The inhibitory effect of secretory leukocyte protease inhibitor (SLPI) on formation of neutrophil extracellular traps.

abstract：:Microorganisms interact with the immune system in multiple ways. In an interaction between a microorganism and its host, the defense of the host does not go unchallenged. Microorganisms have for decades been suspected of possessing the capabilities of hiding from and escaping the consequences of immune surveillance. E...

journal_title：Journal of leukocyte biology

authors： Kotwal GJ

更新日期：1997-10-01 00:00:00

abstract：:Mast cells and MDSCs are increased by parasitic infection and tumor growth. We previously demonstrated that enhanced MDSC development in ADAM10 transgenic mice yielded resistance to Nb infection and that coculturing MDSCs and mast cells enhanced cytokine production. In the current work, we show that MDSC-mast cell coc...

journal_title：Journal of leukocyte biology

authors： Morales JK,Saleem SJ,Martin RK,Saunders BL,Barnstein BO,Faber TW,Pullen NA,Kolawole EM,Brooks KB,Norton SK,Sturgill J,Graham L,Bear HD,Urban JF Jr,Lantz CS,Conrad DH,Ryan JJ

更新日期：2014-04-01 00:00:00

abstract：:Prostaglandin J2 metabolite 15-deoxy-delta(12,14)-prostaglandin J2 (15-PGJ2) appears to possess anti-inflammatory properties. Unlike other prostaglandins, it has no known plasma membrane receptor. Its effects have been thought to occur through activation of the nuclear peroxisome proliferator-activated receptor gamma ...

journal_title：Journal of leukocyte biology

authors： Guyton K,Bond R,Reilly C,Gilkeson G,Halushka P,Cook J

更新日期：2001-04-01 00:00:00

abstract：:The cytosolic adaptor molecule SKAP-HOM, similar to the T cell-specific homologue SKAP55, interacts directly with ADAP, and both molecules are involved in inside-out signaling. Previous studies have shown that in the absence of SKAP-HOM, antigen receptor-triggered integrin-mediated adhesion is impaired severely in B c...

journal_title：Journal of leukocyte biology

authors： Reinhold A,Reimann S,Reinhold D,Schraven B,Togni M

更新日期：2009-07-01 00:00:00

abstract：:Infection with the opportunistic pathogen Pseudomonas aeruginosa is effectively controlled through tightly coordinated inflammation in healthy individuals. Dysregulated inflammation in cystic fibrosis greatly increases susceptibility to P. aeruginosa and lung damage. Recently, we identified regulator of calcineurin-1,...

journal_title：Journal of leukocyte biology

authors： Pang Z,Junkins RD,MacNeil AJ,McCormick C,Cheng Z,Chen WM,Lin TJ

更新日期：2017-12-01 00:00:00

abstract：:Although a number of chemokine receptors display coreceptor activities in vitro, chemokine receptor 5 (CCR5) and CXC chemokine receptor 4 (CXCR4) remain the major coreceptors used by the human immunodeficiency virus type 1 (HIV-1). In this study, we used an envelope-mediated fusion assay to demonstrate low CCR4 corece...

journal_title：Journal of leukocyte biology

authors： Agrawal L,Vanhorn-Ali Z,Alkhatib G

更新日期：2002-11-01 00:00:00

abstract：:Blocking monoclonal antibodies (mAbs) specific to mouse interleukin-1 receptor antagonist (IL-1ra) were prepared by immunizing Armenian hamsters with recombinant mouse IL-1ra. A sensitive and specific ELISA against mouse IL-1ra was also established. In Propionibacterium acnes-induced liver injury, P. acnes induced tra...

journal_title：Journal of leukocyte biology

authors： Fujioka N,Mukaida N,Harada A,Akiyama M,Kasahara T,Kuno K,Ooi A,Mai M,Matsushima K

更新日期：1995-07-01 00:00:00

abstract：:Potential mechanisms underlying impaired chemotactic responsiveness of neonatal neutrophils were investigated. Two distinct chemoattractants were compared: bacterially derived N-formyl-methionyl-leucyl-phenylalanine (fMLP) and a unique chemotactic monoclonal antibody, designated DL1.2, which binds to a neutrophil anti...

journal_title：Journal of leukocyte biology

authors： Weinberger B,Laskin DL,Mariano TM,Sunil VR,DeCoste CJ,Heck DE,Gardner CR,Laskin JD

更新日期：2001-12-01 00:00:00

abstract：:Rats were injected with phenylhydrazine (PHZ) for periods of up to 6 months, during which time a marked leukocytosis was induced. The highest leukocyte counts occurred within 4-5 days following injection. An initial injection of 4 mg/100 gm body weight evoked a mean total leukocyte count of 129 X 10(3) cells/microlite...

journal_title：Journal of leukocyte biology

authors： Dornfest BS,Lapin DM,Naughton BA,Adu S,Korn L,Gordon AS

更新日期：1986-01-01 00:00:00

abstract：:In this report, the construction of a functional, immunocompetent, full-thickness skin equivalent (SE) is described, consisting of an epidermal compartment containing keratinocytes, melanocytes, and human LCs derived from the MUTZ-3 cell line (MUTZ-LC) and a fibroblast-populated dermal compartment. The CD1a(+)Langerin...

journal_title：Journal of leukocyte biology

authors： Ouwehand K,Spiekstra SW,Waaijman T,Scheper RJ,de Gruijl TD,Gibbs S

更新日期：2011-11-01 00:00:00

abstract：:Anti-proteinase-3 (anti-PR3) or anti-myeloperoxidase (anti-MPO) antibodies are capable of activating human neutrophils primed by TNF-alpha in vitro. We described previously the involvement of FcgammaRIIa and beta(2) integrins in this neutrophil activation. In the literature, the requirement of TNF priming has been att...

journal_title：Journal of leukocyte biology

authors： Reumaux D,Hordijk PL,Duthilleul P,Roos D

更新日期：2006-12-01 00:00:00

abstract：:Microbicidal activity of neutrophils is usually measured by colony-counting techniques after cell lysis in distilled water. While studying the effect of the reduced nicotinamide adenine dinucleotide phosphate-oxidase inhibitor diphenyleneiodonium (DPI) on the staphylocidal activity of neutrophils, we obtained inconsis...

journal_title：Journal of leukocyte biology

authors： Decleva E,Menegazzi R,Busetto S,Patriarca P,Dri P

更新日期：2006-01-01 00:00:00

abstract：:NLRs are cytoplasmic proteins that sense cellular stress and intracellular damage resulting from pathogen uptake. To date, the role of NLRs has been studied using combinations of NLR and TLR agonists, but the interplay between two different NLRs remains uncharacterized. In this study, we employed microarrays to invest...

journal_title：Journal of leukocyte biology

authors： Conforti-Andreoni C,Beretta O,Licandro G,Qian HL,Urbano M,Vitulli F,Ricciardi-Castagnoli P,Mortellaro A

更新日期：2010-12-01 00:00:00

abstract：:IL-18 has a potential to up-regulate the Th1 and Th2 immune responses. It is known that IL-18, in synergy with IL-12, augments the Th1 response to bacterial infections, but it also augments the Th2 response to allergic disorders in the absence of IL-12. Although the Th1 and Th2 immune responses cross-regulate each oth...

journal_title：Journal of leukocyte biology

authors： Kinoshita M,Miyazaki H,Ono S,Seki S

更新日期：2013-05-01 00:00:00

abstract：:During inflammation the balance between cell activation and cell death is determined by the tight regulation of multiple intracellular enzyme cascades. Key regulatory steps often involve protein kinases. We show that the prototypical pro-inflammatory molecule, bacterial lipopolysaccharide, activates multiple protein k...

journal_title：Journal of leukocyte biology

authors： Lee J,Mira-Arbibe L,Ulevitch RJ

更新日期：2000-12-01 00:00:00

abstract：:Viral recognition programs DCs to express Signal 3 molecules that promote the differentiation of effector CD8(+) T cells. Besides IL-12, another DC-derived IL-12 family member, IL-27, has been reported to contribute herein, but its specific role is not well understood. Here, we show that whereas IL-12 potently induces...

journal_title：Journal of leukocyte biology

authors： de Groot R,van Beelen AJ,Bakdash G,Taanman-Kueter EW,de Jong EC,Kapsenberg ML

更新日期：2012-09-01 00:00:00

abstract：:In vitro studies have suggested that targeting interleukin (IL)-1 and tumor necrosis factor (TNF) can be used to regulate intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) and potentially treat kidney inflammation. We therefore evaluated ICAM-1 and VCAM-1 regulation in knockout ...

journal_title：Journal of leukocyte biology

authors： Burne MJ,Elghandour A,Haq M,Saba SR,Norman J,Condon T,Bennett F,Rabb H

更新日期：2001-08-01 00:00:00

abstract：:In the absence of IL-10, colonic inflammation ensues, which is characterized by high levels of IL-17. Here, we demonstrate a direct correlation between ICOS expression and IL-17 production in cIELs. IL-10(-/-) mice had increased numbers of cIELs and greater colon weight. Although the CD69 early activation antigen was ...

journal_title：Journal of leukocyte biology

authors： Schaefer JS,Montufar-Solis D,Vigneswaran N,Klein JR

更新日期：2010-02-01 00:00:00

abstract：:Neutrophils are quickly recruited to tissues in response to proinflammatory cues; however, little is known about tissue neutrophil phenotypes in health. We employ a multicolor flow cytometric approach to assess surface markers of activation on neutrophils from the bone marrow, blood, peritoneum, spleen, liver, fat, co...

journal_title：Journal of leukocyte biology

authors： Chadwick JW,Fine N,Khoury W,Tasevski N,Sun CX,Boroumand P,Klip A,Glogauer M

更新日期：2020-11-04 00:00:00

abstract：:Genomic, transcriptomic and proteomic databases indicate that the N-terminal 322 residues encoded by the presumptive LOC100996504 gene, which is adjacent to the ARHGEF18 guanine nucleotide exchange factor gene on chromosome 19, constitute the N-terminal portion of a 1361-residue isoform of ARHGEF18, dubbed LOCGEF-X3. ...

journal_title：Journal of leukocyte biology

authors： Turton KB,Wilkerson EM,Hebert AS,Fogerty FJ,Schira HM,Botros FE,Coon JJ,Mosher DF

更新日期：2018-07-01 00:00:00

abstract：:Human neutrophils generate oxygen reduction products as a consequence of membrane interactions with a number of stimuli. One oxygen-centered free radical (superoxide) has been unequivocally shown to result from this "respiratory burst," and some experimental evidence for another (hydroxyl radical) has been published, ...

journal_title：Journal of leukocyte biology

authors： Britigan BE,Cohen MS,Rosen GM

更新日期：1987-04-01 00:00:00

abstract：:Zinc is an essential element important for growth, the nervous system, and especially the immune system. Zinc deficiency as well as levels well above normal, due to high-dose treatment, showed an impaired immune function. This review summarizes the current status of zinc's significance for leukocyte biology and health...

journal_title：Journal of leukocyte biology

authors： Wellinghausen N,Rink L

更新日期：1998-11-01 00:00:00

abstract：:Polymorphonuclear leukocytes (PMNs) are crucial for initial control of Streptococcus pneumoniae (pneumococcus) lung infection; however, as the infection progresses their persistence in the lungs becomes detrimental. Here we explored why the antimicrobial efficacy of PMNs declines over the course of infection. We found...

journal_title：Journal of leukocyte biology

authors： Siwapornchai N,Lee JN,Tchalla EYI,Bhalla M,Yeoh JH,Roggensack SE,Leong JM,Bou Ghanem EN

更新日期：2020-09-01 00:00:00

abstract：:Lysophosphatidylcholines (lysoPCs) are effective polymorphonuclear neutrophil (PMN) priming agents implicated in transfusion-related acute lung injury (TRALI). LysoPCs cause ligation of the G2A receptor, cytosolic Ca2+ flux, and activation of Hck. We hypothesize that lysoPCs induce Hck-dependent activation of protein ...

journal_title：Journal of leukocyte biology

authors： Kelher MR,McLaughlin NJ,Banerjee A,Elzi DJ,Gamboni F,Khan SY,Meng X,Mitra S,Silliman CC

更新日期：2017-01-01 00:00:00

abstract：:High mobility group box 1 (HMGB1) is one of the recently defined damage-associated molecular pattern molecules, passively released from necrotic cells and secreted by activated macrophage/monocytes. Whether cytolytic cells induce HMGB1 release from tumor cells is not known. We developed a highly sensitive method for d...

journal_title：Journal of leukocyte biology

authors： Ito N,DeMarco RA,Mailliard RB,Han J,Rabinowich H,Kalinski P,Stolz DB,Zeh HJ 3rd,Lotze MT

更新日期：2007-01-01 00:00:00

abstract：:Previously, we demonstrated the stimulus-specific ability of platelet lysate or release products to inhibit neutrophil functions in response to f-met-leu-phe (fMLP) or phorbol myristate acetate (PMA). The present study further characterizes these activities and identifies one of the platelet inhibitors of neutrophil s...

journal_title：Journal of leukocyte biology

authors： McGarrity ST,Stephenson AH,Hyers TM,Webster RO

更新日期：1988-11-01 00:00:00

abstract：:Several members of the cytokine network play an important role in controlling the replication of the human immunodeficiency virus (HIV) in several experimental systems. Their effects can be categorized in the following three functional groups: (1) HIV-inductive cytokines; (2) HIV-suppressive cytokines; (3) cytokines w...

journal_title：Journal of leukocyte biology

authors： Vicenzi E,Biswas P,Mengozzi M,Poli G

更新日期：1997-07-01 00:00:00

abstract：:Structurally, the monocyte chemotactic proteins MCP-1, -2, and -3 form a subfamily of the C-C or beta-chemokines. Like other chemokines, MCPs are produced by a variety of cells on stimulation with cytokines (interleukin-1, tumor necrosis factor-alpha, interferon-gamma), bacterial and viral products or mitogens. MCP-1 ...

journal_title：Journal of leukocyte biology

authors： Proost P,Wuyts A,Van Damme J

更新日期：1996-01-01 00:00:00

abstract：:IL-10 is a key anti-inflammatory cytokine secreted by activated macrophages as a feedback control mechanism to prevent excessive inflammatory responses. Here, we define multiple intracellular trafficking pathways involved in the secretion of newly synthesized IL-10 from macrophages following TLR4 activation with LPS, ...

journal_title：Journal of leukocyte biology

authors： Stanley AC,Lieu ZZ,Wall AA,Venturato J,Khromykh T,Hamilton NA,Gleeson PA,Stow JL

更新日期：2012-12-01 00:00:00

abstract：:IL-31, a newly identified member of the IL-6 cytokine family, is involved in many pathological conditions, including atopic dermatitis and pruritis. In this study, we investigated how expression of IL-31 is regulated in T cells and mast cells. We observed that expression of IL-31 required a calcium signal and was depe...

journal_title：Journal of leukocyte biology

authors： Park K,Park JH,Yang WJ,Lee JJ,Song MJ,Kim HP

更新日期：2012-02-01 00:00:00