Abstract:
:Growth hormone controls somatic growth in mammals by regulating the production of IGF-1, which is predominantly made by the liver. The development of cells within the MPS is controlled by the lineage-specific growth factor M-CSF (CSF-1). In this review, we summarize the role of CSF-1-dependent macrophages in somatic growth and organogenesis. We propose that macrophages are the major extrahepatic source of IGF-1 and that a surge of CSF-1 production contributes to the control of postnatal growth and organ maturation. Accordingly, CSF-1 may be considered a part of the GH/IGF-1 axis.
journal_name
J Leukoc Bioljournal_title
Journal of leukocyte biologyauthors
Gow DJ,Sester DP,Hume DAdoi
10.1189/jlb.0310158subject
Has Abstractpub_date
2010-09-01 00:00:00pages
475-81issue
3eissn
0741-5400issn
1938-3673pii
jlb.0310158journal_volume
88pub_type
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