The ea22 gene of lambdoid phages: preserved prolysogenic function despite of high sequence diversity.

Abstract:

:The exo-xis region of lambdoid phages contains open reading frames and genes that appear to be evolutionarily important. However, this region has received little attention up to now. In this study, we provided evidence that ea22, the largest gene of this region, favors the lysogenic pathway over the lytic pathway in contrast to other characterized exo-xis region genes including ea8.5, orf61, orf60a, and orf63. Our assays also suggest some functional analogies between Ea22 and the phage integrase protein (Int). While it is unsurprising that Ea22 operates similarly in both λ and Stx phages, we have observed some distinctions that may arise from considerable sequence dissimilarity at the carboxy termini of each protein.

journal_name

Virus Genes

journal_title

Virus genes

authors

Dydecka A,Bloch S,Necel A,Topka G,Węgrzyn A,Tong J,Donaldson LW,Węgrzyn G,Nejman-Faleńczyk B

doi

10.1007/s11262-020-01734-8

subject

Has Abstract

pub_date

2020-04-01 00:00:00

pages

266-277

issue

2

eissn

0920-8569

issn

1572-994X

pii

10.1007/s11262-020-01734-8

journal_volume

56

pub_type

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