Dexamethasone enhances LPS induction of tissue factor expression in human monocytic cells by increasing tissue factor mRNA stability.

abstract：:Neutrophils, an essential component of the innate immune system, are produced at a rate 10(11) cells/day and are consequently the most abundant leukocyte in the blood. These granulocytes have a relatively short half-life (6-8 h) in the blood, and as a result of the cytotoxic nature of their contents, it is critical th...

journal_title：Journal of leukocyte biology

authors： Rankin SM

更新日期：2010-08-01 00:00:00

abstract：:The in vitro studies have proposed that human Th1 cells favor expression of CXCR3 or CCR5, whereas Th2 cells favor CCR3 and CCR4. In this study, the in vivo relevance of expression of these chemokine receptors on Th cells was investigated in patients with atopic dermatitis (AD) as the Th2-dominated disorder and nonato...

journal_title：Journal of leukocyte biology

authors： Yamamoto J,Adachi Y,Onoue Y,Adachi YS,Okabe Y,Itazawa T,Toyoda M,Seki T,Morohashi M,Matsushima K,Miyawaki T

更新日期：2000-10-01 00:00:00

abstract：:Increasing the dietary alpha-linolenate (18:3n - 3)/linoleate (18:2n - 6) ratio results in an increase in lipopolysaccharide (LPS)-stimulated tumor necrosis factor (TNF) production in mouse resident and casein-induced peritoneal macrophages [3]. We found that prostaglandin E2 (PGE2) production is inversely related to ...

journal_title：Journal of leukocyte biology

authors： Watanabe S,Onozaki K,Yamamoto S,Okuyama H

更新日期：1993-02-01 00:00:00

abstract：:Several lines of evidence support the concept that NK cells play an important role in control of hepatitis C virus (HCV) infection via cytokine secretion and cytotoxicity. IL-7 is a homeostatic cytokine with a role in T cell development, activation, proliferation, and cytokine secretion. The IL-7Rα chain [cluster of d...

journal_title：Journal of leukocyte biology

authors： Judge CJ,Kostadinova L,Sherman KE,Butt AA,Falck-Ytter Y,Funderburg NT,Landay AL,Lederman MM,Sieg SF,Sandberg JK,Anthony DD

更新日期：2017-07-01 00:00:00

abstract：:The field of innate immunity is witnessing a paradigm shift regarding "memory" and "programming" dynamics. Past studies of innate leukocytes characterized them as first responders to danger signals with no memory. However, recent findings suggest that innate leukocytes, such as monocytes and neutrophils, are capable o...

journal_title：Journal of leukocyte biology

authors： Lee C,Geng S,Zhang Y,Rahtes A,Li L

更新日期：2017-09-01 00:00:00

abstract：:Fetal alcohol spectrum disorder (FASD), which results from ethanol exposure during pregnancy, and alcohol use disorder (AUD), which includes both binge and chronic alcohol abuse, are strikingly common and costly at personal and societal levels. These disorders are associated with significant pathology, including that ...

journal_title：Journal of leukocyte biology

authors： Kane CJ,Drew PD

更新日期：2016-11-01 00:00:00

abstract：:Eosinophils are traditionally associated with allergic and parasitic inflammation. More recently, eosinophils have also been shown to have roles in diverse processes including development, intestinal health, thymic selection, and B-cell survival with the majority of these insights being derived from murine models and ...

journal_title：Journal of leukocyte biology

authors： Nguyen WNT,Jacobsen EA,Finney CAM,Colarusso P,Patel KD

更新日期：2020-07-01 00:00:00

abstract：:In previous studies, macrophages have been shown to influence in vitro colony formation by erythroid progenitors (CFU-E). To determine whether the origin of the macrophages influences their effects on in vitro erythropoiesis, plasma clot cultures of CFU-E were grown over adherent monolayers of macrophages from various...

journal_title：Journal of leukocyte biology

authors： Johnson CS,Furmanski P

更新日期：1984-11-01 00:00:00

abstract：:Underlying acquired immunity to the fungus Candida albicans is usually present in adult immunocompetent individuals and is presumed to prevent mucosal colonization progressing to symptomatic infection. Exploration of immunological events leading to Candida resistance or susceptibility has indicated the central role of...

journal_title：Journal of leukocyte biology

authors： Romani L

更新日期：2000-08-01 00:00:00

abstract：:The viral CC chemokines MC148, encoded by the poxvirus molluscum contagiosum, and viral macrophage inflammatory protein (vMIP)-I and vMIP-II, encoded by human herpesvirus 8, were probed on the murine CC receptor (CCR) 8 in parallel with human CCR8. In calcium mobilization assays, vMIP-I acted as a high-affinity agonis...

journal_title：Journal of leukocyte biology

authors： Lüttichau HR,Gerstoft J,Schwartz TW

更新日期：2001-08-01 00:00:00

abstract：:Secreted IgM (sIgM) is a multifunctional evolutionary conserved antibody that is critical for the maintenance of tissue homeostasis as well as the development of fully protective humoral responses to pathogens. Constitutive secretion of self- and polyreactive natural IgM, produced mainly by B-1 cells, provides a circu...

journal_title：Journal of leukocyte biology

authors： Blandino R,Baumgarth N

更新日期：2019-11-01 00:00:00

abstract：:Intact cellular migration is critically important for the induction and regulation of the immune response. The Wiskott-Aldrich syndrome protein (WASP) regulates surface receptor signaling to the actin cytoskeleton in hematopoietic cells and thus plays a pivotal role in cellular locomotion. WASP deficiency causes the W...

journal_title：Journal of leukocyte biology

authors： Snapper SB,Meelu P,Nguyen D,Stockton BM,Bozza P,Alt FW,Rosen FS,von Andrian UH,Klein C

更新日期：2005-06-01 00:00:00

abstract：:Interleukin-10 (IL-10) is a potent anti-inflammatory cytokine with numerous immunomodulatory effects, including the inhibition of proinflammatory cytokine production. The mechanisms by which IL-10 exerts these effects still remain largely unknown. As there is evidence that suggests IL-10-mediated cytokine suppression ...

journal_title：Journal of leukocyte biology

authors： Williams L,Jarai G,Smith A,Finan P

更新日期：2002-10-01 00:00:00

abstract：:Monocytes have been categorized in three main subpopulations based on CD14 and CD16 surface expression. Classical monocytes express the CD14(++)CD16(-)CCR2(+) phenotype and migrate to inflammatory sites by quickly responding to CCL2 signaling. Here, we identified and characterized the expansion of a novel monocyte sub...

journal_title：Journal of leukocyte biology

authors： Gama L,Shirk EN,Russell JN,Carvalho KI,Li M,Queen SE,Kalil J,Zink MC,Clements JE,Kallas EG

更新日期：2012-05-01 00:00:00

abstract：:TKs are intracellular signaling molecules essential for cell homeostasis. Inhibition of TKs is used in treatment of malignancies and diabetes mellitus. The present study evaluated the role of Flt3 in antigen-induced arthritis. Mice were immunized with mBSA, and arthritis was induced by an i.a. injection of mBSA. Treat...

journal_title：Journal of leukocyte biology

authors： Dehlin M,Andersson S,Erlandsson M,Brisslert M,Bokarewa M

更新日期：2011-10-01 00:00:00

abstract：:Mast cell activation requires Cl(-) flux, which maintains the driving force for entry of extracellular calcium and initiates release of mediators such as histamine. However, chloride channel expression in mast cells has been poorly understood. For the first time, reverse transcriptase-polymerase chain reaction shows t...

journal_title：Journal of leukocyte biology

authors： Kulka M,Gilchrist M,Duszyk M,Befus AD

更新日期：2002-01-01 00:00:00

abstract：:Poxviruses encode a variety of immunomodulatory proteins that subvert the cytokine networks of infected hosts. Myxoma virus, a poxvirus pathogen of rabbits, expresses two distinct 35- to 40-kDa secreted glycoproteins that bind a broad spectrum of chemokines. The first of these, designated M-T7, is encoded by the T7 ge...

journal_title：Journal of leukocyte biology

authors： Lalani AS,McFadden G

更新日期：1997-11-01 00:00:00

abstract：:The ability of neutrophils to sense and migrate toward damaged tissue is a vital component of the innate immune response. Paradoxically, this same migration serves as the hallmark of a number of inflammatory conditions, including ischemic reperfusion injury, atherosclerosis, arthritis, and Crohn's disease. More recent...

journal_title：Journal of leukocyte biology

authors： Maher BM,Dhonnchu TN,Burke JP,Soo A,Wood AE,Watson RW

更新日期：2009-01-01 00:00:00

abstract：:PGG-glucan (Betafectin) is a soluble, highly purified yeast (1,3)-beta-glucan with broad anti-infective and immunomodulatory activities. These studies evaluated the ability of PGG-glucan to directly elicit O2- and tumor necrosis factor alpha (TNF-alpha) production by rat leukocytes in vitro. Particulate beta-glucan st...

journal_title：Journal of leukocyte biology

authors： Michalek M,Melican D,Brunke-Reese D,Langevin M,Lemerise K,Galbraith W,Patchen M,Mackin W

更新日期：1998-09-01 00:00:00

abstract：:Activation of Kupffer cells is a prominent feature of necro-inflammatory liver injury. We have recently demonstrated that 5-lipoxygenase (5-LO) and its accessory protein, 5-LO-activating protein (FLAP), are essential for the survival of Kupffer cells in culture, as their inhibition drives these liver resident macropha...

journal_title：Journal of leukocyte biology

authors： Titos E,Clària J,Planagumà A,López-Parra M,González-Périz A,Gaya J,Miquel R,Arroyo V,Rodés J

更新日期：2005-10-01 00:00:00

abstract：:The restriction of herpes simplex virus type 1 (HSV-1) gene expression in nonpermissive murine resident peritoneal macrophages (ResPMO) was analyzed at the level of transcription. Using nuclear run-on assays, we established that transcription of a representative gene from each HSV-1 kinetic class was initiated in both...

journal_title：Journal of leukocyte biology

authors： Wu L,Morahan PS,Leary K

更新日期：1993-01-01 00:00:00

abstract：:Constitutive expression of cell-associated, but not secreted, interleukin-1alpha (IL-1alpha) by oncogene-transformed fibrosarcoma cells induced regressing tumors in mice, a phenomenon that was abrogated by the IL-1 inhibitor, the IL-1 receptor antagonist (IL-1Ra). On the contrary, non-IL-1alpha-expressing tumor cells ...

journal_title：Journal of leukocyte biology

authors： Dvorkin T,Song X,Argov S,White RM,Zoller M,Segal S,Dinarello CA,Voronov E,Apte RN

更新日期：2006-07-01 00:00:00

abstract：:Soluble mediators and inducible cell-surface and matrix-bound molecules coordinate the cascade of events giving rise to leukocyte emigration. Knowledge of the specific mechanisms underlying the attraction of cells into a local site, however, remains sketchy. In particular, it is unclear how chemoattractants cause rapi...

journal_title：Journal of leukocyte biology

authors： Wiedermann CJ,Reinisch N,Bellmann R,Schratzberger P,Kowald E,Kähler CM

更新日期：1995-10-01 00:00:00

abstract：:The rapid and efficient expansion of CD8(+) memory T cells after the second encounter with a pathogen constitutes a hallmark trait of adaptive immunity. Yet, the contribution of CD4(+) T cells to the expansion of memory CD8(+) T cells remains the subject of controversy. Here, we show that, antigen-specific CD4(+) T ce...

journal_title：Journal of leukocyte biology

authors： Shi M,Hao S,Chan T,Xiang J

更新日期：2006-12-01 00:00:00

abstract：:Neutrophils are the first cells arriving at sites of tissue injury or infection to combat invading pathogens. Successful neutrophil recruitment to sites of inflammation highly depends on specific molecular mechanisms, fine-tuning the received information into signaling pathways and converting them into well-described ...

journal_title：Journal of leukocyte biology

authors： Begandt D,Thome S,Sperandio M,Walzog B

更新日期：2017-09-01 00:00:00

abstract：:Neutrophil extracellular traps (NETs), web-like DNA structures, provide efficient means of eliminating invading microorganisms but can also present a potential threat to its host because it is a likely source of autoantigens or by promoting bystander tissue damage. Therefore, it is important to identify mechanisms tha...

journal_title：Journal of leukocyte biology

authors： Zabieglo K,Majewski P,Majchrzak-Gorecka M,Wlodarczyk A,Grygier B,Zegar A,Kapinska-Mrowiecka M,Naskalska A,Pyrc K,Dubin A,Wahl SM,Cichy J

更新日期：2015-07-01 00:00:00

abstract：:Neutrophil's responses to G protein-coupled chemoattractants are highly dependent on store-operated calcium (Ca(2+)) entry (SOCE). Platelet-activating factor (PAF), a primary chemoattractant, simultaneously increases cytosolic-free Ca(2+), intracellular pH (pH(i)), ERK1/2, and Akt/protein kinase B (PKB) phosphorylatio...

journal_title：Journal of leukocyte biology

authors： Sandoval AJ,Riquelme JP,Carretta MD,Hancke JL,Hidalgo MA,Burgos RA

更新日期：2007-11-01 00:00:00

abstract：:In recent years, it has become appreciated that immune cells have different metabolic profiles depending on their activation status. During sepsis, circulating leukocytes go through a hyperinflammatory state, which can be accompanied or followed by defective antimicrobial defenses (also described as immune tolerance o...

journal_title：Journal of leukocyte biology

authors： Arts RJ,Gresnigt MS,Joosten LA,Netea MG

更新日期：2017-01-01 00:00:00

abstract：:Macrophages play an important role in effector mechanisms of various chronic inflammatory diseases. We studied the effect of gluten, the agent inducing celiac disease, and other food antigens on the activation of macrophages. Nitric oxide (NO) and cytokine production were followed as markers of activation, using cultu...

journal_title：Journal of leukocyte biology

authors： Tucková L,Flegelová Z,Tlaskalová-Hogenová H,Zídek Z

更新日期：2000-03-01 00:00:00

abstract：:Toll-like receptor 2 (TLR2) and -4 mediate signals from a great variety of bacterial gut products, giving the host a panel of microbe-recognizing receptors. Under homeostatic conditions, TLRs act as protective receptors of the intestinal epithelium. When homeostasis is disrupted in diseases such as inflammatory bowel ...

journal_title：Journal of leukocyte biology

authors： Gomariz RP,Arranz A,Abad C,Torroba M,Martinez C,Rosignoli F,Garcia-Gómez M,Leceta J,Juarranz Y

更新日期：2005-08-01 00:00:00