Diagnosis and risk stratification in patients with acute coronary syndromes according to ESC guidelines.

abstract：:SK, t-PA or APSAC were incubated in human plasma (adjusted to 300,000 platelets/mm3), in vitro, for up to 90 minutes using concentrations which were equivalent to those achieved in the treatment of AMI patients. Aggregation was measured in response to ADP and collagen. SK inhibited platelet aggregation after a 60 minu...

journal_title：Thrombosis research

authors： Fears R,Ferres H,Greenwood HC

更新日期：1990-11-15 00:00:00

abstract：:Concentration-response relationships of human platelet aggregation rates were analyzed for a variety of agonists and inhibitors. Their approximation by the Hill equation showed that the values of the Hill coefficient (h) were agonist-dependent and increased as follows: hADP = hL-EPINEPHRINE = hPAF = hPGH2 = hU46619 le...

journal_title：Thrombosis research

authors： Vrzheshch PV,Tatarintsev AV,Yershov DE,Varfolomeyev SD

更新日期：1992-06-01 00:00:00

abstract：:Pregnancy induces several haemostatic perturbations. Some authors described possible acquired activated protein C resistance (APCR) during normal pregnancy. We wanted to test this possibility and to evaluate if this acquired APCR might contribute to the known increased tendency to thrombosis associated with pregnancy....

journal_title：Thrombosis research

authors： Schlit AF,Col-De Beys C,Moriau M,Lavenne-Pardonge E

更新日期：1996-11-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:According to US Food and Drugs Administration (FDA), 2 hour recombinant tissue plasminogen activator (rt-PA) 100mg infusion is recommended for eligible patients with acute pulmonary embolism (PE). However,there exists evidence implying that a lower dosage of rt-PA can be equally effective but p...

journal_title：Thrombosis research

authors： Zhang Z,Zhai ZG,Liang LR,Liu FF,Yang YH,Wang C

更新日期：2014-03-01 00:00:00

abstract：:The turnover of tissue plasminogen activator (tPA) was studied in rabbits using a double-label technique which allowed the comparison of various tPA derivatives with a standard tPA in individual animals. Purified recombinant tPA (Alteplase) was labelled with 125I and used as a standard for each experiment. Various tPA...

journal_title：Thrombosis research

authors： Beebe DP,Aronson DL

更新日期：1988-07-01 00:00:00

abstract：INTRODUCTION:Dabigatran (Dabi) is not routinely monitored. However, in emergency cases quantitative assessment is required and laboratories must provide suitable tests at all hours. Little is known about Dabi effects on thrombin generation. MATERIALS AND METHODS:Patient samples (n=241) were analyzed for functional Dab...

journal_title：Thrombosis research

authors： Helin TA,Lemponen M,Hjemdahl P,Rönquist-Nii Y,Lassila R,Joutsi-Korhonen L

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND:The CHADS2 and CHA2DS2-VASc scores are well-established clinical scales to estimate the risk of stroke in patients with atrial fibrillation (AF). However, the predictive power of the two scales concerning left atrial thrombus (LAT) or spontaneous echo contrast (SEC) has not been well investigated. Therefore,...

journal_title：Thrombosis research

authors： Han D,Chu Y,Wu Y,Wang X

更新日期：2020-11-01 00:00:00

abstract：:Platelet aggregation, lipoprotein lipase activity, coagulation parameters and routine blood chemistry were measured in a randomised study of 21 surgical patients before, immediately after and 3 months after operation. Sodium heparin 5000 IU was given subcutaneously to 11 patients every 12 hours for 7 days, the first i...

journal_title：Thrombosis research

authors： Törngren S,Norén I,Forsskåhl B,Sipilä H

更新日期：1983-06-01 00:00:00

abstract：:Three commercial thrombin preparations used clinically to stop topical bleeding were studied. The specific activities of these preparations were 1,064 U/mg (human); 59 U/mg (bovine) and 147 U/mg (bovine). SDS-PAGE analysis of the human product produced one major band corresponding to a molecular weight of alpha-thromb...

journal_title：Thrombosis research

authors： Suzuki S,Sakuragawa N

更新日期：1989-02-01 00:00:00

abstract：IMPORTANCE:Unprovoked venous thromboembolism (VTE) can be the first manifestation of cancer. It is unclear if extensive screening for occult cancer including a comprehensive computed tomography (CT) scan of the abdomen/pelvis is cost-effective in this patient population. OBJECTIVE:To assess the health care related cos...

journal_title：Thrombosis research

authors： Coyle K,Carrier M,Lazo-Langner A,Shivakumar S,Zarychanski R,Tagalakis V,Solymoss S,Routhier N,Douketis J,Coyle D

更新日期：2017-03-01 00:00:00

abstract：INTRODUCTION:Venous thromboembolism (VTE) occurs frequently in at-risk hospitalized patients, and prophylaxis of VTE is significantly underused. We sought to preliminarily assess the validity of Caprini risk assessment model, a famous individual VTE risk assessment model, in Chinese hospitalized patients with VTE. MAT...

journal_title：Thrombosis research

authors： Zhou HX,Peng LQ,Yan Y,Yi Q,Tang YJ,Shen YC,Feng YL,Wen FQ

更新日期：2012-11-01 00:00:00

abstract：:Activation of the coagulation and inflammatory systems are physiologically occurring during pregnancy. However, excess activation of either system is well documented in gestational vascular diseases (GVD). GVD are placenta-mediated pregnancy complications and a major cause of feto-maternal morbidity and mortality. The...

journal_title：Thrombosis research

authors： Kohli S,Isermann B

更新日期：2017-03-01 00:00:00

abstract：:A simple and discriminating assay for the determination of the fast-acting plasminogen activator inhibitor (PAI) activity in human plasma is described. The method is based on the inhibition of purified tissue plasminogen activator (tPA) by plasma diluted with a PAI-depleted plasma and the subsequent measurement of res...

journal_title：Thrombosis research

authors： Contant G,Martinoli JL

更新日期：1989-11-01 00:00:00

abstract：INTRODUCTION:Maximal exercise may be a trigger for cardiovascular events. The aim of the study was to investigate changes in blood coagulation and fibrinolysis following maximal short-term exercises with different durations up to 90 s. METHODS:A total of 15 healthy nonsmokers underwent three isokinetic maximal tests o...

journal_title：Thrombosis research

authors： Hilberg T,Prasa D,Stürzebecher J,Gläser D,Schneider K,Gabriel HH

更新日期：2003-03-15 00:00:00

abstract：BACKGROUND:The Clauss fibrinogen method and thrombin clotting time (TCT) are still routinely used in patients with cirrhosis to define fibrinogen concentration and clotting potential. The thromboelastometric functional fibrinogen FIBTEM assay evaluates the strength of fibrin-based clots in whole blood, providing inform...

journal_title：Thrombosis research

authors： Vucelic D,Jesic R,Jovicic S,Zivotic M,Grubor N,Trajkovic G,Canic I,Elezovic I,Antovic A

更新日期：2015-06-01 00:00:00

abstract：:This study focused on the clinical outcomes in multiple myeloma (MM) patients with venous thromboembolism (VTE) who received low-molecular-weight heparin (dalteparin) therapy. Changes in D-dimer levels before and after VTE were also evaluated. Among 549 patients treated with various chemotherapeutic agents, a total of...

journal_title：Thrombosis research

authors： Lee SE,Jeon YW,Yoon JH,Cho BS,Eom KS,Kim YJ,Kim HJ,Lee S,Cho SG,Kim DW,Lee JW,Min WS,Kim M,Min CK

更新日期：2015-11-01 00:00:00

abstract：INTRODUCTION:To determine whether the HIT IgG class platelet factor 4 (PF4) enzyme immunoabsorbant assay (EIA) influenced the duration of parenteral direct thrombin inhibitor (pDTI) therapy or bleeding risk in patients started on pDTI for a presumed diagnosis of HIT. MATERIALS/METHODS:187 patients started on pDTI for ...

journal_title：Thrombosis research

authors： Reagan JL,Ingham RR 2nd,Dalia S,Butera JN,Sweeney JD

更新日期：2014-07-01 00:00:00

abstract：:The thrombolytic efficacy of recombinant tissue-type plasminogen activator (tPA) in the presence and absence of a thromboxane synthase inhibitor was studied in a model of femoral artery thrombosis in the anesthetized rabbit. The thrombus was formed by injection of thrombin and whole blood into an isolated segment of t...

journal_title：Thrombosis research

authors： Shebuski RJ,Storer BL,Fujita T

更新日期：1988-12-01 00:00:00

abstract：:Surviving an embolism exposes patients to potential long-term complications, such as altered quality of life, persistent dyspnea, impaired exercise capacity or pulmonary hypertension. The common objective factor in most of these situations is the presence of residual pulmonary vascular obstruction (RPVO). Planar venti...

journal_title：Thrombosis research

authors： Bonnefoy PB,Margelidon-Cozzolino V,Catella-Chatron J,Ayoub E,Guichard JB,Murgier M,Bertoletti L

更新日期：2019-12-01 00:00:00

abstract：:Recombinant forms of human antithrombin (AT) were expressed in COS-1 cells, and their interaction with human thrombin characterized by comparing the reactivity of two engineered mutant forms of AT with the wild-type recombinant. Both mutant forms contained single amino acid substitutions of Asp (G392D) or Pro (G392P) ...

journal_title：Thrombosis research

authors： Sheffield WP,Blajchman MA

更新日期：1994-08-01 00:00:00

abstract：INTRODUCTION:Ticagrelor and prasugrel are recommended as first line therapy in patients with acute coronary syndromes (ACS). However, patients with anemia are commonly treated with clopidogrel in routine clinical practice. The RENAMI registry (REgistry of New Antiplatelet therapy in patients with acute Myocardial Infar...

journal_title：Thrombosis research

authors： Guerrero C,Garay A,Ariza-Solé A,Formiga F,Raposeiras-Roubín S,Abu-Assi E,D'Ascenzo F,Kinnaird T,Manzano-Fernández S,Alegre O,Sánchez-Salado JC,Lorente V,Templin C,Velicki L,Xanthopoulou I,Cerrato E,Rognoni A,Boccuzzi G

更新日期：2018-07-01 00:00:00

abstract：:The procoagulant cellular activity (PCA) of leukemic cells was evaluated, before and after endotoxin stimulation, in 38 patients with acute leukemia at presentation subdivided according to the FAB classification. In the M4 and M5 subgroups the stimulated leukemic cells showed a significant increase in the production o...

journal_title：Thrombosis research

authors： Guarini A,Gugliotta L,Catani L,Chetti L,Macchi S,Tura S

更新日期：1987-03-01 00:00:00

abstract：OBJECTIVES:To measure the variations of different parameters in the hemostatic system and to analyze their roles in the development of hemostatic disorder in patients with orthotopic liver transplantation (OLT) procedures routinely performed without venovenous bypass. METHODS:The blood coagulation and fibrinolysis par...

journal_title：Thrombosis research

authors： Wang Y,Liu Y,Han R,Zhu Z,Zhang Y,Wang X,Wang L,Shen Z

更新日期：2008-01-01 00:00:00

abstract：:We have determined that pp60c-src, a protein tyrosine kinase abundant in normal platelets, is present at comparable levels in platelets that are deficient in dense granules (Hermansky-Pudlak syndrome). Relative quantitation of pp60c-src was performed by immunoblot analysis after protein separation by sodium dodecyl su...

journal_title：Thrombosis research

authors： Sorisky A,Lages B,Weiss HJ,Rittenhouse SE

更新日期：1992-01-01 00:00:00

abstract：:The presence of Factor XIII subunit a was demonstrated in human monocytes by immunoperoxidase staining using specific antisera against Factor XIII and its subunits. This finding was verified by immunobiochemical techniques, as well. In an immunoblotting system after SDS polyacrylamide gel electrophoresis of denatured ...

journal_title：Thrombosis research

authors： Muszbek L,Adány R,Szegedi G,Polgár J,Kávai M

更新日期：1985-02-01 00:00:00

abstract：BACKGROUND:Although excess platelet activation, as indicated by increased plasma beta thromboglobulin (beta-TG), has been shown in pregnancy-induced hypertension (PIH), platelet adhesion, platelet morphology and a comparison of platelet and soluble (plasma) levels of the adhesion molecules P-selectin (pPsel and sPsel, ...

journal_title：Thrombosis research

authors： Karalis I,Nadar SK,Al Yemeni E,Blann AD,Lip GY

更新日期：2005-01-01 00:00:00

abstract：INTRODUCTION:To evaluate the pathogenetic role of tissue factor (TF), tissue factor pathway inhibitor (TFPI), and neutrophil elastase in acute respiratory distress syndrome (ARDS), as well as to test the hypothesis that TFPI levels modified by neutrophil activation are not sufficient to prevent TF-dependent intravascul...

journal_title：Thrombosis research

authors： Gando S,Kameue T,Matsuda N,Hayakawa M,Morimoto Y,Ishitani T,Kemmotsu O

更新日期：2003-01-25 00:00:00

abstract：:A blinded randomized multicenter trial of two non-activated prothrombin complex concentrates was carried out to determine the clinical effectivity in the treatment of acute hemarthrosis in hemophiliac patients with inhibitors. The one product was prepared via DEAE Sephadex chromatography, while the second was fraction...

journal_title：Thrombosis research

authors： Gomperts ED,Fannon RB,Lee ML,Kingdon HS,Kantrowitz JL,Addiego JE Jr,Carney J,Corrigan JJ,Hathaway W,Hilgartner MW

更新日期：1986-06-15 00:00:00

abstract：:The inhibition of one- and two-chain forms of tissue-type plasminogen activator by a series of peptide derivatives of arginine chloromethyl ketone was studied. Both forms of the enzyme were inhibited by such reagents at varying rates, dependent on the peptide sequence of the inhibitor. The order of relative effectiven...

journal_title：Thrombosis research

authors： Green GD

更新日期：1986-10-15 00:00:00

abstract：:Cancer is frequently associated with activation of blood coagulation, which in turn has been suggested to promote tumor growth and metastasis. Indeed, low molecular weight heparin treatment significantly prolongs the survival of a wide variety of patients with cancer. Based on this notion that anticoagulant treatment ...

journal_title：Thrombosis research

authors： Spek CA,Arruda VR

更新日期：2012-04-01 00:00:00