当前位置： SCI文献检索 > JOURNAL OF LEUKOCYTE BIOLOGY期刊下所有文献 > Frequencies of FoxP3+ naive T cells are related to both viral load and naive T cell proliferation responses in HIV disease.

Frequencies of FoxP3+ naive T cells are related to both viral load and naive T cell proliferation responses in HIV disease.

Abstract：

:HIV infection results in depletion and dysfunction of naïve CD4(+) T cells. The mechanisms underlying these deficiencies are not understood. We investigated the frequencies of CD4(+) naïve subsets in HIV disease as defined by expression of CD25 and/or FoxP3 and the relationship of these frequencies to naïve T cell proliferation function. We observed increased proportions of CD25(+)FoxP3(+) and CD25(+)FoxP3(-) cells and decreased proportions of CD25(-)FoxP3(-) cells within the naïve CD4(+) cell compartment from HIV-infected persons compared with findings in healthy donors. These perturbations were related to higher plasma HIV RNA levels but not with higher immune activation, as measured by the proportions of CD38(+) memory CD4(+) T cells. Naïve T cell proliferation responses to mitogen stimulation were inversely related to the frequencies and absolute numbers of FoxP3(+) naïve T cells. MDA, a marker of oxidative stress, and sCD14, a marker of monocyte activation and a surrogate for microbial translocation, were increased in serum samples from HIV(+) donors; however, neither marker was related to naïve T cell function in HIV(+) donors. These observations suggest that alterations in naïve T cell subset frequencies could contribute to naïve T cell dysfunction in HIV disease, but these alterations are not necessarily the result of chronic immune activation.

journal_name

J Leukoc Biol

journal_title

Journal of leukocyte biology

authors

Rodriguez B,Bazdar DA,Funderburg N,Asaad R,Luciano AA,Yadavalli G,Kalayjian RC,Lederman MM,Sieg SF

doi

10.1189/jlb.1210661

subject

Has Abstract

pub_date

2011-09-01 00:00:00

pages

621-8

issue

3

eissn

0741-5400

issn

1938-3673

pii

jlb.1210661

journal_volume

90

pub_type

杂志文章

相关文献

JOURNAL OF LEUKOCYTE BIOLOGY文献大全
  • Linking the "two-hit" response following injury to enhanced TLR4 reactivity.

    abstract：:Severe injury can initiate an exaggerated systemic inflammatory response and multiple organ failure (MOF) if a subsequent immune stimulus, "second hit", occurs. Using a mouse thermal injury model, we tested whether changes in innate immune cell reactivity following injury can contribute to the development of heightene...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1189/jlb.0704382

    authors： Murphy TJ,Paterson HM,Kriynovich S,Zang Y,Kurt-Jones EA,Mannick JA,Lederer JA

    更新日期：2005-01-01 00:00:00

  • The THC-induced suppression of Th1 polarization in response to Legionella pneumophila infection is not mediated by increases in corticosterone and PGE2.

    abstract：:T helper cell type 1 (Th1)-polarizing cytokines are induced by Legionella pneumophila infection and are suppressed by pretreatment with marijuana cannabinoids (CB). Glucocorticoids and prostaglandin E2(PGE2) are also reported to suppress Th1 polarization and are induced by Delta9-tetrahydrocannabinol (THC), so their r...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1189/jlb.0304184

    authors： Newton CA,Lu T,Nazian SJ,Perkins I,Friedman H,Klein TW

    更新日期：2004-10-01 00:00:00

  • Disruption of the Nramp1 (also known as Slc11a1) gene in Kupffer cells attenuates early-phase, warm ischemia-reperfusion injury in the mouse liver.

    abstract：:As the natural resistance-associated macrophage protein 1 Nramp1 (also known as Slc11a1) modulates Kupffer cell (KC) activation, and KC are responsible for the early phase of warm ischemia/reperfusion (I/R) to the liver, we hypothesized that livers of Nramp1(-/-) mice will be protected from early-phase I/R injury comp...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：

    authors： Wyllie S,Seu P,Gao FQ,Gros P,Goss JA

    更新日期：2002-11-01 00:00:00

  • Systemic inflammatory response syndrome-related lymphopenia is associated with adenosine A1 receptor dysfunction.

    abstract：:SIRS is associated with lymphopenia, and prolonged lymphopenia of septic patients has been associated with increased mortality risk. We hypothesize that elevated adenosine during SIRS down-regulates Gi-coupled A1R, which signals an effect that sensitizes a cAMP-dependent lymphotoxic response. In this study, we evaluat...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1189/jlb.3A0816-345RR

    authors： Riff R,Cohen Y,Eini-Rider H,Naamani O,Mazar J,Haviv YS,Chaimovitz C,Douvdevani A

    更新日期：2017-07-01 00:00:00

  • A new role for monoamine oxidases in the modulation of macrophage-inducible nitric oxide synthase gene expression.

    abstract：:This report focuses on the modulatory role of endogenous H(2)O(2) on lipopolysaccharide (LPS)/interferon-gamma (IFN-gamma)-induced inducible nitric oxide synthase (NOS2) gene expression in rat peritoneal macrophages. Exogenously added H(2)O(2) was initially found to inhibit the synthesis of NOS2, which prompted us to ...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1189/jlb.1003459

    authors： Vega A,Chacón P,Monteseirín J,El Bekay R,Alvarez M,Alba G,Conde J,Martín-Nieto J,Bedoya FJ,Pintado E,Sobrino F

    更新日期：2004-06-01 00:00:00

  • Regulatory B cells and advances in transplantation.

    abstract：:The effects of B cell subsets with regulatory activity on the immune response to an allograft have evoked increasing interest. Here, we summarize the function and signaling of regulatory B cells (Bregs) and their potential effects on transplantation. These cells are able to suppress the immune system directly via liga...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章,评审

    doi：10.1002/JLB.5RU0518-199R

    authors： Li J,Luo Y,Wang X,Feng G

    更新日期：2019-04-01 00:00:00

  • Phagocytosis of gram-negative bacteria by a unique CD14-dependent mechanism.

    abstract：:THP-1-derived cell lines were stably transfected with constructs encoding glycophosphatidylinositol (GPI)-anchored or transmembrane forms of human CD14. CD14 expression was associated with enhanced phagocytosis of serum (heat-inactivated)-opsonized Escherichia coli (opEc). Both the GPI-anchored and transmembrane forms...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1002/jlb.62.6.786

    authors： Schiff DE,Kline L,Soldau K,Lee JD,Pugin J,Tobias PS,Ulevitch RJ

    更新日期：1997-12-01 00:00:00

  • Potential role of cyclophilin A in regulating cytokine secretion.

    abstract：:Cyclophilin A (CypA), a peptidylprolyl cis-trans isomerase, is a ubiquitous and multifunctional protein. In addition to its role as a host-cell receptor for cyclosporine A, CypA has diverse functions in inflammatory conditions and diseases. CypA secreted in response to inflammatory stimuli binds to the cell surface vi...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章,评审

    doi：10.1189/jlb.3RU0317-090RR

    authors： Dawar FU,Xiong Y,Khattak MNK,Li J,Lin L,Mei J

    更新日期：2017-10-01 00:00:00

  • Renin modulates HIV replication in T cells.

    abstract：:HIV is known to subvert cellular machinery to enhance its replication. Recently, HIV has been reported to enhance TC renin expression. We hypothesized that HIV induces and maintains high renin expression to promote its own replication in TCs. Renin enhanced HIV replication in TCs in a dose-dependent manner. (P)RR-defi...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1189/JLB.2A0414-192R

    authors： Chandel N,Ayasolla K,Lan X,Rai P,Mikulak J,Husain M,Malhotra A,McGowan J,Singhal PC

    更新日期：2014-10-01 00:00:00

  • Cross-talk between tumor cells and neutrophils through the Fas (APO-1, CD95)/FasL system: human glioma cells enhance cell viability and stimulate cytokine production in neutrophils.

    abstract：:Many tumor cells are resistant to Fas-mediated killing, which has been primarily used as a mechanism to evade immune attack. In this study, we found a new action of Fas on tumors where activation of the Fas signal may force tumor cells to produce survival factors for neutrophils. Human peripheral circulating neutrophi...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1189/jlb.0702375

    authors： Hor WS,Huang WL,Lin YS,Yang BC

    更新日期：2003-03-01 00:00:00

  • Orphan nuclear receptors in T lymphocyte development.

    abstract：:Lymphocyte development is initiated from hematopoietic stem cells and can be divided into multiple phenotypically distinct stages. Transcription factors play important roles in programming the developmental process of lymphocytes. Recent studies have identified key roles of several orphan nuclear receptors in T lympho...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章,评审

    doi：

    authors： He YW

    更新日期：2002-09-01 00:00:00

  • Role of IFN-γ in the establishment of anterior chamber-associated immune deviation (ACAID)-induced CD8+ T regulatory cells.

    abstract：:Introduction of alloantigens into the AC induces a form of immune tolerance known as ACAID, which induces antigen-specific CD8+ Tregs, contributing to ocular immune privilege by down-regulating immune responses. Recent evidence suggests IFN-γ is needed for the suppressive function of CD8+ ACAID Tregs. This study teste...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1189/jlb.0311173

    authors： Paunicka K,Chen PW,Niederkorn JY

    更新日期：2012-03-01 00:00:00

  • Dendritic cell differentiation pathways of CD34+ cells from the peripheral blood of head and neck cancer patients.

    abstract：:Patients with head and neck squamous cell carcinoma (HNSCC) have increased levels of immune-suppressive peripheral blood CD34+ cells. This study showed that the peripheral blood CD34+ cells of HNSCC patients are capable of differentiating into dendritic cells. Because CD34+ cells can differentiate through several path...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1002/jlb.65.5.623

    authors： Lathers DM,Lubbers E,Wright MA,Young MR

    更新日期：1999-05-01 00:00:00

  • Liver natural killer and natural killer T cells: immunobiology and emerging roles in liver diseases.

    abstract：:Hepatic lymphocytes are enriched in NK and NKT cells that play important roles in antiviral and antitumor defenses and in the pathogenesis of chronic liver disease. In this review, we discuss the differential distribution of NK and NKT cells in mouse, rat, and human livers, the ultrastructural similarities and differe...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章,评审

    doi：10.1189/JLB.0309135

    authors： Gao B,Radaeva S,Park O

    更新日期：2009-09-01 00:00:00

  • IL-12 and IL-18 induce MAP kinase-dependent adhesion of T cells to extracellular matrix components.

    abstract：:Cytokines and chemokines play an essential role in recruiting leukocytes from the circulation to the peripheral sites of inflammation by modulating cellular interactions with endothelial cell ligands and extracellular matrix (ECM). Herein, we examined regulation of T cell adhesion to ECM ligands by two major proinflam...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：

    authors： Ariel A,Novick D,Rubinstein M,Dinarello CA,Lider O,Hershkoviz R

    更新日期：2002-07-01 00:00:00

  • Macrophage uptake and accumulation of folates are polarization-dependent in vitro and in vivo and are regulated by activin A.

    abstract：:Vitamin B9, commonly known as folate, is an essential cofactor for one-carbon metabolism that enters cells through three major specialized transporter molecules (RFC, FR, and PCFT), which differ in expression pattern, affinity for substrate, and ligand-binding pH dependency. We now report that the expression of the fo...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1189/jlb.0613345

    authors： Samaniego R,Palacios BS,Domiguez-Soto Á,Vidal C,Salas A,Matsuyama T,Sánchez-Torres C,de la Torre I,Miranda-Carús ME,Sánchez-Mateos P,Puig-Kröger A

    更新日期：2014-05-01 00:00:00

  • IL-20 receptor cytokines in autoimmune diseases.

    abstract：:IL-19, IL-20, and IL-24 are the members of IL-10 family. They are also known as IL-20 receptor (IL-20R) cytokines as they all signal through the IL-20RA/IL-20RB receptor complex; IL-20 and IL-24 (but not IL-19) also signal through the IL-20RB/IL22RA1 receptor complex. Despite their protein structure homology and share...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章,评审

    doi：10.1002/JLB.MR1117-471R

    authors： Chen J,Caspi RR,Chong WP

    更新日期：2018-11-01 00:00:00

  • Secretory leukocyte proteinase inhibitor is a major leukocyte elastase inhibitor in human neutrophils.

    abstract：:Secretory leukocyte proteinase inhibitor (SLPI) is the main neutrophil elastase (HLE) inhibitor found in the upper airways during pulmonary inflammation. It has been shown to be synthesized and secreted in vitro by epithelial cells and has been localized in tracheal glands and bronchiolar epithelial cells by immunocyt...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1002/jlb.61.6.695

    authors： Sallenave JM,Si Tahar M,Cox G,Chignard M,Gauldie J

    更新日期：1997-06-01 00:00:00

  • Analysis of the synergistic stimulation of mouse macrophage proliferation by macrophage colony-stimulating factor (CSF-1) and tumor necrosis factor alpha (TNF-alpha).

    abstract：:Tumor necrosis factor alpha (TNF-alpha) more than doubles tritiated thymidine ([3H]TdR) uptake in mouse macrophages stimulated by macrophage colony-stimulating factor (CSF-1). However, nothing is known of how TNF-alpha affects this increase or even whether it is manifested by increased cellular proliferation. Here we ...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1002/jlb.54.1.65

    authors： Guilbert LJ,Winkler-Lowen B,Smith A,Branch DR,Garcia-Lloret M

    更新日期：1993-07-01 00:00:00

  • LPS resistance in monocytic cells caused by reverse signaling through transmembrane TNF (mTNF) is mediated by the MAPK/ERK pathway.

    abstract：:The transmembrane form of tumor necrosis factor (mTNF), expressed on activated monocytes (MO) and macrophages (MPhi), is able to induce apoptosis in human endothelial cells (EC). Apoptosis is mediated by two distinct mechanisms: direct cell contact and a yet-unidentified soluble protein, death factor X. In addition, m...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1189/jlb.0703343

    authors： Kirchner S,Boldt S,Kolch W,Haffner S,Kazak S,Janosch P,Holler E,Andreesen R,Eissner G

    更新日期：2004-02-01 00:00:00

  • Below the surface: The inner lives of TLR4 and TLR9.

    abstract：:TLRs are a class of pattern recognition receptors (PRRs) that detect invading microbes by recognizing pathogen-associated molecular patterns (PAMPs). Upon PAMP engagement, TLRs activate a signaling cascade that leads to the production of inflammatory mediators. The localization of TLRs, either on the plasma membrane o...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章,评审

    doi：10.1002/JLB.3MIR1218-483RR

    authors： Marongiu L,Gornati L,Artuso I,Zanoni I,Granucci F

    更新日期：2019-07-01 00:00:00

  • Human B lymphoblastoid cells contain distinct patterns of cathepsin activity in endocytic compartments and regulate MHC class II transport in a cathepsin S-independent manner.

    abstract：:Endocytic proteolysis represents a major functional component of the major histocompatibility complex class II antigen-presentation machinery. Although transport and assembly of class II molecules in the endocytic compartment are well characterized, we lack information about the pattern of endocytic protease activity ...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1189/jlb.0803367

    authors： Lautwein A,Kraus M,Reich M,Burster T,Brandenburg J,Overkleeft HS,Schwarz G,Kammer W,Weber E,Kalbacher H,Nordheim A,Driessen C

    更新日期：2004-05-01 00:00:00

  • Dexamethasone enhances LPS induction of tissue factor expression in human monocytic cells by increasing tissue factor mRNA stability.

    abstract：:Glucocorticoids, such as dexamethasone (Dex), are used clinically in the treatment of various inflammatory diseases. Dex acts by inhibiting the expression of inflammatory mediators, such as tumor necrosis factor alpha (TNF-alpha) and monocyte chemoattractant protein-1 (MCP-1). It is surprising that Dex enhances bacter...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1189/jlb.0204068

    authors： Reddy KV,Bhattacharjee G,Schabbauer G,Hollis A,Kempf K,Tencati M,O'Connell M,Guha M,Mackman N

    更新日期：2004-07-01 00:00:00

  • Protein phenotypes of mouse macrophages activated in vivo for tumor cell killing.

    abstract：:We have shown previously that the cellular proteins 47b and 71/73 could be used to construct phenotypes that distinguish among bone marrow culture-derived (BMCD) macrophages that were either unstimulated or primed by gamma interferon or fully activated for tumor cell killing by gamma interferon in combination with lip...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1002/jlb.42.3.213

    authors： MacKay RJ,Russell SW

    更新日期：1987-09-01 00:00:00

  • The role of the Src family kinase Lyn in the immunomodulatory activities of cathelicidin peptide LL-37 on monocytic cells.

    abstract：:Cathelicidin LL-37 is a multifunctional, immunomodulatory and antimicrobial host-defense peptide of the human immune system. Here, we identified the role of SFKs in mediating the chemokine induction activity of LL-37 in monocytic cells. LL-37 induced SFK phosphorylation; and chemical inhibitors of SFKs suppressed chem...

    journal_title：Journal of leukocyte biology

    pub_type： 临床试验,杂志文章

    doi：10.1189/jlb.0411191

    authors： Nijnik A,Pistolic J,Cho P,Filewod NC,Falsafi R,Ramin A,Harder KW,Hancock RE

    更新日期：2012-04-01 00:00:00

  • Mutz-3-derived Langerhans cells are a model to study HIV-1 transmission and potential inhibitors.

    abstract：:Sexual transmission is the primary route of HIV-1 infection, and DC subsets are thought to be involved in viral dissemination to T cells. In the genital mucosa, two main subsets of DCs are present: epithelial LCs capture and degrade HIV-1 through C-type lectin Langerin, whereas subepithelial DCs express DC-SIGN, which...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1189/jlb.0809577

    authors： de Jong MA,de Witte L,Santegoets SJ,Fluitsma D,Taylor ME,de Gruijl TD,Geijtenbeek TB

    更新日期：2010-04-01 00:00:00

  • Living on the edge: Pain control by blood leukocytes at the borders of the central nervous system.

    abstract：:Discussion on the impact of blood leukocytes accumulating at the borders of the central nervous system on the development of neuropathic pain. ...

    journal_title：Journal of leukocyte biology

    pub_type： 评论,社论

    doi：10.1002/JLB.4CE0619-175R

    authors： Pinho-Ribeiro FA

    更新日期：2019-09-01 00:00:00

  • Rat IgG mediated circulatory cell depletion in mice requires mononuclear phagocyte system and is facilitated by complement.

    abstract：:Application of exogenous Abs targeting cell surface Ags has been widely used as an experimental approach to induce cell depletion or to inhibit receptor functionality. Moreover, Ab therapy is emerging as one of the mainstream strategies for cancer treatment. Previous studies on the mechanisms of Ab-mediated cell deple...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1002/JLB.4A1219-078R

    authors： Sun D,Sun P,He S,Shi M

    更新日期：2020-03-01 00:00:00

  • Differential expression of beta 2-integrins and cytokine production between gammadelta and alphabeta T cells in experimental autoimmune encephalomyelitis.

    abstract：:The expression of beta 2-integrins on gammadelta T cells in naïve mice or those with experimental autoimmune encephalomyelitis (EAE) remains poorly characterized. We compared beta 2-integrin expression and cytokine production between gammadelta and alphabeta T cells over the acute course of EAE. We observed that unlik...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1189/jlb.0407263

    authors： Smith SS,Barnum SR

    更新日期：2008-01-01 00:00:00

  • Lessons from a double-transgenic neutrophil approach to induce antiproteinase 3 antibody-mediated vasculitis in mice.

    abstract：:ANCA to either PR3 or MPO are found in patients with necrotizing vasculitis and glomerulonephritis. ANCA binding to their target antigens on neutrophils and subsequent neutrophil activation are pivotal disease mechanisms that lead to vascular inflammation and necrosis. ANCA interaction with PR3 is more complex than wi...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1189/jlb.5A0116-037R

    authors： Schreiber A,Eulenberg-Gustavus C,Bergmann A,Jerke U,Kettritz R

    更新日期：2016-12-01 00:00:00