Abstract:
:The exo-xis region of lambdoid phages contains open reading frames and genes that appear to be evolutionarily important. However, this region has received little attention up to now. In this study, we provided evidence that ea22, the largest gene of this region, favors the lysogenic pathway over the lytic pathway in contrast to other characterized exo-xis region genes including ea8.5, orf61, orf60a, and orf63. Our assays also suggest some functional analogies between Ea22 and the phage integrase protein (Int). While it is unsurprising that Ea22 operates similarly in both λ and Stx phages, we have observed some distinctions that may arise from considerable sequence dissimilarity at the carboxy termini of each protein.
journal_name
Virus Genesjournal_title
Virus genesauthors
Dydecka A,Bloch S,Necel A,Topka G,Węgrzyn A,Tong J,Donaldson LW,Węgrzyn G,Nejman-Faleńczyk Bdoi
10.1007/s11262-020-01734-8subject
Has Abstractpub_date
2020-04-01 00:00:00pages
266-277issue
2eissn
0920-8569issn
1572-994Xpii
10.1007/s11262-020-01734-8journal_volume
56pub_type
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