Abstract:
:C1qR(P) is a type I cell surface glycoprotein that has been shown to enhance ingestion of suboptimally opsonized targets by phagocytes in vitro. In this study, we developed and characterized polyclonal antibodies to study the tissue distribution of this receptor targeted to either the N- or C-terminal portion of the molecule. C1qR(P) was detected in vascular endothelial cells and in a subset of pyramidal neurons in the brain, as well as neutrophils, but it was absent in most tissue macrophages. Analysis of in vitro differentiation of blood monocytes to dendritic cells demonstrated a down-regulation of the receptor as monocytes differentiate to dendritic cells, providing a possible explanation for the lack of reactivity of these cells in tissue. The predominant presence of C1qR(P) in endothelial cells, while compatible with a phagocytic role in host defense and/or clearance of cellular material, suggests other possible novel roles for this receptor.
journal_name
J Leukoc Bioljournal_title
Journal of leukocyte biologyauthors
Fonseca MI,Carpenter PM,Park M,Palmarini G,Nelson EL,Tenner AJsubject
Has Abstractpub_date
2001-11-01 00:00:00pages
793-800issue
5eissn
0741-5400issn
1938-3673journal_volume
70pub_type
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