Abstract:
:Viral recognition programs DCs to express Signal 3 molecules that promote the differentiation of effector CD8(+) T cells. Besides IL-12, another DC-derived IL-12 family member, IL-27, has been reported to contribute herein, but its specific role is not well understood. Here, we show that whereas IL-12 potently induces inflammatory cytokines (i.e., IFN-γ and TNF-α, but not IL-2), IL-27 excels in inducing proliferation and a cytotoxic profile (GrB, cytotoxicity of target cells) in human naïve CD8(+) T cells. Compared with bacterial cell-wall peptidoglycan, viral dsRNA-mimic poly (I:C) is superior in priming human BDCA1(+) peripheral blood DCs to produce IL-12 and IL-27, which promote inflammatory cytokines and a cytotoxic profile in differentiating CD8(+) T cells, respectively. These data support the concept that viral dsRNA-activated human DCs produce IL-27 to act as a specialized procytotoxic, antiviral cytokine in the development of effector CD8(+) T cells.
journal_name
J Leukoc Bioljournal_title
Journal of leukocyte biologyauthors
de Groot R,van Beelen AJ,Bakdash G,Taanman-Kueter EW,de Jong EC,Kapsenberg MLdoi
10.1189/jlb.0112045subject
Has Abstractpub_date
2012-09-01 00:00:00pages
605-10issue
3eissn
0741-5400issn
1938-3673pii
jlb.0112045journal_volume
92pub_type
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