Extracellular adenosine enhances the ability of PMNs to kill Streptococcus pneumoniae by inhibiting IL-10 production.

abstract：:In this study, we test the hypothesis that cAMP, acting as an extracellular mediator, affects the physiology and function of human myeloid cells. The cAMP is a second messenger recognized as a universal regulator of several cellular functions in different organisms. Many studies have shown that extracellular cAMP exer...

journal_title：Journal of leukocyte biology

authors： Sciaraffia E,Riccomi A,Lindstedt R,Gesa V,Cirelli E,Patrizio M,De Magistris MT,Vendetti S

更新日期：2014-07-01 00:00:00

abstract：:Sexual transmission is the primary route of HIV-1 infection, and DC subsets are thought to be involved in viral dissemination to T cells. In the genital mucosa, two main subsets of DCs are present: epithelial LCs capture and degrade HIV-1 through C-type lectin Langerin, whereas subepithelial DCs express DC-SIGN, which...

journal_title：Journal of leukocyte biology

authors： de Jong MA,de Witte L,Santegoets SJ,Fluitsma D,Taylor ME,de Gruijl TD,Geijtenbeek TB

更新日期：2010-04-01 00:00:00

abstract：:T-cell recognition of foreign antigen and migration to specific anatomic sites in vivo involves transient adhesive contacts between beta1 integrins expressed on T cells and cell surface proteins or extracellular-matrix components. Engagement of the CD3-T-cell receptor (CD3-TCR) complex initiates a complex signaling ca...

journal_title：Journal of leukocyte biology

authors： Woods ML,Shimizu Y

更新日期：2001-06-01 00:00:00

abstract：:C1qR(P) is a type I cell surface glycoprotein that has been shown to enhance ingestion of suboptimally opsonized targets by phagocytes in vitro. In this study, we developed and characterized polyclonal antibodies to study the tissue distribution of this receptor targeted to either the N- or C-terminal portion of the m...

journal_title：Journal of leukocyte biology

authors： Fonseca MI,Carpenter PM,Park M,Palmarini G,Nelson EL,Tenner AJ

更新日期：2001-11-01 00:00:00

abstract：:CD5L, a soluble protein belonging to the SRCR superfamily, is expressed mostly by macrophages in lymphoid and inflamed tissues. The expression of this protein is transcriptionally controlled by LXRs, members of the nuclear receptor family that play major roles in lipid homeostasis. Research undertaken over the last de...

journal_title：Journal of leukocyte biology

authors： Sanjurjo L,Aran G,Roher N,Valledor AF,Sarrias MR

更新日期：2015-08-01 00:00:00

abstract：:Genetic variation in the major histocompatibility complex (MHC) influences susceptibility and immune responses to Mycobacterium tuberculosis in mice and humans, but connections among the severity of tuberculosis (TB), dynamic changes in T cell responses to mycobacteria, and MHC genetic polymorphisms are poorly charact...

journal_title：Journal of leukocyte biology

authors： Pichugin AV,Petrovskaya SN,Apt AS

更新日期：2006-04-01 00:00:00

abstract：:We have shown previously that ulcerogenic (type I) strains of Helicobacter pylori (Hp) retard their entry into macrophages. However, the signaling pathways that regulate Hp phagocytosis are largely undefined. We show here that Hp strongly activated class IA phosphoinositide3-kinases (PI3Ks) in macrophages, coincident ...

journal_title：Journal of leukocyte biology

authors： Allen LA,Allgood JA,Han X,Wittine LM

更新日期：2005-07-01 00:00:00

abstract：:NLRP3 is the most crucial member of the NLR family, as it detects the existence of pathogen invasion and self-derived molecules associated with cellular damage. Several studies have reported that excessive NLRP3 inflammasome-mediated caspase-1 activation is a key factor in the development of diseases. Recent studies h...

journal_title：Journal of leukocyte biology

authors： Lin YC,Huang DY,Wang JS,Lin YL,Hsieh SL,Huang KC,Lin WW

更新日期：2015-05-01 00:00:00

abstract：:The effect of recombinant human interleukin-2 (IL-2) on tumor cell cycle kinetics was evaluated in rats bearing the Walker-256 carcinosarcoma. Seven days after implantation, tumor-bearing rats were infused intravenously with IL-2 at a dose of 500 mg/kg body weight or 5% dextrose for 6 h. Tumor cell mean DNA synthesis ...

journal_title：Journal of leukocyte biology

authors： Wan JM,Bistrian BR,Figoni MA,Istfan NW

更新日期：1994-02-01 00:00:00

abstract：:The human polyomavirus JCV lytically infects oligodendrocytes of immunosuppressed individuals leading to the fatal demyelinating disease termed progressive multifocal leukoencephalopathy (PML). Dementia, hemiparesis, and hemianopsia are the predominant presenting signs of PML. Asymptomatic JCV infection is common worl...

journal_title：Journal of leukocyte biology

authors： Jensen PN,Major EO

更新日期：1999-04-01 00:00:00

abstract：:Tyrosine phosphorylation is an important component of the signaling pathways responsible for the activation of the macrophage respiratory burst. Because the virulence plasmid of Yersinia enterocolitica encodes a phosphotyrosine phosphatase, YopH, it is possible that the pathogenic strategy of Y. enterocolitica involve...

journal_title：Journal of leukocyte biology

authors： Green SP,Hartland EL,Robins-Browne RM,Phillips WA

更新日期：1995-06-01 00:00:00

abstract：:Interactions between chemokines and their specific receptors are important for leukocyte trafficking. The CC-chemokine monocyte chemoattractant protein-1 (MCP-1) and its specific receptor CCR2 are essential in monocytic infiltration and have been associated with several inflammatory diseases. It has been reported that...

journal_title：Journal of leukocyte biology

authors： Zhou Y,Yang Y,Warr G,Bravo R

更新日期：1999-02-01 00:00:00

abstract：:Stromal cell-derived factor 1alpha (SDF-1alpha) is the exclusive ligand for the chemokine receptor CXCR4. This receptor plays a pivotal role in immune responses, the pathogenesis of infection such as HIV, and cellular trafficking. However, the signaling mechanisms regulating SDF-driven T cell migration are not well de...

journal_title：Journal of leukocyte biology

authors： Shahabi NA,McAllen K,Sharp BM

更新日期：2008-03-01 00:00:00

abstract：:The Fc gamma receptor IIB (FcγRIIB/CD32B) was generated million years ago during evolution. It is the sole inhibitory receptor for IgG, and has long been associated with the regulation of humoral immunity and innate immune homeostasis. However, new and surprising functions of FcγRIIB are emerging. In particular, FcγRI...

journal_title：Journal of leukocyte biology

authors： Roghanian A,Stopforth RJ,Dahal LN,Cragg MS

更新日期：2018-02-06 00:00:00

abstract：:CD4(+) T cell help contributes critically to DC-induced CD8(+) CTL immunity. However, precisely how these three cell populations interact and how CD4(+) T cell signals are delivered to CD8(+) T cells in vivo have been unclear. In this study, we developed a novel, two-step approach, wherein CD4(+) T cells and antigen-p...

journal_title：Journal of leukocyte biology

authors： Ahmed KA,Wang L,Munegowda MA,Mulligan SJ,Gordon JR,Griebel P,Xiang J

更新日期：2012-08-01 00:00:00

abstract：:Galectin-1 (Gal-1) is a beta-galactoside-binding protein endowed with anti-inflammatory properties. The purpose of this study was to investigate the effects of endogenous and exogenous Gal-1 on neutrophil recruitment onto TNF-treated endothelium. The effect of human recombinant (hr)Gal-1 on markers of neutrophil activ...

journal_title：Journal of leukocyte biology

authors： Cooper D,Norling LV,Perretti M

更新日期：2008-06-01 00:00:00

abstract：:Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a naturally occurring growth factor produced by several cell types in response to a variety of stimuli. GM-CSF has potent stimulatory effects on the growth and maturation of hematopoietic cells and has profound effects on mature circulating effector cells. C...

journal_title：Journal of leukocyte biology

authors： Hill AD,Naama HA,Calvano SE,Daly JM

更新日期：1995-12-01 00:00:00

abstract：:Severe injury can initiate an exaggerated systemic inflammatory response and multiple organ failure (MOF) if a subsequent immune stimulus, "second hit", occurs. Using a mouse thermal injury model, we tested whether changes in innate immune cell reactivity following injury can contribute to the development of heightene...

journal_title：Journal of leukocyte biology

authors： Murphy TJ,Paterson HM,Kriynovich S,Zang Y,Kurt-Jones EA,Mannick JA,Lederer JA

更新日期：2005-01-01 00:00:00

abstract：:That monocytes can differentiate into macrophages or dendritic cells (DCs) makes them an essential link between innate and adaptive immunity. However, little is known about how interactions with pathogens or T cells influence monocyte engagement toward DCs. We approached this point in cultures where granulocyte macrop...

journal_title：Journal of leukocyte biology

authors： Rosenzwajg M,Jourquin F,Tailleux L,Gluckman JC

更新日期：2002-12-01 00:00:00

abstract：:Colorectal cancer is the second most common cause of cancer-related death. Novel prognostic factors should be identified and validated to refine the present tumor-node-metastasis system. The presence of immune cells infiltrating colorectal cancers is a common phenomenon. However, the current belief is that clinically ...

journal_title：Journal of leukocyte biology

authors： Pagès F,Galon J,Fridman WH

更新日期：2008-10-01 00:00:00

abstract：:Eosinophils are traditionally associated with allergic and parasitic inflammation. More recently, eosinophils have also been shown to have roles in diverse processes including development, intestinal health, thymic selection, and B-cell survival with the majority of these insights being derived from murine models and ...

journal_title：Journal of leukocyte biology

authors： Nguyen WNT,Jacobsen EA,Finney CAM,Colarusso P,Patel KD

更新日期：2020-07-01 00:00:00

abstract：:Developmental delays, which impair antibacterial host defense, are present in the neutrophil system of human preterm neonates. We hypothesized that diminished production of interleukin-8 (IL-8), a neutrophil chemotactic peptide, might in part be responsible for these defects. To test this, monocytes from the blood of ...

journal_title：Journal of leukocyte biology

authors： Schibler KR,Trautman MS,Liechty KW,White WL,Rothstein G,Christensen RD

更新日期：1993-04-01 00:00:00

abstract：:We investigated the pathogenesis of lung injury in sepsis (septic adult respiratory distress syndrome) by focusing on the functional changes of alveolar macrophages (AMs). Sepsis was induced in male WK rats by cecal ligation and puncture. Histological examination of the lungs from this experimental model revealed edem...

journal_title：Journal of leukocyte biology

authors： Goya T,Abe M,Shimura H,Torisu M

更新日期：1992-08-01 00:00:00

abstract：:IL-7R, FLT3, and CD43 are surface antigens expressed during the transition from pro-B to pre-B cells in BM. To understand interactions between their signaling pathways, we analyzed spontaneous mouse B-LBLs with dual MLV integration into Stat5a and Fiz1 or Stat5a and Hipk2. MLV integration resulted in up-regulation of ...

journal_title：Journal of leukocyte biology

authors： Tsuruyama T,Imai Y,Takeuchi H,Hiratsuka T,Maruyama Y,Kanaya K,Kaszynski R,Jin G,Okuno T,Ozeki M,Nakamura T,Takakuwa T,Manabe T,Tamaki K,Hiai H

更新日期：2010-07-01 00:00:00

abstract：:Mast cell activation requires Cl(-) flux, which maintains the driving force for entry of extracellular calcium and initiates release of mediators such as histamine. However, chloride channel expression in mast cells has been poorly understood. For the first time, reverse transcriptase-polymerase chain reaction shows t...

journal_title：Journal of leukocyte biology

authors： Kulka M,Gilchrist M,Duszyk M,Befus AD

更新日期：2002-01-01 00:00:00

abstract：:Fluoroquinolones have immunomodulatory properties and interfere with cytokine production. The aim of this study was to characterize the extent of the superinduced mRNA levels in activated human lymphocytes incubated with ciprofloxacin (5 and 80 micro g/ml) using a cytokine gene expression microarray from R and D Syste...

journal_title：Journal of leukocyte biology

authors： Eriksson E,Forsgren A,Riesbeck K

更新日期：2003-09-01 00:00:00

abstract：:Fluid-phase endocytosis is stimulated by H-ras-linked growth factor receptors and this stimulation requires activation of rab5. We utilized a GFP-rab5a:wt fusion protein to monitor GFP-rab5a:wt activation in living fibroblasts and in J774 macrophages. Control CHO cells that expressed GFP-rab5a:wt were cultured in seru...

journal_title：Journal of leukocyte biology

authors： Roberts RL,Barbieri MA,Ullrich J,Stahl PD

更新日期：2000-11-01 00:00:00

abstract：:The identification of an anti-tumor effect displayed by cells of innate immunity has opened new scenarios, not only in the field of allo-HSCT but also for nontransplanted patients with hematological malignancies or solid tumors. Donor-derived NK cells have been shown to contribute to the eradication of malignant cells...

journal_title：Journal of leukocyte biology

authors： Locatelli F,Merli P,Rutella S

更新日期：2013-12-01 00:00:00

abstract：:Changes in leukocyte subpopulations and function after spaceflight have been observed but the mechanisms underlying these changes are not well defined. This study investigated the effects of short-term spaceflight (8-15 days) on circulating leukocyte subsets, stress hormones, immunoglobulin levels, and neutrophil func...

journal_title：Journal of leukocyte biology

authors： Stowe RP,Sams CF,Mehta SK,Kaur I,Jones ML,Feeback DL,Pierson DL

更新日期：1999-02-01 00:00:00

abstract：:Evidence that gamma/delta T cells play a broad, immunoregulatory role has been accumulating steadily. We show here that myeloid cells are disregulated after peritoneal infection with Listeria monocytogenes in mice lacking gamma/delta T cells. Inflammatory populations of neutrophils and monocytes recruited to the site ...

journal_title：Journal of leukocyte biology

authors： Skeen MJ,Freeman MM,Ziegler HK

更新日期：2004-07-01 00:00:00