The role of haemostasis in placenta-mediated complications.

abstract：:Acute promyelocytic leukemia (APL) has become the most curable form of acute myeloid leukemia after the advent of all-trans retinoic acid (ATRA). However, early deaths (ED) mostly due to the disease-associated coagulopathy remain the major cause of treatment failure. In particular, hemorrhagic events account for 40-65...

journal_title：Thrombosis research

authors： Breccia M,Lo Coco F

更新日期：2014-05-01 00:00:00

abstract：INTRODUCTION:Flow cytometry (FCM) is the most commonly used method for detection of platelet-derived microparticles (PDMPs), but it is poorly standardized and mainly used for "bedside" analyses in fresh samples. If PDMPs could be analyzed in previously frozen samples it would increase the usefulness of the method. Howe...

journal_title：Thrombosis research

authors： Mobarrez F,Antovic J,Egberg N,Hansson M,Jörneskog G,Hultenby K,Wallén H

更新日期：2010-03-01 00:00:00

abstract：:We report an inbred family with two cases of homozygous protein C deficiency and review 11 other such cases. Both patients presented in the second half of their first year of life with recurrent rapidly disappearing ecchymotic skin lesions, disseminated intravascular coagulation, and venous thrombosis. Successful trea...

journal_title：Thrombosis research

authors： Tuddenham EG,Takase T,Thomas AE,Awidi AS,Madanat FF,Abu Hajir MM,Kernoff PB,Hoffbrand AV

更新日期：1989-03-01 00:00:00

abstract：PURPOSE:By using endovascular techniques, we set up an animal model of mesenteric venous thrombosis to avoid surgical laparotomy. MATERIALS AND METHODS:Ten pigs underwent percutaneous transhepatic puncture to create animal model of acute superior mesenteric venous thrombosis. Experimental animals were injected with th...

journal_title：Thrombosis research

authors： Kai L,Jiaxiang M,Xinxin F,Baochen L,Weiwei D,Xingjiang W,Shuofei Y,Jieshou L

更新日期：2015-12-01 00:00:00

abstract：:The three polypeptide chains of fibrinogen, A alpha, B beta and gamma chain, are synthesized on separate polysomes. Fully formed fibrinogen is a six chain, disulfide-linked, dimeric molecule with a molecular weight of 340kDa. Previous pulse-chase studies with L-35 S methionine using the human hepatocellular carcinoma ...

journal_title：Thrombosis research

authors： Yu S,Kong V,Kudryk B,Redman C

更新日期：1987-04-15 00:00:00

abstract：:The release of arachidonic acid, and its subsequent conversion to thromboxane A2, is an important component of platelet activation. The precise mechanism of arachidonic acid release is unknown although cytosolic phospholipase A2 (cPLA2) has been implicated. In the present study the effects of three agonists, the serin...

journal_title：Thrombosis research

authors： McNicol A,Shibou TS

更新日期：1998-10-01 00:00:00

abstract：:The use of platinum based chemotherapy in ovarian malignancy and other cancer types is known to be associated with deep vein thrombosis. In a prospective study of 47 patients with ovarian cancer of International Federation of Gynecology and Obstetrics stage Ib-IV, serial rheological parameters were determined (plasma ...

journal_title：Thrombosis research

authors： von Tempelhoff GF,Niemann F,Schneider DM,Kirkpatrick CJ,Hommel G,Heilmann L

更新日期：1998-04-15 00:00:00

abstract：BACKGROUND:HELLP (Hemolysis, elevated liver enzymes and low platelets) syndrome is a severe and acute pregnancy-related disorder that occurs in approximately 2.5 per 1000 deliveries and represents a major cause of maternal and perinatal morbidity and mortality. This syndrome has been suggested to be a microangiopathy a...

journal_title：Thrombosis research

authors： Bazzan M,Todros T,Tedeschi S,Ardissino G,Cardaropoli S,Stella S,Montaruli B,Marchese C,Roccatello D,Cugno M

更新日期：2020-12-01 00:00:00

abstract：INTRODUCTION:Reports on the prevalence and risk factors of atherothrombotic events (AEs) are conflicting in persons with hemophilia (PWH). METHODS:This study evaluated the prevalence and risk factors of AEs among 1054 male hemophilia patients, using data collected from Taiwan's National Health Insurance Research Datab...

journal_title：Thrombosis research

authors： Wang JD,Chan WC,Fu YC,Tong KM,Chang ST,Hwang WL,Lin CH,Tsan YT

更新日期：2015-03-01 00:00:00

abstract：INTRODUCTION:Clinical trials have provided evidence about efficacy and safety of extended thromboprophylaxis among total hip replacement (THR) patients. There is a lack of evidence on effectiveness and safety of extended treatment in unselected patients from routine clinical practice. We examined the effectiveness and ...

journal_title：Thrombosis research

authors： Pedersen AB,Sorensen HT,Mehnert F,Johnsen SP,Overgaard S

更新日期：2015-02-01 00:00:00

abstract：:An abnormal prothrombin has been detected in a 26-year-old female, who had no history of excessive bleeding. Prothrombin activity was approximately 10% when measured using either the classical one-stage assay or the assay with Echis carinatus venom, whereas prothrombin antigen level was normal. In keeping with current...

journal_title：Thrombosis research

authors： Morishita E,Saito M,Asakura H,Jokaji H,Uotani C,Kumabashiri I,Yamazaki M,Hachiya H,Okamura M,Matsuda T

更新日期：1991-06-15 00:00:00

abstract：:Catharsius protease-1 (CPM-1) was isolated from the whole body of the dung beetles, Catharsius molossus, using three purification steps (ammonium sulfate fractionation, gel filtration on Bio-Gel P-60, and affinity chromatography on DEAE Affi-Gel Blue gel). The purified CPM-1 that has a molecular weight of 27 kDa was a...

journal_title：Thrombosis research

authors： Ahn MY,Hahn BS,Ryu KS,Kim JW,Kim I,Kim YS

更新日期：2003-01-01 00:00:00

abstract：:Nineteen patients, (2 adults, 17 children) with inherited bleeding disorders were infused with n-heptane-suspended-heated clotting factor concentrates. Twelve of the nineteen were previously untreated. Six patients were infused with Profilnine Heat-Treated and 13 with Profilate Heat-Treated. Five separate centers part...

journal_title：Thrombosis research

authors： Carnelli V,Gomperts ED,Friedman A,Aledort L,Hilgartner M,Dietrich S,Fedor EJ

更新日期：1987-06-15 00:00:00

abstract：:An in vivo rabbit model of venous thrombosis which includes physiological blood flow was used to compare the efficacy of the potent and specific factor Xa inhibitor recombinant tick anticoagulant peptide (rTAP) with standard heparin in the prevention of venous thrombus formation. In anesthetized rabbits, an autologous...

journal_title：Thrombosis research

authors： Fioravanti C,Burkholder D,Francis B,Siegl PK,Gibson RE

更新日期：1993-08-15 00:00:00

abstract：:Chloroquine inhibited aggregation of rat blood platelets in a dose-dependent way. The inhibitory effect decreased, depending on the aggregation stimulus used, in the rank order of potency: ADP > thrombin > A23187. Effect of 1 millimolar chloroquine on A23187-stimulated aggregation was significantly decreased or comple...

journal_title：Thrombosis research

authors： Jancinová V,Nosál R,Petríková M

更新日期：1994-06-01 00:00:00

abstract：BACKGROUND:Tissue factor pathway inhibitor-2 (TFPI-2) regulates matrix metalloproteinases activation and extracellular matrix degradation. Over-expression of TFPI-2 enhances atherosclerotic plaque stability. The aim of this study is to investigate the effect of conditional knockout (KO) of TFPI-2 in vascular endothelia...

journal_title：Thrombosis research

authors： Hong J,Liu R,Chen L,Wu B,Yu J,Gao W,Pan J,Luo X,Shi H

更新日期：2016-01-01 00:00:00

abstract：INTRODUCTION:Tissue factor plays a key role in the extrinsic coagulation pathway and is induced by inflammatory cytokines. Atrial myocarditis has been detected recently in some patients with lone atrial fibrillation. Virchow's triad of low blood flow, hypercoagulability, and endothelial dysfunction, enhances thrombus f...

journal_title：Thrombosis research

authors： Nakamura Y,Nakamura K,Fukushima-Kusano K,Ohta K,Matsubara H,Hamuro T,Yutani C,Ohe T

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:Pregnancy is a hypercoagulable state associated with an increased risk of venous thrombosis, which begins during the first trimester, but the exact time of onset is unknown. Thrombin generation, a laboratory marker of thrombosis risk, increases during normal pregnancy but it is unclear exactly how early this...

journal_title：Thrombosis research

authors： Bagot CN,Leishman E,Onyiaodike CC,Jordan F,Freeman DJ

更新日期：2017-09-01 00:00:00

abstract：:A simple and discriminating assay for the determination of the fast-acting plasminogen activator inhibitor (PAI) activity in human plasma is described. The method is based on the inhibition of purified tissue plasminogen activator (tPA) by plasma diluted with a PAI-depleted plasma and the subsequent measurement of res...

journal_title：Thrombosis research

authors： Contant G,Martinoli JL

更新日期：1989-11-01 00:00:00

abstract：:Most proteolytic enzymes that cleave glycoprotein lb (GPlb) also cleave other glycoproteins or receptors on the surface of platelets. We have used an O-sialoglycoprotein endoprotease from Pasteurella haemolytica that selectively cleaves the heavily O-glycosylated GPlb, but does not cleave N-linked glycoproteins or ung...

journal_title：Thrombosis research

authors： Kinlough-Rathbone RL,Perry DW,Rand ML,Packham MA

更新日期：2000-07-15 00:00:00

abstract：INTRODUCTION:We examined a 6-month-old girl with inherited fibrinogen abnormality and no history of bleeding or thrombosis. Routine coagulation screening tests showed a markedly low level of plasma fibrinogen determined by functional measurement and also a low level by antigenic measurement (functional/antigenic ratio=...

journal_title：Thrombosis research

authors： Ikeda M,Kobayashi T,Arai S,Mukai S,Takezawa Y,Terasawa F,Okumura N

更新日期：2014-08-01 00:00:00

abstract：:The purpose of this study was to determine whether plasma von Willebrand factor concentrations are correlated with the degree of intestinal ischaemia-reperfusion injury. Forty-six anaesthetised adult Wistar rats were divided into five groups. The sham-operated group (S, n=10) had laparotomy and isolation of the superi...

journal_title：Thrombosis research

authors： Abu-Zidan FM,Farrant G,Zwi LJ,Simovic MO,Day T,Bonham MJ,Windsor JA

更新日期：1999-06-15 00:00:00

abstract：:The Calibrated Automated Thrombogram (CAT), a plate-based assay that measures thrombin generation and inhibition in plasma samples, is modified to measure the procoagulant activity of phospholipid associated with plasma microparticles (MP). The assay uses a tissue factor trigger without addition of 4 μM exogenous phos...

journal_title：Thrombosis research

authors： Owen BA,Xue A,Heit JA,Owen WG

更新日期：2011-01-01 00:00:00

abstract：:Increased fibrinolytic activity is a well recognized constant finding observed during cardiopulmonary bypass (CPB). The purpose of the present work was to study and estimate the factors involved in the plasminogen activation and prekallikrein-kallikrein systems in a population of adult patients undergoing open heart s...

journal_title：Thrombosis research

authors： Baños G,de la Peña A,Izaguirre R

更新日期：1992-09-01 00:00:00

abstract：:The effect of several vitamin K (Vit K) analogues on the aggregation of human platelets was examined. The analogues were potent inhibitors of aggregation induced by ADP, thrombin, collagen and arachidonate but were less active against aggregation induced by the calcium ionophore A23187. Vit K3 also prevented platelet ...

journal_title：Thrombosis research

authors： Blackwell GJ,Radomski M,Moncada S

更新日期：1985-01-01 00:00:00

abstract：:A recently developed platelet aggregometer using a laser light scattering method is capable of monitoring the increase in size of small-sized platelet aggregates (diameter 9-25 microm), which cannot be detected with the conventional methods. Whether coronary spasm can cause platelet aggregation in the coronary circula...

journal_title：Thrombosis research

authors： Miyamoto S,Ogawa H,Soejima H,Takazoe K,Kajiwara I,Shimomura H,Sakamoto T,Yoshimura M,Kugiyama K,Yasue H,Ozaki Y

更新日期：2001-09-01 00:00:00

abstract：INTRODUCTION:Increased levels of circulating tissue factor (TF)-positive microvesicles (MVs) may increase the risk of thrombosis. Indeed, TF-positive MVs are detected in plasma of patients with various types of diseases. In this study, we measured levels of MV TF activity in non-cancer severely ill patients and cancer ...

journal_title：Thrombosis research

authors： Hisada Y,Thålin C,Lundström S,Wallén H,Mackman N

更新日期：2018-05-01 00:00:00

abstract：:Platelets from rats fed a diet high in linoleic acid (6%) bound increased amounts of fibrinogen on stimulation with ADP, compared to those from rats fed diets with low (2%) or no linoleic acid. However, this increased fibrinogen binding was associated with a decrease in platelet aggregation induced by ADP. Changes in ...

journal_title：Thrombosis research

authors： McGregor L,Toor B,McGregor JL,Renaud S,Clemetson KJ

更新日期：1984-04-01 00:00:00

abstract：:When human citrated plasma is dialysed against a phosphate buffer containing Ca++, citrate anions are removed, thrombin is generated and soluble fibrinogen derivatives (fibrin monomers and/or soluble fibrin polymers) are formed. These derivatives are able to combine with human or bovine elastin to form a very stable a...

journal_title：Thrombosis research

authors： Rabaud M,Lefebvre F,Piquet Y,Belloc F,Chevaleyre J,Roudaut MF,Bricaud H

更新日期：1986-07-15 00:00:00

abstract：UNLABELLED:Disturbances of coagulation and fibrinolysis have been reported in patients with chronic uremia. Studies of different coagulation and fibrinolysis parameters in regularly dialyzed patients have yielded conflicting results. Global fibrinolytic capacity (GFC) examines the function of the entire fibrinolytic sy...

journal_title：Thrombosis research

authors： Agras PI,Baskin E,Cengiz N,Kirazli S,Saatci U,Ozbek N

更新日期：2005-01-01 00:00:00