) and often require thromboprophylaxis, but patient selection and adequate therapeutic decisions may be difficult due to the heterogeneity and the complexity of this population. We conducted a survey among a large cohort of Italian ph...

    journal_title:Thrombosis research

    pub_type: 杂志文章


    authors: Dentali F,Pomero F,La Regina M,Orlandini F,Turato S,Mazzone A,Nozzoli C,Fontanella A,Ageno W,Agnelli G,Campanini M

    更新日期:2014-09-01 00:00:00

  • Recombinant γT305A fibrinogen indicates severely impaired fibrin polymerization due to the aberrant function of hole 'A' and calcium binding sites.

    abstract:INTRODUCTION:We examined a 6-month-old girl with inherited fibrinogen abnormality and no history of bleeding or thrombosis. Routine coagulation screening tests showed a markedly low level of plasma fibrinogen determined by functional measurement and also a low level by antigenic measurement (functional/antigenic ratio=...

    journal_title:Thrombosis research

    pub_type: 杂志文章


    authors: Ikeda M,Kobayashi T,Arai S,Mukai S,Takezawa Y,Terasawa F,Okumura N

    更新日期:2014-08-01 00:00:00