Functional analysis of human spuma retrovirus genome.

Abstract:

:Human spuma retrovirus (HSRV) belongs to retroviruses that possess a complex genome organization. HSRV carries at least three extra genes in the region between env and the 3' long terminal repeat, which are not found in simple retroviruses. Via alternative splicing, these HSRV genes can encode several proteins. To genetically study the requirements of these viral proteins for viral replication in tissue cultures, a number of mutant viruses were constructed from an infectious molecular clone of HSRV. All mutants grew normally in the cell lines tested, except for those lacking transcriptional transactivator activity. By reporter-based transient assay systems, no Rev/Rex equivalent was detected in the HSRV proteins.

journal_name

Virus Genes

journal_title

Virus genes

authors

Adachi A,Sakai H,Tokunaga K,Kawamura M

doi

10.1007/BF01701657

subject

Has Abstract

pub_date

1995-01-01 00:00:00

pages

15-20

issue

1

eissn

0920-8569

issn

1572-994X

journal_volume

11

pub_type

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