The iron export protein ferroportin 1 is differentially expressed in mouse macrophage populations and is present in the mycobacterial-containing phagosome.

abstract：:STAT1 is a key effector of cytokines involved in the resistance to pathogens; its identified transcriptional targets mediate the innate immune response involved in the defense against viruses and bacteria. Little is known about the role of STAT1 in adaptive immunity, including its impact on BCR or surface Ig expressio...

journal_title：Journal of leukocyte biology

authors： Najjar I,Deglesne PA,Schischmanoff PO,Fabre EE,Boisson-Dupuis S,Nimmerjahn F,Bornkamm GW,Dusanter-Fourt I,Fagard R

更新日期：2010-06-01 00:00:00

abstract：:New tools are required to expedite the development of an effective vaccine against the blood-stage infection with the human malaria parasite Plasmodium falciparum. This work describes the assessment of the ADRB assay in a mouse model, characterizing the functional interaction between antimalarial serum antibodies and ...

journal_title：Journal of leukocyte biology

authors： Llewellyn D,de Cassan SC,Williams AR,Douglas AD,Forbes EK,Adame-Gallegos JR,Shi J,Pleass RJ,Draper SJ

更新日期：2014-02-01 00:00:00

abstract：:Intact cellular migration is critically important for the induction and regulation of the immune response. The Wiskott-Aldrich syndrome protein (WASP) regulates surface receptor signaling to the actin cytoskeleton in hematopoietic cells and thus plays a pivotal role in cellular locomotion. WASP deficiency causes the W...

journal_title：Journal of leukocyte biology

authors： Snapper SB,Meelu P,Nguyen D,Stockton BM,Bozza P,Alt FW,Rosen FS,von Andrian UH,Klein C

更新日期：2005-06-01 00:00:00

abstract：:Monocytes have been categorized in three main subpopulations based on CD14 and CD16 surface expression. Classical monocytes express the CD14(++)CD16(-)CCR2(+) phenotype and migrate to inflammatory sites by quickly responding to CCL2 signaling. Here, we identified and characterized the expansion of a novel monocyte sub...

journal_title：Journal of leukocyte biology

authors： Gama L,Shirk EN,Russell JN,Carvalho KI,Li M,Queen SE,Kalil J,Zink MC,Clements JE,Kallas EG

更新日期：2012-05-01 00:00:00

abstract：:In this study, we examined the expression of nerve growth factor (NGF) and its receptors in mouse macrophages and the mechanisms involved in the effect of NGF on tumor necrosis factor (TNF)-alpha production. Macrophages expressed NGF and the NGF receptors TrkA and p75. Treatment of J744 cells or peritoneal macrophages...

journal_title：Journal of leukocyte biology

authors： Barouch R,Kazimirsky G,Appel E,Brodie C

更新日期：2001-06-01 00:00:00

abstract：:Precursors of dendritic cells (pre-DCs) arise in the bone marrow (BM), egress to the blood, and finally migrate to peripheral tissue, where they differentiate to conventional dendritic cells (cDCs). Upon their activation, antigen-bearing cDCs migrate from peripheral tissue to regional lymph nodes (LNs) in a manner dep...

journal_title：Journal of leukocyte biology

authors： Nakano H,Lyons-Cohen MR,Whitehead GS,Nakano K,Cook DN

更新日期：2017-05-01 00:00:00

abstract：:Antibody-facilitated macrophage (MP) destruction of Trypanosoma musculi involves ingestion and intracellular degradation of the parasites. It is likely, however, as we show here, that death of the trypanosomes is extracellular and it is the corpses that are ingested by MPs. We have utilized both peritoneal MPs and a c...

journal_title：Journal of leukocyte biology

authors： Albright JW,Stewart MJ,Latham PS,Albright JF

更新日期：1994-11-01 00:00:00

abstract：:Structurally, the monocyte chemotactic proteins MCP-1, -2, and -3 form a subfamily of the C-C or beta-chemokines. Like other chemokines, MCPs are produced by a variety of cells on stimulation with cytokines (interleukin-1, tumor necrosis factor-alpha, interferon-gamma), bacterial and viral products or mitogens. MCP-1 ...

journal_title：Journal of leukocyte biology

authors： Proost P,Wuyts A,Van Damme J

更新日期：1996-01-01 00:00:00

abstract：:Recombinant fusion proteins consisting of the extracellular domain of immunoregulatory proteins and the constant domain of immunoglobulin G (IgG) are a novel class of human therapeutics. IgG isoforms exert different levels of immune effector functions, such as complement lysis and antibody-dependent cell cytotoxicity ...

journal_title：Journal of leukocyte biology

authors： Taylor L,Bachler M,Duncan I,Keen S,Fallon R,Mair C,McDonald TT,Schwarz H

更新日期：2002-09-01 00:00:00

abstract：:Aged and protein-malnourished hosts have diminished febrile responses and increased morbidity and mortality from infection that could be due to deficiencies in the production of certain monokines. In this study, the ability of peritoneal macrophages from aged and protein-malnourished rats to produce IL-1 and TNF was e...

journal_title：Journal of leukocyte biology

authors： Bradley SF,Vibhagool A,Kunkel SL,Kauffman CA

更新日期：1989-06-01 00:00:00

abstract：:The effects of brefeldin A, monensin, and the weak base NH4Cl on the biosynthesis and processing of cathepsin G and neutrophil elastase of myeloid cells were investigated. Monoblast-like U-937 cells were biosynthetically labeled with [35S]methionine, followed by subcellular fractionation, immunoprecipitation, and anal...

journal_title：Journal of leukocyte biology

authors： Lindmark A,Gullberg U,Olsson I

更新日期：1994-01-01 00:00:00

abstract：:An epithelial cell line, IT-45R1, has been established from a thymus of normal Wistar rat and was found to produce growth factor which stimulated the proliferation of bone marrow cells. This growth factor induced the formation of colonies composed of macrophages, granulocytes, or both, in semi-solid medium and stimula...

journal_title：Journal of leukocyte biology

authors： Nanno M,Takahashi T,Sakata T,Horikawa T,Sako T,Suzuki R,Itoh T,Kumagai K

更新日期：1991-12-01 00:00:00

abstract：:Infection with the opportunistic pathogen Pseudomonas aeruginosa is effectively controlled through tightly coordinated inflammation in healthy individuals. Dysregulated inflammation in cystic fibrosis greatly increases susceptibility to P. aeruginosa and lung damage. Recently, we identified regulator of calcineurin-1,...

journal_title：Journal of leukocyte biology

authors： Pang Z,Junkins RD,MacNeil AJ,McCormick C,Cheng Z,Chen WM,Lin TJ

更新日期：2017-12-01 00:00:00

abstract：:Individuals with T2D and PD suffer significantly from the ability of one disease to intensify the other. Disease-associated inflammation is one mechanism thought to fuel this pathogenic feed-forward loop. Several lines of evidence indicate that proinflammatory B cells promote T2D and PD; thus, B cells are top candidat...

journal_title：Journal of leukocyte biology

authors： Zhu M,Belkina AC,DeFuria J,Carr JD,Van Dyke TE,Gyurko R,Nikolajczyk BS

更新日期：2014-08-01 00:00:00

abstract：:Enhancer of zeste homolog 2 (EZH2) is aberrantly expressed or mutated in multiple types of cancer cells and plays an oncogenic role in tumorigenesis and development in most cancers. Results from pilot clinical studies have implied that EZH2 inhibitors have therapeutic potential against some cancers. However, the exact...

journal_title：Journal of leukocyte biology

authors： Shao FF,Chen BJ,Wu GQ

更新日期：2020-10-11 00:00:00

abstract：:An important mediator of inflammation is prostaglandin E2 (PGE2 ), whose levels are determined by the activity of the enzyme cyclooxygenase (COX). Of the two isoforms of the enzyme, COX-2 has been shown to be induced in macrophages during inflammation. Although general COX inhibitors, belonging to the class of nonster...

journal_title：Journal of leukocyte biology

authors： Akter S,Sharma RK,Sharma S,Rastogi S,Fiebich BL,Akundi RS

更新日期：2021-01-13 00:00:00

abstract：:Over 1.4 million Americans have been diagnosed with inflammatory bowel disease (IBD), and ulcerative colitis (UC) makes up approximately half of those diagnoses. As a disease, UC cycles between periods of remission and flare, which is characterized by intense abdominal pain, increased weight loss, intestinal inflammat...

journal_title：Journal of leukocyte biology

authors： Cannon AR,Kuprys PV,Cobb AN,Ding X,Kothari AN,Kuo PC,Eberhardt JM,Hammer AM,Morris NL,Li X,Choudhry MA

更新日期：2018-09-01 00:00:00

abstract：:The activation of dendritic cells (DC) via Toll-like receptors (TLRs) plays a decisive role in shaping the outcome of primary immune responses. Following TLR engagement by microbial products, DC migrate from peripheral tissues to lymphoid organs and up-regulate major histocompatibility complex and costimulatory molecu...

journal_title：Journal of leukocyte biology

authors： Mazzoni A,Segal DM

更新日期：2004-05-01 00:00:00

abstract：:Although a number of chemokine receptors display coreceptor activities in vitro, chemokine receptor 5 (CCR5) and CXC chemokine receptor 4 (CXCR4) remain the major coreceptors used by the human immunodeficiency virus type 1 (HIV-1). In this study, we used an envelope-mediated fusion assay to demonstrate low CCR4 corece...

journal_title：Journal of leukocyte biology

authors： Agrawal L,Vanhorn-Ali Z,Alkhatib G

更新日期：2002-11-01 00:00:00

abstract：:Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a naturally occurring growth factor produced by several cell types in response to a variety of stimuli. GM-CSF has potent stimulatory effects on the growth and maturation of hematopoietic cells and has profound effects on mature circulating effector cells. C...

journal_title：Journal of leukocyte biology

authors： Hill AD,Naama HA,Calvano SE,Daly JM

更新日期：1995-12-01 00:00:00

abstract：:LPS induces dendritic cell (DC) activation, but the precise in vivo mechanism is unclear since DCs express low levels of TLR4. Here, it is shown that DCs can be activated in response to LPS through a bystander mechanism. This result was obtained using chimeric mice reconstituted with LPS-responsive and nonresponsive b...

journal_title：Journal of leukocyte biology

authors： Yadav R,Zammit DJ,Lefrancois L,Vella AT

更新日期：2006-12-01 00:00:00

abstract：:The IL-1-related molecules, IL-1 and IL-18, can promote Th2 cytokine production by IgE/antigen-FcepsilonRI-stimulated mouse mast cells. Another IL-1-related molecule, IL-33, was identified recently as a ligand for T1/ST2. Although mouse mast cells constitutively express ST2, the effects of IL-33 on mast cell function ...

journal_title：Journal of leukocyte biology

authors： Ho LH,Ohno T,Oboki K,Kajiwara N,Suto H,Iikura M,Okayama Y,Akira S,Saito H,Galli SJ,Nakae S

更新日期：2007-12-01 00:00:00

abstract：:High mobility group box 1 (HMGB1) is one of the recently defined damage-associated molecular pattern molecules, passively released from necrotic cells and secreted by activated macrophage/monocytes. Whether cytolytic cells induce HMGB1 release from tumor cells is not known. We developed a highly sensitive method for d...

journal_title：Journal of leukocyte biology

authors： Ito N,DeMarco RA,Mailliard RB,Han J,Rabinowich H,Kalinski P,Stolz DB,Zeh HJ 3rd,Lotze MT

更新日期：2007-01-01 00:00:00

abstract：:Inbred mouse strains have been known for many years to vary in their degree of susceptibility to different types of infectious diseases. The genetic basis of these interstrain differences is sometimes simple but often complex. In a few cases, positional cloning has been used successfully to identify single gene effect...

journal_title：Journal of leukocyte biology

authors： Fortier A,Min-Oo G,Forbes J,Lam-Yuk-Tseung S,Gros P

更新日期：2005-06-01 00:00:00

abstract：:Cyclophilin A (CypA), a peptidylprolyl cis-trans isomerase, is a ubiquitous and multifunctional protein. In addition to its role as a host-cell receptor for cyclosporine A, CypA has diverse functions in inflammatory conditions and diseases. CypA secreted in response to inflammatory stimuli binds to the cell surface vi...

journal_title：Journal of leukocyte biology

authors： Dawar FU,Xiong Y,Khattak MNK,Li J,Lin L,Mei J

更新日期：2017-10-01 00:00:00

abstract：:CD163, a monocyte and macrophage-specific surface glycoprotein, which is increased by interleukin-10 and glucocorticoids, is a scavenger receptor for hemoglobin/haptoglobin complexes. We report a rapid and highly reproducible rise in soluble CD163 in the plasma of human volunteers given intravenous lipopolysaccharide ...

journal_title：Journal of leukocyte biology

authors： Hintz KA,Rassias AJ,Wardwell K,Moss ML,Morganelli PM,Pioli PA,Givan AL,Wallace PK,Yeager MP,Guyre PM

更新日期：2002-10-01 00:00:00

abstract：:The Hedgehog (Hh) family of signaling molecules functions in the development of numerous tissues during embryogenesis and has also been involved in adult self-renewing tissues. Recent results have demonstrated that the different components of the Hh signaling pathway are expressed in the human thymus. In this study, w...

journal_title：Journal of leukocyte biology

authors： Varas A,Hernández-López C,Valencia J,Mattavelli S,Martínez VG,Hidalgo L,Gutiérrez-Frías C,Zapata AG,Sacedón R,Vicente A

更新日期：2008-06-01 00:00:00

abstract：:Extracellular ATP mediates a diverse array of biological responses in many cell types and tissues, including immune cells. We have demonstrated that ATP induces purinergic receptor P2X(7) mediated membrane permeabilization, apoptosis, and cytokine expression in murine mast cells (MCs). Here, we report that MCs deficie...

journal_title：Journal of leukocyte biology

authors： Bulanova E,Budagian V,Orinska Z,Koch-Nolte F,Haag F,Bulfone-Paus S

更新日期：2009-04-01 00:00:00

abstract：:IL-17 has been associated with selected inflammatory and autoimmune diseases. We characterized the expression of this proinflammatory cytokine following HSV-1 corneal infection and investigated whether IL-17R signaling modulated the host response to the viral pathogen at early time-points postinfection. IL-17 was elev...

journal_title：Journal of leukocyte biology

authors： Molesworth-Kenyon SJ,Yin R,Oakes JE,Lausch RN

更新日期：2008-02-01 00:00:00

abstract：:IL-1 receptor-associated kinase (IRAK) 4 is a central enzyme of the TLR pathways. This study tested the hypothesis that IRAK4 kinase activity is prerequisite for regulating innate immunity during infections with intracellular bacteria. To this end, we analyzed responses of macrophages obtained from mice expressing wil...

journal_title：Journal of leukocyte biology

authors： Pattabiraman G,Murphy M,Agliano F,Karlinsey K,Medvedev AE

更新日期：2018-10-01 00:00:00