The significance of zinc for leukocyte biology.

abstract：:Many tumor cells are resistant to Fas-mediated killing, which has been primarily used as a mechanism to evade immune attack. In this study, we found a new action of Fas on tumors where activation of the Fas signal may force tumor cells to produce survival factors for neutrophils. Human peripheral circulating neutrophi...

journal_title：Journal of leukocyte biology

authors： Hor WS,Huang WL,Lin YS,Yang BC

更新日期：2003-03-01 00:00:00

abstract：:To assess the effect of hypoxemia on the responses of polymorphonuclear neutrophils (PMN) during an inflammatory response, rats were maintained in a low F1O2 atmosphere (9% O2) or room air for 12 h before intrathoracic injection of carrageenin or intradermal injections of agonists. After 4 h, hypoxemic rats had 50% mo...

journal_title：Journal of leukocyte biology

authors： Tremblay PB,Macari DM,Martel D,du Souich P,Barja-Fidalgo C,Marleau S

更新日期：2000-06-01 00:00:00

abstract：:Interleukin-15 (IL-15) is a cytokine that possesses interesting, potential therapeutic properties. However, based on several parameters including activation of neutrophils, it is also recognized as a proinflammatory cytokine. The mechanisms by which IL-15 activates human neutrophil functions are not fully understood. ...

journal_title：Journal of leukocyte biology

authors： Ratthé C,Girard D

更新日期：2004-07-01 00:00:00

abstract：:The human activation antigen CD69 is an early inducible surface glycoprotein acquired by T cells in the thymus at the stage of positive selection and during activation of mature lymphoid cells both in vivo and in vitro. We have studied the regulatory influence of CD69 activation pathway on the glycolytic process and t...

journal_title：Journal of leukocyte biology

authors： Conde M,Montaño R,Moreno-Aurioles VR,Ramirez R,Sanchez-Mateos P,Sanchez-Madrid F,Sobrino F

更新日期：1996-08-01 00:00:00

abstract：:The preferential association of some chemokine receptors with human Th1 or Th2 cells has recently been reported. In this study, the expression of CCR3, CCR5, CXCR3, and CXCR4 were analyzed by flow cytometry in three distinct in vitro models of Th1/Th2 polarization, activated naive and memory T cells, and T-cell clones...

journal_title：Journal of leukocyte biology

authors： Annunziato F,Cosmi L,Galli G,Beltrame C,Romagnani P,Manetti R,Romagnani S,Maggi E

更新日期：1999-05-01 00:00:00

abstract：:Discussion on Tregs that have anti-inflammatory and anti-atherogenic properties as an ideal therapeutic target to reduce fatal cardiovascular deaths following major noncardiac surgery. ...

journal_title：Journal of leukocyte biology

authors： Kyaw T,Bobik A

更新日期：2020-05-01 00:00:00

abstract：:The effect of coupling C3bi to immunoglobulin G (IgG) immune complexes (IC) on their ability to produce protein tyrosine phosphorylation and activation of the mitogen-activated protein kinase (MAPK) and the Akt/protein kinase B (PKB) routes was assessed in human monocytes. Cross-linking Fc receptors for IgG activated ...

journal_title：Journal of leukocyte biology

authors： Trinidad AG,de la Puerta ML,Fernández N,Bayón Y,Crespo MS,Alonso A

更新日期：2006-05-01 00:00:00

abstract：:This study was initiated to identify and characterize thyroid fibrosis in a murine model of granulomatous experimental autoimmune thyroiditis (G-EAT) and determine if TGF-beta1 might be involved in fibrosis. G-EAT was induced by transfer of mouse thyroglobulin-sensitized spleen cells activated in vitro with thyroglobu...

journal_title：Journal of leukocyte biology

authors： Chen K,Wei Y,Sharp GC,Braley-Mullen H

更新日期：2000-12-01 00:00:00

abstract：:Life stress is a major risk factor in the onset and exacerbation of mast cell-associated diseases, including allergy/anaphylaxis, asthma, and irritable bowel syndrome. Although it is known that mast cells are highly activated upon stressful events, the mechanisms by which stress modulates mast cell function and diseas...

journal_title：Journal of leukocyte biology

authors： Ayyadurai S,Gibson AJ,D'Costa S,Overman EL,Sommerville LJ,Poopal AC,Mackey E,Li Y,Moeser AJ

更新日期：2017-12-01 00:00:00

abstract：:Activation of Kupffer cells is a prominent feature of necro-inflammatory liver injury. We have recently demonstrated that 5-lipoxygenase (5-LO) and its accessory protein, 5-LO-activating protein (FLAP), are essential for the survival of Kupffer cells in culture, as their inhibition drives these liver resident macropha...

journal_title：Journal of leukocyte biology

authors： Titos E,Clària J,Planagumà A,López-Parra M,González-Périz A,Gaya J,Miquel R,Arroyo V,Rodés J

更新日期：2005-10-01 00:00:00

abstract：:Sexual transmission is the primary route of HIV-1 infection, and DC subsets are thought to be involved in viral dissemination to T cells. In the genital mucosa, two main subsets of DCs are present: epithelial LCs capture and degrade HIV-1 through C-type lectin Langerin, whereas subepithelial DCs express DC-SIGN, which...

journal_title：Journal of leukocyte biology

authors： de Jong MA,de Witte L,Santegoets SJ,Fluitsma D,Taylor ME,de Gruijl TD,Geijtenbeek TB

更新日期：2010-04-01 00:00:00

abstract：:Exposure of the macrophage-like cell line J774.1 to 20 gray of cobalt-60 gamma radiation resulted in a block of tritiated thymidine incorporation, along with an increase in cell "activation," as assessed by increases in lysosomal enzyme and ectoenzyme content, PMA-induced H2O2 production, and NBT staining, ingestion o...

journal_title：Journal of leukocyte biology

authors： Gallin EK,Green SW,Sheehy PA

更新日期：1985-09-01 00:00:00

abstract：:Freeze-fracture analysis has shown that treatment of cells with phorbol myristate acetate (PMA) results in a loss of intramembranous particles (IMP) associated with the external leaflet of their plasma membranes. It has also been demonstrated that phorbol esters markedly enhance the sensitivity of tumor targets to nat...

journal_title：Journal of leukocyte biology

authors： Nabi ZF,Zucker-Franklin D,Baten A

更新日期：1989-03-01 00:00:00

abstract：:Compared with CD4+25+ regulatory T cells (Tregs), the mechanisms for natural, polyclonal CD8+25+ Treg immune suppression have been significantly less studied. We previously showed that polyclonal T cells can acquire antigen-specific targeting activity through arming with exosomal peptide-MHC (pMHC). In this study, we ...

journal_title：Journal of leukocyte biology

authors： Mu C,Zhang X,Wang L,Xu A,Ahmed KA,Pang X,Chibbar R,Freywald A,Huang J,Zhu Y,Xiang J

更新日期：2017-05-01 00:00:00

abstract：:Recombinant tissue plasminogen activator (t-PA), the only approved stroke treatment, is used for clot lysis within the occluded brain artery. Unfortunately, matrix metalloproteinase-9 (MMP-9) concentration increases after t-PA treatment and has been related to hemorrhagic transformation after ischemic stroke. Although...

journal_title：Journal of leukocyte biology

authors： Cuadrado E,Ortega L,Hernández-Guillamon M,Penalba A,Fernández-Cadenas I,Rosell A,Montaner J

更新日期：2008-07-01 00:00:00

abstract：:The oxidative metabolic burst of stimulated human polymorphonuclear leukocytes (PMNs) has been evaluated by the measurement of oxygen consumption, chemiluminescence, and oxygen radicals (O2-, H2O2, OH-) derived from activation of the hexose monophosphate shunt (HMPS). PMNs from patients with chronic granulomatous dise...

journal_title：Journal of leukocyte biology

authors： Hassan NF,Campbell DE,Douglas SD

更新日期：1988-04-01 00:00:00

abstract：:The nucleosome, the basic structure of chromatin and normal product of cell apoptosis, plays a pivotal role both in the induction and the pathogenesis of systemic lupus erythematosus (SLE). Nucleosomes have been found to circulate at high levels in patients with SLE and apoptosis of lymphoid cells is increased during ...

journal_title：Journal of leukocyte biology

authors： Laderach D,Bach JF,Koutouzov S

更新日期：1998-12-01 00:00:00

abstract：:CD8(+) T cells play an important role in immune regulation and effective immune responses against tumor cells, viral infection, and intracellular pathogens. In this report, using tiger or 10BiT mice, we defined a population of IL-10-producing CD8(+) T cells that were induced by IL-4. These IL-10(+)CD8(+) T cells posse...

journal_title：Journal of leukocyte biology

authors： Zhao Y,Zhao H,Sun Y,Hao J,Qi X,Zhou X,Wu Z,Wang P,Kaech SM,Weaver CT,Flavell RA,Zhao L,Yao Z,Yin Z

更新日期：2013-12-01 00:00:00

abstract：:Mycobacterium avium complex (MAC) is a significant cause of opportunistic infection in patients with acquired immunodeficiency syndrome. Although the major route of entry of MAC is via the gastrointestinal tract, MAC can infect humans through the respiratory tract and eventually encounter alveolar macrophages within t...

journal_title：Journal of leukocyte biology

authors： Lopez JP,Clark E,Shepherd VL

更新日期：2003-10-01 00:00:00

abstract：:IL-27, an IL-12 family member, was initially described as a proinflammatory cytokine. Nevertheless, it also poses anti-inflammatory activity, being involved in suppressing development of TH-17 cells as well as in the induction of inhibitory Tr1 cells. Recent data obtained in mice suggest that it can down-modulate the ...

journal_title：Journal of leukocyte biology

authors： Karakhanova S,Bedke T,Enk AH,Mahnke K

更新日期：2011-06-01 00:00:00

abstract：:THP-1 cells are a monocyte-like cell line derived from a patient with acute monocytic leukemia and unlike other leukemic cell lines has a normal diploid karyotype. We have characterized Fc gamma R expression on this cell line by flow cytometry, radiolabeled IgG1 and monoclonal antibody (mAb) binding assays, and bioche...

journal_title：Journal of leukocyte biology

authors： Fleit HB,Kobasiuk CD

更新日期：1991-06-01 00:00:00

abstract：:Experimental autoimmune uveoretinitis (EAU) is a T helper type 1 cell-mediated autoimmune disease, which serves as a model of human chronic uveitis. In this model, cells of a monocyte/macrophage lineage and retinal antigen (Ag)-specific T cells infiltrate into the retina and cause inflammatory lesion, where proinflamm...

journal_title：Journal of leukocyte biology

authors： Kitamei H,Iwabuchi K,Namba K,Yoshida K,Yanagawa Y,Kitaichi N,Kitamura M,Ohno S,Onoé K

更新日期：2006-06-01 00:00:00

abstract：:ANCA to either PR3 or MPO are found in patients with necrotizing vasculitis and glomerulonephritis. ANCA binding to their target antigens on neutrophils and subsequent neutrophil activation are pivotal disease mechanisms that lead to vascular inflammation and necrosis. ANCA interaction with PR3 is more complex than wi...

journal_title：Journal of leukocyte biology

authors： Schreiber A,Eulenberg-Gustavus C,Bergmann A,Jerke U,Kettritz R

更新日期：2016-12-01 00:00:00

abstract：:The effect of a 6-kDa thymic peptide (TP) on the oxidative burst of the murine macrophage cell line J774 was determined. TP was incubated with J774 cells at 37 degrees C and 5% CO2 for 18 h, oxidative burst was triggered by zymosan, and chemiluminescence was amplified by luminol and measured in an automated luminomete...

journal_title：Journal of leukocyte biology

authors： Park CS,Li L,Lau BH

更新日期：1994-04-01 00:00:00

abstract：:Intravenous administration of lipopolysaccharide (LPS) to rats increased the production of nitric oxide (NO) metabolites (NOx) by blood polymorphonuclear neutrophils (PMN) in vitro. Both dexamethasone and L-NMMA, added in vitro to neutrophil cultures, inhibited the production of NO. On the other hand, the production o...

journal_title：Journal of leukocyte biology

authors： Fierro IM,Nascimento-DaSilva V,Arruda MA,Freitas MS,Plotkowski MC,Cunha FQ,Barja-Fidalgo C

更新日期：1999-04-01 00:00:00

abstract：:Constitutive expression of cell-associated, but not secreted, interleukin-1alpha (IL-1alpha) by oncogene-transformed fibrosarcoma cells induced regressing tumors in mice, a phenomenon that was abrogated by the IL-1 inhibitor, the IL-1 receptor antagonist (IL-1Ra). On the contrary, non-IL-1alpha-expressing tumor cells ...

journal_title：Journal of leukocyte biology

authors： Dvorkin T,Song X,Argov S,White RM,Zoller M,Segal S,Dinarello CA,Voronov E,Apte RN

更新日期：2006-07-01 00:00:00

abstract：:IL-18 has a potential to up-regulate the Th1 and Th2 immune responses. It is known that IL-18, in synergy with IL-12, augments the Th1 response to bacterial infections, but it also augments the Th2 response to allergic disorders in the absence of IL-12. Although the Th1 and Th2 immune responses cross-regulate each oth...

journal_title：Journal of leukocyte biology

authors： Kinoshita M,Miyazaki H,Ono S,Seki S

更新日期：2013-05-01 00:00:00

abstract：:Phagocytosis is the process whereby cells engulf large particles, usually over 0.5 micro m in diameter. Phagocytosis is triggered by the interaction of opsonins that cover the particle to be internalized with specific receptors on the surface of the phagocyte. The best-studied phagocytic receptors include the Fc recep...

journal_title：Journal of leukocyte biology

authors： García-García E,Rosales C

更新日期：2002-12-01 00:00:00

abstract：:Spatial analyses of the distribution of Ca2+ in resting and activated T and B lymphocytes have shown that the bulk of increased [Ca2+]i appears to be associated with the nuclear region. These observations suggest that Ca2+ is released from the perinuclear space or that it diffuses to the nucleoplasm, or both. We have ...

journal_title：Journal of leukocyte biology

authors： Gagné D,Ahnadi CE,Martel J,Payet MD,Dupuis G

更新日期：1997-12-01 00:00:00

abstract：:We have demonstrated previously that binding of ephrin-A1 to EphA receptors on human CD4(+) and CD8(+) T cells stimulates migration. Two EphA receptors have been reported in T cells: EphA1 at the protein level and EphA4 at the mRNA level. In this study, we wanted to investigate the expression profile of these receptor...

journal_title：Journal of leukocyte biology

authors： Holen HL,Nustad K,Aasheim HC

更新日期：2010-06-01 00:00:00